Magnetoresistance behavior of a ferromagnetic shape memory alloy: Ni_1.75Mn_1.25Ga

A negative-positive-negative switching behavior of magnetoresistance (MR) with temperature is observed in a ferromagnetic shape memory alloy Ni_1.75Mn_1.25Ga. In the austenitic phase between 300 and 120 K, MR is negative due to s-d scattering. Curiously, below 120K MR is positive, while at still lower temperatures in the martensitic phase, MR is negative again. The positive MR cannot be explained by Lorentz contribution and is related to a magnetic transition. Evidence for this is obtained from ab initio density functional theory, a decrease in magnetization and resistivity upturn at 120 K. Theory shows that a ferrimagnetic state with anti-ferromagnetic alignment between the local magnetic moments of the Mn atoms is the energetically favoured ground state. In the martensitic phase, there are two competing factors that govern the MR behavior: a dominant negative trend up to the saturation field due to the decrease of electron scattering at twin and domain boundaries; and a weaker positive trend due to the ferrimagnetic nature of the magnetic state. MR exhibits a hysteresis between heating and cooling that is related to the first order nature of the martensitic phase transition.Comment: 17 pages, 5 figures. Accepted in Phys. Rev.

Medicinal Plants Diversity and their Conservation Status in Wildlife Institute of India (WII) Campus, Dehradun

The present paper deals with the status and distribution pattern of medicinal plants in Wildlife Institute of India campus, Dehradun, Uttarakhand, India. Based on extensive literature survey, of the total (#605 plants) 63% are medicinal plants. These medicinal plants comprise of 63 trees, 55 shrubs, 208 herbs, 34 climbers, 3 ferns and 10 grasses belong to 94 families. Poaceae, Asteraceae, Cyperaceae and Euphorbiaceae are the largest families and have more than 20 species of medicinal plants. Fabaceae, Asteraceae, Poaceae, Euphorbiaceae, Lamiaceae, Malvaceae, Acanthaceae, Apocynaceae, Caesalpiniaceae, Verbenaceae, Cucurbitaceae and Solanaceae are the dominant families with high species diversity. The nativity of plants shows that 21 species are from Himalayan region and 101 from Indian oriental region, while remaining are from various parts of the world. Pyrus pashia and Rubia cordifolia have the distribution up to cool temperate region among trees and climbers, respectively. Among plant parts, bark, leaves and roots are mainly used for trees, shrubs and climbers, respectively. However, the entire plant of herbs, grasses and sedges and leaves and roots of ferns are used. Most of the species of trees, herbs and climbers are used for diarrhoea/dysentery, shrubs for cough/cold, grasses and sedges for fever and ferns for skin diseases. The conservation efforts have been discussed in the paper

The devices, experimental scaffolds, and biomaterials ontology (DEB): a tool for mapping, annotation, and analysis of biomaterials' data

The size and complexity of the biomaterials literature makes systematic data analysis an excruciating manual task. A practical solution is creating databases and information resources. Implant design and biomaterials research can greatly benefit from an open database for systematic data retrieval. Ontologies are pivotal to knowledge base creation, serving to represent and organize domain knowledge. To name but two examples, GO, the gene ontology, and CheBI, Chemical Entities of Biological Interest ontology and their associated databases are central resources to their respective research communities. The creation of the devices, experimental scaffolds, and biomaterials ontology (DEB), an open resource for organizing information about biomaterials, their design, manufacture, and biological testing, is described. It is developed using text analysis for identifying ontology terms from a biomaterials gold standard corpus, systematically curated to represent the domain's lexicon. Topics covered are validated by members of the biomaterials research community. The ontology may be used for searching terms, performing annotations for machine learning applications, standardized meta-data indexing, and other cross-disciplinary data exploitation. The input of the biomaterials community to this effort to create data-driven open-access research tools is encouraged and welcomed.Preprin

IMAGES II. A surprisingly low fraction of undisturbed rotating spiral disks at z~0.6: The morpho-kinematical relation 6 Gyrs ago

