A bi-objective model for the integrated frequency-timetabling problem

The urban transport planning process has four basic activities: network design, timetable construction, vehicle scheduling and crew scheduling. In this work we focus on the urban bus timetable construction problem which has two sub-activities: bus frequency calculation and bus departures setting. Typically, these sub-activities are done sequentially, which has some drawbacks: to overcome these drawback we propose to integrate both these sub-activities. We take into consideration: multiple planning periods, synchronizations events (a synchronization occurs when two buses from different routes arrive to a node within a time window), fixed and variable operations costs and uncertain demand in each period

An extensive search algorithm to find feasible healthy menus for humans.

Promoting healthy lifestyles is nowadays a public priority among most public entities. The ability to design an array of nutritious and appealing diets is very valuable. Menu Planning still presents a challenge which complexity derives from the problems’ many dimensions and the idiosyncrasies of human behavior towards eating. Among the difculties encountered by researchers when facing the Menu Planning Problem, being able of fnding a rich feasible region stands out. We consider it as a system of inequalities to which we try to fnd solutions. We have developed and implemented a two-phase algorithm -that mainly stems from the Randomized Search and the Genetic- that is capable of rapidly fnding an pool of solutions to the system with the aim of properly identifying the feasible region of the underlying problem and proceed to its densifcation. It consists of a hybrid algorithm inspired on a GRASP metaheuristic and a later recombination. First, it generates initial seeds, identifying best candidates and guiding the search to create solutions to the system, thus attempting to verify every inequality. Afterwards, the recombination of diferent promising candidates helps in the densifcation of the feasible region with new solutions. This methodology is an adaptation of other previously used in literature, and that we apply to the MPP. For this, we generated a database of a 227 recipes and 272 ingredients. Applying this methodology to the database, we are able to obtain a pool of feasible (healthy and nutritious) complete menus for a given D number of days.Open Access granted by Universidad de Málaga / CBUA. This work has been partially supported by the Spanish *Ministerio de Ciencia, Innovación y Universidades *(MCIU/AEI/FEDER, UE) with grant ref PID2019-104263RBC42; and Junta de Andalucía with grant refs. P18-RT-1566, (contract ref CI-21-228) UMA18-FEDERJA- 065. Funding for open access charge: Universidad de Málaga / CBU

Virtual reality simulation of a quadrotor to monitor dependent people at home

Unmanned aerial vehicles (UAVs) represent an assistance solution for home care of dependent persons. These aircraft can cover the home, accompany the person, and position themselves to take photographs that can be analyzed to determine the person's mood and the assistance needed. In this context, this work principally aims to design a tool to aid in the development and validation of the navigation algorithms of an autonomous vision-based UAV for monitoring dependent people. For that, a distributed architecture has been proposed based on the real-time communication of two modules, one of them in charge of the dynamics of the UAV, the trajectory planning and the control algorithms, and the other devoted to visualizing the simulation in an immersive virtual environment. Thus, a system has been developed that allows the evaluation of the behavior of the assistant UAV from a technological point of view, as well as to carry out studies from the assisted person's viewpoint. An initial validation of a quadrotor model monitoring a virtual character demonstrates the advantages of the proposed system, which is an effective, safe and adaptable tool for the development of vision-based UAVs to help dependents at home.This work was partially supported by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación/European Regional Development Fund under PID2019106084RB-I00 and DPI2016-80894-R grants, and by CIBERSAM of the Instituto de Salud Carlos III

Toxina botulínica para uso terapéutico

From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; ArgentinaFil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; ArgentinaFil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; ArgentinaFil: de Jong, L.I.T.. Universidad Nacional de Cuyo; ArgentinaFil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; ArgentinaFil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; Argentin

Diagnostic and Prognostic Value of Cardiac Imaging in Amyloidosis

[Abstract] Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac amyloidosis. These entities have a poor prognosis, so accurate diagnostic techniques are imperative for determining an early therapeutic approach. Recent advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to histological confirmation, such as endomyocardial biopsy. We performed a review on the diagnostic and prognostic implications of different cardiac imaging techniques in cardiac amyloidosis. We mainly focus on reviewing echocardiography, cardiac magnetic resonance, computed tomography and nuclear imaging techniques and the different safety measurements that can be done with each of them

CSA06 Computing, Software and Analysis challenge at the Spanish Tier-1 and Tier-2 sites

This note describes the participation of the Spanish centres PIC, CIEMAT and IFCA as Tier-1 and Tier-2 sites in the CMS CSA06 Computing, Software and Analysis challenge. A number of the facilities, services and workflows have been demonstrated at the 2008 25% scale. Very valuable experience has been gained running the complex computing system under realistic conditions at a significant scale. The focus of this note is on presenting achieved results, operational experience and lessons learnt during the challenge

www.ideotalex.eu Nuevos Servicios.

