A Multi-item Inventory Model

During the last fifteen years there has been a rapid growth of interest in scientific inventory control; the use of mathematical models to obtain rules for operating inventory systems. The subject has attracted such wide interest that today every serious student in the Industrial Engineering and related fields is expected to have had some experience with inventory models. Originally, the development of inventory models had practical applications as an immediate objective. Today, inventory models are being developed at many different levels, ranging from the direct application in practical problems to the development of abstract mathematical models. The earliest derivation of the simple lot size formula was obtained by Ford Harris of the Westinghouse Corporation in 1915. Subsequently, it has been developed and applied independently by many individuals and is often referred to as the Wilson Formula after R.H. Wilson, who developed it as an integral part of inventory control procedure which he applied in many organizations. (See more in text

Effect of Network Structure on Free Volume and Gas Transport Properties of Thiol-Ene and Epoxy-Amine Networks

Network parameters such as cross-link density or intermolecular interactions were used as effective parameters to control polymer chain packing or free volume and thereby control the mass transport properties of networks. A series of polyethylene glycol (PEG) based thiol-ene elastomeric networks having a broad range of molecular weight between cross-links, Mc, (inverse of cross-link density) was prepared. The specific volume of the networks was studied as a function of temperature and pressure using high pressure dilatometry, and the obtained PVT data was fit using Simha-Somcynsky equation of state (S-S eos) analysis. Fractional free volume, quantified through S-S eos analysis, changed linearly as a function of cross-link density of the networks proving that the system obeyed Fox and Loshaek model. Average free volume hole size, h\u3e, of the networks was directly probed using positron annihilation lifetime spectroscopy (PALS). h\u3e of the networks also changed linearly as a function of cross-link density. Typically, in traditional elastomers, changing cross-link density also causes simultaneous changes in chemical nature or polarity of the system, therefore those systems deviate from Fox and Loshaek model. Internal pressure Pi of the networks, calculated from PVT data, showed similar values for all networks, and the same was the case for storage permittivity values obtained from dielectric spectroscopy analysis. This proved that the chemical nature of the networks was unaffected and cross-link density was the only parameter controlling the free volume of the networks. Gas diffusivity of the networks obeyed Cohen Turnbull model, and thus the experimental gas diffusivity trends were modeled as a function of molecular weight between cross-links of the networks. The effect of intermolecular (repulsive) interactions on free volume and gas transport was studied in a series of perfluorinated thiol-ene elastomers. Perfluorinated thiol-ene elastomers were prepared via 2-step synthesis. In the first step, a four-functional thiol was converted into a three functional thiol containing a perfluorinated dangling moiety via Thio Michael addition reaction with a perfluorinated acrylate. The modified thiol monomer was then reacted with triene to obtain perfluorinated thiol-ene networks. Fluorine content was varied by changing the length of perfluorinated moiety used in Thio Michael addition and this enabled the synthesis of a series of perfluorinated networks containing perfluorinated dangling moieties of different lengths. Fast reaction kinetics of thiol-ene chemistry prevented the phase separation of perfluorinated moieties and locked-in the thermodynamically frustrated perfluorinated moieties within the thiol-ene scaffold. The repulsive interactions between highly non-polar perfluorinated moieties and polar thiol-ene backbone created huge free volume pockets in the network. For the biggest perfluorinated dangling moiety used in this study, h\u3e increased by four times in comparison to an unmodified network. The gas transport properties showed a significant improvement as a function of the length of the dangling moiety. But gas diffusivity of the networks did not obey Cohen Turnbull model. The deviation was explained by the static nature of free volume pockets around perfluorinated moieties, and percolation of free volume pockets as the sizes of free volume cavities increased. The 2-step synthetic approach was taken a step further to prepare a series of hybrid thiol-ene elastomers containing varying concentrations of polar PEG moieties and non-polar perfluorinated moieties. The effect of PEG and perfluorinated concentrations (or attractive and repulsive interactions) on chain packing was studied. PEG moieties improved CO2 gas permeability and selectivity because of the Lewis acid-base type interactions between PEG and CO2. In the final chapter, the effect of moisture sorption on free volume, oxygen, and water vapor transport was studied on five different epoxy-amine networks having Tgs in the range between -11 °C to 227 °C. Water sorption did not show any effect on h\u3e of elastomeric networks. Whereas, glassy networks showed a V-shaped trend when h\u3e was plotted as a function of relative humidity or water content. The decrease in h\u3e was due to water molecules filling free volume holes. Increasing water concentration in the networks beyond 75% relative humidity (RH) resulted in swelling of the networks and thereby h\u3e increase. Effect of water sorption on oxygen permeability of the glassy networks also showed a similar V-shaped trend, but the mechanism was more complex as water sorption affected both oxygen diffusivity and solubility. Water vapor permeability of the glassy networks was unaffected until 75% RH. Beyond 75% RH, free volume increase due to swelling resulted in water vapor permeability increase

