Economic analysis of flood risk applied to the rehabilitation of drainage networks

Over time, cities have grown, developing various activities and accumulating important economic assets. Floods are a problem that worry city administrators who seek to make cities more resilient and safer. This increase in flood events is due to different causes: poor planning, population increase, aging of networks, etc. However, the two main causes for the increase in urban flooding are the increment in frequency of extreme rainfall, generated mainly by climate change, and the increase in urbanized areas in cities, which reduce green areas, decreasing the percentage of water that seeps naturally into the soil. As a contribution to solve these problems, the work presented shows a method to rehabilitate drainage networks that contemplates implementing different actions in the network: renovation of pipes, construction of storm tanks and installation of hydraulic controls. This work focuses on evaluating the flood risk in economic terms. To achieve this, the expected annual damage from floods and the annual investments in infrastructure to control floods are estimated. These two terms are used to form an objective function to be minimized. To evaluate this objective function, an optimization model is presented that incorporates a genetic algorithm to find the best solutions to the problem; the hydraulic analysis of the network is performed with the SWMM model. This work also presents a strategy to reduce computation times by reducing the search space focused mainly on large networks. This is intended to show a complete and robust methodology that can be used by managers and administrators of drainage networks in cities

Particle methods parallel implementations by GP-GPU strategies

This paper outlines the problems found in the parallelization of SPH (Smoothed Particle Hydrodynamics) algorithms using Graphics Processing Units. Different results of some parallel GPU implementations in terms of the speed-up and the scalability compared to the CPU sequential codes are shown. The most problematic stage in the GPU-SPH algorithms is the one responsible for locating neighboring particles and building the vectors where this information is stored, since these specific algorithms raise many difficulties for a data-level parallelization. Because of the fact that the neighbor location using linked lists does not show enough data-level parallelism, two new approaches have been proposed to minimize bank conflicts in the writing and subsequent reading of the neighbor lists. The first strategy proposes an efficient coordination between CPU-GPU, using GPU algorithms for those stages that allow a straight forward parallelization, and sequential CPU algorithms for those instructions that involve some kind of vector reduction. This coordination provides a relatively orderly reading of the neighbor lists in the interactions stage, achieving a speed-up factor of x47 in this stage. However, since the construction of the neighbor lists is quite expensive, it is achieved an overall speed-up of x41. The second strategy seeks to maximize the use of the GPU in the neighbor’s location process by executing a specific vector sorting algorithm that allows some data-level parallelism. Although this strategy has succeeded in improving the speed-up on the stage of neighboring location, the global speed-up on the interactions stage falls, due to inefficient reading of the neighbor vectors. Some changes to these strategies are proposed, aimed at maximizing the computational load of the GPU and using the GPU texture-units, in order to reach the maximum speed-up for such codes. Different practical applications have been added to the mentioned GPU codes. First, the classical dam-break problem is studied. Second, the wave impact of the sloshing fluid contained in LNG vessel tanks is also simulated as a practical example of particle methods

Antiangiogenic Therapy in Epithelial Ovarian Cancer

Approximately 75% of women with ovarian cancer are diagnosed at advanced stages (FIGO stage III/IV), with 15-23 months median global survival and 20% 5-year survival. Angiogenesis plays an important role in tumour development and proliferation. Increased angiogenesis is associated with worse clinical outcome in ovarian cancer. Here we review the play of bevacizumab in the treatment of ovarian cancer and also other antiangiogenic drugs. In total, to date there are no promising results for most of the reviewed antiangiogenic agents, except those already known for bevacizumab, trebananib, pazopanib, cediranib and nintedanib. Ongoing research will shed more light on this fascinating tumour process and its control

Transient phenomena during the emptying process of a single pipe with water air interaction

