2,214 research outputs found
OVI, NV and CIV in the Galactic Halo: II. Velocity-Resolved Observations with Hubble and FUSE
We present a survey of NV and OVI (and where available CIV) in the Galactic
halo, using data from the Far Ultraviolet Spectroscopic Explorer (FUSE) and the
Hubble Space Telescope (HST) along 34 sightlines. These ions are usually
produced in nonequilibrium processes such as shocks, evaporative interfaces, or
rapidly cooling gas, and thus trace the dynamics of the interstellar medium.
Searching for global trends in integrated and velocity-resolved column density
ratios, we find large variations in most measures, with some evidence for a
systematic trend of higher ionization (lower NV/OVI column density ratio) at
larger positive line-of-sight velocities. The slopes of log[N(NV)/N(OVI)] per
unit velocity range from -0.015 to +0.005, with a mean of
-0.0032+/-0.0022(r)+/-0.0014(sys) dex/(km/s). We compare this dataset with
models of velocity-resolved high-ion signatures of several common physical
structures. The dispersion of the ratios, OVI/NV/CIV, supports the growing
belief that no single model can account for hot halo gas, and in fact some
models predict much stronger trends than are observed. It is important to
understand the signatures of different physical structures to interpret
specific lines of sight and future global surveys.Comment: ApJ in press 43 pages, 22 fig
Speeding up Simplification of Polygonal Curves using Nested Approximations
We develop a multiresolution approach to the problem of polygonal curve
approximation. We show theoretically and experimentally that, if the
simplification algorithm A used between any two successive levels of resolution
satisfies some conditions, the multiresolution algorithm MR will have a
complexity lower than the complexity of A. In particular, we show that if A has
a O(N2/K) complexity (the complexity of a reduced search dynamic solution
approach), where N and K are respectively the initial and the final number of
segments, the complexity of MR is in O(N).We experimentally compare the
outcomes of MR with those of the optimal "full search" dynamic programming
solution and of classical merge and split approaches. The experimental
evaluations confirm the theoretical derivations and show that the proposed
approach evaluated on 2D coastal maps either shows a lower complexity or
provides polygonal approximations closer to the initial curves.Comment: 12 pages + figure
Cold Dust but Warm Gas in the Unusual Elliptical Galaxy NGC 4125
Data from the Herschel Space Observatory have revealed an unusual elliptical galaxy, NGC 4125, which has strong and extended submillimeter emission from cold dust but only very strict upper limits to its CO and Hi emission. Depending on the dust emissivity, the total dust mass is 2-5 x 10(6) M-circle dot. While the neutral gas-to-dust mass ratio is extremely low (= 10(4) K faster than the dust is evaporated. If galaxies like NGC 4125, where the far-infrared emission does not trace neutral gas in the usual manner, are common at higher redshift, this could have significant implications for our understanding of high redshift galaxies and galaxy evolution.Canadian Space AgencyNatural Sciences and Engineering Research Council of CanadaAgenzia Spaziale Italiana (ASI) I/005/11/0BMVIT (Austria)ESA-PRODEX (Belgium)CEA/CNES (France)DLR (Germany)ASI/INAF (Italy)CICYT/MCYT (Spain)CSA (Canada)NAOC (China)CEA, (France)CNES (France)CNRS (France)ASI (Italy)MCINN (Spain)SNSB (Sweden)STFC (UK)NASA (USA)National Aeronautics and Space AdministrationAstronom
ALMA Resolves 30 Doradus: Sub-parsec Molecular Cloud Structure Near the Closest Super-Star Cluster
We present ALMA observations of 30 Doradus -- the highest resolution view of
molecular gas in an extragalactic star formation region to date (~0.4pc x
0.6pc). The 30Dor-10 cloud north of R136 was mapped in 12CO 2-1, 13CO 2-1, C18O
2-1, 1.3mm continuum, the H30alpha recombination line, and two H2CO 3-2
transitions. Most 12CO emission is associated with small filaments and clumps
(<1pc, ~1000 Msun at the current resolution). Some clumps are associated with
protostars, including "pillars of creation" photoablated by intense radiation
from R136. Emission from molecular clouds is often analyzed by decomposition
into approximately beam-sized clumps. Such clumps in 30 Doradus follow similar
trends in size, linewidth, and surface density to Milky Way clumps. The 30
Doradus clumps have somewhat larger linewidths for a given size than predicted
by Larson's scaling relation, consistent with pressure confinement. They extend
to higher surface density at a given size and linewidth compared to clouds
studied at 10pc resolution. These trends are also true of clumps in Galactic
infrared-dark clouds; higher resolution observations of both environments are
required. Consistency of clump masses calculated from dust continuum, CO, and
the virial theorem reveals that the CO abundance in 30 Doradus clumps is not
significantly different from the LMC mean, but the dust abundance may be
reduced by ~2. There are no strong trends in clump properties with distance
from R136; dense clumps are not strongly affected by the external radiation
field, but there is a modest trend towards lower dense clump filling fraction
deeper in the cloud.Comment: accepted to Ap
The Three Pillars of Natural Product Dereplication. Alkaloids from the Bulbs of Urceolina peruviana (C. Presl) J.F. Macbr. as a Preliminary Test Case
