71 research outputs found
Extraluminal Amyloidoma of the Pelvic Cavity Causing Large Bowel Obstruction
Amyloidosis is a group of diverse disorders that fall into several major categories: primary, secondary, dialysis-associated, and hereditary forms. Clinically, amyloidosis may be categorized as localized or systemic. The gastrointestinal tract is among the most common places for deposition of amyloid, but large, localized amyloid deposits are an uncommon occurrence and rarely cause extraluminal bowel compression resulting in obstruction as was seen in the case presented in this clinical scenario
The BOOMERANG North America Instrument: a balloon-borne bolometric radiometer optimized for measurements of cosmic background radiation anisotropies from 0.3 to 4 degrees
We describe the BOOMERANG North America (BNA) instrument, a balloon-borne
bolometric radiometer designed to map the Cosmic Microwave Background (CMB)
radiation with 0.3 deg resolution over a significant portion of the sky. This
receiver employs new technologies in bolometers, readout electronics,
millimeter-wave optics and filters, cryogenics, scan and attitude
reconstruction. All these subsystems are described in detail in this paper. The
system has been fully calibrated in flight using a variety of techniques which
are described and compared. It has been able to obtain a measurement of the
first peak in the CMB angular power spectrum in a single balloon flight, few
hours long, and was a prototype of the BOOMERANG Long Duration Balloon (BLDB)
experiment.Comment: 40 pages, 22 figures, submitted to Ap
Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients : an interventional, randomized, double-blind clinical trial
BACKGROUND:
COPD is often associated with cardiovascular comorbidity. Treatment guidelines recommend therapy with bronchodilators as first choice. We investigated the acute effect of single-dose indacaterol on lung hyperinflation in COPD subjects, for the first time evaluating the potential effects on right heart performance.
METHODS:
In this Phase IV, randomized, interventional, double-blind, crossover clinical study, we recruited 40 patients (50-85 years of age) with stable COPD. Patients were treated with 150 \u3bcg indacaterol or placebo and after 60 minutes (T60) and 180 minutes (T180) the following tests were performed: trans-thoracic echocardiography (TTE), plethysmography, diffusing capacity of the lung for carbon monoxide, saturation of peripheral oxygen, and visual analog scale dyspnea score. Patients underwent a crossover re-challenge after a further 72 hours of pharmacological washout. All TTE measurements were conducted blindly by the same operator and further interpreted by two different blinded operators. Consensus decisions were taken on every value and parameter. The primary outcome was the effect of the reduction of residual volume and functional residual capacity on right heart systolic and diastolic function indexes evaluated by TTE in patients treated with indacaterol, as compared to placebo.
RESULTS:
Vital capacity, inspiratory capacity, and forced expiratory volume in 1 second were significantly increased by indacaterol, when compared with placebo, while residual volume, intrathoracic gas volume, and specific airway resistance were significantly reduced in patients treated with indacaterol. Tricuspid annular plane systolic excursion was significantly increased versus placebo, paralleled by an increase of tricuspid E-wave deceleration time. The cardiac frequency was also significantly reduced in indacaterol-treated patients.
CONCLUSION:
Indacaterol significantly reduces lung hyperinflation in acute conditions, with a clinically relevant improvement of dyspnea. These modifications are associated with a significant increase of the right ventricular compliance indexes and may have a role in improving left ventricular preload leading to a reduction in cardiac frequency
A new approach to cosmological perturbations in f(R) models
We propose an analytic procedure that allows to determine quantitatively the
deviation in the behavior of cosmological perturbations between a given f(R)
modified gravity model and a LCDM reference model. Our method allows to study
structure formation in these models from the largest scales, of the order of
the Hubble horizon, down to scales deeply inside the Hubble radius, without
employing the so-called "quasi-static" approximation. Although we restrict our
analysis here to linear perturbations, our technique is completely general and
can be extended to any perturbative order.Comment: 21 pages, 2 figures; Revised version according to reviewer's
suggestions; Typos corrected; Added Reference
Probing the accelerating Universe with radio weak lensing in the JVLA Sky Survey
We outline the prospects for performing pioneering radio weak gravitational
lensing analyses using observations from a potential forthcoming JVLA Sky
Survey program. A large-scale survey with the JVLA can offer interesting and
unique opportunities for performing weak lensing studies in the radio band, a
field which has until now been the preserve of optical telescopes. In
particular, the JVLA has the capacity for large, deep radio surveys with
relatively high angular resolution, which are the key characteristics required
for a successful weak lensing study. We highlight the potential advantages and
unique aspects of performing weak lensing in the radio band. In particular, the
inclusion of continuum polarisation information can greatly reduce noise in
weak lensing reconstructions and can also remove the effects of intrinsic
galaxy alignments, the key astrophysical systematic effect that limits weak
lensing at all wavelengths. We identify a VLASS "deep fields" program (total
area ~10-20 square degs), to be conducted at L-band and with high-resolution
(A-array configuration), as the optimal survey strategy from the point of view
of weak lensing science. Such a survey will build on the unique strengths of
