I Never Had to Use the Library in High School : A Library Instruction Program for At-Risk Students

Most academic library instruction is limited to one class period, despite empirical evidence that this approach is likely less effective than more sustained instruction. To determine if additional sessions would boost student learning and reduce library anxiety, the authors collaborated with representatives from a program for at-risk undergraduates to develop a three-workshop model for basic instruction and orientation. They first delivered the program during the summer of 2012 and subsequently offered it to three additional groups of students, including a cohort of doctoral students in the sciences. This article describes the process of designing the workshops and evaluating their effectiveness, with special attention to demonstrating how the program supported the parent institution’s goals and mission

Methodological quality of systematic reviews and clinical trials on women's health published in a Brazilian evidence-based health journal

OBJECTIVES: To assess the quality of systematic reviews and clinical trials on women's health recently published in a Brazilian evidence-based health journal. METHOD: All systematic reviews and clinical trials on women's health published in the last five years in the Brazilian Journal of Evidence-based Health were retrieved. Two independent reviewers critically assessed the methodological quality of reviews and trials using AMSTAR and the Cochrane Risk of Bias Table, respectively. RESULTS: Systematic reviews and clinical trials accounted for less than 10% of the 61 original studies on women's health published in the São Paulo Medical Journal over the last five years. All five reviews were considered to be of moderate quality; the worst domains were publication bias and the appropriate use of study quality in formulating conclusions. All three clinical trials were judged to have a high risk of bias. The participant blinding, personnel and outcome assessors and allocation concealment domains had the worst scores. CONCLUSIONS: Most of the systematic reviews and clinical trials on women's health recently published in a Brazilian evidence-based journal are of low to moderate quality. The quality of these types of studies needs improvement

Centro Cochrane do Brasil: 15º aniversário

Universidade Federal de São Paulo (UNIFESP) Program on Internal Medicine and TherapeuticsBrazilian Cochrane CenterDivision of Emergency and Evidence-Based MedicineUNIFESP, Program on Internal Medicine and TherapeuticsSciEL

PELAKSANAAN PENDAFTARAN HAK MILIK MELALUI PROGRAM PENDAFTARAN TANAH SISTEMATIS LENGKAP DALAM RANGKA MEWUJUDKAN KEPASTIAN HUKUM DI KOTA SORONG

2023 PTSL activities have been carried out in Sorong City, Klaurung District, Klasuat Village and Giwu village. The completion of Systematic Land Registration Activities is also one of them agenda set by the City of Sorong, in order to assist the people of Sorong City in registering their land rights, in order to obtain legal certainty. That The focus of this research is Complete Systematic Land Registration Activities program which will be implemented in 2023 in Giwu Village and Klasuat Village, Sorong City, Southwest Papua Province. In this research. The author can conclude that implementation of Complete Systematic Land Registration Activities by The Sorong City Land Office has been implemented in good stages in accordance with the Regulation of the Minister of Agrarian Affairs and Spatial Planning/Head of the National Land Agency Number 6 of 2018 in Article 4 paragraph (4). In this research the author provides advice to the Land Office in counseling is carried out more frequently, not just once to the community, more through and understand land division and can carry out good activities: Complete Land Registration Activities Systematically

Membangkitkan Minat, Membangun Masa Depan: Pembelajaran Interaktif dengan Kebutuhan Keluargaku untuk Siswa TK Bina Bunga Bangsa Surabaya

Berhemat adalah gaya hidup yang sangat bermanfaat bagi siapapun. Hidup hemat memampukan seseorang untuk mengetahui apa yang dibutuhkan dan apa yang diinginkan, gaya hidup hemat juga membantu seseorang untuk tidak bertindak secara impulsif dalam memenuhi kebutuhan dan keinginan. Dengan adanya kegiatan pengabdian masyarakat ini, diharapkan siswa-siswi taman kanak-kanak dapat menumbuhkan kesadaran akan pentingnya mengenal kebutuhan hidup dan dapat berhemat. Gaya hidup berhemat ini cukup krusial untuk diberikan pada usia muda untuk menghindari sifat impulsif membeli. Hal ini dikarenakan sifat membeli secara impulsif tanpa memikirkan kebutuhan dan keinginan, akan mengarah kepada pembelian yang tidak berguna dan hanya memenuhi rasa keinginan di awal. Metode yang dilakukan dalam kegiatan pengabdian masyarakat terdiri dari tiga langkah, yaitu persiapan, pelaksanaan, dan kegiatan evaluasi. Kegiatan yang digunakan adalah metode pembelajaran interaktif sehingga para siswa-siswi didorong untuk menjadi aktif dalam berpartisipasi sehingga akan menimbulkan rasa percaya diri dan dapat lebih fokus. Hasil dari kegiatan pengabdian masyarakat menunjukkan siswa-siswa yang semakin sadar akan kebutuhan-kebutuhan yang ada seperti makan, air, hingga listrik dan mampu berpartisipasi secara aktif dalam kegiatan. Siswa-siswi TK menjadi lebih sadar akan barang-barang yang digunakan memerlukan biaya dan harus berhemat

