Proyecto de articulación de la media educativa con el programa Ingeniería de Sistemas y Computación en la Universidad Tecnológica de Pereira

Este proyecto muestra una gran variedad de contenidos sobre la problemática nacional y mundial que existe sobre el déficit de ingenieros en sistemas y de personas capacitadas en carreras tecnológicas, además, se plantea una posible estrategia que ayudaría a mejorar la cantidad de estudiantes interesados por este programa motivándolos específicamente a ingresar a la Universidad Tecnológica de Pereira para cursar la carrera Ingeniería de Sistemas y Computación catalogada como la carrera del hoy y del mañana sin lugar a duda. Dicha estrategia incluye interactuar con los estudiantes de grado 11 de tres colegios del municipio de Guática, con el objetivo de orientar a los alumnos sobre ¿Qué es un ingeniero de sistemas?,¿qué hace un ingeniero de sistemas?,¿por qué es tan importante estudiarla hoy en día?, ¿Qué posibles apoyos y becas pueden obtener del gobierno y de la universidad?, planteándoles un concepto claro de lo que en realidad se estudia en dicho programa y de sus grandes posibilidades que tienen en el campo laboral de la actualidad

La visión integradora de la investigación en ciencias del deporte

Grupo de Investigación BIOFANEX (Biological and Functional Analysis of Exercise) CTS97

Exercise, bone mineral density and quality of life in menopause women

El objetivo del presente estudio ha sido evaluar la densidad mineral ósea (DMO) y su relación con el perfil de calidad de vida (CV), en un grupo de mujeres menopáusicas, antes y después de realizar un programa de ejercicio físico terapéutico, en comparación con un grupo control, utilizando como instrumentos de medida la absorción radiológica de doble energía (DEXA) y el cuestionario “Perfil de Calidad de Vida para Enfermos Crónicos” (PECVEC) de Siegrist, Broer y Junge. Nuestros resultados muestran cambios significativos en la CV y DMO en relación con el desempeño físico.Actividad Física y DeporteMedicinaTerapia y Rehabilitació

Secuencias gráficas Paleolítico-Postpaleolítico en la Sierra de San Pedro. Tajo internacional. Cáceres

The UAH team is developing successive projects of heritage evaluation in the International Tagus, focused on the megalithic culture. Our surveys, based on the theoretical statement of a predictive model that considers the presence of outdoor paintings, make the Sierra de San Pedro one of the most important schematic painting groups of the Iberian Peninsula. Its parallel development to the sites with outdoor engravings in the International Tagus draws a complex set of symbols with a major role in the definition of megalithic territories. The identification of Palaeolithic figures coincides with similar recurrences documented in outdoor sites of the western peninsula, pointing to the resort to the past as one of the arguments of vindication and use of traditional territories.El equipo de la UAH viene desarrollando sucesivos proyectos de valoración patrimonial en el Tajo Internacional centrados en la cultura megalítica. Nuestras prospecciones a partir de la exposición teórica de un modelo predictivo que considera la presencia de pinturas al aire libre, hacen de la Sierra de San Pedro uno de los más importantes conjuntos de la pintura esquemática de la Península Ibérica. Su desarrollo paralelo a los yacimientos con grabados al aire libre del Tajo Internacional dibuja un complejo entramado de símbolos con un importante papel en la definición de los territorios megalíticos. La identificación de figuras paleolíticas coincide con recurrencias similares documentadas en los yacimientos al aire libre del occidente peninsular, apuntando al recurso al pasado como uno de los argumentos de reivindicación y uso de territorios tradicionales

