Las órdenes religiosas y la crisis en el nombramiento de obispos en Castilla bajo Felipe IV (1621-1665)

La Iglesia española del siglo XVII destacó, sobre la de otros países católicos de la Europa occidental, por el alto porcentaje de miembros de las órdenes religiosas -especialmente dominicos- nombrados obispos. Su autoridad como predicadores y teólogos, en la tradición postridentina, les hacía candidatos eminentemente aptos para el cargo, pero tenían poca experiencia en asuntos de gobierno -requisito fundamental para un episcopado que trabajaba en estrecha alianza con el Estado. Las presiones, tanto políticas como fiscales, a las cuales fue sujeta esta alianza en tiempos de Felipe IV provocaron una crisis sin precedentes en la provisión de candidatos a obispados en Castilla, lo cual favoreció el ascenso de las órdenes religiosas en la carrera episcopal.L'Església espanyola del segle XVII va destacar, per sobre de la d'altres països catòlics de l'Europa occidental, per l'alt percentatge de membres dels ordes religiosos -especialment dominics- nomenats bisbes. Tot i que la seva autoritat com a predicadors i teòlegs, en la tradició posttridentina, els feia candidats eminentment aptes per al càrrec, tenien poca experiència en assumptes de govern -requisit fonamental per a un episcopat que treballava en estreta aliança amb l'Estat. Les pressions, tant polítiques com fiscals, a les quals es va veure sotmesa aquesta aliança en temps de Felip IV van provocar una crisi sense precedents en la provisió de candidats a bisbats a Castella, la qual cosa va afavorir l'ascens dels ordes religiosos en la carrera episcopal.The seventeenth-century Spanish Church stood out among other Catholic countries of western Europe on account of the high percentage of members of the religious orders -especially Dominicans- recruited as bishops. While their authority as preachers and theologians, schooled in the post-Tridentine tradition, made them eminently suitable candidates for office, they had little of the secular experience regarded as a fundamental requirement of an episcopate that worked in close alliance with the state. The political and fiscal pressures placed on this alliance under Philip IV prompted an unprecedented crisis in the preferment of candidates to Castilian bishoprics, which resulted in the rise of the religious orders in the career of bishop

Supporting service change in palliative care: a framework approach

Copyright 2014 Mark Allen Healthcare. editorially accepted manuscript version of the paper reproduced here with permission from the publisher.Background Palliative care services are increasingly identifying areas for improvement, then trying to create appropriate changes in response. Nurses in particular are often expected to take leading roles in Quality Improvement (QI) but are not necessarily trained or supported in these processes. Methods. A framework approach to change was developed to guide services through a change cycle, and delivered via workshops by representatives of three national projects in Australia. Participants were predominantly nurses (80%) with the majority over the age of 50 (62.4%). The workshops and the framework were positively evaluated with participants feeling confident in a number of QI related activities following workshop training. Discussion. Recognising and addressing problems in clinical practice and service delivery is an important way for nurses to ensure quality care for patients, however, they need support in developing the skills and knowledge that are essential to successful QI activities

Detection of a CMB decrement towards a cluster of mJy radiosources

We present the results of radio, optical and near-infrared observations of the field of TOC J0233.3+3021, a cluster of milliJansky radiosources from the TexOx Cluster survey. In an observation of this field with the Ryle Telescope (RT) at 15 GHz, we measure a decrement in the cosmic microwave background (CMB) of $-675 \pm 95 \mu$Jy on the RT's $\approx$ 0.65 k$\lambda$ baseline. Using optical and infrared imaging with the McDonald 2.7-m Smith Reflector, Calar Alto 3.5-m telescope and UKIRT, we identify the host galaxies of five of the radiosources and measure magnitudes of $R \approx 24$, $J \approx 20$, $K \approx 18$. The CMB decrement is consistent with the Sunyaev-Zel'dovich (SZ) effect of a massive cluster of galaxies, which if modelled as a spherical King profile of core radius $\theta_C = 20^{\prime\prime}$ has a central temperature decrement of $900 \mu$K. The magnitudes and colours of the galaxies are consistent with those of old ellipticals at $z \sim 1$. We therefore conclude that TOC J0233.3+3021 is a massive, high redshift cluster. These observations add to the growing evidence for a significant population of massive clusters at high redshift, and demonstrate the effectiveness of combining searches for AGN `signposts' to clusters with the redshift-independence of the SZ effect.Comment: Six pages; accepted for publication in MNRAS. Version with full-resolution UV plot available from http://www.mrao.cam.ac.uk/~garret/MB185.p

Magnetosomes and Magnetosome Mimics: Preparation, Cancer Cell Uptake and Functionalization for Future Cancer Therapies.

