« Etude intégrée de l'environnement de la région de Nouakchott ».

82 p.Rapport scientifique du projet CAMPUS n°97-315-104

« Rapport sur les risques d'inondation de la zone littorale de Nouakchott ».

30 p.Rapport d'expertise, Ministère des pêches et de l'Economie maritime, Ambassade de France, Union mondiale pour la natur

Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymph-nodes

International audiencePurpose: Metastatic breast cancer is a leading cause of mortality in women, partly on account of brain metastases. However, the mechanisms by which cancer cells cross the blood-brain barrier remain undeciphered. Most molecular studies predicting metastatic risk have been performed on primary breast cancer samples. Here we studied metastatic lymph-nodes from patients with breast cancers to identify markers associated with the occurrence of brain metastases. Results: Transcriptomic analyses identified CDKN2A/p16 as a gene potentially associated with brain metastases. Materials and Methods: Fifty-two patients with HER2-overexpressing or triplenegative breast carcinoma with lymph nodes and distant metastases were included in this study. Transcriptomic analyses were performed on laser-microdissected tumor cells from 28 metastatic lymph-nodes. Supervised analyses compared the transcriptomic profiles of women who developed brain metastases and those who did not. As a validation series, we studied metastatic lymph-nodes from 24 other patients. Immunohistochemistry investigations showed that p16 mean scores were significantly higher in patients with brain metastases than in patients without (7.4 vs. 1.7 respectively, p < 0.01). This result was confirmed on the validation series. Multivariate analyses showed that the p16 score was the only variable positively associated with the risk of brain metastases (p = 0.01)

Randomised clinical trial: oesophageal radiofrequency energy delivery versus sham for PPI-refractory heartburn

International audienc