Vibrational analysis and thermal behavior of salvia hispanica, nigella sativa and papaver somniferum seeds

Introduction: Salvia hispanica L., Nigella sativa L. and Papaver somniferum L. are involved in opiate-dependent behavior. It is known that the seeds of these three herbs contain high amounts of antioxidants, which are helpful in disease prevention, but further research is needed on some of their other phytochemical components (terpene alkaloids, benzoquinones and others), which are claimed to affect human opioid receptors. Methods: Seeds from the three afore mentioned plants have been studied by ATR-FTIR vibrational spectroscopy and thermo analytical techniques (TG/DTG, DTA and DSC). Results: The infrared spectrum has confirmed the presence of the ester carbonyl of terpenoid alkaloids (such as nigellamine) and the fully conjugated cyclic dione structure of quinones (e.g., thymoquinone). As regards the thermal stability of these seeds, small differences have been observed in their thermal profiles (endothermic effects at around 333C for chia, 268C for black cumin and 319C for poppy seeds), which can be ascribed to their different content in carbohydrates. Conclusions: The functional groups of the main active constituents and the thermal behavior of these three seeds have been elucidated

Implementation and validation of an economic module for the epidemiological model Be-FAST to predict the costs generated by livestock diseases epidemics. Application to the Classical Swine Fever case in Spain.

Classical Swine Fever (CSF) is one of the most harmful livestock di-seases for the economy of the swine sector worldwide. Specifically in Spain, the costs in the two last CSF outbreaks (1997 and 2001) have been estimated above 108 million euros. In this work, we aim to evaluate the economic impact of important livestock disease epidemics, and particularly the CSF in Spain. This study starts with a preliminary classification of the costs associated with CSF epidemics. In order to estimate the expected costs of a given epidemic in a considered area, a new economic module has been integrated into the epidemiological model Be-FAST, a time-spatial stochastic spread mathematical model for studying the transmission of diseases within and between farms. The input data for economic parameters have been obtained from entities related with the swine industry in Spain. The new Be-FAST module is tested by comparing the results obtained with historical data from CSF epidemics in Spain. The outcomes show that severe CSF epidemics also have a strong economic impact with around 80% of the costs related to animal culling, while costs associated with control measures are directly associated with the number of infected farms and the duration of the epidemic. The results presented in this work are expected to provide valuable information to decision makers, including animal health officials and insurance companies, and can be extended to other livestock diseases or used to predict the economic impact of future outbreaks

3D pore analysis of sedimentary rocks

A 3D representation of the internal structure and fabric of sedimentary rocks is of paramount interest to evaluate their structural parameters such as porosity, pore-size distribution and permeability. The classical experimental technique to evaluate the pore space volume and pore size distribution is the Mercury Intrusion Porosimetry (MIP). Computer-based methods use 3D imaging technologies such as Computer Tomography (CT) scanned images to construct and evaluate a 3D virtual representation of the internal pore distribution. In this work, based on a three samples set of sandstone, we apply two numerical (computer-based) methods in order to reconstruct and analyse the internal pore network, and compare it with the results obtained by MIP analysis. The first numerical method performs a virtual simulation of MIP. The second one obtains a graph of pores using a sphere-filling based approach. For all methods, we compute the global porosity and the pore-size distribution. Moreover, with the numerical methods, we obtain the total porosity and a graph representing the pore space that can be visualized with 3D illustration techniques.Postprint (published version

An analysis of the similarities in the ATR-FTIR spectra from Argania spinosa, Rosa rubiginosa and Elaeis guineensis oils

The attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) spectra of the essential oil from Rosa rubiginosa L. seeds and the vegetable oils from Argania spinosa L. kernel and Elaeis guineensis Jacq. pulp show important similitudes that hamper their identification by vibrational spectroscopy techniques if they are not complemented with well-established methods such as gas chromatography. Nevertheless, the observed similarities in structure-composition-traditional uses between Argania spinosa and Rosa rubiginosa oils suggest that they could be interchangeable when skin physicians, dermatologic-surgeons or cosmetologists perceive in their practice that one of the oils produces an allergic reaction or other side effects, although further activity studies are needed

