Savannah Hockey Classic Attendance Motivation

The Savannah Hockey Classic has become a very successful annual university club hockey team tournament. The 21st edition of the tournament was held in January 2020 in Savannah, Ga. featuring the Georgia Institute of Technology, University of Florida, Florida State University, and University of Georgia club hockey teams—the same teams that have comprised the tournament for many years. This study utilized Personal Investment Theory (Braskamp, 1986) and the SPEED scale (Funk, Filo, Beaton, & Pritchard, 2009) for attendance motivation assessment. Social interaction motivations were significantly higher for county residents, spectators attending with friends, spectators attending with family, and past Savannah Hockey Classic attendees. Motivations related to athlete performance were significantly higher for those who had attended the event in the past. Excitement based motivations were greater for those who had attended the event in the past as well as for those who identified as a fan of one of the teams. There were significant differences related to the esteem and diversion constructs for those who had a team rooting interest. The article fills a gap in the literature by providing the first study of club hockey attendance motivations

Feeding Fiber from Wet Corn Gluten Feed and Corn Silage in Feedlot Diets Containing Wet Distillers Grains Plus Solubles

A feedlot experiment evaluated the effect of increasing fiber in distillers grains diets on ADG, F:G, and nutrient mass balance. The treatments consisted of 1) 30% modified distillers grains plus solubles, no roughage (MDGS), and 2) 30% modified distillers grains plus solubles, 30% wet corn gluten feed, and 15% corn silage (MDGS+fiber). The remainder of each diet consisted of a 1:1 ratio of high moisture corn and dry rolled corn and 5% supplement. Feeding MDGS+fiber increased (P \u3c 80.02) ADG, DMI, and HCW; however, it did not improve F:G compared to MDGS. By increasing the fiber content of the diet, more organic matter (OM) and N remained in the manure. Percentage N loss was not different between dietary treatments; however, amount of N lost increased with MDGS + fiber due to the greater N intake and excretion

Effect of Pen Cleaning Frequency and Feeding Distillers Grains and Wheat Straw on Nutrient Mass Balance and Performance of Feedlot Steers

Two experiments, calves fed November to May (WINTER) and yearlings fed May to September (SUMMER), were conducted to evaluate the effects of feeding a high level of wet distillers grains plus soluble (WDGS) and wheat straw or a corn control diet (CON) on average daily gain (ADG), feed-to-gain (F:G), manure nitrogen (N), and N losses. In both experiments, the CON treatment had greater dry matter intake(DMI), ADG hot carcass weight (HCW), marbling and fat depth. There was greater N intake and N excretion for both the WINTER and SUMMER experiments on the WDGS. However, for the WINTER experiment there was no difference in the amount of N in the manure due to diet or pen cleaning frequency. In the SUMMER experiment, cleaning pens monthly almost doubled dry matter (DM), organic matter (OM), and N removed in manure. There was a tendency for the WDGS treatment to have greater N loss than the control treatment in the WINTER experiment and a significant increase in N losses for the WDGS treatment in the SUMMER experiment, despite the greater amount of manure N removed

Nab-paclitaxel-based compared to docetaxel-based induction chemotherapy regimens for locally advanced squamous cell carcinoma of the head and neck

We previously reported that nab-paclitaxel-based induction chemotherapy (IC) and concurrent chemoradiotherapy resulted in low relapse rates (13%) and excellent survival in head and neck squamous cell carcinoma (HNSCC). We compare the disease-specific survival (DSS) and overall survival (OS) between patients given nab-paclitaxel, cisplatin, and fluorouracil with cetuximab (APF-C) and historical controls given docetaxel, cisplatin, and fluorouracil with cetuximab (TPF-C). Patients with locally advanced HNSCC were treated with APF-C (n = 30) or TPF-C (n = 38). After 3 cycles of IC, patients were scheduled to receive cisplatin concurrent with definitive radiotherapy. T and N classification and smoking history were similar between the two groups and within p16-positive and p16-negative subsets. The median duration of follow-up for living patients in the APF-C group was 43.5 (range: 30–58) months versus 52 (range: 13–84) months for TPF-C. The 2-year DSS for patients treated with APF-C was 96.7% [95% Confidence Interval (CI): 85.2%, 99.8%] and with TPF-C was 77.6% (CI: 62.6%, 89.7%) (P = 0.0004). Disease progression that resulted in death was more frequent in the TPF-C group (39%) compared with the APF-C group (3%) when adjusted for competing risks of death from other causes (Gray's test, P = 0.0004). In p16 positive OPSCC, the 2-year DSS for APF-C was 100% and for TPF-C was 74.6% (CI: 47.4%, 94.6%) (P = 0.0019) and the 2-year OS for APF-C was 94.1% (CI: 65.0%, 99.2%) and for TPF-C was 74.6% (CI: 39.8%, 91.1%) (P = 0.013). In p16 negative HNSCC, the 2-year DSS for APF-C was 91.7% (CI: 67.6%, 99.6%) and for TPF-C was 82.6% (CI: 64.4%, 94.8%) (P = 0.092). A 2-year DSS and OS were significantly better with a nab-paclitaxel-based IC regimen (APF-C) compared to a docetaxel-based IC regimen (TPF-C) in p16-positive OPSCC

