MARKETING ESTRATÉGICO PARA SUBCULTURAS: UM ESTUDO SOBRE HOSPITALIDADE E GASTRONOMIA VEGETARIANA EM RESTAURANTES DA CIDADE DE SÃO PAULO

This study deals with hospitality from a perspective of receiving and welcoming in the commercial context of restaurants, whose existence in relation to consumers belonging to the vegetarian subculture is outlined based on the understanding of their motives and consumer habits. With the support of an exploratory survey, this work seeks, initially, to discover some consumer habits and attitudes of vegetarians who frequent restaurants in the city of São Paulo. With the data from this survey, a semi-structured observation script was formed. Seven restaurants were studied, in the same city, recommended by the subculture and considered appropriate for vegetarians. It was observed that even when serving a subculture, this does not always occur as a strategic decision, result of a market focus, a fact which could lead to its lack of success. The study of restaurants reveals nuances in vegetarian gastronomy that are unknown by the majority of catering establishments. Key words: Vegetarian gastronomy; Hospitality; Restaurants.Este estudio versa sobre la hospitalidad, bajo el enfoque del recibir y del acoger, en el contexto comercial de restaurantes, cuya existencia con relación a los consumidores pertenecientes a la subcultura vegetariana se delinea con la comprensión de sus motivaciones y de sus hábitos de consumo. Con el apoyo de una pesquisa exploratoria, se buscó, en una primera etapa, conocer algunos hábitos y actitudes de consumo de vegetarianos que frecuentan restaurantes en la ciudad de São Paulo. Con los datos de esta investigación, se formateó un plan semi-estructurado de observación. Se estudiaron siete restaurantes de la misma ciudad, indicados por la subcultura, considerados aptos a atender vegetarianos. Se percibe que, aún cuando hay atención a la subcultura, eso no siempre ocurre como una decisión estratégica, resultado del foco en el mercado, hecho que puede incurrir en su fracaso. El estudio de los restaurantes permitió revelar nuances de la gastronomía vegetariana, aún desconocida por gran parte de las empresas de servicios de alimentación. Palabras-clave: Gastronomía vegetariana; Hospitalidad; Restaurantes.Este estudo versa sobre a hospitalidade, sob o enfoque do receber e do acolher, no contexto comercial de restaurantes, cuja existência em relação aos consumidores pertencentes a subcultura vegetariana se delineia com a compreensão das suas motivações e dos seus hábitos de consumo. Com o apoio de uma pesquisa exploratória, buscou-se, em uma primeira etapa, conhecer alguns hábitos e atitudes de consumo de vegetarianos que freqüentam restaurantes na cidade de São Paulo. Com os dados desta pesquisa, formatou-se um roteiro semi-estruturado de observação. Foram estudados sete restaurantes da mesma cidade, indicados pela subcultura, considerados aptos a atender vegetarianos. Percebe-se que, mesmo quando há atendimento à subcultura, isso nem sempre ocorre como uma decisão estratégica, resultado do foco no mercado, fato que pode incorrer no seu insucesso. O estudo dos restaurantes permitiu revelar nuances da gastronomia vegetariana, ainda desconhecida por grande parte das empresas de serviços de alimentação. Palavras-chave: Gastronomia vegetariana; Hospitalidade; Restaurantes

Disease Phenotype and Outcome Depending on the Age at Disease Onset in Patients Carrying the R92Q Low-Penetrance Variant in TNFRSF1A Gene

Aparició en l'adult; Malalties autoinflamatòries; Variants de baixa penetrànciaAparición en el adulto; Enfermedades autoinflamatorias; Variantes de baja penetranciaAdult onset; Autoinflammatory diseases; Low-penetrance variantsBackground: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease caused by mutations in the TNFRSF1A gene. R92Q, a low-penetrance variant, is usually associated with a milder TRAPS phenotype than structural or pathogenic mutations. No studies differentiating R92Q-related disease in patients with pediatric and adult onset have been performed to date. Objective: To analyze clinical features and disease outcomes in patients diagnosed with TRAPS associated with R92Q variant and to investigate differences between patients with pediatric and adult disease onset. Methods: A retrospective review of patients with R92Q-related disease from four reference centers for autoinflammatory diseases was performed. Clinical and laboratory features, family history of autoinflammatory diseases, treatments received, and outcomes during follow-up were recorded and separately analyzed in pediatric and adult patients. Our results were included in the analysis with other reported pediatric and adult R92Q-related disease series. Results: Our series encompassed 18 patients (9 females and 9 males) with R92Q variant. In 61% of patients, disease onset occurred during infancy and in 39%, during adulthood, with a median diagnostic delay of 5 years and a follow-up of 5.4 years. A positive family history of autoinflammatory disease was detected in 28% of patients. All patients presented with febrile recurrent episodes. Other common symptoms included arthralgia/arthritis (61%), myalgia (39%), asthenia/fatigue (44%), abdominal pain (39%), headache (33%), odynophagia (33%), skin rash (28%), and chest pain (22%). During attacks, 80% of patients increased acute phase reactants levels. No patient had developed amyloidosis during the study period. At the end of follow-up, 28% of patients were asymptomatic and treatment free, 50% were receiving non-steroidal anti-inflammatory drugs or glucocorticoids on demand, and 22% were being treated with biologic agents. When differences between pediatric and adult patients were globally analyzed, adults tended to have longer attacks duration and presented more frequently with chest pain and headache, while abdominal pain, vomiting, cervical adenitis, and pharyngitis predominated in pediatric patients. No differences in outcomes and treatment requirements were observed in both age groups. Conclusion: This study has contributed to characterize R92Q-related disease by identifying trends in disease phenotypes depending on the age at disease onset.This study has been supported by Ministerio de Economía y Competitividad (SAF 14/57708-R) and co-funded by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, and Una manera de hacer Europa (JH-R)

