Twitter as a New Engagement Opportunity. Analysis of the Questions and Answers between the Italian Prime Minister and Citizens

Twitter as a New Engagement Opportunity. Analysis of the Questions and Answers between the Italian Prime Minister and Citizen

Searching for the Dimensions of Today’s Political Incivility

Incivility in public discourse is a central concern for scholars and citizens alike. However, the definitions of the concept offered by scholars are dissimilar and difficult to compare. This research, which adopts an approach based on citizens’ perceptions of incivility, addresses this issue by empirically testing a three-dimensional model of political incivility. The findings of a survey of 797 students to track differences in perceptions of specific types of uncivil speech show that political incivility consists of a three-dimensional concept, that is, incivility as “impoliteness,” as “individual delegitimization,” and as “institutional delegitimization.” Future studies can use this model to corroborate these results and verify whether this composition of the concept holds up in other contexts

“Lavoro”. Il rotocalco della Cgil

dalla Premessa. "La vicenda del settimanale «Lavoro», è esemplare delle vicissitudini, delle ambizioni e delle delusioni della stampa sindacale italiana e di quella della Cgil in particolare. «Lavoro», infatti, soprattutto nel periodo della direzione di Gianni Toti – un giornalista prestato al sindacato, che si rivelò poi, negli anni successivi, artista tra i più fantasiosi e innovativi comparsi sulla scena culturale italiana del dopoguerra – fu il tentativo più coerente di creare un modello di informazione che ponesse al suo centro il mondo del lavoro, la vita di lavoratrici e lavoratori, le risposte sindacali alle urgenze materiali della vita delle persone più umili che nella stampa degli anni cinquanta erano o trascurate o affrontate con un campionario retorico incapace di rappresentare onestamente la durezza delle loro condizioni di esistenza. Il presupposto su cui la linea editoriale di «Lavoro» si costruisce anno dopo anno è quello di un movimento operaio ricco di una cultura autonoma, che sa sottrarsi agli stereotipi borghesi, e di una stampa sindacale capace di confrontarsi con i media dei grandi gruppi di informazione riprendendone le forme più nuove ma per farne veicolo di contenuti diversi". Il volume ripercorre quel periodo cercando di cogliere il modello di giornalismo sotteso all'esperimento editoriale più riuscito e di successo del sindacato italiano

Ripensare il cyberbullismo tra social media e messaggi d'odio. Pratiche, ibridazioni e trattorie di ricerca

L’articolo risponde alle recenti preoccupazioni per la crescita dei messaggi d’odio nel dibattito pubblico online, che coinvolge attori differenti tra cui gli stessi rappresentanti politici. Concentrandosi in particolare sui giovani, si propo-ne di esaminare il fenomeno del cyberbullismo all’interno di un framework più ampio, in grado di collegare i comportamenti bullizzanti alla crescita di inciviltà nel discorso pubblico. La ricognizione teorica su incivility e cyberbullismo mo-stra aree di sovrapposizione a conferma del fatto che non si tratta di fenomeni individuali ma che riguardano l’intera società. L’articolo identifica traiettorie di ricerca e interventi utili a contrastarne la diffusione pervasiva.The article addresses issues in response to the concern about the growth of hate messages in online public debate which involves different actors including politicians. Focusing in particular on young people, it aims at examining cyberbullying within a broader framework, linking the bullying behavior to the growth of incivility in public discourse, especially on social media. The theoretical overview of incivility and cyberbullying shows areas of overlap, confirming the fact that these are not individual phenomena, but they affect the whole society. The article identifies trajectories of research, as well as useful interventions to counteract their pervasive spread

I discorsi d’odio online in una prospettiva comunicativa: un’agenda per la ricerca

The phenomenon of hate speech has become a predominant component of public debate and a point of great interest in academic research. Plenty of studies investigating the various expressions of hate speech, including online hate speech, have been conducted. Despite the efforts made, however, the outlines of this phenomenon remain extremely uncertain. In fact, limitations in the intention to reduce hate speech to a purely legal approach is emerging. Even though the latter was originally the dominant approach, it appears to be inadequate for capturing a fluid and ever-changing phenomenon such as the hate speech today. Despite the similarities with offline hatred, online hatred has widened to include the most diverse expressions, messages, and hostility practices, which can be either organized or individual, and often implicit. All these features proper of the online hate speech make it difficult to establish, according to the specific circumstances, whether these are forms openly aimed at inciting hatred and violence against target groups likely to harm victims. Nonetheless, distinguishing the different roles of the actors involved into the spread of hate speech (e.g. perpetrators of online speech, more or less aware spreaders of hate, victims) can be a source of uncertainty. Building on this foundation, the article aims to investigate hate speech of today’s world through a multidimensional framework fit into the context of hybrid media. Moving from Lasswell (1948)’s Communication Model, this contribution illustrates the importance of observing all the dimensions involved in hate speech, including the communicator, the message, the receiver, considering as well the digital media’s context and the related specific properties, and the consequences arising from the interaction between the different dimensions. The idea behind this proposal is that in order to understand both mechanisms and hallmarks of ordinary online hate practices, it is necessary to move away from specific and fragmented approaches. These, indeed, (selectively) analyse specific portions of the phenomenon while losing sight of other dimensions’ roles and their action and feedback relations. The transformative nature of hate speech requires the adoption of an innovative approach, which cannot be limited to the compilation of a list of examples and cases to be banned. On the contrary, it should aim for tuning in to cultural and digital practices used by users in the production of hate speech. Because, if it is true that online hate does not differ from hate tout court, it is also true that progressive communicative shifts might occur and lead to the transformation of forms of discrimination into something apparently harmless such as “just funny stuff”