We present a first combined analysis of the morphological and dynamical properties for the Intermediate MAss Galaxy Evolution Sequence (IMAGES) sample. It is a representative sample of 52 z~0.6 galaxies with Mstell from 1.5 to 15 10^10Msun and possessing 3D resolved kinematics and HST deep imaging in at least two broad band filters. We aim at evaluate robustly the evolution of rotating spirals since z~0.6, as well as to test the different schemes for classifying galaxies morphologically. We used all the information provided by multi-band images, color maps and 2 dimensional light fitting to assign to each object a morphological class. We divided our sample between spiral disks, peculiar objects, compact objects and mergers. Using our morphological classification scheme, 4/5 of identified spirals are rotating disks and more than 4/5 of identified peculiar galaxies show complex kinematics, while automatic classification methods such as Concentration-Asymmetry and GINI-M20 severely overestimate the fraction of relaxed disk galaxies. Using this methodology, we find that the fraction of rotating spirals has increased by a factor ~ 2 during the last 6 Gyrs, a much higher fraction that found previously based on morphologies alone. These rotating spiral disks are forming stars very rapidly, doubling their stellar masses over the last 6 Gyrs, while most of their stars have been formed few Gyrs earlier, which reveals the presence of a large gas supply. Because they are likely the progenitors of local spirals, we can conjecture how their properties are evolving. Their disks show some evidence for an inside-out growth and the gas supply/accretion is not made randomly as the disk need to be stable in order to match the local disk properties.Comment: Typos corrected, reference adde

FORMULATION DEVELOPMENT & EVALUATION OF EFFERVESCENT TABLET OF ALENDRONATE SODIUM WITH VITAMIN D3

Alendronate sodium is a bisphosphonates which has antiresorptive effect which is implicated in the prophylaxis and treatment of osteoporosis. The objective of this study was to formulate effervescent tablet of Alendronate sodium with Vitamin D3 against osteoporosis thereby improving patient compliance.                                                                                                                          As per revised definition proposed to US FDA, Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration.         Effervescent tablets were formulated using citric acid and sodium bicarbonate as effervescent composition by wet granulation. The drug-excipient compatibility study done by DSC & FTIR analysis and it reveals absence of interaction between the drug and excipients. The flowability study of precompression blend shows good flow properties. Formulation was evaluated for weight variation, thickness, hardness, solution time, pH of solution & content uniformity. All the evaluation parameters were within the limit and complies specifications as per U.S.P. & B.P. From the Stability analysis may be inferred that there was no degradation and change in the formulation.                                                                                                                                                  The Effervescent tablet of Sodium Alendronate and Vitamin D3 is a new pharmaceutical formulation to be taken orally and offering a considerable advantage: avoidance of gastro-intestinal disorders, to the limits of the possible. As compared to the pure drug and marketed tablet, this formulation displayed significantly effective in the oral osteoporosis treatment in post menopausal women

IMAGES I. Strong evolution of galaxy kinematics since z=1

(abbreviated) We present the first results of the ESO large program, ``IMAGES'' which aims at obtaining robust measurements of the kinematics of distant galaxies using the multi-IFU mode of GIRAFFE on the VLT. 3D spectroscopy is essential to robustly measure the often distorted kinematics of distant galaxies (e.g., Flores et al. 2006). We derive the velocity fields and $\sigma$-maps of 36 galaxies at 0.4<z<0.75 from the kinematics of the [OII] emission line doublet, and generate a robust technique to identify the nature of the velocity fields based on the pixels of the highest signal-to-noise ratios (S/N). We have gathered a unique sample of 63 velocity fields of emission line galaxies (W0([OII]) > 15 A) at z=0.4-0.75, which are a representative subsample of the population of M_stellar>1.5x10^{10} M_sun emission line galaxies in this redshift range, and are largely unaffected by cosmic variance. Taking into account all galaxies -with or without emission lines- in that redshift range, we find that at least 41+/-7% of them have anomalous kinematics, i.e., they are not dynamically relaxed. This includes 26+/-7% of distant galaxies with complex kinematics, i.e., they are not simply pressure or rotationally supported. Our result implies that galaxy kinematics are among the most rapidly evolving properties, because locally, only a few percent of the galaxies in this mass range have complex kinematics.Comment: 17 pages, 6 figures, Accepted by A&