Geosystems representation with emphasis in water resources studies in the hydrographic basin of Cachoeira river, Brazil

Estudos de Geografia Física demandam uma leitura de ambientes que conceba os atributos naturais e antrópicos como forças motrizes de sistemas que alteram, ao longo do tempo, fluxo de energia e matéria no espaço geográfico. Essa é a questão central ao qual se aplica a Teoria Geral dos Sistemas, que define os geossistemas como categoria de análise de estudos da paisagem. Considerando tal método, o objetivo central dessa pesquisa foi representar os geossistemas da bacia hidrográfica do rio Cachoeira, Nordeste do Brasil, utilizando-os como recortes para compreensão da hidrografia da área de estudo. Foram definidos 8 geossistemas que apontam interações específicas das unidades do meio físico da paisagem. As informações desses geossistemas contribuem de forma analística para a compreensão de cenários hidrológicos e produção de água numa bacia de importância socioeconomica regional19675367Studies of Physical Geography requirea reading of environments involvingthe natural and anthropic attributes as driving forces of systems that change, over time, the flow of energy and matter in the geographic space. This is the central question to which the General Systems Theory applies, which defines geosystems as the category of analysis of landscape studies. Considering this method, the central objective of this research was to delimit the geosystems of the basinof the Cachoeira river, Northeast of Brazil, using them as cuttings to understand the hydrography of the study area. Eight geosystems have been defined that indicate specific interactions of the units of the physical environment of the landscape. The information from these geosystems contributestoanalytically to the understanding of hydrological scenarios and water production in a hydrographic basin of regional socioeconomicimportanc

Water resources precification mechanisms: a geosystems perspective

O uso racional dos recursos hídricos em determinado recorte geográfico é fundamental para manutenção das atividades socioeconômicas, da garantia energética e alimentar para as formas de vida da biosfera. A qualidade da água, que é resultado da interação da mesma com as características geossistêmicas de uma bacia hidrográfica, pode ser estimada e consequentemente caracterizada para definir o seu valor monetário para os diversos tipos de atividades econômicas. A questão central do trabalho é construída para evidenciar que, no Brasil, é possível pensar numa abordagem integrada que permite valorar a água em função de sua qualidade, envolvendo coeficientes quantificados originados dos sistemas naturais e antrópicos da bacia hidrográfica. Essa é uma afirmativa que exige um olhar geográfico, pois tal ciência possibilita conectar análises multidisciplinares referentes a água. As nuances metodológicas subsidiam a definição de valores ajustados em função de tais características, sendo uma metodologia passível de implementação por parte do Sistema Nacional de Recursos Hídricos20693648COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPSem informação2016/00007-3The rational use of water resources in a given geographical area has bee n s e e n a s fundamental for the maintenance of socioeconomic activities and the security of energy and food for biosphere life forms. The quality of water,which is the result of the interaction of the same company as geosystemic characteristics of a waters h e d , can be estimated andconsequently characterized to define its monetary value for the various types of economic activities. Thecentral question of the work is built for evidence, inBrazil, it is possible to think of approaching the measure that allows to evaluate a water in function of its quality involving quantified coefficients originated from the natural and anthropic systems of the watershed. This is an affirmation that requires a geographical review, since this science makes it possible to connect multidisciplinary analysisrelated to water. The methodological featuressubsidize th e definition of adjusted values in functionof these characteristics, being a methodology that can be implemented by the National Water Resources Syste

Guidelines on the diagnosis and treatment for acute promyelocytic leukemia: Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines Project: Associacao Medica Brasileira - 2013

