Azo-Dye Carcinogenesis: Ribonucleotides and Ribonucleases

IN " precancerous liver " and hepatomas obtained from rats fed a hepatocarcinogen, there are so many biochemical abnormalities that it is difficult to decide which of them reflect fundamental steps in neoplasia (Reid, 1962a), although changes not crucial to neoplasia may nevertheless give guidance to pharmacologists (Potter, 1962). For the present purpose of elucidating the mechanism of hepatocarcinogenesis, certain questions can usefully be posed concerning each change observed in hepatoma nodules:-(1) is the change, as observed in the tissue mass examined, truly attributable to living hepatoma cells as distinct from dying cells or non-hepatoma cells in the sample? (2) is the change, as found in primary hepatomas induced by a particular agent, an irreducible property of all hepatomas? (3) is the change an early event, observable in the " precancerous " liver obtained by feeding the agent for a few weeks only, or a late event associated with the actual appearance of cancer cells? With precancerous liver further questions arise: (4) are there changes which are lacking, or converse in direction, in the hepatoma ultimately obtained? (5) is each observed change specific both in being attributabl

Discovery of very nearby ultracool dwarfs from DENIS

We report new spectroscopic results, obtained with UKIRT/CGS4, of a sample of 14 candidate ultracool dwarfs selected from the DENIS (Deep Near-Infrared Survey of the Southern Sky) database. A further object, selected from the 2MASS Second Incremental Release, was observed at a later epoch with the same instrument. Six objects are already known in the literature; we re-derive their properties. A further four prove to be very nearby (~10 pc) mid-to-late L-dwarfs, three unknown hitherto, two of which are almost certainly substellar. These findings increase the number of L-dwarfs known within ~10 pc by ~25%. The remainder of the objects discussed here are early L or very late M-type dwarfs lying between ~45 and 15 pc and are also new to the literature. Spectral types have been derived by direct comparison with J-,H- and K- band spectra of known template ultracool dwarfs given by Leggett et al. (ftp://ftp.jach.hawaii.edu/pub/ukirt/skl/dL.spectra/) For the known objects, we generally find agreement to within ~1 subclass with previously derived spectral types. Distances are determined from the most recent M_J vs. spectral type calibrations, and together with our derived proper motions yield kinematics for most targets consistent with that expected for the disk population; for three probable late M-dwarfs, membership of a dynamically older population is postulated. The very nearby L-type objects discussed here are of great interest for future studies of binarity and parallaxes.Comment: 4 pages, 2 figures, accepted in A&A Letter

Large Magnetic Fields and Motions of OH Masers in W75 N

We report on a second epoch of VLBA observations of the 1665 and 1667 MHz OH masers in the massive star-forming region W75 N. We find evidence to confirm the existence of very strong (~40 mG) magnetic fields near source VLA 2. The masers near VLA 2 are dynamically distinct and include a very bright spot apparently moving at 50 km/s relative to those around VLA 1. This fast-moving spot may be an example of a rare class of OH masers seen in outflows in star-forming regions. Due to the variability of these masers and the rapidity of their motions, tracking these motions will require multiple observations over a significantly shorter time baseline than obtained here. Proper motions of the masers near VLA 1 are more suggestive of streaming along magnetized shocks rather than Keplerian rotation in a disk. The motions of the easternmost cluster of masers in W75 N (B) may be tracing slow expansion around an unseen exciting source.Comment: 7 pages including 4 figures (2 color) & 3 tables, to appear in Ap

Forever Young: High Chromospheric Activity in M subdwarfs

We present spectroscopic observations of two halo M subdwarfs which have H alpha emission lines. We show that in both cases close companions are the most likely cause of the chromospheric activity in these old, metal-poor stars. We argue that Gl 781 A's unseen companion is most likely a cool helium white dwarf. Gl 455 is a near-equal-mass M subdwarf (sdM) system. Gl 781 A is rapidly rotating with v sin i = 30 km/s. The properties of the chromospheres and X-ray coronae of these systems are compared to M dwarfs with emission (dMe). The X-ray hardness ratios and optical chromospheric lines emission ratios are consistent with those seen in dMe stars. Comparison to active near-solar metallicity stars indicates that despite their low metallicity ([m/H] = -1/2), the sdMe stars are roughly as active in both X-rays and chromospheric emission. Measured by L_X/L_bol, the activity level of Gl 781 A is no more than a factor of 2.5 subluminous with respect to near-solar metallicity stars.Comment: 16 pages including 1 figure, AASTeX, to appear in May 1998 A.