Digitalna katastarska izmjera za identifikaciju prisvajanja zemljišta primjenom prostornih tehnologija

Digital Cadastral Surveying is the need of present and future generations. The invention of Computer has revamped the face of the world dynamically. Every day in our life is digitalised and with out computers the world could not perform efficiently. The Computers, Satellite images, Aerial digital images could be efficaciously used in the creation of new experimental methodologies for Cadastral Surveying. Land records are obtained by Cadastral Surveying, which in turn provides the cornerstone for Land Use Planning. Land Use planning is influenced by many factors directly and indirectly. Land encroachment is found to be one of the direct factors affecting Land Use Planning. The Land Encroachments are identified by digitisation and overlaying analysis using standard GIS software, GPS Equipments for obtaining Ground Control Points, with Satellite images and Aerial images combined with conventional land records available with the Government Authority. Disquisition of Land encroachment is undertaken in this paper, to find the encroachment and its types. The problems involved in the encroachments, their detrimental effects on country’s growth are considered while formation of methodology to the serve the purpose of its creation. Pros and Cons of the technology is known from the work and explained. This is a Research application requiring hybridization of technologies to obtain high quality spatial surveying products.Digitalna katastarska izmjera potreba je sadašnjih i budućih generacija. Pojava računala promijenila je u dinamičkom smislu cijeli svijet. Bez digitalnih uređaja i bez računala svijet ne može učinkovito funkcionirati. Računala, satelitske i zračne digitalne snimke mogu se učinkovito upotrebljavati u kreiranju novih eksperimentalnih metoda katastarske izmjere. Podaci u zemljišnim knjigama dobiveni su katastarskom izmjerom, što nam osigurava temeljne podatke za planiranje i upotrebu zemljišta. Planiranje upotrebe zemljišta pod utjecajem je brojnih čimbenika, izravno i neizravno. Prisvajanje zemljišta moguće je identificirati digitalizacijom i razlikovnom analizom pomoću standardnih GIS softvera, uz upotrebu GPS uređaja, satelitskih i aerofotogrametrijskih snimki u kombinaciji s uobičajenim podacima iz zemljišnih knjiga. Rasprava u ovom radu provodi se u svrhu otkrivanja vrsta i tipova prisvajanja zemljišta. Razmatraju se problemi koji nastaju zbog prisvajanja te njihovi štetni utjecaji na državu koja ima tendenciju rasta i širenja, kao i definiranje metodologije koja služi njezinom stvaranju. Prednosti i nedostaci takve tehnologije objašnjeni su u radu. Primjena istraživanja zahtijeva hibridnu tehnologiju za dobivanje visoko kvalitetnih rezultata

Stability Analysis of Uncertain Temperature control system with two additive delays and nonlinear perturbation

In this paper, the problem of robust delay-dependent stability criterion is considered for a class of linear continuous time heat exchanger system with constant additive state-delays and bounded nonlinear perturbations using Lyapunov-Krasovskii (LK) functional approach.  In the proposed delay-dependent stability analysis, the time-delays are considered to be time-invariant.  In the proposed delay-dependent stability analysis, a candidate LK functional is considered, and take the time-derivative of the functional is bounded using the Jenson integral inequality.  The proposed stability analysis finally culminates into a stability criterion in LMI framework.  The effectiveness of the proposed stability criterion is illustrated using a network controlled temperature control of heat exchanger syste

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer

Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically reprogram tumor cells. In this study, we show that non-cytotoxic nanomolar DAC concentrations modify the bladder cancer transcriptome to activate NOTCH1 at the mRNA and protein level, increase double-stranded RNA sensors and CK5-dependent differentiation. Importantly, DAC treatment increases ICN1 expression (the active intracellular domain of NOTCH1) significantly inhibiting cell proliferation and causing changes in cell size inducing morphological alterations reminiscent of senescence. These changes were not associated with β-galactosidase activity or increased p16 levels, but instead were associated with substantial IL-6 release. Increased IL-6 release was observed in both DAC-treated and ICN1 overexpressing cells as compared to control cells. Exogenous IL-6 expression was associated with a similar enlarged cell morphology that was rescued by the addition of a monoclonal antibody against IL-6. Treatment with DAC, overexpression with ICN1 or addition of exogenous IL-6 showed CK5 reduction, a surrogate marker of differentiation. Overall this study suggests that in MIBC cells, DNA hypomethylation increases NOTCH1 expression and IL-6 release to induce CK5-related differentiation.Fil: Ramakrishnan, Swathi. Roswell Park Cancer Institute; Estados UnidosFil: Hu, Qiang. Roswell Park Cancer Institute; Estados UnidosFil: Krishnan, Nithya. Roswell Park Cancer Institute; Estados UnidosFil: Wang, Dan. Roswell Park Cancer Institute; Estados UnidosFil: Smit, Evelyn. Roswell Park Cancer Institute; Estados UnidosFil: Granger, Victoria. Roswell Park Cancer Institute; Estados UnidosFil: Rak, Monika. Jagiellonian University; PoloniaFil: Attwood, Kristopher. Roswell Park Cancer Institute; Estados UnidosFil: Johnson, Candace. Roswell Park Cancer Institute; Estados UnidosFil: Morrison, Carl. Roswell Park Cancer Institute; Estados UnidosFil: Pili, Roberto. Indiana University; Estados UnidosFil: Chatta, Gurkamal. Roswell Park Cancer Institute; Estados UnidosFil: Guru, Khurshid. Roswell Park Cancer Institute; Estados UnidosFil: Gueron, Geraldine. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: McNally, Lacey. University of Louisville; Estados UnidosFil: Wang, Jianmin. Roswell Park Cancer Institute; Estados UnidosFil: Woloszynska-Read, Anna. Roswell Park Cancer Institute; Estados Unido

Grid-Enabled Non-Invasive Blood Glucose Measurement

Abstract. Earth and life sciences are at the forefront to successfully include computational simulations and modeling. Medical applications are often mentioned as the killer applications for the Grid. The complex methodology and models of Traditional Chinese Medicine offer different approaches to diagnose and treat a persons health condition than typical Western medicine. A possibility to make this often hidden knowledge ex-plicit and available to a broader audience will result in mutual synergies for Western and Chinese medicine as well as improved patient care. This paper proposes the design and implementation of a method to accurately estimate blood glucose values using a novel non-invasive method based on electro-transformation measures in human body meridians. The frame-work used for this scientific computing collaboration, namely the China-Austria Data Grid (CADGrid) framework, provides an Intelligence Base offering commonly used models and algorithms as Web/Grid-Services. The controlled execution of the Non-Invasive Blood Glucose Measure-ment Service and the management of scientific data that arise from model execution can be seen as the first application on top of the CADGrid

Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression.

Cyst-forming Apicomplexa (CFA) of the Sarcocystidae have a ubiquitous presence as pathogens of humans and farm animals transmitted through the food chain between hosts with few notable exceptions. The defining hallmark of this family of obligate intracellular protists consists of their ability to remain for very long periods as infectious tissue cysts in chronically infected intermediate hosts. Nevertheless, each closely related species has evolved unique strategies to maintain distinct reservoirs on global scales and ensuring efficient transmission to definitive hosts as well as between intermediate hosts. Here, we present an in-depth comparative mRNA expression analysis of the tachyzoite and bradyzoite stages of Besnoitia besnoiti strain Lisbon14 isolated from an infected farm animal based on its annotated genome sequence. The B. besnoiti genome is highly syntenic with that of other CFA and also retains the capacity to encode a large majority of known and inferred factors essential for completing a sexual cycle in a yet unknown definitive host. This work introduces Besnoitia besnoiti as a new model for comparative biology of coccidian tissue cysts which can be readily obtained in high purity. This model provides a framework for addressing fundamental questions about the evolution of tissue cysts and the biology of this pharmacologically intractable infectious parasite stage

Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression

Cyst-forming Apicomplexa (CFA) of the Sarcocystidae have a ubiquitous presence as pathogens of humans and farm animals transmitted through the food chain between hosts with few notable exceptions. The defining hallmark of this family of obligate intracellular protists consists of their ability to remain for very long periods as infectious tissue cysts in chronically infected intermediate hosts. Nevertheless, each closely related species has evolved unique strategies to maintain distinct reservoirs on global scales and ensuring efficient transmission to definitive hosts as well as between intermediate hosts. Here, we present an in-depth comparative mRNA expression analysis of the tachyzoite and bradyzoite stages of Besnoitia besnoiti strain Lisbon14 isolated from an infected farm animal based on its annotated genome sequence. The B. besnoiti genome is highly syntenic with that of other CFA and also retains the capacity to encode a large majority of known and inferred factors essential for completing a sexual cycle in a yet unknown definitive host. This work introduces Besnoitia besnoiti as a new model for comparative biology of coccidian tissue cysts which can be readily obtained in high purity. This model provides a framework for addressing fundamental questions about the evolution of tissue cysts and the biology of this pharmacologically intractable infectious parasite stage