A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug–Drug Interaction

BACKGROUND: Fusidic acid (FA) has been used for decades for bone infection, including prosthetic joint infection (PJI), often in combination with rifampin (RIF). An FA/RIF pharmacokinetic interaction has not previously been described. METHODS: In a phase 2 open-label randomized study, we evaluated oral FA/RIF vs standard-of-care (SOC) intravenous antibiotics for treatment of hip or knee PJI. Outcome assessment occurred at reimplantation (week 12) for subjects with 2-stage exchange, and after 3 or 6 months of treatment for subjects with hip or knee debride and retain strategies, respectively. RESULTS: Fourteen subjects were randomized 1:1 to FA/RIF or SOC. Pharmacokinetic profiles were obtained for 6 subjects randomized to FA/RIF. FA concentrations were lower than anticipated in all subjects during the first week of therapy, and at weeks 4 and 6, blood levels continued to decline. By week 6, FA exposures were 40%-45% lower than expected. CONCLUSIONS: The sponsor elected to terminate this study due to a clearly illustrated drug-drug interaction between FA and RIF, which lowered FA levels to a degree that could influence subject outcomes. Optimization of FA exposure if used in combination with RIF should be a topic of future research. CLINICAL TRIALS REGISTRATION: NCT01756924

A solvable model of axisymmetric and non-axisymmetric droplet bouncing

We introduce a solvable Lagrangian model for droplet bouncing. The model predicts that, for an axisymmetric drop, the contact time decreases to a constant value with increasing Weber number, in qualitative agreement with experiments, because the system is well approximated as a simple harmonic oscillator. We introduce asymmetries in the velocity, initial droplet shape, and contact line drag acting on the droplet and show that asymmetry can often lead to a reduced contact time and lift-off in an elongated shape. The model allows us to explain the mechanisms behind non-axisymmetric bouncing in terms of surface tension forces. Once the drop has an elliptical footprint the surface tension force acting on the longer sides is greater. Therefore the shorter axis retracts faster and, due to the incompressibility constraints, pumps fluid along the more extended droplet axis. This leads to a positive feedback, allowing the drop to jump in an elongated configuration, and more quickly

Animales en la poesía : una selección

RESUMEN : La presente es una antología de poemas sobre animales que hemos decidido llamar así, simplemente, Animales en la poesía, distinto al título de Bestiario, que contemplamos inicialmente, debido a cierta generalización que, bajo ese nombre, se reúne animales de toda índole, incluso aquellos pequeños animales que poco prefiguran un bestiario. Esta designación, justamente, designaría una reunión de bestias y estas están definidas, genéricamente, como animales de cuatro patas; entonces ello desmentiría o se prestaría para equívocos...CONTENIDO : Animales en la poesía. -- Kuyata. -- Poema con caballos rojos. -- Un cruce. -- Insectos en la misa. -- Gato casero. -- El gallinazo gira sobre los árboles. -- La serpiente que danza. -- El dragón azulado. -- A un perro. -- Ciervo. -- Cervatillo. -- Avechucho. -- Necoclí. -- Pez muerto. -- En el bosque, al lado del mar. -- Sobre las colinas. -- La perrita coja. -- El loro. -- Giran, giran. -- Pájaros. -- Cangrejos en el Morrosquillo. -- Garcilla bueyera. -- El burro. -- El gatopájaro. -- Bestia mía. -- Habla la vaca (fragmento). -- Un pueblo de amos... -- La mosca. -- Una avispa sobre el agua. -- Hormiga y faraona. -- Tulipanes rojos. -- La mariposa. -- El armadillo. -- Olvidadas ya la libertad y la floresta. -- Verdor. -- Reciclando. -- Milacos. -- Respuesta al párroco. -- La más pequeña abeja. -- El cóndor. -- La canción de los osos. -- Espíritu de pájaro. -- Aves de mar. -- La sirena. -- Un mono