Multi-hop hierarchical routing based on the node health status in wireless sensor network

© Springer Nature Switzerland AG 2019. This paper proposed multi-hop hierarchical routing to monitor forest fire using wireless sensor network. The node health status is introduced in choosing Cluster Head (CH) in order to avoid route breakages caused by CH that burns off. CHs transmit their data to the closest CH which is in the direction to the Base Station. The performance of the proposed method is compared to the Leach, MTE, and the direct algorithm. The extensive simulation is done by NS2 with results showing that the proposed method outperforms others in term of the number of packets received, energy consumed, the number of nodes alive, and average end to end delay

IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

The accumulation of fibroblasts, their synthesis of extracellular matrix (ECM) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator of airway remodeling in asthma. However, the contribution of IL-17 to the pro-fibrotic phenotype of bronchial fibroblasts is not well-characterized. In this study, we investigated whether IL-17 induced autophagy regulates mitochondrial and pro-fibrotic function in bronchial fibroblasts. The primary cultured bronchial fibroblasts isolated from non-asthmatic (NHBF) and severe asthmatic (DHBF) subjects were treated with IL-17 in order to ascertain its effect on mitochondrial function, mitochondrial quality control, and apoptosis using immunoblotting and flow cytometric analyses. At baseline, DHBF exhibited higher levels of mitophagy and mitochondrial biogenesis compared to NHBF. Immunohistochemical evaluation of bronchial biopsies showed intense PINK1 immunoreactivity in severe asthma than in control. IL-17 intensified the mitochondrial dysfunction and impaired the mitochondrial quality control machinery in NHBF and DHBF. Moreover, IL-17 augmented a pro-fibrotic and anti-apoptotic response in both group of fibroblasts. Inhibition of autophagy using bafilomycin-A1 reduced PINK1 expression in NHBF and restored the IL-17 mediated changes in PINK1 to their basal levels in DHBF. Bafilomycin-A1 also reversed the IL-17 associated fibrotic response in these fibroblasts, suggesting a role for IL-17 induced autophagy in the induction of fibrosis in bronchial fibroblasts. Taken together, our findings suggest that IL-17 induced autophagy promotes mitochondrial dysfunction and fibrosis in bronchial fibroblasts from both non-asthmatic and severe asthmatic subjects. Our study provides insights into the therapeutic potential of targeting autophagy in ameliorating fibrosis, particularly in severe asthmatic individuals

IMAGES-III: The evolution of the Near-Infrared Tully-Fisher relation over the last 6 Gyr

Using the multi-integral field spectrograph GIRAFFE at VLT, we have derived the K-band Tully-Fisher relation (TFR) at z~0.6 for a representative sample of 65 galaxies with emission lines. We confirm that the scatter in the z~0.6 TFR is caused by galaxies with anomalous kinematics, and find a positive and strong correlation between the complexity of the kinematics and the scatter that they contribute to the TFR. Considering only relaxed-rotating disks, the scatter, and possibly also the slope of the TFR, do not appear to evolve with z. We detect an evolution of the K-band TFR zero point between z~0.6 and z=0, which, if interpreted as an evolution of the K-band luminosity of rotating disks, would imply that a brightening of 0.66+/-0.14 mag occurs between z~0.6 and z=0. Any disagreement with the results of Flores et al. (2006) are attributed to both an improvement of the local TFR and the more detailed accurate measurement of the rotation velocities in the distant sample. Most of the uncertainty can be explained by the relatively coarse spatial-resolution of the kinematical data. Because most rotating disks at z~0.6 are unlikely to experience further merging events, one may assume that their rotational velocity does not evolve dramatically. If true, our result implies that rotating disks observed at z~0.6 are rapidly transforming their gas into stars, to be able to double their stellar masses and be observed on the TFR at z=0. The rotating disks observed are indeed emission-line galaxies that are either starbursts or LIRGs, which implies that they are forming stars at a high rate. Thus, a significant fraction of the rotating disks are forming the bulk of their stars within 6 to 8 Gyr, in good agreement with former studies of the evolution of the M-Z relation.Comment: 17 pages, 11 figures, accepted for publication in A&A. v2 taking into account comments from language edito