Magnetic magnetite nanoparticles (MNP) are heralded as model vehicles for nanomedicine, particularly cancer therapeutics. However, there are many methods of synthesizing different sized and coated MNP, which may affect their performance as nanomedicines. Magnetosomes are naturally occurring, lipid-coated MNP that exhibit exceptional hyperthermic heating, but their properties, cancer cell uptake and toxicity have yet to be compared to other MNP. Magnetosomes can be mimicked by coating MNP in either amphiphilic oleic acid or silica. In this study, magnetosomes are directly compared to control MNP, biomimetic oleic acid and silica coated MNP of varying sizes. MNP are characterized and compared with respect to size, magnetism, and surface properties. Small (8 ± 1.6 nm) and larger (32 ± 9.9 nm) MNP are produced by two different methods and coated with either silica or oleic acid, increasing the size and the size dispersity of the MNP. The coated larger MNP are comparable in size (49 ± 12.5 nm and 61 ± 18.2 nm) to magnetosomes (46 ± 11.8 nm) making good magnetosome mimics. All MNP are assessed and compared for cancer cell uptake in MDA-MB-231 cells and importantly, all are readily taken up with minimal toxic effect. Silica coated MNP show the most uptake with greater than 60% cell uptake at the highest concentration, and magnetosomes showing the least with less than 40% at the highest concentration, while size does not have a significant effect on uptake. Finally, surface functionalization is demonstrated for magnetosomes and silica coated MNP using biotinylation and EDC-NHS, respectively, to conjugate fluorescent probes. The modified particles are visualized in MDA-MB-231 cells and demonstrate how both naturally biosynthesized magnetosomes and biomimetic silica coated MNP can be functionalized and readily up taken by cancer cells for realization as nanomedical vehicles

The extraordinary radio galaxy MRC B1221-423: probing deeper at radio and optical wavelengths

We present optical spectra and high-resolution multi-wavelength radio observations of the compact steep-spectrum radio source MRC B1221-423 (z=0.1706). MRC B1221-423 is a very young (~10^5 yr), powerful radio source which is undergoing a tidal interaction with a companion galaxy. We find strong evidence of interaction between the AGN and its environment. The radio morphology is highly distorted, showing a dramatic interaction between the radio jet and the host galaxy, with the jet being turned almost back on itself. H I observations show strong absorption against the nucleus at an infall velocity of ~250 km/s compared to the stellar velocity, as well as a second, broader component which may represent gas falling into the nucleus. Optical spectra show that star formation is taking place across the whole system. Broad optical emission lines in the nucleus show evidence of outflow. Our observations confirm that MRC B1221-423 is a young radio source in a gas-rich nuclear environment, and that there was a time delay of a few x 100 Myr between the onset of star formation and the triggering of the AGN.Comment: 15 pages, 13 figures, to appear in MNRA

Genetical and comparative genomics of Brassica under altered Ca supply identifies Arabidopsis Ca-transporter orthologs

Although Ca transport in plants is highly complex, the overexpression of vacuolar Ca2+ transporters in crops is a promising new technology to improve dietary Ca supplies through biofortification. Here, we sought to identify novel targets for increasing plant Ca accumulation using genetical and comparative genomics. Expression quantitative trait locus (eQTL) mapping to 1895 cis- and 8015 trans-loci were identified in shoots of an inbred mapping population of Brassica rapa (IMB211 x R500); 23 cis- and 948 trans-eQTLs responded specifically to altered Ca supply. eQTLs were screened for functional significance using a large database of shoot Ca concentration phenotypes of Arabidopsis thaliana. From 31 Arabidopsis gene identifiers tagged to robust shoot Ca concentration phenotypes, 21 mapped to 27 B. rapa eQTLs, including orthologs of the Ca2+ transporters At-CAX1 and At-ACA8. Two of three independent missense mutants of BraA.cax1a, isolated previously by targeting induced local lesions in genomes, have allele-specific shoot Ca concentration phenotypes compared with their segregating wild types. BraA.CAX1a is a promising target for altering the Ca composition of Brassica, consistent with prior knowledge from Arabidopsis. We conclude that multiple-environment eQTL analysis of complex crop genomes combined with comparative genomics is a powerful technique for novel gene identification/prioritization

The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Genomic screening is routinely used to guide the treatment of cancer patients in many countries. However, several multi-layered factors make this effort difficult to deliver within a clinically relevant timeframe. Here we share the learnings from the CRUK-funded Stratified Medicine Programme for advanced NSCLC patients, which could be useful to better plan future studies

Support from the UK Department of Health through its Health Technology Assessment Programme and Arthritis Research

ABSTRACT. Objective. Our aim was to determine areal bone mineral density (BMD a ) and disease-related factors linked with BMD a in adults with a history of juvenile idiopathic arthritis (JIA). Methods. Men and women with a history of JIA attending a young adult rheumatology clinic in Newcastle, UK, underwent dual energy x-ray absorptiometry (DEXA) of the lumbar spine and total hip. Information was obtained about disease duration and subtype, previous treatment including corticosteroid and methotrexate therapy, and large-joint replacement. Subjects completed the modified Health Assessment Questionnaire (HAQ). Blood was taken for assessment of C-reactive protein, erythrocyte sedimentation rate, and rheumatoid factor (RF). Results. Seventy-one women and 16 men, mean age 28.7 and 31.4 years, and mean disease duration 20.6 and 24.0 years, respectively, were studied. Mean BMD a was 0.982 (Z-score = -0.328; 95% CI -0.657, 0.001) and 1.028 g/cm 2 (Z-score = -0.251; 95% CI -1.266, 0.764) in women and men, respectively, at the spine and 0.817 (Z-score = -0.542; 95% CI -0.975, -0.109) and 0.857 g/cm 2 (Z-score = -0.176; 95% CI -2.323, 1.971) at the hip. After adjusting for age and sex, increasing HAQ score was associated with both lower spine BMD a and hip BMD a . Compared with patients with oligoarticular disease, those with enthesitis-related arthritis had higher BMD a at the spine, while those with extended oligoarticular and polyarticular RF-negative disease had lower hip BMD a . Oral corticosteroids and the presence of a large-joint replacement were associated with lower BMD a at both the spine and hip. Conclusion. There was a trend toward low BMD a in women with a history of JIA. These patients may be at risk of the complications of osteoporosis including fragility fractures and should be considered for targeted preventive measures. (First Release June 15 2011

Genetical and comparative genomics of Brassica under altered Ca supply identifies Arabidopsis Ca-transporter orthologs

Although Ca transport in plants is highly complex, the overexpression of vacuolar Ca2+ transporters in crops is a promising new technology to improve dietary Ca supplies through biofortification. Here, we sought to identify novel targets for increasing plant Ca accumulation using genetical and comparative genomics. Expression quantitative trait locus (eQTL) mapping to 1895 cis- and 8015 trans-loci were identified in shoots of an inbred mapping population of Brassica rapa (IMB211 x R500); 23 cis- and 948 trans-eQTLs responded specifically to altered Ca supply. eQTLs were screened for functional significance using a large database of shoot Ca concentration phenotypes of Arabidopsis thaliana. From 31 Arabidopsis gene identifiers tagged to robust shoot Ca concentration phenotypes, 21 mapped to 27 B. rapa eQTLs, including orthologs of the Ca2+ transporters At-CAX1 and At-ACA8. Two of three independent missense mutants of BraA.cax1a, isolated previously by targeting induced local lesions in genomes, have allele-specific shoot Ca concentration phenotypes compared with their segregating wild types. BraA.CAX1a is a promising target for altering the Ca composition of Brassica, consistent with prior knowledge from Arabidopsis. We conclude that multiple-environment eQTL analysis of complex crop genomes combined with comparative genomics is a powerful technique for novel gene identification/prioritization