Intraosseous Synovial Sarcoma of the Proximal Tibia

Synovial Sarcoma is a malignant mesenchymal tumor that comprises 5–10% of all soft tissue sarcomas. The mean age of onset is thirty years old. Intraosseous presentation is very rare and has only been documented a few times. We report herein a case of a 53-year-old man with synovial sarcoma arising in the left proximal tibia. The patient underwent a wide surgical resection and reconstruction, followed by adjuvant chemotherapy. Three years later, the patient developed a local recurrence that resulted in an above-the-knee amputation. Eight months later, the patient has completed chemotherapy and is without signs of recurrence. The current recommended treatment for synovial sarcoma is wide surgical resection followed by chemotherapy as well as long-term followup. Despite improved surgical techniques, long-term survival rates remain low

The HERMES Solar Atlas and the spectroscopic analysis of the seismic solar analogue KIC3241581

Solar-analog stars provide an excellent opportunity to study the Sun's evolution, i.e. the changes with time in stellar structure, activity, or rotation for solar-like stars. The unparalleled photometric data from the NASA space telescope Kepler allows us to study and characterise solar-like stars through asteroseismology. We aim to spectroscopically investigate the fundamental parameter and chromospheric activity of solar analogues and twins, based on observations obtained with the HERMES spectrograph and combine them with asteroseismology. Therefore, we need to build a solar atlas for the spectrograph, to provide accurate calibrations of the spectroscopically determined abundances of solar and late type stars observed with this instrument and thus perform differential spectral comparisons. We acquire high-resolution and high signal-to-noise spectroscopy to construct three solar reference spectra by observing the reflected light of Vesta and Victoria asteroids and Europa (100<S/N<450) with the \Hermes spectrograph. We then observe the Kepler solar analog KIC3241581 (S/N~170). We constructed three solar spectrum atlases from 385 to 900 nm obtained with the Hermes spectrograph from observations of two bright asteroids and Europa. A comparison between our solar spectra atlas to the Kurucz and HARPS solar spectrum shows an excellent agreement. KIC3241581 was found to be a long-periodic binary system. The fundamental parameter for the stellar primary component are Teff=5689+/-11K, logg=4.385+/-0.005, [Fe/H]=+0.22+/-0.01, being in agreement with the published global seismic values confirming its status of solar analogue. KIC 3241581 is a metal rich solar analogue with a solar-like activity level in a binary system of unknown period. The chromospheric activity level is compatible to the solar magnetic activity.Comment: 12 pages, 8 figures, accepted for publication in A&

Dynamic compartmentalization of bacteria: accurate division in E. coli

Positioning of the midcell division plane within the bacterium E. coli is controlled by the min system of proteins: MinC, MinD and MinE. These proteins coherently oscillate from end to end of the bacterium. We present a reaction--diffusion model describing the diffusion of min proteins along the bacterium and their transfer between the cytoplasmic membrane and cytoplasm. Our model spontaneously generates protein oscillations in good agreement with experiments. We explore the oscillation stability, frequency and wavelength as a function of protein concentration and bacterial length.Comment: 4 pages, 4 figures, Latex2e, Revtex

Measuring longitudinal amplitudes for electroproduction of pseudoscalar mesons using recoil polarization in parallel kinematics

We propose a new method for measuring longitudinal amplitudes for electroproduction of pseudoscalar mesons that exploits a symmetry relation for polarization observables in parallel kinematics. This polarization technique does not require variation of electron scattering kinematics and avoids the major sources of systematic errors in Rosenbluth separation.Comment: intended for Phys. Rev. C as a Brief Repor

A comparison of laboratory, clinical and self-report measures of prospective memory in healthy adults and individuals with brain injury

Individuals with traumatic brain injury (TBI) have demonstrated deficits in prospective memory (PM) functioning when compared to healthy adults. These deficits have been measured using laboratory measures, clinical measures and self-report questionnaires. However, PM has been shown to involve multiple cognitive processes and have a variety of stages. Thus, it is not known if these measures all assess the same aspects of PM. Thus, this study was designed to measure the convergent validity of the three types of PM measures in both healthy adults and individuals with TBI. We aimed to investigate the convergent validity of the three types of tasks in two ways. First, we sought to investigate if the PM deficits experienced by people with TBI are consistent across tasks. And, second, we sought to examine the relationship between the three types of tasks. Results demonstrated that while all three types of measures were sensitive to PM deficits in TBI, there were differences in the aspects/processes of PM being measured. Data from the laboratory measure suggested a specific difficulty with detecting the correct cue. Data from the clinical measure suggested that TBI has a greater effect on time-based cues than event-based cues and that the primary deficit is a prospective intention retrieval deficit rather than the retrospective memory component. In addition, those with TBI did not differ from healthy adults when the time delay was short enough, suggesting that PM is not universally impaired. Data from the self-report questionnaire suggested that those with TBI are more sensitive to difficulties with basic activities of daily living rather than instrumental activities on daily living. These results are discussed in terms of rehabilitation techniques that could focus first on cue detection and use basic activities of daily living as outcome measures

Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution.

