Health Literacy: Addressing Well-Being: A Review

Literacy forms an important input in overall development of individual enabling them to comprehend their social, political and cultural environment better and respond to it. Health literacy requires knowledge of health topics. People with limited health literacy often lack knowledge or have misinformation about the body as well as the nature and causes of disease. Without this knowledge, they may not understand the relationship between lifestyle factors such as diet and exercise and various health outcomes. Health literacy plays a key role on the overall health and wellbeing and is now recognized as a determinant of health and has been made a priority of public health agendas, as there is existence of clear scientific evidence regarding its association with health outcomes such as use of health care services, hospitalizations, mortality rates, and adherence to treatment regimens. Therefore, responsive health system that eliminates barriers to clear communication and provides usable and actionable health information and services is important to uplift the current situation

HIV Patient with Mucous Membrane Pemphigoid: A Case Report

Background: Mucous Membrane Pemphigoid, a new denomination of cicatricial pemphigoid, encompasses a group of chronic subepithelial autoimmune blistering diseases that predominantly affect the oral cavity and the eyes (conjunctivitis and symblepharon).Case Details: A rare case of Mucous Membrane Pemphigoid (MMP) in a human immunodeficiency virus (HIV) positive patient is discussed with clinicohistopathological presentation.Conclusion: Since our patient was HIV-positive and had lesions restricted to the oral mucosa with ocular involvement, only topical and intralesional steroids were preferred as the first line of treatment. Systemic corticosteroid therapy raises a concern regarding immunosuppression.Keywords: HIV, MMP, Cicatricial pemphigoid

Oral Health Knowledge, Attitude and Practices among Adults toward Tooth Loss and Utilization of Dental Services in Moradabad District

Background and objectives: For centuries, people have accepted tooth loss as an inevitable part of the human condition. Tooth loss impairs the quality of life, often substantially, andaffects the well being of the person. The objectives of study were to evaluate behavioral characteristics of the adults like beliefs about tooth loss and utilization of available health services which might be associated with tooth loss. Methodology: A cross-sectional survey was conducted on 1,200 adults of Moradabad district, aged 35 to 74 years, 565 from urban area and 635 from rural area who were selected by multistage systematic random sampling technique. Data was collected by an interview followed by examination for the numberof missing teeth. Results: Mean number of missing teeth in the study population was 4.2. Around half of the study population, i.e. 51.1% of the adults claimed that they had no dental treatment facilities nearby. Among the 602 adults (50.2%) who had utilized dental services earlier, greatest response for reason of dental visit was for extraction of teeth  (48.7%). Conclusion: The findings from this study are useful in identifying the sociodemographic and behavioral characteristics associated with tooth loss among the study population. The insights gained from this study illustrate the need for tailoring Oral Health Promotion Programs and Services for the community, as the modification of these nondisease independent factors can reduce the tooth loss and improve the oral health of the adults of Moradabad district

Penetration of the Stigma and Style Elicits a Novel Transcriptome in Pollen Tubes, Pointing to Genes Critical for Growth in a Pistil

Pollen tubes extend through pistil tissues and are guided to ovules where they release sperm for fertilization. Although pollen tubes can germinate and elongate in a synthetic medium, their trajectory is random and their growth rates are slower compared to growth in pistil tissues. Furthermore, interaction with the pistil renders pollen tubes competent to respond to guidance cues secreted by specialized cells within the ovule. The molecular basis for this potentiation of the pollen tube by the pistil remains uncharacterized. Using microarray analysis in Arabidopsis, we show that pollen tubes that have grown through stigma and style tissues of a pistil have a distinct gene expression profile and express a substantially larger fraction of the Arabidopsis genome than pollen grains or pollen tubes grown in vitro. Genes involved in signal transduction, transcription, and pollen tube growth are overrepresented in the subset of the Arabidopsis genome that is enriched in pistil-interacted pollen tubes, suggesting the possibility of a regulatory network that orchestrates gene expression as pollen tubes migrate through the pistil. Reverse genetic analysis of genes induced during pollen tube growth identified seven that had not previously been implicated in pollen tube growth. Two genes are required for pollen tube navigation through the pistil, and five genes are required for optimal pollen tube elongation in vitro. Our studies form the foundation for functional genomic analysis of the interactions between the pollen tube and the pistil, which is an excellent system for elucidation of novel modes of cell–cell interaction

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Assessment of Dental caries status, Periodontal health and oral hygiene practices among two Populations of Moradabad city, India

Background: Ever since the beginning of the universe mankind had struggled constantly for their livelihood, Moradabad is branded as the &ldquo;Brass city&rdquo; of India, which comprises of a large number of populations working in different industries. Objective: To assess and compare the oral health status of workers employed in brass industries with non industrial workers of Moradabad city. Material and Methods: A total of 500 workers from each group aged 30-50 with 5 years working experience were selected through random sampling. Type III examination was performed by recording who oral health assessment form. To compare the proportion chi-square test was used. Mean values were compared using students t-test. SPSS version 15.0 was used for statistical analyses. Results: The prevalence of dental caries as Mean DMFT score was significantly higher in Non Industrial Group i.e. 3.57&plusmn;2.74 while it was 2.88&plusmn;2.14 in brass workers. Periodontal diseases were higher among production workers that belong to brass industries. The prevalence of Oral Mucosal Lesions was significantly higher among Production Workers. Bleeding was more pronounced in general population but calculus and pockets were seen more in brass workers. The requirement of prosthetic status was also more prevalent among industry subjects. &nbsp;Conclusion: The Oral health status of Brass Industry Workers was relatively poor with poor periodontal health when compared to General Population. Further studies of oral occupational disease should be conducted in order to check or confirm previous reports and to discover possible manifestations arising in new industries.DOI: http://dx.doi.org/10.3126/ijosh.v3i2.631

Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses

Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity by inducing type I IFN (IFN-αβ). In this study, we show that DNA is also sensed via STING to suppress immunity by inducing IDO. STING gene ablation abolished IFN-αβ and IDO induction by dendritic cells (DCs) after DNA nanoparticle (DNP) treatment. Marginal zone macrophages, some DCs, and myeloid cells ingested DNPs, but CD11b(+) DCs were the only cells to express IFN-β, whereas CD11b(+) non-DCs were major IL-1β producers. STING ablation also abolished DNP-induced regulatory responses by DCs and regulatory T cells, and hallmark regulatory responses to apoptotic cells were also abrogated. Moreover, systemic cyclic diguanylate monophosphate treatment to activate STING induced selective IFN-β expression by CD11b(+) DCs and suppressed Th1 responses to immunization. Thus, previously unrecognized functional diversity among physiologic innate immune cells regarding DNA sensing via STING is pivotal in driving immune responses to DNA