Universidade Estadual de CampinasUniversidade de São PauloUniversidade Federal de São Paulo (UNIFESP)Universidade de BrasiliaUniversidade Federal do Rio Grande do SulUniversidade Federal de Minas GeraisUniversidade Federal de PernambucoUNIFESP, EPMSciEL

Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines

We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. the death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).Med Sch Riberao Preto, Dept Internal Med, Ribeirao Preto, BrazilHosp Amaral Carvalho, Bone Marrow Transplantat Unit, Jau, BrazilUniv Fed Minas Gerais, Hematol Serv, Belo Horizonte, MG, BrazilSanta Casa São Paulo, Hematol Serv, São Paulo, BrazilFundacao Pio XII Barretos, Barretos, BrazilClin Hematol Riberao Preto, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Hematol & Hemotherapy, São Paulo, BrazilUniv Estadual Campinas, Hemoctr, Campinas, BrazilSt Jude Childrens Hosp, Internal Outreach Program, Memphis, TN USAUniversidade Federal de São Paulo, Dept Hematol & Hemotherapy, São Paulo, BrazilWeb of Scienc

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

Simple Summary In solid tumors, the altered expression of embryonic genes such as the SLIT-ROBO family has been associated with poor prognosis, while little is known about their role in acute myeloid leukemia (AML). Previous studies reported frequent hypermethylation of SLIT2 mediated by the methyltransferase enzyme EZH2 and more recently the PML protein, which are commonly found to be aberrantly expressed in AML. Here, we aim to assess retrospectively the clinical relevance of the SLIT2 gene in acute promyelocytic leukemia, a homogenous subtype of AML. We demonstrated that reduced SLIT2 expression was associated with high leukocyte counts and reduced overall survival in different APL cohorts. STLI2 treatment decreased APL growth, while SLIT2 knockdown accelerated cell cycle progression and proliferation. Finally, reduced expression of SLIT2 in murine APL blasts resulted in fatal leukemia associated with increased leukocyte counts in vivo. These findings demonstrate that SLIT2 can be considered as a prognostic marker in APL, and a potential candidate for clinical studies of a more heterogeneous disease, such as AML. The SLIT-ROBO axis plays an important role in normal stem-cell biology, with possible repercussions on cancer stem cell emergence. Although the Promyelocytic Leukemia (PML) protein can regulate SLIT2 expression in the central nervous system, little is known about SLIT2 in acute promyelocytic leukemia. Hence, we aimed to investigate the levels of SLIT2 in acute promyelocytic leukemia (APL) and assess its biological activity in vitro and in vivo. Our analysis indicated that blasts with SLIT2(high) transcript levels were associated with cell cycle arrest, while SLIT2(low) APL blasts displayed a more stem-cell like phenotype. In a retrospective analysis using a cohort of patients treated with all-trans retinoic acid (ATRA) and anthracyclines, high SLIT2 expression was correlated with reduced leukocyte count (p = 0.024), and independently associated with improved overall survival (hazard ratio: 0.94; 95% confidence interval: 0.92-0.97; p <0.001). Functionally, SLIT2-knockdown in primary APL blasts and cell lines led to increased cell proliferation and resistance to arsenic trioxide induced apoptosis. Finally, in vivo transplant of Slit2-silenced primary APL blasts promoted increased leukocyte count (p = 0.001) and decreased overall survival (p = 0.002) compared with the control. In summary, our data highlight the tumor suppressive function of SLIT2 in APL and its deteriorating effects on disease progression when downregulated

The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL)

Objectives: Several clinical trials conducted in Europe and US reported favorable outcomes of patients with APL treated with the combination of all trans retinoic acid (ATRA) and anthracyclines. Nevertheless, the results observed in developing countries with the same regimen was poorer, mainly due to high early mortality mainly due bleeding. The International Consortium on Acute Promyelocytic Leukemia (IC-APL) is an initiative of the International Members Committee of the ASH and the project aims to reduce this gap through the establishment of international network, which was launched in Brazil, Mexico and Uruguay. Methods: The IC-APL treatment protocol is similar to the PETHEMA 2005, but changing idarubicin to daunorubicin. All patients with a suspected diagnosis of APL were immediately started on ATRA, while bone marrow samples were shipped to a national central lab where genetic verification of the diagnosis was performed. The immunofluorescence using an anti-PML antibody allowed a rapid confirmation of the diagnosis and, the importance of supportive measures was reinforced. Results: The interim analysis of 97 patients enrolled in the IC-APL protocol showed that complete remission (CR) rate was 83% and the 2-year overall survival and disease-free survival were 80% and 90%, respectively. Of note, the early mortality rate was reduced to 7.5%. Discussion: The results of IC-APL demonstrate the impact of educational programs and networking on the improvement of the leukemia treatment outcome in developing countries