Identifying common user behaviour in multilingual search logs

The LADS (Log Analysis for Digital Societies) task at CLEF aims at investigating user actions in a multilingual setting. We carried out an analysis of search logs with the objectives of investigating how users from different linguistic or cultural backgrounds behave in search, and how the discovery of patterns in user actions could be used for community identification. The findings confirm that users from a different background behave differently, and that there are identifiable patterns in the user actions. The findings suggest that there is scope for further investigation of how search logs can be exploited to personalise and improve cross-language search as well as improve the TEL search system

DCU-TCD@LogCLEF 2010: re-ranking document collections and query performance estimation

This paper describes the collaborative participation of Dublin City University and Trinity College Dublin in LogCLEF 2010. Two sets of experiments were conducted. First, different aspects of the TEL query logs were analysed after extracting user sessions of consecutive queries on a topic. The relation between the queries and their length (number of terms) and position (first query or further reformulations) was examined in a session with respect to query performance estimators such as query scope, IDF-based measures, simplified query clarity score, and average inverse document collection frequency. Results of this analysis suggest that only some estimator values show a correlation with query length or position in the TEL logs (e.g. similarity score between collection and query). Second, the relation between three attributes was investigated: the user's country (detected from IP address), the query language, and the interface language. The investigation aimed to explore the influence of the three attributes on the user's collection selection. Moreover, the investigation involved assigning different weights to the three attributes in a scoring function that was used to re-rank the collections displayed to the user according to the language and country. The results of the collection re-ranking show a significant improvement in Mean Average Precision (MAP) over the original collection ranking of TEL. The results also indicate that the query language and interface language have more in uence than the user's country on the collections selected by the users

Multilingual adaptive search for digital libraries

This paper describes a framework for Adaptive Multilingual Information Retrieval (AMIR) which allows multilingual resource discovery and delivery using on-the-fly machine translation of documents and queries. Result documents are presented to the user in a contextualised manner. Challenges and affordances of both Adaptive and Multilingual IR, with a particular focus on Digital Libraries, are detailed. The framework components are motivated by a series of results from experiments on query logs and documents from The European Library. We conclude that factoring adaptivity and multilinguality aspects into the search process can enhance the user’s experience with online Digital Libraries

Isotopic Scaling of Heavy Projectile Residues from the collisions of 25 MeV/nucleon 86Kr with 124Sn, 112Sn and 64Ni, 58Ni

The scaling of the yields of heavy projectile residues from the reactions of 25 MeV/nucleon 86Kr projectiles with 124Sn,112Sn and 64Ni, 58Nitargets is studied. Isotopically resolved yield distributions of projectile fragments in the range Z=10-36 from these reaction pairs were measured with the MARS recoil separator in the angular range 2.7-5.3 degrees. The velocities of the residues, monotonically decreasing with Z down to Z~26-28, are employed to characterize the excitation energy. The yield ratios R21(N,Z) for each pair of systems are found to exhibit isotopic scaling (isoscaling), namely, an exponential dependence on the fragment atomic number Z and neutron number N. The isoscaling is found to occur in the residue Z range corresponding to the maximum observed excitation energies. The corresponding isoscaling parameters are alpha=0.43 and beta=-0.50 for the Kr+Sn system and alpha=0.27 and beta=-0.34 for the Kr+Ni system. For the Kr+Sn system, for which the experimental angular acceptance range lies inside the grazing angle, isoscaling was found to occur for Z<26 and N<34. For heavier fragments from Kr+Sn, the parameters vary monotonically, alpha decreasing with Z and beta increasing with N. This variation is found to be related to the evolution towards isospin equilibration and, as such, it can serve as a tracer of the N/Z equilibration process. The present heavy-residue data extend the observation of isotopic scaling from the intermediate mass fragment region to the heavy-residue region. Such high-resolution mass spectrometric data can provide important information on the role of isospin in peripheral and mid-peripheral collisions, complementary to that accessible from modern large-acceptance multidetector devices.Comment: 8 pages, 6 figures, submitted to Phys. Rev.

Fragment Isospin as a Probe of Heavy-Ion Collisions

Isotope ratios of fragments produced at mid-rapidity in peripheral and central collisions of 114Cd ions with 92Mo and 98Mo target nuclei at E/A = 50 MeV are compared. Neutron-rich isotopes are preferentially produced in central collisions as compared to peripheral collisions. The influence of the size (A), density, N/Z, E*/A, and Eflow/A of the emitting source on the measured isotope ratios was explored by comparison with a statistical model (SMM). The mid-rapidity region associated with peripheral collisions does not appear to be neutron-enriched relative to central collisions.Comment: 12 pages including figure

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

Exonic variants present some of the strongest links between genotype and phenotype. However, these variants can have significant inter-individual pathogenicity differences, known as variable penetrance. In this study, we propose a model where genetically controlled mRNA splicing modulates the pathogenicity of exonic variants. By first cataloging exonic inclusion from RNA-sequencing data in GTEx V8, we find that pathogenic alleles are depleted on highly included exons. Using a large-scale phased whole genome sequencing data from the TOPMed consortium, we observe that this effect may be driven by common splice-regulatory genetic variants, and that natural selection acts on haplotype configurations that reduce the transcript inclusion of putatively pathogenic variants, especially when limiting to haploinsufficient genes. Finally, we test if this effect may be relevant for autism risk using families from the Simons Simplex Collection, but find that splicing of pathogenic alleles has a penetrance reducing effect here as well. Overall, our results indicate that common splice-regulatory variants may play a role in reducing the damaging effects of rare exonic variants.</p

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

Exonic variants present some of the strongest links between genotype and phenotype. However, these variants can have significant inter-individual pathogenicity differences, known as variable penetrance. In this study, we propose a model where genetically controlled mRNA splicing modulates the pathogenicity of exonic variants. By first cataloging exonic inclusion from RNA-sequencing data in GTEx V8, we find that pathogenic alleles are depleted on highly included exons. Using a large-scale phased whole genome sequencing data from the TOPMed consortium, we observe that this effect may be driven by common splice-regulatory genetic variants, and that natural selection acts on haplotype configurations that reduce the transcript inclusion of putatively pathogenic variants, especially when limiting to haploinsufficient genes. Finally, we test if this effect may be relevant for autism risk using families from the Simons Simplex Collection, but find that splicing of pathogenic alleles has a penetrance reducing effect here as well. Overall, our results indicate that common splice-regulatory variants may play a role in reducing the damaging effects of rare exonic variants.</p

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

Exonic variants present some of the strongest links between genotype and phenotype. However, these variants can have significant inter-individual pathogenicity differences, known as variable penetrance. In this study, we propose a model where genetically controlled mRNA splicing modulates the pathogenicity of exonic variants. By first cataloging exonic inclusion from RNA-sequencing data in GTEx V8, we find that pathogenic alleles are depleted on highly included exons. Using a large-scale phased whole genome sequencing data from the TOPMed consortium, we observe that this effect may be driven by common splice-regulatory genetic variants, and that natural selection acts on haplotype configurations that reduce the transcript inclusion of putatively pathogenic variants, especially when limiting to haploinsufficient genes. Finally, we test if this effect may be relevant for autism risk using families from the Simons Simplex Collection, but find that splicing of pathogenic alleles has a penetrance reducing effect here as well. Overall, our results indicate that common splice-regulatory variants may play a role in reducing the damaging effects of rare exonic variants.</p