5,340 research outputs found
Baseline LHC machine parameters and configuration of the 2015 proton run
This paper shows the baseline LHC machine parameters for the 2015 start-up.
Many systems have been upgraded during LS1 and in 2015 the LHC will operate at
a higher energy than before and with a tighter filling scheme. Therefore, the
2015 commissioning phase risks to be less smooth than in 2012. The proposed
starting configuration puts the focus on feasibility rather than peak
performance and includes margins for operational uncertainties. Instead, once
beam experience and a better machine knowledge has been obtained, a push in
and performance can be envisaged. In this paper, the focus is on
collimation settings and reach in ---other parameters are covered in
greater depth by other papers in these proceedings.Comment: submitted for publication in a CERN yellow report (Proceedings of the
LHC Performance Workshop - Chamonix 2014
The chemical structure of the very young starless core L1521E
L1521E is a dense starless core in Taurus that was found to have relatively
low molecular depletion by earlier studies, thus suggesting a recent formation.
We aim to characterize the chemical structure of L1521E and compare it to the
more evolved L1544 pre-stellar core. We have obtained 2.52.5
arcminute maps toward L1521E using the IRAM-30m telescope in transitions of
various species. We derived abundances for the species and compared them to
those obtained toward L1544. We estimated CO depletion factors. Similarly to
L1544, -CH and CHOH peak at different positions. Most species
peak toward the -CH peak. The CO depletion factor derived toward the
dust peak is 4.31.6, which is about a factor of three lower
than that toward L1544. The abundances of sulfur-bearing molecules are higher
toward L1521E than toward L1544 by factors of 2-20. The abundance of
methanol is similar toward the two cores. The higher abundances of
sulfur-bearing species toward L1521E than toward L1544 suggest that significant
sulfur depletion takes place during the dynamical evolution of dense cores,
from the starless to pre-stellar stage. The CO depletion factor measured toward
L1521E suggests that CO is more depleted than previously found. Similar
CHOH abundances between L1521E and L1544 hint that methanol is forming at
specific physical conditions in Taurus, characterized by densities of a few
10 cm and (H)10 cm, when CO
starts to catastrophically freeze-out, while water can still be significantly
photodissociated, so that the surfaces of dust grains become rich in solid CO
and CHOH, as already found toward L1544. Methanol can thus provide
selective crucial information about the transition region between dense cores
and the surrounding parent cloud.Comment: Accepted for publication in A&A, abstract abridge
Manejo de Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) na cultura do morangueiro no Rio Grande do Sul.
Esta Circular Técnica tem como objetivo descrever a biologia de F. occidentalis na cultura do morangueiro, caracterizar o tipo de injúria causada pelo inseto em flores e frutos e fornecer informações para o monitoramento e o controle da espécie na cultura no Estado do Rio Grande do Sul.bitstream/item/73816/1/cir090.pd
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Micromixing and microchannel design: Vortex shape and entropy
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.In very recent years microdevices, due to their potency in replacing large-scale conventional laboratory instrumentation, are becoming a fast and low cost technology for the treatment of several chemical and biological processes. In particular microfluidics has been massively investigated, aiming at improving the performance of chemical reactors. This is because of the fact that reaction is often an interface phenomenon where the greater the surface to volume ratio, the higher the reaction speed, and microscale mixing increases the interfacial area (in terms of mixing-induced-by-vortices generation). However, microfluidic systems suffer from the limitation that they are characterized mostly by very low Reynolds numbers, with the consequence that (i) they cannot take advantage from the turbulence mixing support, and (ii) viscosity hampers proper vortex detection. Therefore, the proper design of micro-channels (MCs) becomes essential. In this framework, several geometries have been proposed to induce mixing vortices in MCs. However a quantitative comparison between proposed geometries in terms of their passive mixing
potency can be done only after proper definition of vortex formation (topology, size) and mixing performance. The objective of this study is to test the ability of different fluid dynamic metrics in vortex
detection and mixing effectiveness in micromixers. This is done numerically solving different conditions for the flow in a classic passive mixer, a ring shaped MC. We speculate that MCs design could take advantage from fluidic metrics able to rank properly flow related mixing
Caracterização de danos causados por Anastrepha fraterculus (Wiedemann) (Diptera, Tephritidae) e desenvolvimento larval em frutos de duas cultivares de quivizeiro (Actinidia spp.)