Minimally invasive vs. open segmental resection of the splenic flexure for cancer: a nationwide study of the Italian Society of Surgical Oncology-Colorectal Cancer Network (SICO-CNN)

Background Evidence on the efficacy of minimally invasive (MI) segmental resection of splenic flexure cancer (SFC) is not available, mostly due to the rarity of this tumor. This study aimed to determine the survival outcomes of MI and open treatment, and to investigate whether MI is noninferior to open procedure regarding short-term outcomes. Methods This nationwide retrospective cohort study included all consecutive SFC segmental resections performed in 30 referral centers between 2006 and 2016. The primary endpoint assessing efficacy was the overall survival (OS). The secondary endpoints included cancer-specific mortality (CSM), recurrence rate (RR), short-term clinical outcomes (a composite of Clavien-Dindo > 2 complications and 30-day mortality), and pathological outcomes (a composite of lymph nodes removed >= 12, and proximal and distal free resection margins length >= 5 cm). For these composites, a 6% noninferiority margin was chosen based on clinical relevance estimate. Results A total of 606 patients underwent either an open (208, 34.3%) or a MI (398, 65.7%) SFC segmental resection. At univariable analysis, OS and CSM were improved in the MI group (log-rank test p = 0.004 and Gray's tests p = 0.004, respectively), while recurrences were comparable (Gray's tests p = 0.434). Cox multivariable analysis did not support that OS and CSM were better in the MI group (p = 0.109 and p = 0.163, respectively). Successful pathological outcome, observed in 53.2% of open and 58.3% of MI resections, supported noninferiority (difference 5.1%; 1-sided 95%CI - 4.7% to infinity). Successful short-term clinical outcome was documented in 93.3% of Open and 93.0% of MI procedures, and supported noninferiority as well (difference - 0.3%; 1-sided 95%CI - 5.0% to infinity). Conclusions Among patients with SFC, the minimally invasive approach met the criterion for noninferiority for postoperative complications and pathological outcomes, and was found to provide results of OS, CSM, and RR comparable to those of open resection

Segmental transverse colectomy. Minimally invasive versus open approach: results from a multicenter collaborative study