the JVLA and will remain unsurpassed in terms of its combination of resolution
and sensitivity until the advent of the Square Kilometre Array. We identify the
best fields on the JVLA-accessible sky from the point of view of overlapping
with existing deep optical and near infra-red data which will provide crucial
redshift information and facilitate a host of additional compelling
multi-wavelength science.Comment: Submitted in response to NRAO's recent call for community white
papers on the VLA Sky Survey (VLASS
Cosmology with the Laser Interferometer Space Antenna
The Laser Interferometer Space Antenna (LISA) has two scientific objectives of cosmological focus: to probe the expansion rate of the universe, and to understand stochastic gravitational-wave backgrounds and their implications for early universe and particle physics, from the MeV to the Planck scale. However, the range of potential cosmological applications of gravitational wave observations extends well beyond these two objectives. This publication presents a summary of the state of the art in LISA cosmology, theory and methods, and identifies new opportunities to use gravitational wave observations by LISA to probe the universe
EuCAPT White Paper: Opportunities and Challenges for Theoretical Astroparticle Physics in the Next Decade
Astroparticle physics is undergoing a profound transformation, due to a
series of extraordinary new results, such as the discovery of high-energy
cosmic neutrinos with IceCube, the direct detection of gravitational waves with
LIGO and Virgo, and many others. This white paper is the result of a
collaborative effort that involved hundreds of theoretical astroparticle
physicists and cosmologists, under the coordination of the European Consortium
for Astroparticle Theory (EuCAPT). Addressed to the whole astroparticle physics
community, it explores upcoming theoretical opportunities and challenges for
our field of research, with particular emphasis on the possible synergies among
different subfields, and the prospects for solving the most fundamental open
questions with multi-messenger observations.Comment: White paper of the European Consortium for Astroparticle Theory
(EuCAPT). 135 authors, 400 endorsers, 133 pages, 1382 reference
Laboratori. Scuola e UniversitĂ : Sezione di "Dionysus ex Machina. Rivista online di studi sul teatro antico" 7
La sezione raccoglie documenti dal mondo della scuola e dell'universitĂ , in un'ottica di confronto tra approcci differenti al teatro antico: propone quindi interventi di taglio diverso, dedicati alla riflessione sui filoni della ricerca, alla presentazione di metodologie e tradizioni scientifiche e didattiche, come di esperienze laboratoriali e progetti di messa in scena
Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients: an interventional, randomized, double-blind clinical trial
Pierachille Santus,1,2 Dejan Radovanovic,1,2 Silvia Di Marco,3 Vincenzo Valenti,4,5 Rita Raccanelli,1,2 Francesco Blasi,6,7 Stefano Centanni,8,9 Maurizio Bussotti31Department of Health Sciences, University of Milan, 2Pulmonary Rehabilitation Unit, Fondazione Salvatore Maugeri Scientific Institute of Milan-IRCCS, 3Cardiological Rehabilitation Unit, Fondazione Salvatore Maugeri Rehabilitation Institute of Milan-IRCCS, 4Department of Biomedical Sciences for Health, University of Milan, 5Respiratory Unit, Policlinico San Donato-IRCCS, San Donato Milanese, 6Department of Pathophysiology and Transplantation, University of Milan, 7IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milan, 8Department of Health Sciences, University of Milan, 9Respiratory Unit, Ospedale San Paolo, Milan, ItalyBackground: COPD is often associated with cardiovascular comorbidity. Treatment guidelines recommend therapy with bronchodilators as first choice. We investigated the acute effect of single-dose indacaterol on lung hyperinflation in COPD subjects, for the first time evaluating the potential effects on right heart performance.Methods: In this Phase IV, randomized, interventional, double-blind, crossover clinical study, we recruited 40 patients (50–85 years of age) with stable COPD. Patients were treated with 150 µg indacaterol or placebo and after 60 minutes (T60) and 180 minutes (T180) the following tests were performed: trans-thoracic echocardiography (TTE), plethysmography, diffusing capacity of the lung for carbon monoxide, saturation of peripheral oxygen, and visual analog scale dyspnea score. Patients underwent a crossover re-challenge after a further 72 hours of pharmacological washout. All TTE measurements were conducted blindly by the same operator and further interpreted by two different blinded operators. Consensus decisions were taken on every value and parameter. The primary outcome was the effect of the reduction of residual volume and functional residual capacity on right heart systolic and diastolic function indexes evaluated by TTE in patients treated with indacaterol, as compared to placebo.Results: Vital capacity, inspiratory capacity, and forced expiratory volume in 1 second were significantly increased by indacaterol, when compared with placebo, while residual volume, intrathoracic gas volume, and specific airway resistance were significantly reduced in patients treated with indacaterol. Tricuspid annular plane systolic excursion was significantly increased versus placebo, paralleled by an increase of tricuspid E-wave deceleration time. The cardiac frequency was also significantly reduced in indacaterol-treated patients.Conclusion: Indacaterol significantly reduces lung hyperinflation in acute conditions, with a clinically relevant improvement of dyspnea. These modifications are associated with a significant increase of the right ventricular compliance indexes and may have a role in improving left ventricular preload leading to a reduction in cardiac frequency.Keywords: lung deflation, bronchodilator, cardiac performance, right ventricular function, echocardiograph
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