Bipolar disorders

Bipolar disorder is characterized by (hypo)manic episodes and depressive episodes which alternate with euthymic periods. It causes serious disability with poor outcome, increased suicidality risk, and significant societal costs. This chapter describes the findings of the PET/SPECT research efforts and the current ideas on the pathophysiology of bipolar disorder. First, the cerebral blood flow and cerebral metabolism findings in the prefrontal cortex, limbic system, subcortical structures, and other brain regions are discussed, followed by an overview of the corticolimbic theory of mood disorders that explains these observations. Second, the neurotransmitter studies are discussed. The serotonin transporter alterations are described, and the variation in study results is explained, followed by an overview of the results of the various dopamine receptor and transporter molecules studies, taking into account also the relation to psychosis. Third, a concise overview is given of dominant bipolar disorder pathophysiological models, proposing starting points for future molecular imaging studies. Finally, the most important conclusions are summarized, followed by remarks about the observed molecular imaging study designs specific for bipolar disorder.</p

The transiting exoplanet community early release science program for JWST

The James Webb Space Telescope (JWST) presents the opportunity to transform our understanding of planets and the origins of life by revealing the atmospheric compositions, structures, and dynamics of transiting exoplanets in unprecedented detail. However, the high-precision, time-series observations required for such investigations have unique technical challenges, and prior experience with other facilities indicates that there will be a steep learning curve when JWST becomes operational. In this paper we describe the science objectives and detailed plans of the Transiting Exoplanet Community Early Release Science (ERS) Program, which is a recently approved program for JWST observations early in Cycle 1. The goal of this project, for which the obtained data will have no exclusive access period, is to accelerate the acquisition and diffusion of technical expertise for transiting exoplanet observations with JWST, while also providing a compelling set of representative datasets that will enable immediate scientific breakthroughs. The Transiting Exoplanet Community ERS Program will exercise the time-series modes of all four JWST instruments that have been identified as the consensus highest priorities, observe the full suite of transiting planet characterization geometries (transits, eclipses, and phase curves), and target planets with host stars that span an illustrative range of brightnesses. The observations in this program were defined through an inclusive and transparent process that had participation from JWST instrument experts and international leaders in transiting exoplanet studies. Community engagement in the project will be centered on a two-phase Data Challenge that culminates with the delivery of planetary spectra, time-series instrument performance reports, and open-source data analysis toolkits in time to inform the agenda for Cycle 2 of the JWST mission

Telomere length and bipolar disorder

Variation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD). We used quantitative polymerase chain reactions and a telomere-sequence to single-copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal smears from 63 patients with BD, 74 first-degree relatives (49 relatives had no lifetime psychopathology and 25 had a non-BD mood disorder) and 80 unrelated healthy individuals. Participants also underwent magnetic resonance imaging to determine hippocampal volumes and cognitive assessment to evaluate episodic memory using the verbal paired associates test. Telomere length was shorter in psychiatrically-well relatives (p=0.007) compared to unrelated healthy participants. Telomere length was also shorter in relatives (regardless of psychiatric status; p<0.01) and patients with BD not on lithium (p=0.02) compared to lithium-treated patients with BD. In the entire sample, telomere length was positively associated with left and right hippocampal volume and with delayed recall. This study provides evidence that shortened telomere length is associated with familial risk for BD. Lithium may have neuroprotective properties that require further investigation using prospective designs

Constraining exoplanet metallicities and aerosols with the contribution to ARIEL spectroscopy of exoplanets (CASE)

Launching in 2028, ESA’s 0.64 m2 Atmospheric Remote-sensing Exoplanet Large-survey (ARIEL) survey of ∼1000 transiting exoplanets will build on the legacies of NASA’s Kepler and Transiting Exoplanet Survey Satellite (TESS), and complement the James Webb Space Telescope (JWST) by placing its high-precision exoplanet observations into a large, statistically significant planetary population context. With continuous 0.5–7.8 μm coverage from both FGS (0.5–0.6, 0.6–0.81, and 0.81–1.1 μm photometry; 1.1–1.95 μm spectroscopy) and AIRS (1.95–7.80 μm spectroscopy), ARIEL will determine atmospheric compositions and probe planetary formation histories during its 3.5 yr mission. NASA’s proposed Contribution to ARIEL Spectroscopy of Exoplanets (CASE) would be a subsystem of ARIEL’s Fine Guidance Sensor (FGS) instrument consisting of two visible-to-infrared detectors, associated readout electronics, and thermal control hardware. FGS, to be built by the Polish Academy of Sciences Space Research Centre, will provide both fine guiding and visible to near-infrared photometry and spectroscopy, providing powerful diagnostics of atmospheric aerosol contribution and planetary albedo, which play a crucial role in establishing planetary energy balance. The CASE team presents here an independent study of the capabilities of ARIEL to measure exoplanetary metallicities, which probe the conditions of planet formation, and FGS to measure scattering spectral slopes, which indicate if an exoplanet has atmospheric aerosols (clouds and hazes), and geometric albedos, which help establish planetary climate. Our simulations assume that ARIEL’s performance will be 1.3×the photon-noise limit. This value is motivated by current transiting exoplanet observations: Spitzer/IRAC and Hubble/WFC3 have empirically achieved 1.15×the photon-noise limit. One could expect similar performance from ARIEL, JWST, and other proposed future missions such as HabEx, LUVOIR, and Origins. Our design reference mission simulations show that ARIEL could measure the mass– metallicity relationship of its 1000-planet single-visit sample to &gt;7.5σ and that FGS could distinguish between clear, cloudy, and hazy skies and constrain an exoplanet’s atmospheric aerosol composition to ≳5σ for hundreds of targets, providing statistically transformative science for exoplanet atmospheres