The Photodetector Array Camera and Spectrometer (PACS) on the Herschel Space Observatory

The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submillimetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16x25 pixels, each, and two filled silicon bolometer arrays with 16x32 and 32x64 pixels, respectively, to perform integral-field spectroscopy and imaging photometry in the 60-210\mu\ m wavelength regime. In photometry mode, it simultaneously images two bands, 60-85\mu\ m or 85-125\mu\m and 125-210\mu\ m, over a field of view of ~1.75'x3.5', with close to Nyquist beam sampling in each band. In spectroscopy mode, it images a field of 47"x47", resolved into 5x5 pixels, with an instantaneous spectral coverage of ~1500km/s and a spectral resolution of ~175km/s. We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the Performance Verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions

Performance and calibration of the NIKA camera at the IRAM 30 m telescope

The New IRAM KID Array (NIKA) instrument is a dual-band imaging camera operating with Kinetic Inductance Detectors (KID) cooled at 100 mK. NIKA is designed to observe the sky at wavelengths of 1.25 and 2.14 mm from the IRAM 30 m telescope at Pico Veleta with an estimated resolution of 13\,arcsec and 18 arcsec, respectively. This work presents the performance of the NIKA camera prior to its opening to the astrophysical community as an IRAM common-user facility in early 2014. NIKA is a test bench for the final NIKA2 instrument to be installed at the end of 2015. The last NIKA observation campaigns on November 2012 and June 2013 have been used to evaluate this performance and to improve the control of systematic effects. We discuss here the dynamical tuning of the readout electronics to optimize the KID working point with respect to background changes and the new technique of atmospheric absorption correction. These modifications significantly improve the overall linearity, sensitivity, and absolute calibration performance of NIKA. This is proved on observations of point-like sources for which we obtain a best sensitivity (averaged over all valid detectors) of 40 and 14 mJy.s$^{1/2}$ for optimal weather conditions for the 1.25 and 2.14 mm arrays, respectively. NIKA observations of well known extended sources (DR21 complex and the Horsehead nebula) are presented. This performance makes the NIKA camera a competitive astrophysical instrument

Mapping the hot gas temperature in galaxy clusters using X-ray and Sunyaev-Zel'dovich imaging

We propose a method to map the temperature distribution of the hot gas in galaxy clusters that uses resolved images of the ther- mal Sunyaev-Zel’dovich (tSZ) effect in combination with X-ray data. Application to images from the New IRAM KIDs Array (NIKA) and XMM-Newton allows us to measure and determine the spatial distribution of the gas temperature in the merging cluster MACS J0717.5+3745, at z = 0.55. Despite the complexity of the target object, we find a good morphological agreement between the temperature maps derived from X-ray spectroscopy only – using XMM-Newton (TXMM) and Chandra (TCXO) – and the new gas-mass-weighted tSZ+X-ray imaging method (TSZX). We correlate the temperatures from tSZ+X-ray imaging and those from X-ray spectroscopy alone and find that TSZX is higher than TXMM and lower than TCXO by ∼10% in both cases. Our results are limited by uncertainties in the geometry of the cluster gas, contamination from kinetic SZ (∼10%), and the absolute calibration of the tSZ map (7%). Investigation using a larger sample of clusters would help minimise these effects

Exploiting NIKA2/ XMM-Newton imaging synergy for intermediate-mass high- z galaxy clusters within the NIKA2 SZ large program: Observations of ACT-CL J0215.4+0030 at z ∼0.9

High-resolution mapping of the intracluster medium (ICM) up to high redshift and down to low masses is crucial to derive accurate mass estimates of the galaxy cluster and to understand the systematic eects aecting cosmological studies based on galaxy clusters. We present a spatially resolved Sunyaev-Zel'dovich (SZ)/X-ray analysis of ACT-CL J0215.4+0030, a high-redshift (z = 0:865) galaxy cluster of intermediate mass (M500 ' 3:5 1014 M) observed as part of the ongoing NIKA2 SZ large program, which is a follow-up of a representative sample of objects at 0:5 z 0:9. In addition to the faintness and small angular size induced by its mass and redshift, the cluster is contaminated by point sources that significantly aect the SZ signal. This is therefore an interesting case study for the most challenging sources of the NIKA2 cluster sample. We present the NIKA2 observations of this cluster and the resulting data.We identified the point sources that aect the NIKA2 maps of the cluster as submillimeter galaxies with counterparts in catalogs of sources constructed by the SPIRE instrument on board the Herschel observatory. We reconstructed the ICM pressure profile by performing a joint analysis of the SZ signal and of the point-source component in the NIKA2 150 GHz map. This cluster is a very weak source that lies below the selection limit of the Planck catalog. Nonetheless, we obtained high-quality estimates of the ICM thermodynamical properties with NIKA2. We compared the pressure profile extracted from the NIKA2 map to the pressure profile obtained from X-ray data alone by deprojecting the public XMM-Newton observations of the cluster.We combined the NIKA2 pressure profile with the X-ray deprojected density to extract detailed information on the ICM. The radial distribution of its thermodynamic properties (the pressure, temperature and entropy) indicate that the cluster has a highly disturbed core. We also computed the hydrostatic mass of the cluster, which is compatible with estimations from SZ and X-ray scaling relations. We conclude that the NIKA2 SZ large program can deliver quality information on the thermodynamics of the ICM even for one of its faintest clusters after a careful treatment of the contamination by point sources

