9,861 research outputs found
Vector-valued covariant differential operators for the M\"obius transformation
We obtain a family of functional identities satisfied by vector-valued
functions of two variables and their geometric inversions. For this we
introduce particular differential operators of arbitrary order attached to
Gegenbauer polynomials. These differential operators are symmetry breaking for
the pair of Lie groups that arise from
conformal geometry.Comment: To appear in Springer Proceedings in Mathematics and Statistic
A retrospective study on the effects of illness severity and atrial fibrillation on outcomes in the intensive care unit
Introduction: Atrial fibrillation (AF) is common in patients in
the intensive care unit (ICU) and has been associated with
worse outcomes. However, it is unclear whether AF itself adds
to the risk of death or is merely a marker of illness severity.
We aimed to record the incidence and outcomes of all patients
with different categories of AF and determine whether AF was
an independent predictor of death.<p></p>
Methods: This retrospective cohort study was undertaken in
the ICU of a tertiary-referral university hospital. Category of AF,
sex, C-reactive protein (CRP) level, APACHE II score, predicted
hospital mortality and survival outcomes were analysed from
1084 records. Percentages, medians and interquartile ranges
were used to describe the sample. Chi-square test and the
non-parametric Mann–Whitney U test were used, as appropriate,
for statistical analysis. Logistic regression analyses were
performed to evaluate the association of AF with death in the
ICU adjusting for age, sex, CRP level and APACHE II score.<p></p>
Results: Overall, 13.6% of patients developed new-onset AF
during their critical illness, while 4.3% had a pre-existing history.
The hospital mortality rate was higher in those with AF
compared with those without (47.9% vs. 30.9%, p<0.001) and
higher in those with newly diagnosed AF compared with those
with a prior history (53.1% vs. 31.9%, p=0.012). CRP levels
were higher in those with AF (p<0.001) compared with those
without and higher in those with newly diagnosed AF compared
with those with a prior history (p=0.012). On multivariate
logistic regression analysis, only the APACHE II score was
found to be an independent predictor of death.<p></p>
Conclusion: Despite the higher mortality rate in patients
with AF, the APACHE II score was the only independent predictor of death within the ICU. Prospective studies are required to explore the apparently reduced risk of dying
among those with a prior history of AF.<p></p>
Absolute emission altitude of pulsars: PSRs B1839+09, B1916+14 and B2111+46
We study the mean profiles of the multi--component pulsars PSRs B1839+09,
B1916+14 and B2111+46. We estimate the emission height of the core components,
and hence find the absolute emission altitudes corresponding to the conal
components. By fitting Gaussians to the emission components, we determine the
phase location of the component peaks. Our findings indicate that the emission
beams of these pulsars have the nested core--cone structures. Based on the
phase location of the component peaks, we estimate the aberration--retardation
(A/R) phase shifts in the profiles. Due to the A/R phase shift, the peak of the
core component in the intensity profile and the inflection point of the
polarization angle swing are found to be symmetrically shifted in the opposite
directions with respect to the meridional plane in such a way that the core
shifts towards the leading side and the polarization angle inflection point
towards the trailing side. We have been able to locate the phase location of
the meridional plane and to estimate the absolute emission altitude of both the
core and the conal components relative to the neutron star centre, using the
exact expression for the A/R phase shift given by Gangadhara (2005).Comment: 10 pages, 6 figures, Accepted for Publication in A&
The uncoupling limit of identical Hopf bifurcations with an application to perceptual bistability
We study the dynamics arising when two identical oscillators are coupled near
a Hopf bifurcation where we assume a parameter uncouples the system
at . Using a normal form for identical systems undergoing
Hopf bifurcation, we explore the dynamical properties. Matching the normal form
coefficients to a coupled Wilson-Cowan oscillator network gives an
understanding of different types of behaviour that arise in a model of
perceptual bistability. Notably, we find bistability between in-phase and
anti-phase solutions that demonstrates the feasibility for synchronisation to
act as the mechanism by which periodic inputs can be segregated (rather than
via strong inhibitory coupling, as in existing models). Using numerical
continuation we confirm our theoretical analysis for small coupling strength
and explore the bifurcation diagrams for large coupling strength, where the
normal form approximation breaks down
Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity
The helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development. While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation. In the innate immune system, Id2 is required for the development of mature natural killer (NK) cells, lymphoid tissue-inducer (LTi) cells, and the recently identified interleukin (IL)-22 secreting nonconventional innate lymphocytes found in the gut. In addition, Id2 has been implicated in the development of specific dendritic cell (DC) subsets, decisions determining the formation of αβ and γδ T-cell development, NK T-cell behaviour, and in the maintenance of effector and memory CD8+ T cells in peripheral tissues. Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection
Geography of conservation spending, biodiversity, and culture
We used linear and multivariate models to examine the associations between geography, biodiversity, per capita economic output, national spending on conservation, governance, and cultural traits in 55 countries. Cultural traits and social metrics of modernization correlated positively with national spending on conservation. The global distribution of this spending culture was poorly aligned with the distribution of biodiversity. Specifically, biodiversity was greater in the tropics where cultures tended to spend relatively less on conservation and tended to have higher collectivism, formalized and hierarchical leadership, and weaker governance. Consequently, nations lacking social traits frequently associated with modernization, environmentalism, and conservation spending have the largest component of Earth's biodiversity. This has significant implications for setting policies and priorities for resource management given that biological diversity is rapidly disappearing and cultural traits change slowly. Therefore, we suggest natural resource management adapt to and use characteristics of existing social organization rather than wait for or promote social values associated with conservation spending. Supporting biocultural traditions, engaging leaders to increase conservation commitments, cross-national efforts that complement attributes of cultures, and avoiding interference with nature may work best to conserve nature in collective and hierarchical societies. Spending in modernized nations may be a symbolic response to a symptom of economic development and environmental degradation, and here conservation actions need to ensure that biodiversity is not being lost
Patients' request for and emergency physicians' prescription of antimicrobial prophylaxis for anthrax during the 2001 bioterrorism-related outbreak
BACKGROUND: Inappropriate use of antibiotics by individuals worried about biological agent exposures during bioterrorism events is an important public health concern. However, little is documented about the extent to which individuals with self-identified risk of anthrax exposure approached physicians for antimicrobial prophylaxis during the 2001 bioterrorism attacks in the United States. METHODS: We conducted a telephone survey of randomly selected members of the Pennsylvania Chapter of the American College of Emergency Physicians to assess patients' request for and emergency physicians' prescription of antimicrobial agents during the 2001 anthrax attacks. RESULTS: Ninety-seven physicians completed the survey. Sixty-four (66%) respondents had received requests from patients for anthrax prophylaxis; 16 (25%) of these physicians prescribed antibiotics to a total of 23 patients. Ten physicians prescribed ciprofloxacin while 8 physicians prescribed doxycycline. CONCLUSION: During the 2001 bioterrorist attacks, the majority of the emergency physicians we surveyed encountered patients who requested anthrax prophylaxis. Public fears may lead to a high demand for antibiotic prophylaxis during bioterrorism events. Elucidation of the relationship between public health response to outbreaks and outcomes would yield insights to ease burden on frontline clinicians and guide strategies to control inappropriate antibiotic allocation during bioterrorist events
RF model of the distribution system as a communication channel, phase 2. Volume 3: Appendices
Program documentation concerning the design, implementation, and verification of a computerized model for predicting the steady-state sinusoidal response of radial configured distribution feeders is presented in these appendices
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