Os danos causados por A. fraterculus em três estágios de maturação de frutos de quivizeiro foram avaliados em pomar comercial, e, em laboratório, o desenvolvimento larval da espécie foi estudado, nas cultivares MG06 e Bruno. Frutos das duas cultivares foram infestados com A. fraterculus, em pomar comercial localizado em Farroupilha-RS, no início (30% do tamanho final), metade (90% do tamanho final) e final (ponto de colheita) do ciclo de desenvolvimento, e, em laboratório, desde o início da frutificação até a colheita. Na cultivar MG06, três dias após a primeira infestação, observou-se a formação de exsudato cristalino nos locais de punctura que evolui, na colheita, para rachaduras, depressões e primórdios de galerias nos frutos. Na mesma cultivar, registrou-se fibrose nos frutos infestados no fim do ciclo (ponto de colheita). Apesar de terem sidos computados ovos nos frutos, a campo não houve desenvolvimento larval nessa cultivar. Na Bruno, não foram constatados danos e ovos, indicando a imunidade da cultivar. Não houve queda de frutos atribuída a A. fraterculus nas duas cultivares. Verificou-se o desenvolvimento larval, em laboratório, quando os frutos apresentavam, no mínimo, 6,4% e 7,0% de sólidos solúveis totais, respectivamente, para as cultivares MG06 e Bruno
Design of polarization-insensitive superconducting single photon detectors with high-index dielectrics
In this paper, the design of superconducting-nanowire single-photon detectors
which are insensitive to the polarization of the incident light is
investigated. By using high-refractive-index dielectrics, the index mismatch
between the nanowire and the surrounding media is reduced. This enhances the
absorption of light with electric field vector perpendicular to the nanowire
segments, which is generally hindered in this kind of detectors. Building on
this principle and focusing on NbTiN nanowire devices, we present several
easy-to-realize cavity architectures which allow high absorption efficiency (in
excess of 90%) and polarization insensitivity simultaneously. Designs based on
ultranarrow nanowires, for which the polarization sensitivity is much more
marked, are also presented. Finally, we briefly discuss the specific advantages
of this approach in the case of WSi or MoSi nanowires
The use of thermography to assess the teeth temperature during resection by grinding in piglets
High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes
The development of in vitro models to screen the effect of different concentrations, combinations and temporal sequences of morpho-regulatory factors on stem/progenitor cells is crucial to investigate and possibly recapitulate developmental processes with adult cells. Here, we designed and validated a microfluidic platform to (i) allow cellular condensation, (ii) culture 3D micromasses of human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) under continuous flow perfusion, and (ii) deliver defined concentrations of morphogens to specific culture units. Condensation of hBM-MSCs was obtained within 3 hours, generating micromasses in uniform sizes (56.2 ± 3.9 μm). As compared to traditional macromass pellet cultures, exposure to morphogens involved in the first phases of embryonic limb development (i.e. Wnt and FGF pathways) yielded more uniform cell response throughout the 3D structures of perfused micromasses (PMMs), and a 34-fold higher percentage of proliferating cells at day 7. The use of a logarithmic serial dilution generator allowed to identify an unexpected concentration of TGFβ3 (0.1 ng/ml) permissive to hBM-MSCs proliferation and inductive to chondrogenesis. This proof-of-principle study supports the described microfluidic system as a tool to investigate processes involved in mesenchymal progenitor cells differentiation, towards a ‘developmental engineering’ approach for skeletal tissue regeneration
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Lab-on-Chip for Testing Myelotoxic Effect of Drugs and Chemicals
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.In the last twenty years, one of the main goals in the drug discovery field has been the development
of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative
Methods (ECVAM) has approved the Colony forming Unit-Granulocytes-Macrophages (CFU-GM) test,
which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The
present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip (LoC)
platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput
regime
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