Mapping the kinetic Sunyaev-Zel'dovich effect toward MACS J0717.5+3745 with NIKA

Measurement of the gas velocity distribution in galaxy clusters provides insight into the physics of mergers, through which large scale structures form in the Universe. Velocity estimates within the intracluster medium (ICM) can be obtained via the Sunyaev-Zel’dovich (SZ) effect, but its observation is challenging both in term of sensitivity requirement and control of systematic effects, including the removal of contaminants. In this paper we report resolved observations, at 150 and 260 GHz, of the SZ effect toward the triple merger MACS J0717.5+3745 (z = 0.55), using data obtained with the NIKA camera at the IRAM 30 m telescope. Assuming that the SZ signal is the sum of a thermal (tSZ) and a kinetic (kSZ) component and by combining the two NIKA bands, we extract for the first time a resolved map of the kSZ signal in a cluster. The kSZ signal is dominated by a dipolar structure that peaks at −5.1 and +3.4σ, corresponding to two subclusters moving respectively away and toward us and coincident with the cold dense X-ray core and a hot region undergoing a major merging event. We model the gas electron density and line-of-sight velocity of MACS J0717.5+3745 as four subclusters. Combining NIKA data with X-ray observations from XMM-Newton and Chandra, we fit this model to constrain the gas line-of-sight velocity of each component, and we also derive, for the first time, a velocity map from kSZ data (i.e. that is model- dependent). Our results are consistent with previous constraints on the merger velocities, and thanks to the high angular resolution of our data, we are able to resolve the structure of the gas velocity. Finally, we investigate possible contamination and systematic effects with a special care given to radio and submillimeter galaxies. Among the sources that we detect with NIKA, we find one which is likely to be a high redshift lensed submillimeter galaxy

Multi-probe analysis of the galaxy cluster CL J1226.9+3332: Hydrostatic mass and hydrostatic-To-lensing bias

The precise estimation of the mass of galaxy clusters is a major issue for cosmology. Large galaxy cluster surveys rely on scaling laws that relate cluster observables to their masses. From the high-resolution observations of ∼45 galaxy clusters with the NIKA2 and XMM-Newton instruments, the NIKA2 Sunyaev-Zela'dovich Large Program should provide an accurate scaling relation between the thermal Sunyaev-Zela'dovich effect and the hydrostatic mass. In this paper we present an exhaustive analysis of the hydrostatic mass of the well-known galaxy cluster CL J1226.9+3332, the highest-redshift cluster in the NIKA2 Sunyaev-Zela'dovich Large Program at z=0.89. We combined the NIKA2 observations with thermal Sunyaev-Zela'dovich data from the NIKA, Bolocam, and MUSTANG instruments and XMM-Newton X-ray observations, and tested the impact of the systematic effects on the mass reconstruction. We conclude that slight differences in the shape of the mass profile can be crucial when defining the integrated mass at R500, which demonstrates the importance of the modelling in the mass determination. We prove the robustness of our hydrostatic mass estimates by showing the agreement with all the results found in the literature. Another key factor for cosmology is the bias of the masses estimated assuming the hydrostatic equilibrium hypothesis. Based on the lensing convergence maps from the Cluster Lensing And Supernova survey with Hubble (CLASH) data, we obtain the lensing mass estimate for CL J1226.9+3332. From this we are able to measure the hydrostatic-To-lensing mass bias for this cluster, which spans from 1-bHSE/lens∼0.7 to 1, presenting the impact of data sets and mass reconstruction models on the bias

Characterizing filaments in regions of high-mass star formation: High-resolution submilimeter imaging of the massive star-forming complex NGC 6334 with ArTeMiS