Infrared and radio observations of W51: Another Orion-KL at a distance of 7kpc

The bright infrared sources W51-IRS2 has at least three components with different physical and evolutionary properties. The spatial distribution and the near infrared spectra of the components in IRS2 are remarkably similar to, but more luminous than those found in Orion, where an H2 region of comparable linear size is also located close to a cluster of compact infrared sources. The characteristics of the nearby W51-NORTH H2O maser source, and the detection of 2 micro m H2 quadrupole emission in IRS2 indicate that the mass loss phenomena found in Orion-KL also exist in W51

Symptom screen: diagnostic usefulness in detecting pulmonary tuberculosis in HIV-infected pregnant women in Kenya

OBJECTIVE: To determine the diagnostic usefulness of tuberculosis (TB) symptom screening to detect active pulmonary TB among human immunodeficiency virus (HIV) infected pregnant women in two PMTCT (prevention of mother-to-child transmission) clinics in western Kenya that are supported by the United States Agency for International Development–Academic Model Providing Access to Healthcare partnership. DESIGN: Cross-sectional study. Participants were interviewed for TB symptoms with a standardized questionnaire (cough >2 weeks, fever, night sweats, weight loss or failure to gain weight). Those with cough submitted sputum specimens for smear microscopy for acid-fast bacilli and mycobacterial culture. Women at >14 weeks gestation underwent shielded chest radiography (CXR). RESULTS: Of 187 HIV-infected women, 38 (20%) were symptom screen-positive. Of these, 21 had a cough for >2 weeks, but all had negative sputum smears and mycobacterial cultures. CXRs were performed in 26 symptomatic women: three were suggestive of TB (1 miliary, 1 infiltrates and 1 cavitary). Of 149 women with a negative symptom screen, 100 had a CXR and seven had a CXR suggestive of TB (1 cavitary, 2 miliary and 4 infiltrates). CONCLUSION: This study did not support the utility of isolated symptom screening in identification of TB disease in our PMTCT setting. CXR was useful in identification of TB suspects in both symptomatic and asymptomatic women

Pseudomorphic Growth of a Single Element Quasiperiodic Ultrathin Film on a Quasicrystal Substrate

An ultrathin film with a periodic interlayer spacing was grown by the deposition of Cu atoms on thefivefold surface of the icosahedral Al70 Pd21 Mn9 quasicrystal. For coverages from 5 to 25 monolayers, a distinctive quasiperiodic low-energy electron diffraction pattern is observed. Scanning tunneling microscopy images show that the in-plane structure comprises rows having separations of S = 4.5 �0.2 �A and L = 7.3 0.3 A, whose ratio equals � =1.618... within experimental error. The sequences of such row separations form segments of terms of the Fibonacci sequence, indicative of the formation of a pseudomorphic Cu film

Periodic Radio and H-alpha Emission from the L Dwarf Binary 2MASSW J0746425+200032: Exploring the Magnetic Field Topology and Radius of an L Dwarf

[Abridged] We present an 8.5-hour simultaneous radio, X-ray, UV, and optical observation of the L dwarf binary 2MASSW J0746+20. We detect strong radio emission, dominated by short-duration periodic pulses at 4.86 GHz with P=124.32+/-0.11 min. The stability of the pulse profiles and arrival times demonstrates that they are due to the rotational modulation of a B~1.7 kG magnetic field. A quiescent non-variable component is also detected, likely due to emission from a uniform large-scale field. The H-alpha emission exhibits identical periodicity, but unlike the radio pulses it varies sinusoidally and is offset by exactly 1/4 of a phase. The sinusoidal variations require chromospheric emission from a large-scale field structure, with the radio pulses likely emanating from the magnetic poles. While both light curves can be explained by a rotating mis-aligned magnetic field, the 1/4 phase lag rules out a symmetric dipole topology since it would result in a phase lag of 1/2 (poloidal field) or zero (toroidal field). We therefore conclude that either (i) the field is dominated by a quadrupole configuration, which can naturally explain the 1/4 phase lag; or (ii) the H-alpha and/or radio emission regions are not trivially aligned with the field. Regardless of the field topology, we use the measured period along with the known rotation velocity (vsini=27 km/s), and the binary orbital inclination (i=142 deg), to derive a radius for the primary star of 0.078+/-0.010 R_sun. This is the first measurement of the radius of an L dwarf, and along with a mass of 0.085+/-0.010 M_sun it provides a constraint on the mass-radius relation below 0.1 M_sun. We find that the radius is about 30% smaller than expected from theoretical models, even for an age of a few Gyr.Comment: Submitted to Ap

Modeling near-field radiative heat transfer from sharp objects using a general 3d numerical scattering technique

We examine the non-equilibrium radiative heat transfer between a plate and finite cylinders and cones, making the first accurate theoretical predictions for the total heat transfer and the spatial heat flux profile for three-dimensional compact objects including corners or tips. We find qualitatively different scaling laws for conical shapes at small separations, and in contrast to a flat/slightly-curved object, a sharp cone exhibits a local \emph{minimum} in the spatially resolved heat flux directly below the tip. The method we develop, in which a scattering-theory formulation of thermal transfer is combined with a boundary-element method for computing scattering matrices, can be applied to three-dimensional objects of arbitrary shape.Comment: 5 pages, 4 figures. Corrected background information in the introduction, results and discussion unchange