Prevalence and Causes of Cognitive Impairment and Dementia in a Population-Based Cohort From Northern Portugal

Background: Vascular disease may play an important role in the epidemiology of dementia in countries with high stroke incidence, such as Portugal. Objective: To assess the prevalence and etiology of cognitive impairment in a population-based cohort from Portugal. Methods: Individuals ≥55 years (n = 730) from the EPIPorto cohort were assessed using the Mini-Mental State Examination and the Montreal Cognitive Assessment. Those scoring below the age-/education-adjusted cutoff points were further evaluated to identify dementia or mild cognitive impairment (MCI) and to define its most common causes. Results: Thirty-six cases of MCI/dementia were identified, corresponding to adjusted prevalences of 4.1% for MCI and 1.3% for dementia. The most common cause of MCI/dementia was vascular (52.8%), followed by Alzheimer’s disease (36.1%). Conclusion: These findings highlight the importance of vascular cognitive impairment in the epidemiology of dementia in Portugal and carry an important public health message regarding its prevention and management, possibly extending to other countries with a high-stroke burden.The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research project was financed by the Programa Operacional Competitividade e Internacionalização (POCI) (POCI-01-0145-FEDER-016867), the Programa Operacional Regional do Norte 2014/2020 (NORTE 2020) (NORTE-01-0145-FEDER-000003) and by the Fundação para a Ciência e a Tecnologia, in the context of the Epidemiology Research Unit—Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (POCI-01-0145-FEDER-006862; FCT UID/DTP/04750/2013), and the PhD Grant SFRH/BD/119390/2016 (Natália Araújo), co-funded by the FCT and the POCH/FSE Program

El yacimiento arqueológico de El Saucedo (Talavera La Nueva, Toledo): balance y perspectivas

En este artículo presentamos una síntesis de los trabajos de investigación, conservación y difusión reali-zados en el yacimiento de b'l Saucedo hasta el presente, así como un esbozo de los planes de actuación para el futuro

Mixed Valvular Disease Following Transcatheter Aortic Valve Replacement: Quantification and Systematic Differentiation Using Clinical Measurements and Image-Based Patient‐Specific In Silico Modeling

Background: Mixed valvular disease (MVD), mitral regurgitation (MR) from pre‐existing disease in conjunction with paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR), is one of the most important stimuli for left ventricle (LV) dysfunction, associated with cardiac mortality. Despite the prevalence of MVD, the quantitative understanding of the interplay between pre‐existing MVD, PVL, LV, and post‐TAVR recovery is meager. Methods and Results: We quantified the effects of MVD on valvular‐ventricular hemodynamics using an image‐based patient‐specific computational framework in 72 MVD patients. Doppler pressure was reduced by TAVR (mean, 77%; N=72; P<0.05), but it was not always accompanied by improvements in LV workload. TAVR had no effect on LV workload in 22 patients, and LV workload post‐TAVR significantly rose in 32 other patients. TAVR reduced LV workload in only 18 patients (25%). PVL significantly alters LV flow and increases shear stress on transcatheter aortic valve leaflets. It interacts with mitral inflow and elevates shear stresses on mitral valve and is one of the main contributors in worsening of MR post‐TAVR. MR worsened in 32 patients post‐TAVR and did not improve in 18 other patients. Conclusions: PVL limits the benefit of TAVR by increasing LV load and worsening of MR and heart failure. Post‐TAVR, most MVD patients (75% of N=72; P<0.05) showed no improvements or even worsening of LV workload, whereas the majority of patients with PVL, but without that pre‐existing MR condition (60% of N=48; P<0.05), showed improvements in LV workload. MR and its exacerbation by PVL may hinder the success of TAVR

PVM-based intelligent predictive control of HVAC systems

This paper describes the application of a complete MBPC solution for existing HVAC systems, with a focus on the implementation of the objective function employed. Real-time results obtained with this solution, in terms of economical savings and thermal comfort, are compared with standard, temperature regulated control.(1) (C) 2016, IFAC (International Federation of Antomatic Control) Hosting by Elsevier Ltd. All rights reserved