Barriers to Pregnancy Spacing in Women Living with HIV: A Series of Informational Interviews

For reproductive-age women living with HIV, birth spacing allows for optimization of maternal health and viral suppression to prevent mother-to-child transmission of HIV. We conducted semi-structured informational interviews to explore use of contraception for birth spacing. Interviews were transcribed and analyzed. Audio files were reviewed to capture non-explicit data. We interviewed 18 multiparous HIV positive women. All described experiences with at least one contraceptive method. Six themes emerged: Burden of contraception, Failure of birth control, Impact of youth and lack of life experience, Community beliefs about birth control, Lack of partner cooperation, and Altruism. Women viewed birth spacing favorably. Young age at first delivery, contraceptive side effects, non-adherence to short-acting methods, lack of partner cooperation, and prior contraceptive failure were identified as barriers to ideal birth spacing. Additional outreach is needed in women living with HIV to overcome barriers to planned pregnancy and birth spacing

Multivariate analysis of the displacements of a concrete dam with respect to the action of environmental conditions

A review of the concrete dam’s structural performance is a complex issue comprised of many dimensions. This article proposes a method to assist in monitoring the displacements of structures and foundations of dams, considering the action of environmental conditions. Multivariate techniques are used to analyze the data pendulums, extensometer bases and multiple rods extensometer, along with environmental variables of the concrete surface temperature, ambient temperature and the reservoir water level. Specifically applies to Canonical Correlation Analysis to evaluate the influence of environmental variables in the displacement of structures and foundations. Factor Analysis identifies the factors inherent to the variability of the data. This technique makes it possible to order the variables considering the action of factors. This applies also to Cluster Analysis on the data of dates of measurements, according to the similarities present in the observations. Then, Discriminant Analysis evaluates the formed groups for uniformity. The results demonstrate that the method can distinguish the dam responses and identify the effects of variations in environmental conditions over the displacements of structures and foundations

Transgrediens pachydermodactyly: report of a case

Pachydermodactyly is a rare form of digital fibromatosis involving the proximal portions of the fingers that usually affects young males. We present a 25-year-old male patient with a twoyear history of asymptomatic nodules in the fingers. Three months before the visit, he had observed similar lesions on the feet and right knee. Histopathological analysis showed thickened dermis with proliferation of fibroblasts and collagenous fibers, with deposition of mucinous material. This represents a rare case of pachydermodactyly of transgrediens form.A paquidermodactilia é forma rara de fibromatose digital envolvendo as porções proximais dos dedos, que afeta homens jovens. Apresenta-se caso de paciente de 25 anos com quadro de nódulos assintomáticos nas mãos há dois anos, e há três meses com lesões semelhantes nos pés e no joelho direito. O exame histopatológico revelou espessamento da derme com proliferação de fibroblastos e de fibras colágenas e aumento de mucina. O caso descrito corresponde à paquidermodactilia do tipo transgressiva.Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo (UNIFESP) Departamento de PatologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de DermatologiaUNIFESP, Depto. de PatologiaUNIFESP, Depto. de DermatologiaSciEL

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies.

Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single agent treatment for numerous different malignancies, but its efficacy in limiting bladder malignancies has not been tested. In this study we assessed selinexor-dependent cytotoxicity in several bladder tumor cells and report that selinexor effectively reduced XPO1 expression and limited cell viability in a dose dependent manner. The decrease in cell viability was due to an induction of apoptosis and cell cycle arrest. These results were recapitulated in in vivo studies where selinexor decreased tumor growth. Tumors treated with selinexor expressed lower levels of XPO1, cyclin A, cyclin B, and CDK2 and increased levels of RB and CDK inhibitor p27, a result that is consistent with growth arrest. Cells expressing wildtype RB, a potent tumor suppressor that promotes growth arrest and apoptosis, were most susceptible to selinexor. Cell fractionation and immunofluorescence studies showed that selinexor treatment increased nuclear RB levels and mechanistic studies revealed that RB ablation curtailed the response to the drug. Conversely, limiting CDK4/6 dependent RB phosphorylation by palbociclib was additive with selinexor in reducing bladder tumor cell viability, confirming that RB activity has a role in the response to XPO1 inhibition. These results provide a rationale for XPO1 inhibition as a novel strategy for the treatment of bladder malignancies