none65noThe role of minimally invasive surgery in the treatment of transverse colon cancer is still controversial. The aim of this study is to investigate the advantages of a totally laparoscopic technique comparing open versus laparoscopic/robotic approach. Three hundred and eighty-eight patients with transverse colon cancer, treated with a segmental colon resection, were retrospectively analyzed. Demographic data, tumor stage, operative time, intraoperative complications, number of harvested lymph nodes and recovery outcomes were recorded. Recurrences and death were also evaluated during the follow-up. No differences were found between conventional and minimally invasive surgery, both for oncological long-term outcomes (recurrence rate p = 0.28; mortality p = 0.62) and postoperative complications (overall rate p = 0.43; anemia p = 0.78; nausea p = 0.68; infections p = 0.91; bleeding p = 0.62; anastomotic leak p = 0.55; ileus p = 0.75). Nevertheless, recovery outcomes showed statistically significant differences in favor of minimally invasive surgery in terms of time to first flatus (p = 0.001), tolerance to solid diet (p = 0.017), time to first mobilization (p = 0.001) and hospital stay (p = 0.004). Compared with laparoscopic approach, robotic surgery showed significantly better results for time to first flatus (p = 0.001), to first mobilization (p = 0.005) and tolerance to solid diet (p = 0.001). Finally, anastomosis evaluation confirmed the superiority of intracorporeal approach which showed significantly better results for time to first flatus (p = 0.001), to first mobilization (p = 0.003) and tolerance to solid diet (p = 0.001); moreover, we recorded a statistical difference in favor of intracorporeal approach for infection rate (p = 0.04), bleeding (p = 0.001) and anastomotic leak (p = 0.03). Minimally invasive approach is safe and effective as the conventional open surgery, with comparable oncological results but not negligible advantages in terms of recovery outcomes. Moreover, we demonstrated that robotic approach may be considered a valid option and an intracorporeal anastomosis should always be preferred.noneMilone, Marco; Degiuli, Maurizio; Velotti, Nunzio; Manigrasso, Michele; Vertaldi, Sara; D'Ugo, Domenico; De Palma, Giovanni Domenico; Dario Bruzzese, Giuseppe Servillo, Giuseppe De Simone, Katia Di Lauro, Silvia Sofia, Marco Ettore Allaix, Mario Morino, Rossella Reddavid, Carlo Alberto Ammirati, Stefano Scabini, Gabriele Anania, Cristina Bombardini, Andrea Barberis, Roberta Longhin, Andrea Belli, Francesco Bianco, Giampaolo Formisano, Giuseppe Giuliani, Paolo Pietro Bianchi, Davide Cavaliere, Leonardo Solaini, Claudio Coco, Gianluca Rizzo, Andrea Coratti, Raffaele De Luca, Michele Simone, Alberto Di Leo, Giovanni De Manzoni, Paola De Nardi, Ugo Elmore, Riccardo Rosati, Andrea Vignali, Paolo Delrio, Ugo Pace, Daniela Rega, Antonio Di Cataldo, Giovanni Li Destri, Annibale Donini, Luigina Graziosi, Andrea Fontana, Michela Mineccia, Sergio Gentilli, Manuela Monni, Mario Guerrieri, Monica Ortenzi, Francesca Pecchini, Micaela Piccoli, Italy. Corrado Pedrazzani, Giulia Turri, Sara Pollesel, Franco Roviello, Marco Rigamonti, Michele Zuolo, Mauro Santarelli, Federica Saraceno, Pierpaolo Sileri Giuseppe Sigismondo Sica, Luigi Siragusa Salvatore Pucciarelli, Matteo ZuinMilone, Marco; Degiuli, Maurizio; Velotti, Nunzio; Manigrasso, Michele; Vertaldi, Sara; D'Ugo, Domenico; De Palma, Giovanni Domenico; Dario Bruzzese, Giuseppe Servillo, Giuseppe De Simone, Katia Di Lauro, Silvia Sofia, Marco Ettore Allaix, Mario Morino, Rossella Reddavid, Carlo Alberto Ammirati, Stefano Scabini, Gabriele Anania, Cristina Bombardini, Andrea Barberis, Roberta Longhin, Andrea Belli, Francesco Bianco, Giampaolo Formisano, Giuseppe Giuliani, Paolo Pietro Bianchi, Davide Cavaliere, Leonardo Solaini, Claudio Coco, Gianluca Rizzo, Andrea Coratti, Raffaele De Luca, Michele Simone, Alberto Di Leo, Giovanni De Manzoni, Paola De Nardi, Ugo Elmore, Riccardo Rosati, Andrea Vignali, Paolo Delrio, Ugo Pace, Daniela Rega, Antonio Di Cataldo, Giovanni Li Destri, Annibale Donini, Luigina Graziosi, Andrea Fontana, Michela Mineccia, Sergio Gentilli, Manuela Monni, Mario Guerrieri, Monica Ortenzi, Francesca Pecchini, Micaela Piccoli, Italy. Corrado Pedrazzani, Giulia Turri, Sara Pollesel, Franco Roviello, Marco Rigamonti, Michele Zuolo, Mauro Santarelli, Federica Saraceno, Pierpaolo Sileri Giuseppe Sigismondo Sica, Luigi Siragusa Salvatore Pucciarelli, Matteo Zui

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1

Phosphatidylinositol-4-phosphate (PI4P), a phosphoinositide with key roles in the Golgi complex, is made by Golgi-associated phosphatidylinositol-4 kinases and consumed by the 4-phosphatase Sac1 that, instead, is an ER membrane protein. Here, we show that the contact sites between the ER and the TGN (ERTGoCS) provide a spatial setting suitable for Sac1 to dephosphorylate PI4P at the TGN. The ERTGoCS, though necessary, are not sufficient for the phosphatase activity of Sac1 on TGN PI4P, since this needs the phosphatidyl-four-phosphate-adaptor-protein-1 (FAPP1). FAPP1 localizes at ERTGoCS, interacts with Sac1, and promotes its in-trans phosphatase activity in vitro. We envision that FAPP1, acting as a PI4P detector and adaptor, positions Sac1 close to TGN domains with elevated PI4P concentrations allowing PI4P consumption. Indeed, FAPP1 depletion induces an increase in TGN PI4P that leads to increased secretion of selected cargoes (e.g., ApoB100), indicating that FAPP1, by controlling PI4P levels, acts as a gatekeeper of Golgi exit.Peer reviewe

Molecular determinants of ER-Golgi contacts identified through a new FRET-FLIM system

ER-TGN contact sites (ERTGoCS) have been visualized by electron microscopy, but their location in the crowded perinuclear area has hampered their analysis via optical microscopy as well as their mechanistic study. To overcome these limits we developed a FRET-based approach and screened several candidates to search for molecular determinants of the ERTGoCS. These included the ER membrane proteins VAPA and VAPB and lipid transfer proteins possessing dual (ER and TGN) targeting motifs that have been hypothesized to contribute to the maintenance of ERTGoCS, such as the ceramide transfer protein CERT and several members of the oxysterol binding proteins. We found that VAP proteins, OSBP1, ORP9, and ORP10 are required, with OSBP1 playing a redundant role with ORP9, which does not involve its lipid transfer activity, and ORP10 being required due to its ability to transfer phosphatidylserine to the TGN. Our results indicate that both structural tethers and a proper lipid composition are needed for ERTGoCS integrity.Peer reviewe

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients