Portal hypertension : a review of literature.

A hipertens?o portal representa a complica??o de v?rias doen?as. Entre as afec??es que podem cursar com hipertens?o do sistema porta, destacam-se a cirrose, a forma hep?tica ou hepatoespl?nica da esquistossomose, neoplasias do f?gado, das vias biliares ou do p?ncreas, fen?menos tromboemb?licos da veia porta e mol?stias supra-hep?ticas. Dentre suas consequ?ncias destacam-se varizes de es?fago e a encefalopatia portossist?mica. A press?o no sistema portal, como em qualquer outro sistema vascular, ? o resultado da intera??o entre o fluxo sangu?neo e a resist?ncia vascular que se op?e a esse fluxo. Assim, a press?o portal pode aumentar, se houver aumento do fluxo sangu?neo portal ou aumento da resist?ncia vascular ou ambos. A resist?ncia aumentada do fluxo pode ser pr?-hep?tica, p?s-hep?tica e intra-hep?tica. O diagn?stico ? baseado em crit?rios cl?nicos, frequentemente com conjunto com exames de imagem e endoscopia.Portal hypertension is a complication of various diseases. Among the diseases that may present with hypertension in the portal system, we highlight cirrhosis, hepatic or hepatosplenic form of schistosomiasis, cancer of the liver, biliary tract or pancreatic cancer, thromboembolic events portal vein and hepatic symptoms. Among its consequences stand out esophageal varices and portosystemic encephalopathy. The pressure in the portal system as in any other vascular system, is the result of the interaction between blood flow and vascular resistance that opposes the flow. Thus, portal pressure may increase, if any increase of portal blood flow or increased vascular resistance, or both. The increased flow resistance can be prehepatic, post-hepatic and intrahepatic. The diagnosis was based on clinical criteria, often together with imaging and endoscopy

Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelialmesenchymal transition and stemness in breast cancer cells.

Qa-2 is believed to mediate a protective immune response against cancer; however, little is known about the role of Qa-2 in tumorigenesis. Here, we used 4T1 breast cancer cells to study the involvement of Qa-2 in tumor progression in a syngeneic host. Qa-2 expression was reduced during in vivo tumor growth and in cell lines derived from 4T1-induced tumors. Tumor-derived cells elicited an epithelialmesenchymal transition associated with upregulation of Zeb1 and Twist1/2 and enhanced tumor initiating and invasive capacities. Furthermore, these cells showed increased stem characteristics, as demonstrated by upregulation of Hes1, Sox2 and Oct3/4, and enrichment of CD44high/CD24median/low cells. Remarkably, Qa-2 cell-surface expression was excluded from the CD44high/CD24median/low subpopulation. Tumor-derived cells showed increased Src activity, and treatment of these cells with the Src kinase inhibitor PP2 enhanced Qa-2 but reduced Sox2 and CD44high/CD24median/low expression levels, suggesting that Src signaling, while positively associated with stemness, negatively regulates Qa-2 expression in breast cancer. Finally, overexpression of the Qa-2 family member Q7 on the cell surface slowed down in vivo tumor growth and reduced the metastatic potential of 4T1 cells. These results suggest an anti-malignant role for Qa-2 in breast cancer development, which appears to be absent from cancer stem cells.post-print2122 K

Aplicativo móvel para pais de primeira viagem - cuidados ao recém-nascido: relato de experiência

Objetivo: relatar a trajetória da produção de uma tecnologia educacional sobre cuidados ao recém-nascido para pais de primeira viagem no formato de aplicativo para dispositivo móvel. Método: relato de experiência vivenciado em janeiro a outubro de 2019, realizado no Laboratório de Tecnologias Educacionais de uma universidade pública estadual na região Norte do Brasil. Resultados: elaborou-se a revisão integrativa da literatura, obtendo-se oito artigos e o corpus foi processado no software IRAMUTEQ, que gerou cinco classes. Com base nos resultados da revisão integrativa foi desenvolvida a produção do aplicativo suprindo os requisitos de funcionalidade; usabilidade; confiabilidade; eficiência; manutenibilidade e portabilidade. Conclusão: a experiência de produção de uma tecnologia educacional baseada em evidências científicas e em um modelo de sistemas, no formato de um aplicativo móvel, propiciará ao público-alvo de pais o acesso aos conteúdos atualizados e científicos acerca do cuidado seguro ao recém-nascido

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema