7 research outputs found

    Médicos y depresión: una responsabilidad de todos en la sociedad

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    Dear Editor, In recent years, we have witnessed a growing frequency of cases of depression and their fatal suicidal outcomes. According to data reported by the World Health Organization data (WHO), about 3,000 people commit suicide each day worldwide (equivalent to one every 30 seconds), and an additional 60,000 unsuccessfully attempt to do so, which makes this an extremely important issue (1). This mental health issue is being set aside and ignored, perhaps because it is considered a nuisance, rather than an issue that requires urgent attention and solutions. Not even doctors are exceptions to the trend: this group has displayed a substantial increase in depression and anxiety rates, higher than the rates of the general population. Consequently, the suicide issue requires attention. Here, the issue will be approached from the perspective of healthcare personnel, including doctors.Sra. editora: En la actualidad, los casos de depresión y, a su vez, el fatal desenlace del suicidio, son cada vez más frecuentes. De acuerdo con los datos reportados por la Organización Mundial de la Salud, cerca de 3,000 personas se suicidan cada día en el mundo (lo que equivale a una cada 30 segundos) y otras 60,000 intentan hacerlo, pero no lo logran, haciendo que tal situación cobre gran importancia (1). Tal vez, debido a que se esté dejando de lado, omitiendo, la problemática de salud mental es vista como un problema que nos estorba y no como un problema que requiere pronta atención y solución. De esta problemática los médicos no están exentos: se puede ver, en este grupo, un notorio aumento en tasas de depresión y ansiedad, por encima de lo observado en la población en general. Por lo tanto, el tema del suicidio demanda atención; siendo así, se enfocará su abordaje hacia el personal de salud y, entre estos, a los médicos

    In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19

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    Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively.Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19.Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics.Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at

    TI - Introducción al Diseño Arquitectónico - AR305 - 202102

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    Descripción: El TI - Introducción al diseño arquitectónico es un curso de especialidad en la carrera. Busca que el estudiante se familiarice con la composición arquitectónica mediante la intuición y la plástica. Este es el primero de los diez cursos de talleres de diseño arquitectónico, que constituyen la columna vertebral de la carrera de Arquitectura. En este taller, el estudiante adquiere los fundamentos para el ejercicio de proyectar a través de ejercicios de composición tridimensionales con elementos tales como; punto, línea, plano y volumen como insumo para descubrimiento de. las posibilidades que ofrecen las propiedades de adición, sustracción, repetición, transformación, así como conceptos para el logro de volúmenes armados y excavados. En base a esta experiencia, que ocupa por lo menos la mitad del periodo, se hacen los primeros diseños de espacios (con criterios funcionales muy básicos) en los que se trabaja con escaleras, relaciones espaciales y las nociones de ingresar y circular entre otras estrategias de conexión con la realidad. En el curso TI - Introducción al diseño arquitectónico los contextos pueden ser teóricos, virtuales o conceptuales, la escala es un factor relativo a la composición la creación de espacios para personas y la función forma parte de las reglas de juego de cada ejercicio. Propósito: El curso TI - Introducción al diseño arquitectónico ha sido diseñado con el propósito de permitir al futuro arquitecto desarrollar las competencias iniciales de composición, a través del uso del lenguaje arquitectónico, sistemas ordenadores y resolución de encargos básicos de arquitectura. El curso contribuye a desarrollar la competencia general Pensamiento Innovador y la competencia específica Diseño fundamentado (que corresponde a los criterios NAAB: PC2, PC5 y SC5) ambas en Nivel 1. Sus prerrequisitos son MA95 Nivelación de Física o haber aprobado la prueba de definición de niveles de Física, MA392 Nivelación de Matemática o haber aprobado la prueba de definición de niveles de Matemáticas y AR206 Taller de Aptitud Vocacional para Arquitectura

    International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

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    •We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's. Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days. Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs. Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically

    Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

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