[EN] Emptying pipelines can be critical in many water distribution networks because subatmospheric pressure troughs could cause considerable damage to the system due to the expansion of entrapped air. Researchers have given relatively little attention to emptying processes compared to filling processes. The intricacy of computations of this phenomenon makes it difficult to predict the behaviour during emptying, and there are only a few reliable models in the literature. In this work, a computational model for simulating the transient phenomena in single pipes is proposed, and was validated using experimental results. The proposed model is based on a rigid column to analyse water movement, the air¿water interface, and air pocket equations. Two practical cases were used to validate the model: (1) a single pipe with the upstream end closed, and (2) a single pipe with an air valve installed on the upstream end. The results show how the model accurately predicts the experimental data, including the pressure oscillation patterns and subatmospheric pressure troughs.This study was supported by the Program Fondecyt Regular [Project 1180660] of the Comision Nacional de Investigacion Cientifica y Tecnologica (Conicyt), Chile, http://data.crossref.org/fundingdata/funder/10.13039/501100002848.Fuertes-Miquel, VS.; Coronado-Hernández, OE.; Iglesias Rey, PL.; Mora Melia, D. (2019). Transient phenomena during the emptying process of a single pipe with water air interaction. Journal of Hydraulic Research. 57(3):318-326. https://doi.org/10.1080/00221686.2018.1492465S318326573Bashiri-Atrabi, H., & Hosoda, T. (2015). The motion of entrapped air cavities in inclined ducts. Journal of Hydraulic Research, 53(6), 814-819. doi:10.1080/00221686.2015.1060272Cabrera, E., Abreu, J., Pérez, R., & Vela, A. (1992). Influence of Liquid Length Variation in Hydraulic Transients. Journal of Hydraulic Engineering, 118(12), 1639-1650. doi:10.1061/(asce)0733-9429(1992)118:12(1639)Coronado-Hernández, O. E., Fuertes-Miquel, V. S., Iglesias-Rey, P. L., & Martínez-Solano, F. J. (2018). Rigid Water Column Model for Simulating the Emptying Process in a Pipeline Using Pressurized Air. Journal of Hydraulic Engineering, 144(4), 06018004. doi:10.1061/(asce)hy.1943-7900.0001446Fuertes-Miquel, V. S., López-Jiménez, P. A., Martínez-Solano, F. J., & López-Patiño, G. (2016). Numerical modelling of pipelines with air pockets and air valves. Canadian Journal of Civil Engineering, 43(12), 1052-1061. doi:10.1139/cjce-2016-0209Guinot, V. (2001). The discontinuous profile method for simulating two-phase flow in pipes using the single component approximation. International Journal for Numerical Methods in Fluids, 37(3), 341-359. doi:10.1002/fld.177Hou, Q., Tijsseling, A. S., Laanearu, J., Annus, I., Koppel, T., Bergant, A., … van ’t Westende, J. M. C. (2014). Experimental Investigation on Rapid Filling of a Large-Scale Pipeline. Journal of Hydraulic Engineering, 140(11), 04014053. doi:10.1061/(asce)hy.1943-7900.0000914Izquierdo, J., Fuertes, V. S., Cabrera, E., Iglesias, P. L., & Garcia-Serra, J. (1999). Pipeline start-up with entrapped air. Journal of Hydraulic Research, 37(5), 579-590. doi:10.1080/00221689909498518Laanearu, J., Annus, I., Koppel, T., Bergant, A., Vučković, S., Hou, Q., … van’t Westende, J. M. C. (2012). Emptying of Large-Scale Pipeline by Pressurized Air. Journal of Hydraulic Engineering, 138(12), 1090-1100. doi:10.1061/(asce)hy.1943-7900.0000631Leon, A. S., Ghidaoui, M. S., Schmidt, A. R., & Garcia, M. H. (2010). A robust two-equation model for transient-mixed flows. Journal of Hydraulic Research, 48(1), 44-56. doi:10.1080/00221680903565911Liou, C. P., & Hunt, W. A. (1996). Filling of Pipelines with Undulating Elevation Profiles. Journal of Hydraulic Engineering, 122(10), 534-539. doi:10.1061/(asce)0733-9429(1996)122:10(534)Liu, D., Zhou, L., Karney, B., Zhang, Q., & Ou, C. (2011). Rigid-plug elastic-water model for transient pipe flow with entrapped air pocket. Journal of Hydraulic Research, 49(6), 799-803. doi:10.1080/00221686.2011.621740Malekpour, A., & Karney, B. (2014). Column separation and rejoinder during rapid pipeline filling induced by a partial flow blockage. Journal of Hydraulic Research, 52(5), 693-704. doi:10.1080/00221686.2014.905502Martins, S. C., Ramos, H. M., & Almeida, A. B. (2015). Conceptual analogy for modelling entrapped air action in hydraulic systems. Journal of Hydraulic Research, 53(5), 678-686. doi:10.1080/00221686.2015.1077353Pozos, O., Gonzalez, C. A., Giesecke, J., Marx, W., & Rodal, E. A. (2010). Air entrapped in gravity pipeline systems. Journal of Hydraulic Research, 48(3), 338-347. doi:10.1080/00221686.2010.481839Tijsseling, A. S., Hou, Q., Bozkuş, Z., & Laanearu, J. (2015). Improved One-Dimensional Models for Rapid Emptying and Filling of Pipelines. Journal of Pressure Vessel Technology, 138(3). doi:10.1115/1.4031508Wang, K.-H., Shen, Q., & Zhang, B. (2003). Modeling propagation of pressure surges with the formation of an air pocket in pipelines. Computers & Fluids, 32(9), 1179-1194. doi:10.1016/s0045-7930(02)00103-2Wang, H., Zhou, L., Liu, D., Karney, B., Wang, P., Xia, L., … Xu, C. (2016). CFD Approach for Column Separation in Water Pipelines. Journal of Hydraulic Engineering, 142(10), 04016036. doi:10.1061/(asce)hy.1943-7900.0001171Zhou, L., & Liu, D. (2013). Experimental investigation of entrapped air pocket in a partially full water pipe. Journal of Hydraulic Research, 51(4), 469-474. doi:10.1080/00221686.2013.785985Zhou, L., Liu, D., & Karney, B. (2013). Investigation of Hydraulic Transients of Two Entrapped Air Pockets in a Water Pipeline. Journal of Hydraulic Engineering, 139(9), 949-959. doi:10.1061/(asce)hy.1943-7900.0000750Zhou, L., Liu, D., Karney, B., & Wang, P. (2013). Phenomenon of White Mist in Pipelines Rapidly Filling with Water with Entrapped Air Pockets. Journal of Hydraulic Engineering, 139(10), 1041-1051. doi:10.1061/(asce)hy.1943-7900.000076

