Guest Editorial: Business Models/Projects – Design, Venture, Manage and Evaluate

A number of literature reviews on business models and innovation have suggested that business models are mainly rooted in resource-based view (RBV) and transaction cost economics (TCE) theories. Since business models is a burgeoning research field in strategic management, scholars have paid a great attention toward conceptualizing what business models are, how business models are evolved, and what theories explain business models. The special issue welcomed scholars to submit their academic research on various themes in business models, including innovative ideas to architecture ideal business models, motives of innovation in business models, financing business enterprises, venture capitalists role in business projects, bank financing, leasing and contracting in new business projects, inventory and supply chain issues in projects, barriers to success in new business models, evaluating project performance, cost estimation and control in project management, and socially-driven vs. value-driven projects, among others. The special issue call for papers has received a good response from strategy and finance researchers globally. Following double blind review system, we have accepted six articles for the Issue in 2017

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

1,2,3-Triazole-based heterocycles have previously been shown to possess significant anticancer activity in various tumor models. In the present study, we attached a 1,2,3-triazole moiety to the third position of a 1,2-benzisoxazole heterocycle via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with various alkynes and established for the title compounds significant antiproliferative effect against human acute myeloid leukemia (AML) cells. Among the tested compounds, 3-(4-(4-phenoxyphenyl)-1H-1,2,3-triazol-1-yl)benzodisoxazole (PTB) was found to be the most potent antiproliferative agent with an IC50 of 2 μM against MV4-11 cells using MTT assay. Notably, PTB induced cytotoxicity in MOLM13, MOLM14 and MV4-11 cells with selectivity over normal bone marrow cells (C57BL/6). Furthermore, PTB was found to induce cytotoxicity by increasing apoptosis of AML cells (MOLM13, MOLM14 and MV4-11) as well as sub-G1 cell population and apoptotic cells at submicromolar concentrations, as shown by flow cytometry and Annexin-V staining, respectively. On the protein level we suggested histone deacetylases (HDACs) as the potential protein target of those compounds in silico, and the predicted target was next experimentally validated by measuring the variations in the levels of p21, cyclin D and acetylation of histone H3 and tubulin. Molecular docking analysis of the title compounds with the second deacetylase domain of HDAC6 displayed high degree of shape complementarity to the binding site of the enzyme, forming multiple molecular interactions in the hydrophobic region as well as a hydrogen bond to the phenol side-chain of Tyr-782. Thus, 1,2,3-triazole derivatives appear to represent a class of novel, biologically active ligands against histone deacetylases which deserve to be further evaluated in their applications in the cancer field. © 2015 Elsevier Ltd. All rights reserved

Proceedings and recommendations of the National Webinar on Implementation of Access to Plant Genetic Resources and Benefit Sharing

A National Webinar on “Implementation of Access to Plant Genetic Resources and Benefit Sharing (ABS)” was held on August 27, 2020. The meeting was co-organized by UN Environment Implemented GEF Project, Alliance of Bioversity International and the International Center for Tropical Agriculture (CIAT), Delhi Office, India and the Indian Society of Plant Genetic Resources (ISPGR) and was attended by 200 stakeholders from academia, policy, management, farmers and private sector. This document provides briefly the deliberations held during the webinar and the major recommendations which emerged

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b

We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society

Search for gravitational-wave transients associated with magnetar bursts in advanced LIGO and advanced Virgo data from the third observing run

Gravitational waves are expected to be produced from neutron star oscillations associated with magnetar giant f lares and short bursts. We present the results of a search for short-duration (milliseconds to seconds) and longduration (∼100 s) transient gravitational waves from 13 magnetar short bursts observed during Advanced LIGO, Advanced Virgo, and KAGRA’s third observation run. These 13 bursts come from two magnetars, SGR1935 +2154 and SwiftJ1818.0−1607. We also include three other electromagnetic burst events detected by FermiGBM which were identified as likely coming from one or more magnetars, but they have no association with a known magnetar. No magnetar giant flares were detected during the analysis period. We find no evidence of gravitational waves associated with any of these 16 bursts. We place upper limits on the rms of the integrated incident gravitational-wave strain that reach 3.6 × 10−²³ Hz at 100 Hz for the short-duration search and 1.1 ×10−²² Hz at 450 Hz for the long-duration search. For a ringdown signal at 1590 Hz targeted by the short-duration search the limit is set to 2.3 × 10−²² Hz. Using the estimated distance to each magnetar, we derive upper limits upper limits on the emitted gravitational-wave energy of 1.5 × 1044 erg (1.0 × 1044 erg) for SGR 1935+2154 and 9.4 × 10^43 erg (1.3 × 1044 erg) for Swift J1818.0−1607, for the short-duration (long-duration) search. Assuming isotropic emission of electromagnetic radiation of the burst fluences, we constrain the ratio of gravitational-wave energy to electromagnetic energy for bursts from SGR 1935+2154 with the available fluence information. The lowest of these ratios is 4.5 × 103

Near-field vibrations in railway track on soft subgrades for semi high-speed trains

For the development of a high-speed rail network in urbanised areas, ground vibration and associated damage to surrounding structures are major concerns. The problem becomes critical especially in areas with soft soil deposits due to amplification of vibration during Rayleigh wave propagation. In the present study, near field ground vibrations from a high-speed rail ballasted track are predicted for an area which contains predominantly soft marine clay deposits. A two-dimensional finite element model coupled with infinite boundaries is developed in ABAQUS. Using the finite element model, the vibration in terms of peak particle velocity (PPV) and root mean square (RMS) velocity is determined for different train speeds and soil profiles, at varying distances from the track centre. Different soil profiles are considered in this study by varying the thickness and depth of the soft clay layer. From the results, it was observed that maximum ground vibration happens when the train speed is close to the Rayleigh velocity of the soft clay layer. Further, the safe limits for residential and sensitive structures are determined for different conditions based on peak particle velocity. Considering human discomfort during vibration propagation, the vibration level in decibel scale is determined for different track configurations

Atomic structure and radiative properties of He-like Ni26+ ion in dense plasma

The influence of plasma screening on the excitation energies and transition properties of He-like NiThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

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Not AvailablePresent study investigated the effect of long term selection for juvenile body weight and egg production on semen quality in broiler breeder dam line. Semen from males of line selected for juvenile body weight and part period egg production for 19 generations and from control population that was not under any selection programme was collected evaluated for different semen parameters like volume, appearance, motility, concentration, fertilizing ability, live, dead and abnormal spermatozoa. Seminal plasma of the two lines was analysed for protein, cholesterol and nitric oxide levels. The line under selection had significantly (P < 0.05) lower values in fertilizing ability, protein, cholesterol and nitric oxide levels in comparison to control line. These results suggest that selection for higher body weight and egg production in broiler breeders affects the semen quality and fertilizing abilityICAR-DP