Personalidad y su relación con el uso versus abuso del teléfono móvil

Research has confirmed that excessive use of these devices can cause harmful effects on health and social relations of users. The aim of this study is to analyze the personality variables associated with the use versus abuse of mobile-phone. The sample consisted of a total of 165 participants that were divided into three groups depending on the time of daily mobile phone use, the Group 1 using the mobile phone less than an hour a day, the Group 2 using the mobile phone less than two hours a day, and Group 3 using the mobile phone more than four hours a day. The results showed that Group 3 had low scores on Stability, Attention to the Rules, Perfectionism and Self-control and high scores in Animation and Extraversion and Group 2 had higher scores on Extraversion and Anxiety. This study demonstrated the involvement of personality in addiction mobile-phoneResumenLas investigaciones realizadas han confirmado que el uso excesivo del teléfono móvil genera efectos perjudiciales en la salud y en las relaciones sociales. El objetivo del presente estudio es analizar las variables de personalidad asociadas al uso versus abuso del teléfono móvil. Ciento sesenta y cinco participantes fueron divididos en tres grupos en función del tiempo de uso diario del teléfono móvil, el Grupo 1 usaba el teléfono móvil menos de una hora al día, el Grupo 2 usaba el teléfono móvil menos de dos horas al día, y el Grupo 3 usaba el teléfono móvil más de cuatro horas al día. Los resultados mostraron que el Grupo 3 presentaba puntuaciones bajas en Estabilidad, Atención a las Normas, Perfeccionismo y Autocontrol y puntuaciones altas en Animación y Extraversión y el Grupo 2 presentaba puntuaciones altas en Extraversión y Ansiedad. Se resalta la implicación de la personalidad en la adicción al móvil.AbstractResearch has confirmed that excessive use of these devices can cause harmful effects on health and social relations of users. The aim of this study is to analyze the personality variables associated with the use versus abuse of mobile-phone. The sample consisted of a total of 165 participants that were divided into three groups depending on the time of daily mobile phone use, the Group 1 using the mobile phone less than an hour a day, the Group 2 using the mobile phone less than two hours a day, and Group 3 using the mobile phone more than four hours a day. The results showed that Group 3 had low scores on Stability, Attention to the Rules, Perfectionism and Self-control and high scores in Animation and Extraversion and Group 2 had higher scores on Extraversion and Anxiety. This study demonstrated the involvement of personality in addiction mobile-phon

Implementation and validation of an economic module for the epidemiological model Be-FAST to predict the costs generated by livestock diseases epidemics. Application to the Classical Swine Fever case in Spain

Abstract Classical Swine Fever (CSF) is one of the most harmful livestock diseases for the economy of the swine sector worldwide. Specifically in Spain, the costs in the two last CSF outbreaks (1997 and 2001) have been estimated above 108 million euros. In this work, we aim to evaluate the economic impact of important livestock disease epidemics, and particularly the CSF in Spain. This study starts with a preliminary classification of the costs associated with CSF epidemics. In order to estimate the expected costs of a given epidemic in a considered area, a new economic module has been integrated into the epidemiological model Be-FAST, a time-spatial stochastic spread mathematical model for studying the transmission of diseases within and between farms. The input data for economic parameters have been obtained from entities related with the swine industry in Spain. The new Be-FAST module is tested by comparing the results obtained with historical data from CSF epidemics in Spain. The outcomes show that severe CSF epidemics also have a strong economic impact with around 80% of the costs related to animal culling, while costs associated with control measures are directly associated with the number of infected farms and the duration of the epidemic. The results presented in this work * Corresponding author: [email protected] 1 are expected to provide valuable information to decision makers, including animal health officials and insurance companies, and can be extended to other livestock diseases or used to predict the economic impact of future outbreaks

Vasoactive intestinal peptide axis is dysfunctional in patients with Graves’ disease

Vasoactive intestinal peptide (VIP) is a neuropeptide with potent immunoregulatory properties. Reduced serum VIP levels and alterations in VIP receptors/signaling on immune cells have been associated with different inflammatory/autoimmune diseases. However, its role in autoimmune thyroid diseases (AITD) remains unknown. This study examined the interrelationship between VIP system, autoimmune background and thyroid hormones in peripheral immune cells in patients with AITD. Only Graves’ disease (GD) patients showed significantly lower serum VIP levels when compared to healthy subjects and to Hashimoto’s thyroiditis patients. Serum VIP levels were lower at the onset of GD, showing a significant negative correlation with thyroid hormone levels. The expression of VIP receptors, VPAC1 and VPAC2, was significantly upregulated in peripheral blood mononuclear cells (PBMC) from GD patients. There was an impairment of VIP signalling in these patients, probably attributable to a dysfunction of VPAC1 with preservation of VPAC2. The correlation between VPAC1 and thyroid hormone receptor expression in PBMC from healthy subjects was lost in GD patients. In summary, the VIP system is altered in peripheral immune cells of GD patients and this finding is associated with different thyroid hormone receptor patterns, showing a dynamic inter-regulation and a prominent role of VIP in this setting.This work has been supported by Instituto de Salud Carlos III, Spain, cofinanced by FEDER, European Union: RETICS program, Red de Investigación en Inflamación y Enfermedades Reumáticas (RD16/0012/0008, PI17/00027, PI16-02091, PIE13-0004) and from Consejería de Educación, Juventud y Deporte, Comunidad de Madrid: B2017/BMD372

The nanomechanics of neurotoxina proteins reveals common features at the start of the neurodegeneration cascade.

1 pags. -- 56th Annual Meeting of the Biophysical-Society, FEB 25-29, 2012, San Diego, CAAmyloidogenic neurodegenerative diseases are incurable conditions caused by specific largely disordered proteins. However, the underlying molecular mechanism remains elusive. A favored hypothesis postulates that a critical conformational change in the monomer (an ideal therapeutic target) in these ‘‘neurotoxic proteins’’ triggers the pathogenic cascade. Using force spectroscopy with unequivocal singlemolecule identification we demonstrate a rich conformational polymorphism at their monomer level. This polymorphism strongly correlates with amyloidogenesis and neurotoxicity: it is absent in a fibrillization-incompetent mutant, favored by familial-disease mutations and diminished by a surprisingly promiscuous inhibitor of the monomeric b-conformational change and neurodegeneration. The demonstrated ability to inhibit the conformational heterogeneity of these proteins by a single pharmacological agent reveals common features in the monomer and suggests a common pathway to diagnose, prevent, halt or reverse multiple neurodegenerative disease

Reconstruction of Past Environment and Climate Using Wetland Sediment Records from the Sierra Nevada

Understanding the effects of climate change and human activities on fragile mountain ecosystems is necessary to successfully managing these environments under future climate scenarios (e.g., global warming, enhanced aridity). This can be done through the study of paleoecological records, which can provide long paleoenvironmental databases containing information on how ecosystems reacted to climate change and human disturbances before the historical record. These studies can be particularly interesting when focusing on especially warm and/or dry past climatic phases. Biotic (pollen, charcoal) and abiotic (physical, geochemistry) analyses from wetland sediment records from the Sierra Nevada, southern Spain record changes in vegetation, fire history and lake sedimentation since ~11,700 years (cal yr BP). This multiproxy paleoecological study indicates that maxima in temperature and humidity occurred in the area in the Early and Middle Holocene, with a peak in precipitation between ~10,500 and 7000 cal yr BP. This is deduced by maxima in water runoff, the highest abundance of tree species and algae and high total organic carbon values recorded in the alpine wetland’s sedimentary records of the Sierra Nevada during that time period. In the last 7000 cal yr BP, and especially after a transition period between ~7000 and 5000 cal yr BP, a progressive aridification process took place, indicated by the decrease in tree species and the increase in xerophytic herbs in this region and a reduction in water runoff evidenced by the decrease in detritic input in the wetland sedimentary records. An increasing trend in Saharan dust deposition in the Sierra Nevada wetlands is also recorded through inorganic geochemical proxies, probably due to a coetaneous loss of vegetation cover in North Africa. The process of progressive aridification during the Middle and Late Holocene was interrupted by millennial-scale climatic oscillations and several periods of relative humid/droughty conditions and warm/cold periods have been identified in different temperature and/or precipitation proxies. Enhanced human impact has been observed in the Sierra Nevada in the last ~3000 cal yr BP through the increase in fires, grazing, cultivation, atmospheric pollution as well as reforestation by Pinus and the massive cultivation of Olea at lower altitudes.This study was supported by projects CGL2013-47038-R and CGL2017-85415-R funded by Ministerio de Economía y Competitividad of Spain and Fondo Europeo de Desarrollo Regional FEDER; Séneca Project 20788/PI/18; Junta de Andalucía I+D+i Junta de Andalucía 2020 Retos P-20-00059, FEDER Project B-RNM-144-UGR18, UGR-FEDER B-RNM-144-UGR18 Proyectos I + D + i del Programa Operativo FEDER 2018 and the research group RNM-190 (Junta de Andalucía). M.J.R.R. acknowledges the postdoctoral funding provided by the European Commission/H2020 (ERC-2017-ADG, project number 788616). J.C. acknowledges the postdoctoral funding provided by the Academy of Finland (project number 316702). A.G.-A. acknowledges the Ramón y Cajal fellowship RYC-2015-18966 provided by the Ministerio de Economía y Competitividad of the Spanish Government. M.R.G. acknowledges funding by the Juan de la Cierva-Incorporación program in the University of Granada (IJCI-2017-33755) from Secretaría de Estado de I+D+i, Spain. RSA acknowledges several travel grants from Northern Arizona University to support this work

Palynological investigations in the Orce Archaeological Zone, Early Pleistocene of Southern Spain

Palynological investigations in the Orce Archaeological Zone (OAZ) (Guadix-Baza Basin, Granada, Spain), Venta Micena 1 (VM1), Barranco Leon (BL) and Fuente Nueva 3 (FN3) are presented. This archaeological region is con-nected with the first Homo populations in Western Eurasia during the Early Pleistocene. The VM1 pollen record is characterized by Ephedra, and to a lesser extent, Pinus, Juniperus and evergreen Quercus, occassionally accompa-nied by Olea, Genisteae, Erica, deciduous Quercus, Alnus, Castanea, Fraxinus, Salix and Phillyrea. BL is dominated by Juniperus, Olea, Pinus, Poaceae, and evergreen Quercus. FN3 is characterized by an open Mediterranean woodland dominated by evergreen Quercus, Pinus, Juniperus and Olea, accompanied by deciduous Quercus, Castanea, Populus, Salix, Ulmus, Fraxinus, Pistacia, Phillyrea, Genisteae, Erica, Cistus, and Ephedra fragilis. Relic Tertiary taxa in OAZ include Carya, Pterocarya, Eucommia, Zelkova, and Juglans. The Early Pleistocene OAZ vegetation is a mosaic of different landscapes embracing mesophytes, thermophytes, xerophytes, xerothermophytes, and Mediterra-nean elements. These finds are compared with former pollen analyses in the region and beyond within the Ibe-rian Peninsula. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).Peer reviewe