Caracterización de válvulas de admisión y expulsión de aire comerciales

El objetivo del trabajo es estudiar en detalle el comportamiento real de diferentes ventosas (válvulas de admisión y expulsión de aire). La primera parte del trabajo describe las diferentes técnicas experimentales de caracterización de ventosas. En la segunda parte se utiliza el banco de pruebas de válvulas de aire construido por Bermad CS en su fábrica de Evron, Israel, para realizar los ensayos de caracterización estática a diferentes ventosas comerciales. Finalmente se realiza un estudio comparativo del comportamiento de los diferentes modelos analizados, analizando los coeficientes más adecuados para la caracterización matemática de estos elementos

Intercalation of Hydrotalcites with Hexacyanoferrate(II) and (III)-a ThermoRaman Spectroscopic Study

Raman spectroscopy using a hot stage indicates that the intercalation of hexacyanoferrate(II) and (III) in the interlayer space of a Mg,Al hydrotalcites leads to layered solids where the intercalated species is both hexacyanoferrate(II) and (III). Raman spectroscopy shows that depending on the oxidation state of the initial hexacyanoferrate partial oxidation and reduction takes place upon intercalation. For the hexacyanoferrate(III) some partial reduction occurs during synthesis. The symmetry of the hexacyanoferrate decreases from Oh existing for the free anions to D3d in the hexacyanoferrate interlayered hydrotalcite complexes. Hot stage Raman spectroscopy reveals the oxidation of the hexacyanoferrate(II) to hexacyanoferrate(III) in the hydrotalcite interlayer with the removal of the cyanide anions above 250 °C. Thermal treatment causes the loss of CN ions through the observation of a band at 2080 cm-1. The hexacyanoferrate (III) interlayered Mg,Al hydrotalcites decomposes above 150 °C

Cryptographic properties of Boolean functions defining elementary cellular automata

In this work, the algebraic properties of the local transition functions of elementary cellular automata (ECA) were analysed. Specifically, a classification of such cellular automata was done according to their algebraic degree, the balancedness, the resiliency, nonlinearity, the propagation criterion and the existence of non-zero linear structures. It is shown that there is not any ECA satisfying all properties at the same time