Context. Herschel observations of nearby molecular clouds suggest that interstellar filaments and prestellar cores represent two fundamental steps in the star formation process. The observations support a picture of low-mass star formation according to which filaments of ~0.1 pc width form first in the cold interstellar medium, probably as a result of large-scale compression of interstellar matter by supersonic turbulent flows, and then prestellar cores arise from gravitational fragmentation of the densest filaments. Whether this scenario also applies to regions of high-mass star formation is an open question, in part because the resolution of Herschel is insufficient to resolve the inner width of filaments in the nearest regions of massive star formation. Aims. In an effort to characterize the inner width of filaments in high-mass star-forming regions, we imaged the central part of the NGC 6334 complex at a resolution higher by a factor of >3 than Herschel at 350 μm. Methods. We used the large-format bolometer camera ArTéMiS on the APEX telescope and combined the high-resolution ArTéMiS data at 350 μm with Herschel/HOBYS data at 70–500 μm to ensure good sensitivity to a broad range of spatial scales. This allowed us to study the structure of the main narrow filament of the complex with a resolution of 8″ or <0.07 pc at d ~ 1.7 kpc. Results. Our study confirms that this filament is a very dense, massive linear structure with a line mass ranging from ~500 M⊙/pc to ~2000 M⊙/pc over nearly 10 pc. It also demonstrates for the first time that its inner width remains as narrow as W ~ 0.15 ± 0.05 pc all along the filament length, within a factor of <2 of the characteristic 0.1 pc value found with Herschel for lower-mass filaments in the Gould Belt. Conclusions. While it is not completely clear whether the NGC 6334 filament will form massive stars in the future, it is two to three orders of magnitude denser than the majority of filaments observed in Gould Belt clouds, and has a very similar inner width. This points to a common physical mechanism for setting the filament width and suggests that some important structural properties of nearby clouds also hold in high-mass star-forming regions

The XXL Survey: XLIV. Sunyaev-Zel'dovich mapping of a low-mass cluster at z ∼1: A multi-wavelength approach

High-mass clusters at low redshifts have been intensively studied at various wavelengths. However, while more distant objects at lower masses constitute the bulk population of future surveys, their physical state remain poorly explored to date. In this paper, we present resolved observations of the Sunyaev-Zel'dovich (SZ) effect, obtained with the NIKA2 camera, towards the cluster of galaxies XLSSC 102, a relatively low-mass system (M500 ∼ 2 × 1014 M·) at z = 0.97 detected from the XXL survey. We combine NIKA2 SZ data, XMM-Newton X-ray data, and Megacam optical data to explore, respectively, the spatial distribution of the gas electron pressure, the gas density, and the galaxies themselves. We find significant offsets between the X-ray peak, the SZ peak, the brightest cluster galaxy, and the peak of galaxy density. Additionally, the galaxy distribution and the gas present elongated morphologies. This is interpreted as the sign of a recent major merging event, which induced a local boost of the gas pressure towards the north of XLSSC 102 and stripped the gas out of the galaxy group. The NIKA2 data are also combined with XXL data to construct the thermodynamic profiles of XLSSC 102, obtaining relatively tight constraints up to about ∼r500, and revealing properties that are typical of disturbed systems. We also explore the impact of the cluster centre definition and the implication of local pressure substructure on the recovered profiles. Finally, we derive the global properties of XLSSC 102 and compare them to those of high-mass-and-low-redshift systems, finding no strong evidence for non-standard evolution. We also use scaling relations to obtain alternative mass estimates from our profiles. The variation between these different mass estimates reflects the difficulty to accurately measure the mass of low-mass clusters at z ∼ 1, especially with low signal-to-noise ratio data and for a disturbed system. However, it also highlights the strength of resolved SZ observations alone and in combination with survey-like X-ray data. This is promising for the study of high redshift clusters from the combination of eROSITA and high resolution SZ instruments and will complement the new generation of optical surveys from facilities such as LSST and Euclid

Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides

Abstract Cell-penetrating peptides (CPPs) have been used in basic and preclinical research in the past 30 years to facilitate drug delivery into target cells. However, translation toward the clinic has not been successful so far. Here, we studied the pharmacokinetic (PK) and biodistribution profiles of Shuttle cell-penetrating peptides (S-CPP) in rodents, combined or not with an immunoglobulin G (IgG) cargo. We compared two enantiomers of S-CPP that contain both a protein transduction domain and an endosomal escape domain, with previously shown capacity for cytoplasmic delivery. The plasma concentration versus time curve of both radiolabelled S-CPPs required a two-compartment PK analytical model, which showed a fast distribution phase (t1/2α ranging from 1.25 to 3 min) followed by a slower elimination phase (t1/2β ranging from 5 to 15 h) after intravenous injection. Cargo IgG combined to S-CPPs displayed longer elimination half-life, of up to 25 h. The fast decrease in plasma concentration of S-CPPs was associated with an accumulation in target organs assessed at 1 and 5 h post-injection, particularly in the liver. In addition, in situ cerebral perfusion (ISCP) of L-S-CPP yielded a brain uptake coefficient of 7.2 ± 1.1 µl g−1 s−1, consistent with penetration across the blood–brain barrier (BBB), without damaging its integrity in vivo. No sign of peripheral toxicity was detected either by examining hematologic and biochemical blood parameters, or by measuring cytokine levels in plasma. In conclusion, S-CPPs are promising non-toxic transport vectors for improved tissue distribution of drug cargos in vivo