Apresentação dos novos desenvolvimentos da IDE-OTALEX

Coordinación de Asignaturas Obligatorias en el Máster de Ingeniería Química

En este trabajo empírico se mostrará el resultado de coordinar la carga docente por semanas para los alumnos del Máster de Ingeniería Química. Este esfuerzo es necesario para que los alumnos no vayan sobrecargados algunas semanas del curso pero muy aliviados en otras. Para ello el equipo directivo del Máster ha elaborado una encuesta propia para que los alumnos revelen su opinión sobre distintos detalles sobre la calidad del Máster: posibles inconsistencias entre asignaturas, aspectos que más han disfrutado de cada una de las asignaturas, los menos agradables y para que sobre todo indiquen su sensación sobre la carga docente entre otras particularidades. Estas encuestas son muy valiosas ya que muestran claramente áreas de mejora de manera anónima. En total se harán dos encuestas, una para cada cuatrimestre. Una vez con la información de la encuesta analizada tendrá lugar dos reuniones con los coordinadores de las asignaturas obligatorias. La idea es rellenar una tabla con la carga docente de cada asignatura para semana de cada cuatrimestre

Usos y desusos del modelo GPT-3 entre estudiantes de grados de ingeniería

La herramienta ChatGPT, basada en el modelo GPT-3 desarrollado por OpenAI, ya se utiliza por estudiantes de grados de ingeniería como herramienta de apoyo en su proceso de aprendizaje. En este contexto, las implicaciones negativas que presenta el uso de esta herramienta son diversas: dependencia tecnológica, obstaculización del saber y conocer práctico, error en las respuestas, problemas éticos o incluso problemas legales. El uso de esta herramienta sin que los estudiantes hayan recibido formación se considera como problema a investigar. El objetivo es entender en profundidad el contexto tecnológico de la herramienta, cómo se utiliza actualmente entre los estudiantes de ingeniería de un conjunto de universidades privadas y públicas, y su impacto en la educación universitaria. Este artículo es un trabajo en desarrollo donde se presenta el contexto del estudio, la metodología de investigación y unos primeros resultados. Se conduce una encuesta cualitativa-exploratoria con una muestra de más de 360 estudiantes de grados de ingeniería matriculados en diferentes cursos. Se utiliza una estratificación aleatoria para asegurar que la muestra sea representativa de la población. Los resultados sugieren que el modelo GPT-3 puede ser utilizado como una herramienta beneficiosa para los estudiantes de grados de ingeniería.ChatGPT, the tool based on the GPT-3 model developed by OpenAI, is already being used by engineering students for support in their learning process. In this context, the negative implications of using this tool are diverse: technological dependency, hindrance of practical knowledge and understanding, errors in answers, ethical or even legal problems. The use of this tool by students without receiving proper training is considered a problem to be investigated. The goal is to deeply understand the technological context of the tool, how it is currently used among engineering students from a set of private and public universities, and its impact on university education. This paper is a work in progress that presents the context of the study, the research methodology and some preliminary results. A qualitative-exploratory survey is conducted with a sample of more than 360 engineering students enrolled in different courses. Random stratification is used to ensure that the sample is representative of the population. The results suggest that the GPT-3 model can be used as a valuable tool for engineering students

IDE-OTALEX C - primeira IIG transfronteiriça: desenvolvimento, desafios e sustentabilidade.

O Projecto OTALEX foi financiado pelo programa europeu INTERREG IIIA e teve como objectivos estudar e dar a conhecer a realidade de um território, composto pelas regiões do Alentejo em Portugal e da Extremadura em Espanha, separadas convencionalmente pela fronteira administrativa mas unidas pelas suas características físicas, ambientais, sociais e económicas. Tratam-se de espaços rurais de baixa densidade demográfica onde os recursos naturais, culturais e a qualidade do ambiente constituem os seus atractivos fundamentais. A IDE OTALEX é o resultado do esforço, do compromisso e da colaboração entre instituições da fronteira, com implicação aos três níveis administrativos: Nacional, Regional e Local. Apresentam-se os trabalhos de homogeneização e estandartização de dados territoriais do Alentejo e da Extremadura, através de clientes de visualização de mapas, consulta de topónimos e de catálogo, no âmbito da directiva INSPIRE.info:eu-repo/semantics/publishedVersio