Infrared remote sensing of cometary parent volatiles from the ground, air, and space

A balanced view of the present generation of infrared instruments for cometary compositional studies is presented. Ground-based instruments are compared with airborne and spaceborne capabilities. An attempt to give examples of the unique science achievable with each is made, and particular emphasis is on the unique aspects of a dedicated Cometary Composition Telescope in earth orbit for investigating the chemical and structural heterogeneity of the cometary nucleus

A Values-Based Learning Model to Impact Maturational Change: The College Fraternity as Developmental Crucible

The period of late adolescence and early adulthood is a critical time during which individual identity is developed. One fraternity recently implemented a developmental process that facilitated identity maturation within its members by emphasizing self-awareness and reflection. Utilizing a learning model as the core component of all aspects of its programming, the fraternity conducted research to determine the impact of its learning model on the development of self-awareness. This article provides data from three years of implementation that documents significant increases in this critical developmental competency

Gestaltübergänge in der Musik: vom Wandel der Ordnungsprinzipien

In this essay we will refer to categories of Gestalt psychology to explain structural and process-related features of phenomena in the domain of artistic work. In particular we draw on the nexus of the opposing postulates of simplicity and complexity and on the axiom of Gestaltprägnanz in order to explain principles of order of works in the field of arts and music. Gestalt principles are suited for reduction of structural complexity. This turns out as well by characterizing abstract works of art and music of the 20th century.In einem Essay wird auf Kategorien der Gestaltpsychologie zurückgegriffen, um strukturelle und prozessbezogene Besonderheiten von Phänomenen im Bereich der künstlerischen Gestaltung zu erklären. Insbesondere werden der durch die Gestaltpostulate von Einfachheit und Komplexität konstituierte Spannungsbogen sowie Grundsätze der Gestaltprägnanz herangezogen, um Ordnungsprinzipien bildnerischer Kunst und musikalischer Kompositionen aus verschiedenen Genres zu explizieren. Auch zur Charakteristisierung gegenstandsloser Kunstwerke des 20. Jahrhunderts erweisen sich Gestaltprinzipien zur Reduktion von struktureller Komplexität als essentiell

Detailed Radio Spectra of Selected Compact Sources in the Nucleus of M82

We have determined detailed radio spectra for 26 compact sources in the starburst nucleus of M82, between 74 and 1.3 cm. Seventeen show low-frequency turnovers. One other has a thermal emission spectrum, and we identify it as an HII region. The low frequency turnovers are due to absorption by the interstellar gas in M82. New information on the AGN candidate 44.01+595, shows it to have a non-thermal falling powerlaw spectrum at the highest frequencies, and that it is strongly absorbed below 2 GHz. We derive large magnetic fields in the supernova remnants, of order 1-2 milliGauss, hence large pressures in the sources suggest that the brightest ones are either expanding or are strongly confined by a dense interstellar medium. From the largest source in our sample, we derive a supernova rate of 0.016 SN/yr.Comment: 19 pages, 7 tables, 29 figures, LaTeX, requires AAS macros v. 4.0. To appear in ApJ July 20, 199

Public Concern About Monitoring Twitter Users and Their Conversations to Recruit for Clinical Trials: Survey Study

Background: Social networks such as Twitter offer the clinical research community a novel opportunity for engaging potential study participants based on user activity data. However, the availability of public social media data has led to new ethical challenges about respecting user privacy and the appropriateness of monitoring social media for clinical trial recruitment. Researchers have voiced the need for involving users’ perspectives in the development of ethical norms and regulations. Objective: This study examined the attitudes and level of concern among Twitter users and nonusers about using Twitter for monitoring social media users and their conversations to recruit potential clinical trial participants. Methods: We used two online methods for recruiting study participants: the open survey was (1) advertised on Twitter between May 23 and June 8, 2017, and (2) deployed on TurkPrime, a crowdsourcing data acquisition platform, between May 23 and June 8, 2017. Eligible participants were adults, 18 years of age or older, who lived in the United States. People with and without Twitter accounts were included in the study. Results: While nearly half the respondents—on Twitter (94/603, 15.6%) and on TurkPrime (509/603, 84.4%)—indicated agreement that social media monitoring constitutes a form of eavesdropping that invades their privacy, over one-third disagreed and nearly 1 in 5 had no opinion. A chi-square test revealed a positive relationship between respondents’ general privacy concern and their average concern about Internet research (PP=.001) and whether they consider Twitter monitoring for clinical trial recruitment as eavesdropping (PP=.003). As Twitter literacy increased, so did people’s concerns about researchers monitoring Twitter activity. Our data support the previously suggested use of the nonexceptionalist methodology for assessing social media in research, insofar as social media-based recruitment does not need to be considered exceptional and, for most, it is considered preferable to traditional in-person interventions at physical clinics. The expressed attitudes were highly contextual, depending on factors such as the type of disease or health topic (eg, HIV/AIDS vs obesity vs smoking), the entity or person monitoring users on Twitter, and the monitored information. Conclusions: The data and findings from this study contribute to the critical dialogue with the public about the use of social media in clinical research. The findings suggest that most users do not think that monitoring Twitter for clinical trial recruitment constitutes inappropriate surveillance or a violation of privacy. However, researchers should remain mindful that some participants might find social media monitoring problematic when connected with certain conditions or health topics. Further research should isolate factors that influence the level of concern among social media users across platforms and populations and inform the development of more clear and consistent guidelines

Synthesis of a [2]rotaxane through first- and second-sphere coordination

In an effort to expand the application of a new template from interpenetrated to interlocked molecular species, we report the synthesis of a new [2]rotaxane by means of both first- and second-sphere coordination of a palladium(II) dichloride subunit

Comparison of bacterial genome assembly software for MinION data and their applicability to medical microbiology.