High risk of cardiovascular episodes and low adherence to risk factors guidelines in a population with diabetes

Although recent guidelines cover therapeutic goals, effective lipid management of patients with type 1 and type 2 diabetes to reduce cardiovascular disease (CVD) risk is still largely unattained. In the present study, we explored the electronic health records (EHR) at a specialized diabetes outpatient clinic to assess, in a real world database, the prevalence of poor lipid management in people with diabetes, the associated characteristics of this population, and the patterns of medication.Amge

Strong reduction of V4+ amount in vanadium oxide/hexadecylamine nanotubes by doping with Co2+ and Ni2+ ions: EPR and magnetic studies

In this work we present a complete characterization and magnetic study of vanadium oxide/hexadecylamine nanotubes (VOx/Hexa NT's) doped with Co2+ and Ni2+ ions. The morphology of the NT's has been characterized by Transmission Electron Microscopy (TEM) while the metallic elements have been quantified by Instrumental Neutron Activation Analysis (INAA) technique. The static and dynamic magnetic properties were studied collecting data of magnetization as a function of magnetic field and temperature and by Electron Paramagnetic Resonance (EPR). We observed that the incorporation of metallic ions (Co2+, S=3/2 and Ni2+, S=1) decrease notably the amount of V4+ ions in the system, from 14-16% (non-doped case) to 2-4%, with respect to the total vanadium atoms into the tubular nanostructure, improving considerably their potential technological applications as Li-ion batteries cathodes.Comment: 24 pages 10 figue

Desenvolvimento de um Repositório de Imagens e Base de Dados Portuguesa de Casos COVID-19: Aprendizagem e Partilha de Conhecimento em Tempo de Pandemia

info:eu-repo/semantics/publishedVersio

Morphology and thermal stability of alf3 on Cu(100) thin films

Se estudió el crecimiento de películas epitaxiales ultra-delgadas de fluoruro de aluminio en Cu (100) mediante una combinación de técnicas experimentales de física de superficies. La deposición a temperatura ambiente resulta en la decoración de escalones seguida por la formación de islas dendríticas bidimensionales que coalescen para formar películas porosas. Las películas ultra-delgadas (de hasta dos monocapas de espesor) resultan morfológicamente inestables al calentar; parte de la película deja de mojar la superficie del sustrato a alrededor de 430 K con la formación de islas tridimensionales y dejando expuesta un área extensa de la superficie de Cu. En cambio, películas de varios nanómetros de espesor son estables hasta temperaturas cercanas a los 730 K cuando ocurre la desorción molecular. El efecto de la irradiación electrónica también ha sido caracterizado mediante diferentes técnicas espectroscópicas; encontrando que incluso dosis de irradiación reducidas de electrones pueden producir una descomposición significativa del fluoruro de aluminio, resultando en la liberación de moléculas de flúor y la formación de aluminio metálico. Estas características hacen del fluoruro de aluminio un material interesante para aplicaciones en espintrónica.Fil: Ruano Sandoval, Gonzalo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Moreno López, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Passeggi, Mario Cesar Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Vidal, Ricardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Ferron, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Niño, M. A.. Universidad Autónoma de Madrid; EspañaFil: Miranda, R.. Universidad Autónoma de Madrid; EspañaFil: de Miguel, J. J.. Universidad Autónoma de Madrid; Españ

Intrapericardial Extralobar Pulmonary Sequestration Presenting as a Prenatal Intrathoracic Mass

An intrathoracic mass, which persisted during the remaining pregnancy, was first seen during routine ultrasound examination performed at 20 weeks gestation. After birth, the child was asymptomatic. Echocardiography showed the mass to be located intrapericardially. The mass was electively resected via sternotomy 3 weeks after the birth. Microscopic examination showed normal lung tissue surrounded by pleura corresponding to the diagnosis of extralobar pulmonary sequestration. To the authors’ knowledge, this is the earliest described detection of such a lesion. Furthermore, this article reports the unique finding of a feeding vessel from the right pulmonary artery