The Otterbein Miscellany - May 1972

https://digitalcommons.otterbein.edu/miscellany/1016/thumbnail.jp

A Long-Term Vision for an Ecologically Sound Platte River

The Platte River extends about 310 mi (499 km) from North Platte, Nebraska, to its terminus at the Missouri River confluence near Plattsmouth, Nebraska. The Platte River Valley is a continentally significant ecosystem that serves as a major stopover for migratory waterbirds in the Central Flyway including the endangered Whooping Crane (Grus americana) and \u3e1 million Sandhill Cranes (Antigone canadensis) at the peak of spring migration. However, the Platte River Valley also supports a great diversity of avifauna including grassland breeding birds, native stream fish, vascular plants, herpetofauna, mammals, pollinators, and aquatic macroinvertebrates. Despite ongoing conservation efforts since the mid-1970s the ecosystem remains largely conservation dependent and an increasing number of species across taxa are being considered at risk of regional extirpation or outright extinction. However, given the attention provided to conservation in the Platte River Valley and the need to maintain ecologically functional stopover sites in the Central Flyway, there is a great opportunity to create a resilient refugium for biodiversity conservation in the central Great Plains. To that end we convened a working group of \u3e18 individuals representing \u3e9 organizations including representatives from non-profit conservation organizations, universities, and state and federal natural resource agencies to develop a long-term vision for an ecologically sound Platte River Valley (PRV). We met in groups of varying size for \u3e170 hours throughout a more than 3-year period and developed conservation priorities and objectives using a landscape design process. Landscape design is an interdisciplinary conservation planning process that incorporates components of landscape ecology and social dimensions of natural resources with the explicit intention of improving conservation implementation.https://digitalcommons.unl.edu/zeabook/1128/thumbnail.jp

The impact of Mendelian sleep and circadian genetic variants in a population setting

Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, CRY2, CSNK1D and TIMELESS) and delayed sleep phase (CRY1). The association of variants in these genes with extreme sleep conditions were usually based on clinically ascertained families, and their effects when identified in the population are unknown. We aimed to determine the effects of these variants on sleep traits in large population-based cohorts. We performed genetic association analysis of variants previously reported to be causal for Mendelian sleep and circadian conditions. Analyses were performed using 191,929 individuals with data on sleep and whole-exome or genome-sequence data from 4 population-based studies: UK Biobank, FINRISK, Health-2000-2001, and the Multi-Ethnic Study of Atherosclerosis (MESA). We identified sleep disorders from self-report, hospital and primary care data. We estimated sleep duration and timing measures from self-report and accelerometery data. We identified carriers for 10 out of 12 previously reported pathogenic variants for 8 of the 10 genes. They ranged in frequency from 1 individual with the variant in CSNK1D to 1,574 individuals with a reported variant in the PER3 gene in the UK Biobank. No carriers for variants reported in NPSR1 or PER2 were identified. We found no association between variants analyzed and extreme sleep or circadian phenotypes. Using sleep timing as a proxy measure for sleep phase, only PER3 and CRY1 variants demonstrated association with earlier and later sleep timing, respectively; however, the magnitude of effect was smaller than previously reported (sleep midpoint similar to 7 mins earlier and similar to 5 mins later, respectively). We also performed burden tests of protein truncating (PTVs) or rare missense variants for the 10 genes. Only PTVs in PER2 and PER3 were associated with a relevant trait (for example, 64 individuals with a PTV in PER2 had an odds ratio of 4.4 for being "definitely a morning person", P = 4x10(-8); and had a 57-minute earlier midpoint sleep, P = 5x10(-7)). Our results indicate that previously reported variants for Mendelian sleep and circadian conditions are often not highly penetrant when ascertained incidentally from the general population.Peer reviewe