Background:Dedifferentiated chondrosarcomas (DDCSs) are highly malignant tumors with a dismal prognosis and present a significant challenge in clinical management. Methods:In an IRB approved retrospective protocol, we identified 72 patients with DDCS treated at our institution between 1993 and 2017 and reviewed clinicopathological characteristics, treatment modalities, and outcomes to analyze prognostic factors. Results:Femur (44.4%), pelvis (22.2%), and humerus (12.5%) were most commonly involved sites. Twenty-three patients (31.9%) presented with distant metastasis, and 3 (4.2%) of them also had regional lymph node involvement. The median overall survival (OS) was 13.9 months. On multivariate analysis, pathological fracture, larger tumor size, lymph node involvement, metastasis at diagnosis, extraosseous extension, and undifferentiated pleomorphic sarcoma component correlated with worse OS, whereas surgical resection and chemotherapy were associated with improved OS. For progression-free survival (PFS), pathological fracture and metastasis at diagnosis showed increased risk, while chemotherapy was associated with decreased risk. Among patients who received chemotherapy, doxorubicin and cisplatin were significantly associated with improved PFS but not OS. Among patients without metastasis at diagnosis, 17 (34.7%) developed local recurrence. Thirty-one (63.3%) developed distant metastases at a median interval of 18.1 months. On multivariate analysis, R1/R2 resection was related with local recurrence, while macroscopic dedifferentiated component was associated with distant metastasis. Conclusions:The prognosis of DDCS is poor. Complete resection remains a significant prognostic factor for local control. Chemotherapy with doxorubicin and cisplatin seems to have better PFS. More prognostic, multicenter trials are warranted to further explore the effectiveness of chemotherapy in selected DDCS patients

Mass ratio from Doppler beaming and R{\o}mer delay versus ellipsoidal modulation in the Kepler data of KOI-74

We present a light curve analysis and radial velocity study of KOI-74, an eclipsing A star + white dwarf binary with a 5.2 day orbit. Aside from new spectroscopy covering the orbit of the system, we used 212 days of publicly available Kepler observations and present the first complete light curve fitting to these data, modelling the eclipses and transits, ellipsoidal modulation, reflection, and Doppler beaming. Markov Chain Monte Carlo simulations are used to determine the system parameters and uncertainty estimates. Our results are in agreement with earlier studies, except that we find an inclination of 87.0 \pm 0.4\degree, which is significantly lower than the previously published value. We find that the mass ratio derived from the radial velocity amplitude (q=0.104 \pm 0.004) disagrees with that derived from the ellipsoidal modulation (q=0.052 \pm 0.004} assuming corotation). This was found before, but with our smaller inclination, the discrepancy is even larger than previously reported. Accounting for the rapid rotation of the A-star is found to increase the discrepancy even further by lowering the mass ratio to q=0.047 \pm 0.004. These results indicate that one has to be extremely careful in using the amplitude of an ellipsoidal modulation signal in a close binary to determine the mass ratio, when a proof of corotation is not firmly established. The radial velocities that can be inferred from the detected Doppler beaming in the light curve are found to be in agreement with our spectroscopic radial velocity determination. We also report the first measurement of R{\o}mer delay in a light curve of a compact binary. This delay amounts to -56 \pm 17 s and is consistent with the mass ratio derived from the radial velocity amplitude. The firm establishment of this mass ratio at q=0.104 \pm 0.004 leaves little doubt that the companion of KOI-74 is a low mass white dwarf.Comment: 9 pages, 7 figures, 2 tables; accepted for publication in MNRA

Electron Scattering on 3He - a Playground to Test Nuclear Dynamics

The big spectrum of electron induced processes on 3He is illustrated by several examples based on Faddeev calculations with modern nucleon-nucleon and three-nucleon forces as well as exchange currents. The kinematical region is restricted to a mostly nonrelativistic one where the three-nucleon c.m. energy is below the pion production threshold and the three-momentum of the virtual photon is sufficiently below the nucleon mass. Comparisons with available data are shown and cases of agreement and disagreement are found. It is argued that new and precise data are needed to systematically check the present day dynamical ingredients.Comment: 27 pages, 24 figure

Spin-orbit final state interaction in the framework of Glauber theory for (e,e'p) reactions

We investigate the reactions D(e,e'p)n and D(\vec e,e'p)n at GeV energies and discuss the opportunities to distinguish between different models for the nuclear ground state by measuring the response functions. In calculating the final-state interaction (FSI) we employ Glauber theory, and we also include relativistic effects in the electromagnetic current. We include not only the central FSI, but also the spin-orbit FSI which is usually neglected in (e,e'p) calculations within the Glauber framework and we show that this contribution plays a crucial role for the fifth response function. All of the methods developed here can be applied to any target nucleus.Comment: 20 pages, 12 figures, minor change in figures 3 and 4 (changed beam energy), correction of error in figure 4 in the previous replacemen