Demonstration of the First Prototype of RUGBI, Design and Deployment of a Grid for Bioinformatics

présenté par N. Jacq, proceedings publiés par "Studies in health technology and informatics" seriesInternational audienceRUGBI is an industrial and academic project to design and deploy on top of existing technologies a computing grid offering a set of grid and bioinformatics services to analyse proteins. It aims to support life sciences SMEs for computing and storage, to deploy an interregional grid for bioinformatics and to create a biologists community in a grid environment. The proposed demonstration presents the first prototype of RUGBI architecture and bioinformatics services

Transition from antibunching to bunching for two dipole-interacting atoms

It is known that there is a transition from photon antibunching to bunching in the resonance fluorescence of a driven system of two two-level atoms with dipole-dipole interaction when the atomic distance decreases and the other parameters are kept fixed. We give a simple explanation for the underlying mechanism which in principle can also be applied to other systems. PACS numbers 42.50.Ar, 42.50FxComment: Submitted to Phys. Rev. A; 15 pages Latex + 4 figure

AKT activity orchestrates marginal zone B cell development in mice and humans.

The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) D <sup>+</sup> CD27 <sup>+</sup> B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgD <sup>+</sup> CD27 <sup>-</sup> and memory IgD <sup>-</sup> CD27 <sup>+</sup> B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans

Sociologia moral das dependências motivadas: o caso da dependência amorosa

Este artigo propõe um panorama do procedimento e dos métodos da sociologia moral, que se baseiam em uma etnofilosofia da existência social comum e em uma antropologia natural. A primeira parte do texto situa a sociologia moral em relação ao desenvolvimento contemporâneo das pesquisas empíricas sobre a ética, sobretudo no âmbito da psicologia experimental e evolucionista. A segunda parte apresenta alguns elementos de uma teoria das dependências motivadas aos prazeres e às recompensas, desenvolvida a partir do aporte das neurociências da adição e de pesquisas de campo sobre as condutas aditivas e as tentativas de restabelecimento. A terceira parte propõe uma ilustração do método a partir de uma pesquisa recente sobre a dependência amorosa, feita principalmente a partir de um corpus literário e cinematográfico

A multidisciplinary approach of the chronology of early medieval constructions: the case study of St Irenee 's church, Lyon (France)

International audienc

Ravageurs

‪Contexte - Depuis 2016, la noctuelle Spodoptera frugiperda, d'origine américaine, s'est établie en Afrique subsaharienne. Sa grande nuisibilité est constatée notamment sur le maïs. Présentation - Ses caractéristiques sont détaillées : morphologie et critères de différenciation d'avec les trois autres principales espèces de Spodoptera, biologie avec sa nuisibilité et sa longue liste de plantes-hôtes (dont le maïs, le sorgho, le riz, la canne à sucre et le cotonnier), cycle et dégâts. Analyse du risque - Dans un premier temps, les territoires français menacés sont ceux de l'océan Indien (La Réunion, Mayotte). Cependant, l'intensité des échanges internationaux et les capacités de dispersion naturelle du ravageur entraînent un risque plus étendu d'introduction. Une analyse climatique montre un risque d'établissement notable à élevé sur tout le pourtour méditerranéen, y compris le sud de la France, et un risque d'incursions plus au nord

Design and optimization of buck and double buck converters by means of geometric programming

10.1016/j.matcom.2012.03.004This paper describes a new method for determining the optimal components values and switching frequencies of buck DC¿DC converters. First, we revisit some concepts of the optimization technique named geometric programming. Then, we observe that the problem of converter designing can be modeled by means of an objective function and certain constraints which can be written in a specific form known as the posynomial form. The constraints involve expressions that depend on magnitudes such as efficiency, bandwidth, and current and voltage ripples. Specifically, we apply the design method in a synchronous buck converter and a synchronous cascade buck converter. This technique can efficiently determine the optimal sizing of the converter or the infeasibility of the set of design constraints in a quickly manner and, therefore, it can eases the cumbersome task of manually designing buck DC¿DC converters. As an additional result, we conclude that optimal design of the synchronous cascade buck converter performs more efficiently than the optimal design of the synchronous buck converter, given certain realistic set of specifications for wide-range voltage conversion