Security Issues in Service Model of Fog Computing Environment

Fog computing is an innovative way to expand the cloud platform by providing computing resources. The platform is a cloud that has the same data, management, storage and application features, but their origins are different because they are deployed to different locations. The platform system can retrieve a large amount, work in the field, be fully loaded, and mount on a variety of hardware devices. With this utility, Fog Framework is perfect for applications and critical moments. Fog computing is similar to cloud computing, but because of its variability, creates new security and privacy challenges that go beyond what is common for fog nodes. This paper aims to understand the impact of security problems and how to overcome them, and to provide future safety guidance for those responsible for building, upgrading and maintaining fog systems

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

<p>Abstract</p> <p>Background</p> <p>Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths. Thus, novel agents that can downregulate the CXCR4/CXCL12 axis have therapeutic potential in inhibiting cancer metastasis.</p> <p>Methods</p> <p>In this report, we investigated the potential of an agent, plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), for its ability to modulate CXCR4 expression and function in various tumor cells using Western blot analysis, DNA binding assay, transient transfection, real time PCR analysis, chromatin immunoprecipitation, and cellular migration and invasion assays.</p> <p>Results</p> <p>We found that plumbagin downregulated the expression of CXCR4 in breast cancer cells irrespective of their HER2 status. The decrease in CXCR4 expression induced by plumbagin was not cell type-specific as the inhibition also occurred in gastric, lung, renal, oral, and hepatocellular tumor cell lines. Neither proteasome inhibition nor lysosomal stabilization had any effect on plumbagin-induced decrease in CXCR4 expression. Detailed study of the underlying molecular mechanism(s) revealed that the regulation of the downregulation of CXCR4 was at the transcriptional level, as indicated by downregulation of mRNA expression, inhibition of NF-κB activation, and suppression of chromatin immunoprecipitation activity. In addition, using a virtual, predictive, functional proteomics-based tumor pathway platform, we tested the hypothesis that NF-κB inhibition by plumbagin causes the decrease in CXCR4 and other metastatic genes. Suppression of CXCR4 expression by plumbagin was found to correlate with the inhibition of CXCL12-induced migration and invasion of both breast and gastric cancer cells.</p> <p>Conclusions</p> <p>Overall, our results indicate, for the first time, that plumbagin is a novel blocker of CXCR4 expression and thus has the potential to suppress metastasis of cancer.</p

Lost Sanctuary: How to revitalize an abandoned shrine?

This project explores potential actions for revitalizing an abandoned Shinto shrine, Shirahige Daijin, located in Kyoto, Japan. To understand the history and significance of the shrine, the project team conducted interviews with neighbors, attended festivals at active shrines, and visited local government offices. The information collected was then combined into an interactive map that includes photographs, 3D scans, 2D maps, and soundscapes from the site. To explore options for revitalization, the team visited other well-maintained shrines to determine how they attract visitors, generate money, and are maintained. They also spoke to neighbors of Shirahige Daijin to get their views on revitalization. The team also created a stakeholder matrix and a list of community-based future steps for revitalization

Evaluation of the Anatomic Variations of Lingual Foramen and its Bony Canals with CBCT in South Indian Sub-population: A Radiographic Observational Study

Aim: To assess prevalence and morphometrics of lingual foramen and lingual canals using Cone Beam Computerised Tomography (CBCT). Materials and Methods: This was a retrospective observational study, in which 144 CBCT scans were obtained from the archives of Department of Oral radiology, Vishnu dental college, Bhimavaram. Parameters such as number, location, length of the lingual canal, travel path of the lingual canals, distance from the lingual foramen to inferior border, in cases where extra foramen is present an additional criteria involving measurement of the distance between both the foramen &nbsp;was also evaluated. Statistical analysis was done using chi-square test and results were formulated. Results: Lingual foramen was a common observation in all of the examined CBCT scans and 21% of scans showed two lingual foramen. The average distance from the Inferior Lingual Foramen (ILF) to Inferior Border (IB) was 3.3 ± 1.0 mm. The mean length of the Superior Lingual Canal (SLC) was 4.2 ± 1.3mm and the mean length of the ILC (Inferior lingual canal) was 4.2 ± 1.2mm. The majority of the inferior lingual foramen (76%) were inclined and only 0.1% of foramen were vertical. Conclusion: Variations in the prevalence of the lingual foramen are observed due to variations in the ethnicity, geographic location. Detailed evaluation of these anatomic structures using CBCT help in prevention of the complications and will improve the treatment outcome

Saliva as a Diagnostic Tool in Forensic Odontology: Scope and Methods

Human body fluids such as blood and saliva are the most common sources of biological trace material found at a crime scene. Over the last decade or so there has been a growing interest in saliva and its use as a tool in forensic odontology as an alternative to blood or urine. The added advantage of its noninvasive method of collection even by individuals with limited training, makes saliva a popular fluid for forensic analysis. Saliva is mainly looked for in cases of drug abuse, sexual assault, and in cases involving animal or human bites. This oral fluid has an immense role in linking of suspects or victims to a crime scene, as well as in establishing the identity of unknown individuals. This review details about the various application of saliva in the field of forensic odontology such as age, gender and blood group determination, drug, cigarette consumption detection to the storage of saliva samples for future references

Flow regime mapping of liquid-solid inclined fluidized beds

Experiments were conducted to identify the angle of inclination of a fluidized bed so that the fluidizing condition could be retained.nbsp Experimental set up has been specifically fabricated for this purpose with a provision for measurement of angle of inclination accurately.nbsp Further studies were also conducted to identify different flow regimes that appear by using visual inspection technique.nbsp It was observed that apart from fixed and fluidized beds three other regimes viz., channel flow, counter flow and circulatory flow were prominent.nbsp The angle of inclination with horizontal axis was found to be approximately 70 degrees to retain fluidizing conditions

Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India

Breast and/or ovarian cancer (BOC) are among the most frequently diagnosed forms of hereditary cancers and leading cause of death in India. This emphasizes on the need for a cost-effective method for early detection of these cancers. We sequenced 141 unrelated patients and families with BOC using the TruSight Cancer panel, which includes 13 genes strongly associated with risk of inherited BOC. Multi-gene sequencing was done on the Illumina MiSeq platform. Genetic variations were identified using the Strand NGS software and interpreted using the StrandOmics platform. We were able to detect pathogenic mutations in 51 (36.2%) cases, out of which 19 were novel mutations. When we considered familial breast cancer cases only, the detection rate increased to 52%. When cases were stratified based on age of diagnosis into three categories,. 40 years, 40-50 years and >50 years, the detection rates were higher in the first two categories (44.4% and 53.4%, respectively) as compared with the third category, in which it was 26.9%. Our study suggests that next-generation sequencing-based multi-gene panels increase the sensitivity of mutation detection and help in identifying patients with a high risk of developing cancer as compared with sequential tests of individual genes