Dietary modifications engaged in young muslims of Ramadan fasting

La práctica del precepto islámico del Ramadán (R), impone a las personas que lo practican importantes modificaciones fisiológicas y psicológicas debido a las restricciones hídricas y dietéticas a las que se ven sometidos, lo que tiene una especial repercusión en el rendimiento físico e intelectual de los estudiantes musulmanes, particularmente en sociedades multiculturales de tipo occidental, en las que no se producen ajustes horarios, en las actividades diarias. Entre las modificaciones introducidas en los hábitos de vida, por esta causa, destacan los cambios dietéticos, tanto cualitativos como cuantitativos. Por la relevancia de la cuestión y ante el escaso conocimiento de los efectos del Ramadán en estudiantes adolescentes que viven en sociedades no islámicas, se plantea como objetivo de este estudio, el análisis de las modificaciones en macronutrientes, ocurridas durante el R, en un grupo de alumnos musulmanes de ambos sexos, con el fin de solucionar y prevenir algunos de los problemas que se plantean en este periodo. Material y método: Se seleccionaron 55 jóvenes musulmanes (24 hombres y 31 mujeres) con edades comprendidas entre 15 y 18 años, que realizan el R y se analizó la dieta mediante inventario de 3 días, una semana antes del ayuno y en la segunda semana durante éste. Resultados: En el R, no hay cambios significativos en la ingesta calórica de los hombres y sí en el de las mujeres. Se incrementa el consumo de carbohidratos y proteínas y desciende el de grasas. Discusión: Los cambios en R conducen a una dieta más ajustada a las recomendaciones nutricionales, y a esto parece haber contribuido el hecho de que los participantes llevaron a cabo sus comidas en el seno doméstico donde, a pesar del corte occidental de la población, se deja sentir una importante influencia de las tradiciones y hábitos magrebíes, por el contacto fronterizo con Marruecos.The practice of the Islamic precept of Ramadan (R) imposes to those who practice it important physiological and psychological changes due to the water and dietary restrictions they are subjected to, which has a particular impact on the Muslim students’ physical and psychological performances, particularly in multicultural Western societies, where there are no schedule adjustments in daily activities. Among the changes in lifestyle, consequently, the dietary changes are stressed, both qualitative and quantitative. Due to the importance of this issue and facing the limited knowledge the Muslim teenagers who live in non-Islamic societies have about the effects of Ramadan, it is suggested as main objective of this study the analysis of changes in nutrients during R in a group of Muslim students of both sexes, in order to solve and prevent some of the problems shown in this period. Materials and methods: 55 Muslim youngsters were selected (24 men and 31 women) aged between 15 and 18, who practise R; and the diet was analysed by inventory over 3 days, one week before fasting and in the second week during it. Results: In R there are no relevant changes in caloric intake. The consumption of carbohydrates and proteins is increased, and that of fat is decreased. Discussion: the changes in R lead to a diet more regulated to nutritional recommendations; and to this seems to have contributed the fact that the participants took their meals at home, where, in spite of the Western cut of the population, it is felt an important influence of North African traditions and habits, due to its border contact with Morocco

Detection of p190BCR-ABL and p210BCR-ABL Fusion Transcripts in Patients with Chronic Myeloid Leukemia (CML) Using Qualitative RT-PCR

RESUMEN: Introducción: la leucemia mieloide crónica (LMC) se caracteriza por la presencia del cromosoma Filadelfia (Ph) que resulta de la translocación recíproca balanceada t(9;22)(q34;q11); este marcador cromosómico se encuentra con menor frecuencia en pacientes con leucemia linfoide aguda (LLA). Objetivo: determinar la frecuencia de las fusiones génicas BCR-ABL, que codifican para transcriptos p210BCR-ABL y p190 BCR-ABL en pacientes colombianos con diagnóstico de LMC, en diferentes fases de la enfermedad o de su tratamiento. Materiales y métodos: estudio descriptivo de corte transversal de 31 pacientes con LMC (15-78 años). El análisis se hizo a partir de muestras de sangre periférica con la técnica PCR anidada cualitativa para las isoformas P210 BCR-ABL (b3a2 e b2a2) y P190 BCR-ABL (e1a2). Resultados: se detectó el transcripto p210BCR-ABL en 29 de los 31 casos (93,6%). En ellos se identificaron las fusiones génicas b2a2 (16/29; 55,2%), b3a2 (10/29; 34,5%) y la coexpresión b3a2 y b2a2 (3/29; 10,3%). Conclusión: la fusión génica b2a2 fue la más frecuente en esta población con LMCSUMMARY: Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11). This marker chromosome is found less frequently in patients suffering from acute lymphoblastic leukemia. Objective: To determine the frequency of BCR-ABL gene fusions encoding the p210BCR-ABL y p190 BCR-ABL transcripts in Colombian patients diagnosed with CML in different stages of the disease and/or its treatment. Materials and methods: Cross sectional, descriptive study of thirty one CML patients (aged 15-78). Analysis was carried out through qualitative nested PCR for the isoforms P210 BCR-ABL (b3a2 e b2a2) and P190 BCR-ABL (e1a2), and based on peripheral blood samples. Results: In 29 of the 31 patients (93.6%) transcript p210BCR-ABL was detected; b2a2 and b3a2 gene fusions and the coexpression b3a2 and b2a2 were identified in 55.2% (16/29), 34.5% (10/29) and 10.3% (3/29) of the cases, respectively. Conclusion: b2a2 gene fusion was the most frequent in this CML populatio

