397 research outputs found
FIESTA ROC: A new finite element analysis program for solar cell simulation
The Finite Element Semiconductor Three-dimensional Analyzer by Ralph O. Clark (FIESTA ROC) is a computational tool for investigating in detail the performance of arbitrary solar cell structures. As its name indicates, it uses the finite element technique to solve the fundamental semiconductor equations in the cell. It may be used for predicting the performance (thereby dictating the design parameters) of a proposed cell or for investigating the limiting factors in an established design
Control of Multi-level Voltage States in a Hysteretic SQUID Ring-Resonator System
In this paper we study numerical solutions to the quasi-classical equations
of motion for a SQUID ring-radio frequency (rf) resonator system in the regime
where the ring is highly hysteretic. In line with experiment, we show that for
a suitable choice of of ring circuit parameters the solutions to these
equations of motion comprise sets of levels in the rf voltage-current dynamics
of the coupled system. We further demonstrate that transitions, both up and
down, between these levels can be controlled by voltage pulses applied to the
system, thus opening up the possibility of high order (e.g. 10 state),
multi-level logic and memory.Comment: 8 pages, 9 figure
Spectroscopy of a Cooper-Pair box in the Autler-Townes configuration
A theoretical spectroscopic analysis of a microwave driven superconducting
charge qubit (Cooper-pair box coupled) to an RLC oscillator model is performed.
By treating the oscillator as a probe through the backreaction effect of the
qubit on the oscillator circuit, we extract frequency splitting features
analogous to the Autler-Townes effect from quantum optics, thereby extending
the analogies between superconducting and quantum optical phenomenology. These
features are found in a frequency band that avoids the need for high frequency
measurement systems and therefore may be of use in qubit characterization and
coupling schemes. In addition we find this frequency band can be adjusted to
suit an experimental frequency regime by changing the oscillator frequency.Comment: 13 pages, 7 figures. v2: Revised version after referee comments.
Accepted for publication by Physical Review
Energy Down Conversion between Classical Electromagnetic Fields via a Quantum Mechanical SQUID Ring
We consider the interaction of a quantum mechanical SQUID ring with a
classical resonator (a parallel tank circuit). In our model we assume that
the evolution of the ring maintains its quantum mechanical nature, even though
the circuit to which it is coupled is treated classically. We show that when
the SQUID ring is driven by a classical monochromatic microwave source, energy
can be transferred between this input and the tank circuit, even when the
frequency ratio between them is very large. Essentially, these calculations
deal with the coupling between a single macroscopic quantum object (the SQUID
ring) and a classical circuit measurement device where due account is taken of
the non-perturbative behaviour of the ring and the concomitant non-linear
interaction of the ring with this device.Comment: 7 pages, 6 figure
Non-linear Multi-level Dynamics of a SQUID Ring-resonator System in the Hysteretic Regime
We consider the dynamical behavior of a strongly hysteretic SQUID ring coupled to a radio frequency resonator. By experiment we show that this system can display novel multiple level structures in its rf voltage-current characteristics which are solutions of the nonlinear equations of motion describing the system
Quantum Statistics and Entanglement of Two Electromagnetic Field Modes Coupled via a Mesoscopic SQUID Ring
In this paper we investigate the behaviour of a fully quantum mechanical
system consisting of a mesoscopic SQUID ring coupled to one or two
electromagnetic field modes. We show that we can use a static magnetic flux
threading the SQUID ring to control the transfer of energy, the entanglement
and the statistical properties of the fields coupled to the ring. We also
demonstrate that at, and around, certain values of static flux the effective
coupling between the components of the system is large. The position of these
regions in static flux is dependent on the energy level structure of the ring
and the relative field mode frequencies, In these regions we find that the
entanglement of states in the coupled system, and the energy transfer between
its components, is strong.Comment: 15 pages, 19 figures, Uploaded as implementing a policy of arXiving
old paper
Tissue-specific immunopathology in fatal COVID-19