The role and importance of the identification of natural products are discussed in the perspective of the study of secondary metabolites. The rapid identification of already reported compounds, or structural dereplication, is recognized as a key element in natural product chemistry. The biological taxonomy of metabolite producing organisms, the knowledge of metabolite molecular structures, and the availability of metabolite spectroscopic signatures are considered as the three pillars of structural dereplication. The role and the construction of databases is illustrated by references to the KNApSAcK, UNPD, CSEARCH, and COCONUT databases, and by the importance of calculated taxonomic and spectroscopic data as substitutes for missing or lost original ones. Two NMR-based tools, the PNMRNP database that derives from UNPD, and KnapsackSearch, a database generator that provides taxonomically focused libraries of compounds, are proposed to the community of natural product chemists. The study of the alkaloids from Urceolina peruviana, a plant from the Andes used in traditional medicine for antibacterial and anticancer actions, has given the opportunity to test different approaches to dereplication, favoring the use of publicly available data sources
Spitzer View of Massive Star Formation in the Tidally Stripped Magellanic Bridge
The Magellanic Bridge is the nearest low-metallicity, tidally stripped
environment, offering a unique high-resolution view of physical conditions in
merging and forming galaxies. In this paper we present analysis of candidate
massive young stellar objects (YSOs), i.e., {\it in situ, current} massive star
formation (MSF) in the Bridge using {\it Spitzer} mid-IR and complementary
optical and near-IR photometry. While we definitely find YSOs in the Bridge,
the most massive are , found in the Large
Magellanic Cloud (LMC). The intensity of MSF in the Bridge also appears
decreasing, as the most massive YSOs are less massive than those formed in the
past. To investigate environmental effects on MSF, we have compared properties
of massive YSOs in the Bridge to those in the LMC. First, YSOs in the Bridge
are apparently less embedded than in the LMC: 81% of Bridge YSOs show optical
counterparts, compared to only 56% of LMC sources with the same range of mass,
circumstellar dust mass, and line-of-sight extinction. Circumstellar envelopes
are evidently more porous or clumpy in the Bridge's low-metallicity
environment. Second, we have used whole samples of YSOs in the LMC and the
Bridge to estimate the probability of finding YSOs at a given \hi\ column
density, N(HI). We found that the LMC has higher probability than
the Bridge for N(HI) cm, but the trend reverses at
lower N(HI). Investigating whether this lower efficiency relative to HI is due
to less efficient molecular cloud formation, or less efficient cloud collapse,
or both, will require sensitive molecular gas observations.Comment: 41 pages, 20 figures, 6 tables; accepted for publication in ApJ;
several figures are in low resolution due to the size limit here and a high
resolution version can be downloaded via
http://www.astro.virginia.edu/~cc5ye/ms_bridge20140215.pd
PACS photometry of the Herschel Reference Survey - Far-infrared/sub-millimeter colours as tracers of dust properties in nearby galaxies
We present Herschel/PACS 100 and 160 micron integrated photometry for the 323
galaxies in the Herschel Reference Survey (HRS), a K-band-, volume-limited
sample of galaxies in the local Universe. Once combined with the Herschel/SPIRE
observations already available, these data make the HRS the largest
representative sample of nearby galaxies with homogeneous coverage across the
100-500 micron wavelength range. In this paper, we take advantage of this
unique dataset to investigate the properties and shape of the
far-infrared/sub-millimeter spectral energy distribution in nearby galaxies. We
show that, in the stellar mass range covered by the HRS (8<log(M*/Msun)<12),
the far-infrared/sub-millimeter colours are inconsistent with a single modified
black-body having the same dust emissivity index beta for all galaxies. In
particular, either beta decreases, or multiple temperature components are
needed, when moving from metal-rich/gas-poor to metal-poor/gas-rich galaxies.
We thus investigate how the dust temperature and mass obtained from a single
modified black-body depend on the assumptions made on beta. We show that, while
the correlations between dust temperature, galaxy structure and star formation
rate are strongly model dependent, the dust mass scaling relations are much
more reliable, and variations of beta only change the strength of the observed
trends.Comment: 26 pages, 8 figures, 2 tables. Accepted for publication in MNRA
Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver
Antisense oligodeoxynucleotides (ODNs) appear as attractive anti-hepatitis B virus (HBV) agents. We investigated in vivo, in the duck HBV (DHBV) infection model, whether linear polyethylenimine (lPEI)-based intravenous delivery of the natural antisense phosphodiester ODNs (O-ODNs) can prevent their degradation and allow viral replication inhibition in the liver. DHBV-infected Pekin ducklings were injected with antisense O-ODNs covering the initiation codon of the DHBV large envelope protein, either in free form (O-ODN-AS2) or coupled to lPEI (lPEI/O-ODN-AS2). Following optimization of lPEI/O-ODN complex formulation, complete O-ODN condensation into a homogenous population of small (20–60 nm) spherical particles was achieved. Flow cytometry analysis showed that lPEI-mediated transfer allowed the intrahepatic delivery of lPEI/O-ODN-AS2 to increase three-fold as compared with the O-ODN-AS2. Following 9-day therapy the intrahepatic levels of both DHBV DNA and RNA were significantly decreased in the lPEI/O-ODN-AS2-treated group as compared with the O-ODN-AS2-treated, control lPEI/O-ODN-treated, and untreated controls. In addition, inhibition of intrahepatic viral replication by lPEI/O-ODN-AS2 was not associated with toxicity and was comparable with that induced by the phosphorothioate S-ODN-AS2 at a five-fold higher dose. Taken together, our results demonstrate that phosphodiester antisense lPEI/O-ODN complexes specifically inhibit hepadnaviral replication. Therefore we provide here the first in vivo evidence that intravenous treatment with antisense phosphodiester ODNs coupled to lPEI can selectively block a viral disease-causing gene in the liver
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