This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.In the last twenty years, one of the main goals in the drug discovery field has been the development
of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative
Methods (ECVAM) has approved the Colony forming Unit-Granulocytes-Macrophages (CFU-GM) test,
which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The
present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip (LoC)
platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput
regime