Translating the Oxford Nanopore MinION sequencing technology into medical microbiology requires on-going analysis that keeps pace with technological improvements to the instrument and release of associated analysis software. Here, we use a multidrug-resistant Enterobacter kobei isolate as a model organism to compare open source software for the assembly of genome data, and relate this to the time taken to generate actionable information. Three software tools (PBcR, Canu and miniasm) were used to assemble MinION data and a fourth (SPAdes) was used to combine MinION and Illumina data to produce a hybrid assembly. All four had a similar number of contigs and were more contiguous than the assembly using Illumina data alone, with SPAdes producing a single chromosomal contig. Evaluation of the four assemblies to represent the genome structure revealed a single large inversion in the SPAdes assembly, which also incorrectly integrated a plasmid into the chromosomal contig. Almost 50 %, 80 % and 90 % of MinION pass reads were generated in the first 6, 9 and 12 h, respectively. Using data from the first 6 h alone led to a less accurate, fragmented assembly, but data from the first 9 or 12 h generated similar assemblies to that from 48 h sequencing. Assemblies were generated in 2 h using Canu, indicating that going from isolate to assembled data is possible in less than 48 h. MinION data identified that genes responsible for resistance were carried by two plasmids encoding resistance to carbapenem and to sulphonamides, rifampicin and aminoglycosides, respectively.Health Innovation Challenge Fund (WT098600, HICF-T5-342) (Department of Health, Wellcome Trust)This is the final version of the article. It first appeared from the Microbiology Society via http://dx.doi.org/10.1099/mgen.0.00008

Uncertainty Quantification and Certification Prediction of Low-Boom Supersonic Aircraft Configurations

The primary objective of this work was to develop and demonstrate a process for accurate and efficient uncertainty quantification and certification prediction of low-boom, supersonic, transport aircraft. High-fidelity computational fluid dynamics models of multiple low-boom configurations were investigated including the Lockheed Martin SEEB-ALR body of revolution, the NASA 69 Delta Wing, and the Lockheed Martin 1021-01 configuration. A nonintrusive polynomial chaos surrogate modeling approach was used for reduced computational cost of propagating mixed, inherent (aleatory) and model-form (epistemic) uncertainty from both the computation fluid dynamics model and the near-field to ground level propagation model. A methodology has also been introduced to quantify the plausibility of a design to pass a certification under uncertainty. Results of this study include the analysis of each of the three configurations of interest under inviscid and fully turbulent flow assumptions. A comparison of the uncertainty outputs and sensitivity analyses between the configurations is also given. The results of this study illustrate the flexibility and robustness of the developed framework as a tool for uncertainty quantification and certification prediction of low-boom, supersonic aircraft

SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection

Molecular imaging techniques such as single photon emission computed tomography (SPECT) or positron emission tomography are promising tools for noninvasive diagnosis of acute allograft rejection (AR). Given the importance of renal transplantation and the limitation of available donors, detailed analysis of factors that affect transplant survival is important. Episodes of acute allograft rejection are a negative prognostic factor for long-term graft survival. Invasive core needle biopsies are still the “goldstandard” in rejection diagnostics. Nevertheless, they are cumbersome to the patient and carry the risk of significant graft injury. Notably, they cannot be performed on patients taking anticoagulant drugs. Therefore, a noninvasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review SPECT- and PET-based approaches for noninvasive molecular imaging-based diagnostics of acute transplant rejection

Molecular Gas Kinematics in Barred Spiral Galaxies

To quantify the effect that bar driven mass inflow can have on the evolution of a galaxy requires an understanding of the dynamics of the inflowing gas. In this paper we study the kinematics of the dense molecular gas in a set of seven barred spiral galaxies to determine which dynamical effects dominate. The kinematics are derived from observations of the CO J=(1-0) line made with the Berkeley-Illinois-Maryland Association (BIMA) millimeter array. We compare the observed kinematics to those predicted by ideal gas hydrodynamic and ballistic cloud-based models of gas flow in a barred potential. The hydrodynamic model is in good qualitative agreement with both the current observations of the dense gas and previous observations of the kinematics of the ionized gas. The observed kinematics indicate that the gas abruptly changes direction upon entering the dust lanes to flow directly down the dust lanes along the leading edge of the bar until the dust lanes approach the nuclear ring. Near the location where the dust lanes intersect the nuclear ring, we see two velocity components: a low velocity component, corresponding to gas on circular orbits, and a higher velocity component, which can be attributed to the fraction of gas flowing down the bar dust lane which sprays past the contact point toward the other half of the bar. The ballistic cloud-based model of the ISM is not consistent with the observed kinematics. The kinematics in the dust lanes require large velocity gradients which cannot be reproduced by an ISM composed of ballistic clouds with long mean-free-paths. Therefore, even the dense ISM responds to hydrodynamic forces.Comment: To be published in the Astrophysical Journal, Nov. 20, 199