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis

Identifying the complexities of the effect of sex on stroke risk, etiology, and lesion progression may lead to advances in the treatment and care of ischemic stroke (IS) and non-traumatic intracerebral hemorrhage patients (ICH). We studied the sex-related discrepancies on the clinical course of patients with IS and ICH, and we also evaluated possible molecular mechanisms involved. The study's main variable was the patient's functional outcome at 3-months. Logistic regression models were used in order to study the influence of sex on different inflammatory, endothelial and atrial dysfunction markers. We recruited 5,021 patients; 4,060 IS (54.8% male, 45.2% female) and 961 ICH (57.1% male, 42.9% female). Women were on average 5.7 years older than men (6.4 years in IS, 5.1 years in ICH), and more likely to have previous poor functional status, to suffer atrial fibrillation and to be on anticoagulants. IS patients showed sex-related differences at 3-months regarding poorer outcome (55.6% women, 43.6% men, p < 0.0001), but this relationship was not found in ICH (56.8% vs. 61.9%, p = 0.127). In IS, women had higher levels of NT-proBNP and 3-months worse outcome in both cardioembolic and non-cardioembolic stroke patients. Stroke patients showed sex-related differences in pre-hospital data, clinical variables and molecular markers, but only IS patients presented independent sex-related differences in 3-months poor outcome and mortality. There was a relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, resulting in a possible indicator of increased dysfunction

Experiences of water immersion during childbirth: a qualitative thematic synthesis

Background The increasing demand for childbirth care based on physiological principles has led official bodies to encourage health centers to provide evidence‑based care aimed at promoting women’s participation in informed decision‑making and avoiding excessive medical intervention during childbirth. One of the goals is to reduce pain and find alternative measures to epidural anesthesia to enhance women’s autonomy and well‑being during child‑ birth. Currently, water immersion is used as a non‑pharmacological method for pain relief. This review aimed to identify and synthesize evidence on women’s and midwives’ experiences, values, and prefer‑ ences regarding water immersion during childbirth. Methods A systematic review and thematic synthesis of qualitative evidence were conducted. Databases were searched and references were checked according to specific criteria. Studies that used qualitative data collection and analysis methods to examine the opinions of women or midwives in the hospital setting were included. Non‑qualita‑ tive studies, mixed‑methods studies that did not separately report qualitative results, and studies in languages other than English or Spanish were excluded. The Critical Appraisal Skills Program Qualitative Research Checklist was used to assess study quality, and results were synthesized using thematic synthesis. Results Thirteen studies met the inclusion criteria and were included in this review. The qualitative studies yielded three key themes: 1) reasons identified by women and midwives for choosing a water birth, 2) benefits experienced in water births, and 3) barriers and facilitators of water immersion during childbirth. Conclusions The evidence from qualitative studies indicates that women report benefits associated with water birth. From the perspective of midwives, ensuring safe water births requires adequate resources, midwives training, and rig‑ orous standardized protocols to ensure that all pregnant women can safely opt for water immersion during childbirth with satisfactory results

Intra- and extra-hospital improvement in ischemic stroke patients: influence of reperfusion therapy and molecular mechanisms

Neuroprotective treatments in ischemic stroke are focused to reduce the pernicious effect of excitotoxicity, oxidative stress and inflammation. However, those cellular and molecular mechanisms may also have beneficial effects, especially during the late stages of the ischemic stroke. The objective of this study was to investigate the relationship between the clinical improvement of ischemic stroke patients and the time-dependent excitotoxicity and inflammation. We included 4295 ischemic stroke patients in a retrospective study. The main outcomes were intra and extra-hospital improvement. High glutamate and IL-6 levels at 24 hours were associated with a worse intra-hospital improvement (OR:0.993, 95%CI: 0.990-0.996 and OR:0.990, 95%CI: 0.985-0.995). High glutamate and IL-6 levels at 24 hours were associated with better extra-hospital improvement (OR:1.13 95%CI, 1.07-1.12 and OR:1.14, 95%CI, 1.09-1.18). Effective reperfusion after recanalization showed the best clinical outcome. However, the long term recovery is less marked in patients with an effective reperfusion. The variations of glutamate and IL6 levels in the first 24 hours clearly showed a relationship between the molecular components of the ischemic cascade and the clinical outcome of patients. Our findings suggest that the rapid reperfusion after recanalization treatment blocks the molecular response to ischemia that is associated with restorative processes