Research into 3D construction and its applications.

[EN] This article intends to give an understanding of the process of research into cement materials, focussed on 3D printing. A group of four students at the Universitat Polit.cnica de Val.ncia – three architectural engineers and one electronic and automotive industrial engineer, spent three years researching and developing both a mobile 3D printing device; and a cement material to be extruded by this device and be capable of modelling any type of figure with FDM technology. The main objective of this research is the application of this new construction system to the house-building and real estate sector; reducing occupational hazards, costs and waste material.[ES] En el presente artículo se pretende dar a conocer el proceso de investigación sobre materiales cementicios enfocados a la impresión 3D. Un grupo de 4 estudiantes de la Universidad Politécnica de Valencia, 3 Ingenieros de la Edificación y 1 Ingeniero de Electrónica y automatismo Industrial, llevan 3 años investigando y desarrollando tanto un dispositivo de impresión 3D móvil como un material cementicio para ser extrusionado por dicho dispositivo y ser capaz de modelar cualquier tipo de figura con tecnología FDM(ADICIÓN DE CAPAS). El principal objetivo de esta investigación es la aplicación de este nuevo sistema constructivo al sector inmobiliario y construir vviiendas, reduciendo riesgos laborales, costes y material de residuo. Caracterizando nuevas dosificaciones cementicias, conseguimos aumentar su Trabajabilidad y Robustez frente a iclemencias metereológicas que puedan afectar a su reología y comportamiento al momento de su puesta en obra mediante bombeo y extrusión mecánica.Ramírez Collado, V.; Puchades Valencia, JL.; Martín Rodríguez, J.; Muñoz Montes, JG. (2018). Investigación sobre construcción 3D y sus aplicaciones. En CIAB 8. VIII Congreso Internacional de arquitectura blanca. Editorial Universitat Politècnica de València. 190-197. https://doi.org/10.4995/CIAB8.2018.7648OCS19019

Diferenciación y desarrollo postnatal de los tipos de fibras musculares en el cerdo chato murciano

Mediante la técnica que detecta la actividad de la enzima ATPasa miosínica se analiza el tamaño y porcentajes de los distintos tipos de fibras que integran el músculo longísimo lumbar del cerdo “Chato Murciano”, desde el nacimiento hasta los 120 días de edad. Al nacimiento, el músculo longísimo está conformado por un 5,5% de fibras tipo I, de gran tamaño y un 94,5% de fibras tipo II, de menor tamaño. Durante el primer mes de vida postnatal las fibras tipo II se irán diferenciando en nuevas fibras tipo I y subtipos IIA y IIX. A partir de los dos meses tiene lugar un aumento del diámetro fibrilar (hipertrofia) y una distribución fibrilar que recuerda a la de animales adultos. Aunque la hipertrofia observada afecta a los tres tipos de fibras evaluados, parece claro que el crecimiento y conformación muscular en el cerdo chato murciano está muy asociado al notable incremento en diámetro que experimentan las fibras IIX, ya que éstas crecen más rápidamente que las tipo I y IIA

Plasma ACE2 species are differentially altered in COVID-19 patients

Studies are needed to identify useful biomarkers to assess the severity and prognosis of COVID-19 disease, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus. Here, we examine the levels of various plasma species of the SARS-CoV-2 host receptor, the angiotensin-converting enzyme 2 (ACE2), in patients at different phases of the infection. Human plasma ACE2 species were characterized by immunoprecipitation and western blotting employing antibodies against the ectodomain and the C-terminal domain, using a recombinant human ACE2 protein as control. In addition, changes in the cleaved and full-length ACE2 species were also examined in serum samples derived from humanized K18-hACE2 mice challenged with a lethal dose of SARS-CoV-2. ACE2 immunoreactivity was present in human plasma as several molecular mass species that probably comprise truncated (70 and 75 kDa) and full-length forms (95, 100, 130, and 170 kDa). COVID-19 patients in the acute phase of infection (n = 46) had significantly decreased levels of ACE2 full-length species, while a truncated 70-kDa form was marginally higher compared with non-disease controls (n = 26). Levels of ACE2 full-length species were in the normal range in patients after a recovery period with an interval of 58-70 days (n = 29), while the 70-kDa species decreased. Levels of the truncated ACE2 species served to discriminate between individuals infected by SARS-CoV-2 and those infected with influenza A virus (n = 17). In conclusion, specific plasma ACE2 species are altered in patients with COVID-19 and these changes normalize during the recovery phase. Alterations in ACE2 species following SARS-CoV-2 infection warrant further investigation regarding their potential usefulness as biomarkers for the disease process and to asses efficacy during vaccination

