Recombinant factor VIIA is associated with an improved 24‐hour survival without an improvement in inpatient survival in massively transfused civilian trauma patients

OBJECTIVE: To determine whether recombinant factor VIIa (rFVIIa) is associated with increased survival and/or thromboembolic complications. INTRODUCTION: Uncontrollable hemorrhage is the main cause of early mortality in trauma. rFVIIa has been suggested for the management of refractory hemorrhage. However, there is conflicting evidence about the survival benefit of rFVIIa in trauma. Furthermore, recent reports have raised concerns about increased thromboembolic events with rFVIIa use. METHODS: Consecutive massively transfused (> 8 units of red blood cells within 12 h) trauma patients were studied. Data on demographics, injury severity scores, baseline laboratory values and use of rFVIIa were collected. Rate of transfusion in the first 6 h was used as surrogate for bleeding. Study outcomes included 24-hour and in-hospital survival, and thromboembolic events. A multivariable logistic regression analysis was used to determine the impact of rFVIIa on 24-hour and in-hospital survival. RESULTS: Three-hundred and twenty-eight patients were massively transfused. Of these, 72 patients received rFVIIa. As expected, patients administered rFVIIa had a greater degree of shock than the non-rFVIIa group. Using logistic regression to adjust for predictors of death in the regression analysis, rFVIIa was a significant predictor of 24-hour survival (odds ratio (OR) = 2.65; confidence interval 1.26-5.59; p = 0.01) but not of in-hospital survival (OR = 1.63; confidence interval 0.79-3.37; p = 0.19). No differences were seen in clinically relevant thromboembolic events. CONCLUSIONS: Despite being associated with improved 24-hour survival, rFVIIa is not associated with a late survival to discharge in massively transfused civilian trauma patients

Recombinant factor VIIa is associated with an improved 24-hour survival without an improvement in inpatient survival in massively transfused civilian trauma patients

OBJECTIVE: To determine whether recombinant factor VIIa (rFVIIa) is associated with increased survival and/or thromboembolic complications. INTRODUCTION: Uncontrollable hemorrhage is the main cause of early mortality in trauma. rFVIIa has been suggested for the management of refractory hemorrhage. However, there is conflicting evidence about the survival benefit of rFVIIa in trauma. Furthermore, recent reports have raised concerns about increased thromboembolic events with rFVIIa use. METHODS: Consecutive massively transfused (>; 8 units of red blood cells within 12 h) trauma patients were studied. Data on demographics, injury severity scores, baseline laboratory values and use of rFVIIa were collected. Rate of transfusion in the first 6 h was used as surrogate for bleeding. Study outcomes included 24-hour and in-hospital survival, and thromboembolic events. A multivariable logistic regression analysis was used to determine the impact of rFVIIa on 24-hour and in-hospital survival. RESULTS: Three-hundred and twenty-eight patients were massively transfused. Of these, 72 patients received rFVIIa. As expected, patients administered rFVIIa had a greater degree of shock than the non-rFVIIa group. Using logistic regression to adjust for predictors of death in the regression analysis, rFVIIa was a significant predictor of 24-hour survival (odds ratio (OR) = 2.65; confidence interval 1.26-5.59; p = 0.01) but not of in-hospital survival (OR = 1.63; confidence interval 0.79-3.37; p = 0.19). No differences were seen in clinically relevant thromboembolic events. CONCLUSIONS: Despite being associated with improved 24-hour survival, rFVIIa is not associated with a late survival to discharge in massively transfused civilian trauma patients

Technological Mapping of the Photovoltaic Solar Energy Industry by Patent Documents Deposited in Brazil

Photovoltaic solar energy is a renewable form of electricity obtained directly from solar radiation using a semiconductor device called a photovoltaic cell. This article aims to map and identify the main characters and the evolution of the technological challenges presented by the technologies involving photovoltaic solar energy by monitoring patent documents filed between 2003 and 2011. Making it possible for the public to ensure, in practice, the way the expertise obtained from the technical information in documents can aggregate knowledge of a technological standpoint, applied to the photovoltaic solar energy field. So, the study methodology uses the analysis of patent applications filed in the Brazilian office extracted from PatBase® (Minesoft)®. The main areas are: (a) semiconductor devices sensitive to infra-red radiation, light, electromagnetic radiation of shorter wavelength, and others; (b) assemblies consisting of a plurality of individual semiconductor or other solid state devices; and, (c) coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material. This sector is highly influenced by governmental politics such as The Brazilian Normative Resolution 482 of the National Electric Energy Agency (ANEEL) and The Green Patents Program of The Brazilian National Institute of Industrial Property (INPI)

Panorama Nacional das Pesquisas sobre a Gestão do Conhecimento: um estudo a partir da plataforma SciELO

A gestão do conhecimento tem conquistado espaço significativo nas pesquisas de diversas áreas de conhecimento, principalmente ao longo dos últimos anos. Apresenta o panorama de pesquisas que envolvem a gestão do conhecimento no Brasil, em relação às suas características e tendências presentes na base de dados SciELO®. Realiza pesquisa exploratória, cuja amostra é composta de artigos publicados no Brasil coletados nesta plataforma, cujo termo “Gestão do Conhecimento” encontrava-se presente no resumo. Na pesquisa, as seguintes variáveis foram estudadas: a) as áreas temáticas em que os artigos foram publicados; b) ano de publicação; c) os periódicos em que os artigos são publicados; d) idioma de publicação; e) número de autores; f) palavras chave mais citadas; g) instituições de ensino segundo filiação dos autores por artigo; h) bibliografia mais utilizada (autores e livros), e, i) artigos de GC relacionados com engenharia. Verificou-se como panorama geral, que os artigos são em maior parte: publicados em periódicos de ciências sociais aplicadas, redigidos no idioma português, publicados a partir de 2007, possuindo de um a três autores. Identificou-se ainda que a bibliografia utilizada é variada, com predominância de autores estrangeiros

Polymer concrete reinforced with luffa fibers: effect of gamma radiation

The interest of many research groups regarding manufacture of composite materials by using natural fibers is increasing world-wide. The main objectives involve the improvement of mechanical properties, mainly those related to resistance and elasticity. In the present study in a first stage, polymer concrete specimens were elaborated by using an unsaturated polyester resin, silica sand and luffa fibers; after, they were gamma irradiated at different doses and their mechanical properties were evaluated. Two different silica particle sizes (0.15 mm and 0.6 mm), and four different luffa fiber concentrations (0.3, 0.6, 0.9 and 1.2 wt%) were used, as well as 50 and 100 kGy of radiation dose. The results show a gradually diminution of compressive strength and modulus of elasticity when adding luffa fiber concentration. Nevertheless, such mechanical features are increasing when polymer concrete is gamma irradiated.Autonomous University of the State of Mexico (UAEM), Grant 3408/2013M (Megaproyecto

Recovery of cotton fibers from waste Blue-Jeans and its use in polyester concrete

Se estudia el efecto de agregar fibras de algodón, provenientes de pantalones de mezclilla de desecho, en concreto polimérico elaborado con resina poliéster.Currently, the consumer tendency causes that the garments are dismissed more quickly, which generate increment of textile waste, such as Blue-Jeans. In this work, polyester concrete with waste cotton fibers was elaborated, and a novel treatment by gamma irradiation was carried out. The results show up to 40% improvement on the compressive strength, as well as 7% on the flexural strength. Additional improvements for irradiated concrete were obtained, when 300 kGy of irradiation dose was applied. Modifications on the surface, chemical structural and crystallinity of irradiated waste cotton fibers, were related with improvements on the mechanical properties of concrete

Polypropylene Fiber Reinforced Polymer Concrete: effect of gamma radiation

Design of polymer concrete involves extensive studies on their materials in order to get improved properties; specifically on the physicochemical properties of both polymer resin and mineral aggregates, including size and shape of the last one. Alternative studies are focusing on using different materials or methods to obtain such improvements. In this work, polymer concrete was elaborated with unsaturated polyester resin, marble particles and polypropylene fibres, after it was modified by using gamma radiation to achieve a complete polymerization. The results show improvements in the compressive strength and in the modulus of elasticity with 0.2 vol.% of polypropylene fibres and irradiation at a dose of 250 KGy. However, lower compressive strains were obtained when using gamma radiation

Advances in HealthCare teaching: a patent mapping about the models simulators or not used

The objective in this article, the realization of a patent mapping on medical education, especially using simulators, since we know that in the teaching of medicine, the development of technical and motor skills in practice is essential, and historically, this training happens with the use of corpses, small animals and later monitoring procedures. With all the advent of technological innovation, financial, cultural and social changes demanded the emergence of new teaching technologies, and through this study, one of the utilities of the technological mapping of the activity can be confirmed through patent documents, which is to obtain the technological evolution of a given subject, in this case: use of models, including simulators in medical education. The temporal evolution of patent documents referring to medical education peaked from 2009 to 2018, and above all, it can be concluded that the latest technologies are models of simulators and there are indications from the United States in exporting this technology to Brazil. recent. From this mapping, it is possible to subsidize technological innovation strategies and assist in the promotion of policies and legislation aimed at stimulating national entrepreneurship and the generation of business opportunities

Avaliação da usabilidade das redes de sensores subaquáticas através de documentos patentários

As redes de sensores subaquáticas são fundamentais para coleta de dados oceanográficos, tendo diversas aplicações, por exemplo, predições sísmicas, exploração offshore de petróleo e gás, controle da qualidade da água e estudos das interações entre oceanos e atmosfera. Com a finalidade de avaliar as tecnologias envolvidas neste cenário, foram utilizados os dados dos documentos patentários extraídos da base PatBase® (Minesoft®), separados em categorias por meio da leitura dos resumos. Foram selecionados 82 documentos patentários relacionados às redes de sensores subaquáticas entre 2000 e 2011, sendo 28 sobre comunicação, 22 sobre controle, 18 sobre monitoramento e 5 sobre medidas. A evolução temporal revelou um crescimento acentuado a partir de 2006. Ainda, verificou-se que os principais escritórios onde os documentos patentários foram depositados são: (a) da China (SIPO), (b) da Coréia do Sul (KIPO); e, (c) dos Estados Unidos (USPTO)

AVALIAÇÃO DO PERFIL PATENTÁRIO DO EMPREGO DE NANOTECNOLOGIAS NO SETOR TÊXTIL

A nanotecnologia consiste em um importante segmento do setor têxtil, pois dá novas características a fibras, fios e tecidos, além de ser um mercado significativo e crescente. Com a finalidade de avaliar as tecnologias envolvidas neste cenário, foram utilizados os dados dos documentos patentários extraídos da base Epodoc, depositados entre 1998-2008, do setor têxtil que contenham a palavra “nano” no título/ resumo. Estes documentos recuperados tiveram seu resumo analisado selecionando somente os relacionados com a nanotecnologia aplicada no setor têxtil, extraindo: (a) ano de prioridade dos documentos, (b) escritório em que foram depositados; e, (c) inventores. Foram selecionados 127 documentos de prioridade, sendo 116 sobre nano-fibras, destes 87 específicos a nano-fibras de carbono; e, 11 sobre tratamento de nano-fibras. A evolução temporal revelou uma curva-“S”. Verificou-se que os principais escritórios destes documentos prioritários são USPTO, JPO, e KIPI. Os principais depositantes são empresas, seguidas por instituições