A13K-0336: Airborne Multi-Wavelength High Spectral Resolution Lidar for Process Studies and Assessment of Future Satellite Remote Sensing Concepts

NASA Langley recently developed the world's first airborne multi-wavelength high spectral resolution lidar (HSRL). This lidar employs the HSRL technique at 355 and 532 nm to make independent, unambiguous retrievals of aerosol extinction and backscatter. It also employs the standard backscatter technique at 1064 nm and is polarization-sensitive at all three wavelengths. This instrument, dubbed HSRL-2 (the secondgeneration HSRL developed by NASA Langley), is a prototype for the lidar on NASA's planned Aerosols- Clouds-Ecosystems (ACE) mission. HSRL-2 completed its first science mission in July 2012, the Two-Column Aerosol Project (TCAP) conducted by the Department of Energy (DOE) in Hyannis, MA. TCAP presents an excellent opportunity to assess some of the remote sensing concepts planned for ACE: HSRL-2 was deployed on the Langley King Air aircraft with another ACE-relevant instrument, the NASA GISS Research Scanning Polarimeter (RSP), and flights were closely coordinated with the DOE's Gulfstream-1 aircraft, which deployed a variety of in situ aerosol and trace gas instruments and the new Spectrometer for Sky-Scanning, Sun-Tracking Atmospheric Research (4STAR). The DOE also deployed their Atmospheric Radiation Measurement Mobile Facility and their Mobile Aerosol Observing System at a ground site located on the northeastern coast of Cape Cod for this mission. In this presentation we focus on the capabilities, data products, and applications of the new HSRL-2 instrument. Data products include aerosol extinction, backscatter, depolarization, and optical depth; aerosol type identification; mixed layer depth; and rangeresolved aerosol microphysical parameters (e.g., effective radius, index of refraction, single scatter albedo, and concentration). Applications include radiative closure studies, studies of aerosol direct and indirect effects, investigations of aerosol-cloud interactions, assessment of chemical transport models, air quality studies, present (e.g., CALIPSO) and future (e.g., EarthCARE) satellite calibration/validation, and development/assessment of advanced retrieval techniques for future satellite applications (e.g., lidar+polarimeter retrievals of aerosol and cloud properties). We will also discuss the relevance of HSRL-2 measurement capabilities to the ACE remote sensing concept

Mixed Layer Heights Derived from the NASA Langley Research Center Airborne High Spectral Resolution Lidar

The NASA airborne High Spectral Resolution Lidar (HSRL) has been deployed on board the NASA Langley Research Center's B200 aircraft to several locations in North America from 2006 to 2012 to aid in characterizing aerosol properties for over fourteen field missions. Measurements of aerosol extinction (532 nm), backscatter (532 and 1064 nm), and depolarization (532 and 1064 nm) during 349 science flights, many in coordination with other participating research aircraft, satellites, and ground sites, constitute a diverse data set for use in characterizing the spatial and temporal distribution of aerosols, as well as properties and variability of the Mixing Layer (ML) height. We describe the use of the HSRL data collected during these missions for computing ML heights and show how the HSRL data can be used to determine the fraction of aerosol optical thickness within and above the ML, which is important for air quality assessments. We describe the spatial and temporal variations in ML heights found in the diverse locations associated with these experiments. We also describe how the ML heights derived from HSRL have been used to help assess simulations of Planetary Boundary Layer (PBL) derived using various models, including the Weather Research and Forecasting Chemistry (WRF-Chem), NASA GEOS-5 model, and the ECMWF/MACC models

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and signaling responses to inflammatory ligands were assessed in peripheral blood from patients with mild, moderate, and severe COVID-19, at the time of diagnosis. Using an integrated computational approach to analyze the combined plasma and single-cell proteomic data, we identified and independently validated a multivariate model classifying COVID-19 severity (multi-class AUCtraining = 0.799, p-value = 4.2e-6; multi-class AUCvalidation = 0.773, p-value = 7.7e-6). Features of this high-dimensional model recapitulated recent COVID-19 related observations of immune perturbations, and revealed novel biological signatures of severity, including the mobilization of elements of the renin-angiotensin system and primary hemostasis, as well as dysregulation of JAK/STAT, MAPK/mTOR, and NF-κB immune signaling networks. These results provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for the prevention of COVID-19 progression