Ultrasonography in rheumatology: time to learn from patient views

Objective: The objective of this observational, descriptive, cross-sectional, multicentre study was to assess the perceived quality and grade of satisfaction expressed by patients with chronic arthropathies regarding the use of musculoskeletal (MSK) ultrasonography by rheumatologists as an integrated clinical care tool. Methods: All Spanish rheumatology departments with MSK ultrasonography incorporated in their healthcare services were invited to participate in the study. A Spanish-language survey was offered to fill out anonymously to all consecutive patients with chronic arthropathies under follow-up in the rheumatology outpatient clinics who attended their centre for a period of 3 months. The survey consisted of three sections. The first section contained patients’ demographics, disease data, frequency of performing rheumatological ultrasound and information about who performed their ultrasound assessments. The second section consisted of 14 questions about patient’s experience and opinion on different aspects of the management, performance and perceived usefulness of performing ultrasound, to be answered on a Likert scale 1–5. The third section of the survey was addressed to the rheumatologist ultrasonographers. Results: Nine hundred and four patients from 16 university hospital rheumatology departments completed the survey. All questions reached an overall favourable response ≥ 80%. Patients who reported usual ultrasound examinations in their rheumatology care and those in which it was their attending rheumatologist who performed the ultrasound assessments responded more favourably. Conclusion: Our encouraging patient-centred results may be useful in facilitating the implementation of rheumatological ultrasound in rheumatology care worldwide. Key Points • This is the largest multicentre survey carried out in patients with chronic joint diseases designed to assess their experience and perceived benefits with the use of ultrasonography performed by rheumatologists in daily practice. • Musculoskeletal ultrasound incorporated into rheumatology care was very well accepted and valued by most patients. • The patients perceived that ultrasonography helps not only their rheumatologist but also themselves to better understand their condition. • The patients believed that ultrasonography helps them accept and comply with the proposed treatmen

Seguimiento de construcción Edificio 54 en Ford

Trabajo Final de Grado en modalidad convenio con empresa.[ES] Este Trabajo Final de Grado (TFG) consiste en el seguimiento de la construcción de una nave industrial de 15000 m2 dentro de la factoría Ford. Dicha obra se realiza en un periodo de 7 meses. Desde el departamento "Lean Construction Management" se han controlado tiempos de ejecución y el transcurso de la obra para que todo siga según el plan previsto. El funcionamiento de dicho proceso se ejecuta mediante unas tarjetas en las cuales se planifica y escribe lo que se va a ejecutar cada día, una vez a la semana se elabora un informe con estadísticas y gráficas que definen exactamente el estado actual de la ejecución. Con este informe se hacen reuniones con el cliente para explicarle cómo va la obra. En este TFG también se va a explicar la gestión de la prevención, el control calidad, el presupuesto y el seguimiento diario de la obra.[EN] This Bachelor's thesis consists in monitoring the construction of a 15000 m2 warehouse inside the Ford factory. This work is carried on in a period of 7 months. The execution times and the course of the work to keep everything according to plan are controlled from the Lean Construction Management Department. The operation of such a process is executed by a card in which tasks that must be done on day are written. Once a week a report with statistics and graphs that accurately portray the current state of implementation is elaborated. Meetings are maintained with the client to show this report and explain how it is worked . It is also explained the management of prevention, quality control, budget and daily monitoring of the work.Ramírez Collado, V. (2014). Seguimiento de construcción Edificio 54 en Ford. http://hdl.handle.net/10251/45185.Archivo delegad

Derrame pleural como debut de síndrome linfoproliferativo

Extranodal MALT lymphomas are a type of lymphoproliferative syndrome belonging to non-Hodgkin's lymphomas. The most common affectation of these types of lymphomas is the digestive tract (80%), the lung being only 14% of cases. We present the case of a 73 years old woman who goes to progressive dyspnea, with a large right pleural effusion on the chest x-ray. After screening and differential diagnosis of the different types of pleural effusion and the clinical etiological processes involved in its production, the diagnosis of lymphoproliferative process was reached, starting chemotherapy treatment with good evolution of both the pleural effusion and the patient's clinic

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective