Aspectos en torno al «transhumanismo»: perspectivas a partir del concepto nietzscheano de Übermensch.

El presente artículo tiene como objeto ofrecer un contraste y posterior análisis acerca de algunas cuestiones terminológicas en relación con lo que se ha denominado «transhumanismo» como tránsito hacia el «posthumanismo». Para ello, buscaremos justificar que, en el proyecto «transhumanista», existe una génesis inicial que se podría evidenciar desde algunas consideraciones filosóficas que han surgido a partir de la filosofía de F. Nietzsche. Sin embargo, verificaremos que esta relación es solamente propedéutica o iniciática. Hemos de considerar, finalmente, que las perspectivas del «transhumanismo» no son las del Übermensch nietzscheano. Para corroborar la afirmación expuesta se observarán elementos discrepantes, sobre todo en el plano referido a la experiencia humana en lo relativo al dolor y a la muerte. Entendiéndolas como condición necesaria del hombre y no como una cualidad defectuosa que se debiera de anular o corregir.post-print483 K

INGESTÃO DE DICROMATO DE POTÁSSIO INDUZ ALTERAÇÕES MORFOLÓGICAS EM CARDIOMIÓCITOS DE RATOS

The aim of this study was to analyze the effects of diet’s potassium dichromate supplementation on cardiac muscle tissue morphology in rats. Forty male rats were used, divided into G0: basal diet, G1: basal diet + 12 mg.kg-1 potassium dichromate, G2: basal diet + 24 mg.kg-1 and G3: basal diet + 36 mg.kg -1 for 90 days. The animals were euthanized, with heart extraction for morphological analysis and fractal dimension analysis. Anova One-Way, Kruskall-Wallis, Tukey and Dunn were used to compare the results, with p<0.05. There is no differences on body mass and heart mass. G1 showed greater tissue inflammation of compared to G2 and G0. It was concluded that potassium dichromate generates morphological changes by proinflammatory effect in rat cardiomyocytes.O objetivo do estudo foi analisar efeitos da suplementação de dicromato de potássio à dieta sobre a morfologia do tecido muscular cardíaco de ratos. Foram utilizados 40 ratos machos, divididos em G0: dieta basal, G1: dieta basal + 12 mg.kg-1 de dicromato de potássio, G2: dieta basal + 24 mg.kg-1 e G3: dieta basal + 36 mg.kg-1, por 90 dias. Os animais foram eutanasiados, com extração do coração para análises morfológicas e análise da dimensão fractal. Foram utilizados o teste de Levene, Anova One-Way, Kruskall-Wallis, Tukey e Dunn para comparação dos resultados, adotando p<0,05. Não houve diferenças na massa corporal e massa do coração. G1 apresentou maior inflamação tecidual em relação a G2 e G0. Conclui-se que o dicromato de potássio pode gerar alterações morfológicas em decorrência de efeito pró-inflamatório em cardiomiócitos de ratos

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism during infection. In this work, we demonstrate that RamA is a global transcriptional regulator that significantly perturbs the transcriptional landscape of K. pneumoniae, resulting in altered microbe-drug or microbe-host response. This is largely due to the direct regulation of 68 genes associated with a myriad of cellular functions. Importantly, RamA directly binds and activates the lpxC, lpxL-2 and lpxO genes associated with lipid A biosynthesis, thus resulting in modifications within the lipid A moiety of the lipopolysaccharide. RamA-mediated alterations decrease susceptibility to colistin E, polymyxin B and human cationic antimicrobial peptide LL-37. Increased RamA levels reduce K. pneumoniae adhesion and uptake into macrophages, which is supported by in vivo infection studies, that demonstrate increased systemic dissemination of ramA overexpressing K. pneumoniae. These data establish that RamA-mediated regulation directly perturbs microbial surface properties, including lipid A biosynthesis, which facilitate evasion from the innate host response. This highlights RamA as a global regulator that confers pathoadaptive phenotypes with implications for our understanding of the pathogenesis of Enterobacter, Salmonella and Citrobacter spp. that express orthologous RamA proteins

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Voluntad, verdad y libertad en la Obra filosófico – literaria de Friedrich W. Nietzsche. Análisis hermenéutico y prospectivas filosóficas en el período de la postmodernidad.

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