578 research outputs found
Unambiguous determination of spin dephasing times in ZnO
Time-resolved magneto-optics is a well-established optical pump probe
technique to generate and to probe spin coherence in semiconductors. By this
method, spin dephasing times T_2^* can easily be determined if their values are
comparable to the available pump-probe-delays. If T_2^* exceeds the laser
repetition time, however, resonant spin amplification (RSA) can equally be used
to extract T_2^*. We demonstrate that in ZnO these techniques have several
tripping hazards resulting in deceptive values for T_2^* and show how to avoid
them. We show that the temperature dependence of the amplitude ratio of two
separate spin species can easily be misinterpreted as a strongly temperature
dependent T_2^* of a single spin ensemble, while the two spin species have
T_2^* values which are nearly independent of temperature. Additionally,
consecutive pump pulses can significantly diminish the spin polarization, which
remains from previous pump pulses. While this barely affects T_2^* values
extracted from delay line scans, it results in seemingly shorter T_2^* values
in RSA.Comment: 11 pages, 10 figure
Recommended from our members
Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles
Protein kinases are attractive therapeutic targets, but their high sequence and structural conservation complicates the development of specific inhibitors. We recently discovered from a DNA-templated macrocycle library inhibitors with unusually high selectivity among Src-family kinases. Starting from these compounds, we developed and characterized in molecular detail potent macrocyclic inhibitors of Src kinase and its cancer-associated gatekeeper mutant. We solved two co-crystal structures of macrocycles bound to Src kinase. These structures reveal the molecular basis of the combined ATP- and substrate peptide-competitive inhibitory mechanism and the remarkable kinase specificity of the compounds. The most potent compounds inhibit Src activity in cultured mammalian cells. Our work establishes that macrocycles can inhibit protein kinases through a bi-substrate competitive mechanism with high potency and exceptional specificity, reveals the precise molecular basis for their desirable properties, and provides new insights into the development of Src-specific inhibitors with potential therapeutic relevance.Chemistry and Chemical Biolog
Monte-Carlo simulation of supercooled liquids using a self-consistent local temperature
We combine Creutz energy conservation with Kawasaki spin exchange to simulate
the microcanonical dynamics of a system of interacting particles. Relaxation
occurs via Glauber spin-flip activation using a self-consistent temperature.
Heterogeneity in the dynamics comes from finite-size constraints on the spin
exchange that yield a distribution of correlated regions. The simulation
produces a high-frequency response that can be identified with the boson peak,
and a lower-frequency peak that contains non-Debye relaxation and non-Arrhenius
activation, similar to the primary response of supercooled liquids.Comment: 16 pages, 4 figure
Minimal resources for linear optical one-way computing
We address the question of how many maximally entangled photon pairs are
needed in order to build up cluster states for quantum computing using the
toolbox of linear optics. As the needed gates in dual-rail encoding are
necessarily probabilistic with known optimal success probability, this question
amounts to finding the optimal strategy for building up cluster states, from
the perspective of classical control. We develop a notion of classical
strategies, and present rigorous statements on the ultimate maximal and minimal
use of resources of the globally optimal strategy. We find that this strategy -
being also the most robust with respect to decoherence - gives rise to an
advantage of already more than an order of magnitude in the number of maximally
entangled pairs when building chains with an expected length of L=40, compared
to other legitimate strategies. For two-dimensional cluster states, we present
a first scheme achieving the optimal quadratic asymptotic scaling. This
analysis shows that the choice of appropriate classical control leads to a very
significant reduction in resource consumption.Comment: 5 pages, 2 figures, title changed, presentation improved, bounds
improved, minor errors corrected, references update
Pairing correlations and transitions in nuclear systems
We discuss several pairing-related phenomena in nuclear systems, ranging from
superfluidity in neutron stars to the gradual breaking of pairs in finite
nuclei. We describe recent experimental evidence that points to a relation
between pairing and phase transitions (or transformations) in finite nuclear
systems. A simple pairing interaction model is used in order to study and
classify an eventual pairing phase transition in finite fermionic systems such
as nuclei. We show that systems with as few as 10-16 fermions can exhibit clear
features reminiscent of a phase transition.Comment: Proceedings of COMEX1, Sorbonne, Paris, june 10-13 2003. To appear in
Nuclear Physics
Age regression from soft aligned face images using low computational resources
The initial step in most facial age estimation systems consists of accurately aligning a model to the output of a face detector (e.g. an Active Appearance Model). This fitting process is very expensive in terms of computational resources and prone to get stuck in local minima. This makes it impractical for analysing faces in resource limited computing devices. In this paper we build a face age regressor that is able to work directly on faces cropped using a state-of-the-art face detector. Our procedure uses K nearest neighbours (K-NN) regression with a metric based on a properly tuned Fisher Linear Discriminant Analysis (LDA) projection matrix. On FG-NET we achieve a state-of-the-art Mean Absolute Error (MAE) of 5.72 years with manually aligned faces. Using face images cropped by a face detector we get a MAE of 6.87 years in the same database. Moreover, most of the algorithms presented in the literature have been evaluated on single database experiments and therefore, they report optimistically biased results. In our cross-database experiments we get a MAE of roughly 12 years, which would be the expected performance in a real world application
Recommended from our members
Identification of Small Molecules that Enhance Synaptogenesis Using Synapse Microarrays
Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads. Here we report a “synapse microarray” technology that enables ultra-sensitive, high-throughput, and quantitative screening of synaptogenesis. Our platform enables the induction of synaptic structures in regular arrays by precise positioning of non-neuronal cells expressing synaptic proteins, while allowing neurites to grow freely around these cells. The technology increases by tenfold the sensitivity of the traditional assays, and simultaneously decreases the time required to capture synaptogenic events by an order of magnitude. It is readily incorporated into multiwell formats compatible with industrial high-throughput screening platforms. Using this technology, we screened a chemical library and identified novel histone deacetylase inhibitors that improve neuroligin-1 induced synaptogenesis via modulating class-I histone deacetylases. We also found a structure-activity relationship for designing novel potent histone deacetylase inhibitors, which can be applied towards development of new therapeutics
Experimental measurement-based quantum computing beyond the cluster-state model
The paradigm of measurement-based quantum computation opens new experimental
avenues to realize a quantum computer and deepens our understanding of quantum
physics. Measurement-based quantum computation starts from a highly entangled
universal resource state. For years, clusters states have been the only known
universal resources. Surprisingly, a novel framework namely quantum computation
in correlation space has opened new routes to implement measurement-based
quantum computation based on quantum states possessing entanglement properties
different from cluster states. Here we report an experimental demonstration of
every building block of such a model. With a four-qubit and a six-qubit state
as distinct from cluster states, we have realized a universal set of
single-qubit rotations, two-qubit entangling gates and further Deutsch's
algorithm. Besides being of fundamental interest, our experiment proves
in-principle the feasibility of universal measurement-based quantum computation
without using cluster states, which represents a new approach towards the
realization of a quantum computer.Comment: 26 pages, final version, comments welcom
- …