Rationale and design of a randomised controlled trial evaluating the effectiveness of an exercise program to improve the quality of life of patients with heart failure in primary care : the EFICAR study protocol

Background: Quality of life (QoL) decreases as heart failure worsens, which is one of the greatest worries of these patients. Physical exercise has been shown to be safe for people with heart failure. Previous studies have tested heterogeneous exercise programs using different QoL instruments and reported inconsistent effects on QoL. The aim of this study is to evaluate the effectiveness of a new exercise program for people with heart failure (EFICAR), additional to the recommended optimal treatment in primary care, to improve QoL, functional capacity and control of cardiovascular risk factors. Methods/Design: Multicenter clinical trial in which 600 patients with heart failure in NYHA class II-IV will be randomized to two parallel groups: EFICAR and control. After being recruited, through the reference cardiology services, in six health centres from the Spanish Primary Care Prevention and Health Promotion Research Network (redIAPP), patients are followed for 1 year after the beginning of the intervention. Both groups receive the optimized treatment according to the European Society of Cardiology guidelines. In addition, the EFICAR group performs a 3 month supervised progressive exercise program with an aerobic (high-intensity intervals) and a strength component; and the programme continues linked with community resources for 9 months. The main outcome measure is the change in health-related QoL measured by the SF-36 and the Minnesota Living with Heart Failure Questionnaires at baseline, 3, 6 and 12 months. Secondary outcomes considered are changes in functional capacity measured by the 6-Minute Walking Test, cardiac structure (B-type natriuretic peptides), muscle strength and body composition. Both groups will be compared on an intention to treat basis, using multi-level longitudinal mixed models. Sex, age, social class, co-morbidity and cardiovascular risk factors will be considered as potential confounding and predictor variables. Discussion: A key challenges of this study is to guarantee the safety of the patients; however, the current scientific evidence supports the notion of there being no increase in the risk of decompensation, cardiac events, hospitalizations and deaths associated with exercise, but rather the opposite. Safety assurance will be based on an optimized standardised pharmacological therapy and health education for all the participants

Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population

8Pág. Centro de Investigación en Sanidad Animal (CISA)To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children.The study was funded by: Project PI20/00095, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, by Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and Innovation (FIIB HUIS HHEN), and by SERMAS-Fundación para la Investigación Biomédica del Hospital 12 de Octubre. EC-C is supported by the Spanish Society of Paediatrics (Asociación Española de Pediatría); Grant COVID-19 EPICO-AEP 2020. JMM is funded by SERMAS-Fundación para la Investigación Biomédica del Hospital Infanta Sofía y del Henares and by Universidad Europea de Madrid, Spain. MdlS is funded by Grant Cantera de Investigación Santander, Fundación Universidad Europea de Madrid, Spain. ED is funded by the Juan de la Cierva–Incorporación granted by the Spanish Ministry of Science and Innovation. DB-G is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER by ’Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud, 2020 (INT20/00086)’.Peer reviewe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group