Funding: Inflammation in COVID-19: Exploration of Critical Aspects of Pathogenesis (ICECAP) receives funding and support from the Chief Scientist Office (RapidResearch in COVID-19 programme [RARC-19] funding call, “Inflammation in Covid-19: Exploration of Critical Aspects of Pathogenesis; COV/EDI/20/10” to D.A.D., C.D.L., C.D.R., J.K.B., and D.J.H.), LifeArc (through the University of Edinburgh STOPCOVID funding award to K.D., D.A.D., and C.D.L.), UK Research and Innovation (UKRI) (Coronavirus Disease [COVID-19] Rapid Response Initiative; MR/V028790/1 to C.D.L., D.A.D., and J.A.H.), and Medical Research Scotland (CVG-1722-2020 to D.A.D., C.D.L., C.D.R., J.K.B., and D.J.H.). C.D.L. is funded by a Wellcome Trust Clinical Career Development Fellowship(206566/Z/17/Z). J.K.B. and C.D.R. are supported by the Medical Research Council (grant MC_PC_19059) as part of the International Severe AcuteRespiratory Infection Consortium Coronavirus Clinical Characterisation Consortium (ISARIC-4C). D.J.H., I.H.U., and M.E. are supported by the Industrial Centre for Artificial Intelligence Research in Digital Diagnostics. S.P. is supported by Kidney Research UK, and G.T. is supported by the Melville Trust for the Cure and Care of Cancer. Identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and sequencing work was supported by theU.S. Food and Drug Administration grant HHSF223201510104C (“Ebola Virus Disease: correlates of protection, determinants of outcome and clinicalmanagement”; amended to incorporate urgent COVID-19 studies) and contract 75F40120C00085 (“Characterization of severe coronavirus infection inhumans and model systems for medical countermeasure development and evaluation”; awarded to J.A.H.). J.A.H. is also funded by the Centre of Excellence in Infectious Diseases Research and the Alder Hey Charity. R.P.-R. is directly supported by the Medical Research Council Discovery Medicine North Doctoral Training Partnership. The group of J.A.H. is supported by the National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England and in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.Rationale: In life-threatening Covid-19, corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily a direct reaction to the presence of SARS-CoV-2 or an independent immunopathologic process is unknown. Objectives: To determine SARS-CoV-2 organotropism and organ-specific inflammatory responses, and the relationships between viral presence, inflammation, and organ injury. Methods: Tissue was acquired from eleven detailed post-mortem examinations. SARS-CoV-2 organotropism was mapped by multiplex PCR and sequencing, with cellular resolution achieved by in situ viral spike protein detection. Histological evidence of inflammation was quantified from 37 anatomical sites, and the pulmonary immune response characterized by multiplex immunofluorescence. Measurements and main results: Multiple aberrant immune responses in fatal Covid-19 were found, principally involving the lung and reticuloendothelial system, and these were not clearly topologically associated with the virus. Inflammation and organ dysfunction did not map to the tissue and cellular distribution of SARS-CoV-2 RNA and protein, both between and within tissues. An arteritis was identified in the lung, which was further characterised as a monocyte/myeloid-rich vasculitis, and occurred along with an influx of macrophage/monocyte-lineage cells into the pulmonary parenchyma. In addition, stereotyped abnormal reticulo-endothelial responses, including excessive reactive plasmacytosis and iron-laden macrophages, were present and dissociated from viral presence in lymphoid tissues. Conclusions: Tissue-specific immunopathology occurs in Covid-19, implicating a significant component of immune-mediated, virus-independent immunopathology as a primary mechanism in severe disease. Our data highlight novel immunopathological mechanisms, and validate ongoing and future efforts to therapeutically target aberrant macrophage and plasma cell responses as well as promoting pathogen tolerance in Covid-19.Publisher PDFPeer reviewe
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A Search for Dark Higgs Bosons
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
First High-Convergence Cryogenic Implosion in a Near-Vacuum Hohlraum
Recent experiments on the National Ignition Facility [M. J. Edwards et al., Phys. Plasmas 20, 070501 (2013)] demonstrate that utilizing a near-vacuum hohlraum (low pressure gas-filled) is a viable option for high convergence cryogenic deuterium-tritium (DT) layered capsule implosions. This is made possible by using a dense ablator (high-density carbon), which shortens the drive duration needed to achieve high convergence: a measured 40% higher hohlraum efficiency than typical gas-filled hohlraums, which requires less laser energy going into the hohlraum, and an observed better symmetry control than anticipated by standard hydrodynamics simulations. The first series of near-vacuum hohlraum experiments culminated in a 6.8 ns, 1.2 MJ laser pulse driving a 2-shock, high adiabat (α ~ 3.5) cryogenic DT layered high density carbon capsule. This resulted in one of the best performances so far on the NIF relative to laser energy, with a measured primary neutron yield of 1.8×10[superscript 15] neutrons, with 20% calculated alpha heating at convergence ~27×
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