Some Aspects of the Dynamics of a Hunted Bobwhite Population

Dynamics of a hunted bobwhite population have been investigated on a 1,450-acre study area near Carbondale, Illinois since 1952. Habitat conditions have not changed greatly during the study, and November densities have oscillated regularly about a rather stable long-term mean. Most of the variance of annual rates of population change is due to variation in net productivity from spring to fall rather than to variation in net losses from fall to spring. Population declines from November to April averaged 66% (range 36 to 81%); about 0.66 of this resulted from hunting. Post-hunting mortality, which was slightly density-related, partially compensated for hunting losses. Spring densities were correlated with (r = +o.75) and almost as variable as preceding fall populations. Net increases from spring to fall varied from 17 to 383 and averaged 235% of the breeding population. Multiple regression analysis showed that annual rates of productivity were significantly influenced by the combined effect of breeding density, length of snow cover during the previous 2 winters, and amounts of prenesting rainfall. Annual rates of population change were inversely related to the preceding fall density, but strong correlations between successive seasonal population levels caused periods of change as well as highs and lows to persist for several years. Major highs and lows each occurred at 8- to 10-year intervals. It was not clear whether 2 severe winters caused the apparent cyclic regularity or merely accentuated the lows

Tributes to W. A. Brandenburg

Article tributes from different contributors to Brandenbur

Collaborating to Improve Collaboration: Informationist Team Support for an Interdisciplinary Research Group

Objectives Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary research group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Methods A pre-survey was administered to the Research Group to provide a baseline assessment of their use of librarian expertise and library services. The Informationist Team met to identify areas of expertise to support the objectives of the grant. Literature searching, bibliographic citation management and sharing, and data management were the first areas to be considered. Librarians routinely attended lab meetings and shared notes with each other to keep up with researcher needs. When possible, research questions were answered in the lab meetings by librarians. Interviews with Research Group members were used to develop a data management plan. Collaborative tools to facilitate team communication and support research being conducted in multiple buildings on two campuses were investigated. Future work will include publication support, assessing research impact, and appraising the usefulness of the Informationist Team to the Research Group

Justice at Sea: Fishers’ politics and marine conservation in coastal Odisha, India

This is a paper about the politics of fishing rights in and around the Gahirmatha marine sanctuary in coastal Odisha, in eastern India. Claims to the resources of this sanctuary are politicised through the creation of a particularly damaging narrative by influential Odiya environmental actors about Bengalis, as illegal immigrants who have hurt the ecosystem through their fishing practices. Anchored within a theoretical framework of justice as recognition, the paper considers the making of a regional Odiya environmentalism that is, potentially, deeply exclusionary. It details how an argument about ‘illegal Bengalis’ depriving ‘indigenous Odiyas’ of their legitimate ‘traditional fishing rights’ derives from particular notions of indigeneity and territory. But the paper also shows that such environmentalism is tenuous, and fits uneasily with the everyday social landscape of fishing in coastal Odisha. It concludes that a wider class conflict between small fishers and the state over a sanctuary sets the context in which questions about legitimate resource rights are raised, sometimes with important effects, like when out at sea

RACK1 Associates with Muscarinic Receptors and Regulates M2 Receptor Trafficking

Receptor internalization from the cell surface occurs through several mechanisms. Some of these mechanisms, such as clathrin coated pits, are well understood. The M2 muscarinic acetylcholine receptor undergoes internalization via a poorly-defined clathrin-independent mechanism. We used isotope coded affinity tagging and mass spectrometry to identify the scaffolding protein, receptor for activated C kinase (RACK1) as a protein enriched in M2-immunoprecipitates from M2-expressing cells over those of non-M2 expressing cells. Treatment of cells with the agonist carbachol disrupted the interaction of RACK1 with M2. We further found that RACK1 overexpression inhibits the internalization and subsequent down regulation of the M2 receptor in a receptor subtype-specific manner. Decreased RACK1 expression increases the rate of agonist internalization of the M2 receptor, but decreases the extent of subsequent down-regulation. These results suggest that RACK1 may both interfere with agonist-induced sequestration and be required for subsequent targeting of internalized M2 receptors to the degradative pathway

HIV Infection Linked to Injection Use of Oxymorphone in Indiana, 2014-2015

BACKGROUND: In January 2015, a total of 11 new diagnoses of human immunodeficiency virus (HIV) infection were reported in a small community in Indiana. We investigated the extent and cause of the outbreak and implemented control measures. METHODS: We identified an outbreak-related case as laboratory-confirmed HIV infection newly diagnosed after October 1, 2014, in a person who either resided in Scott County, Indiana, or was named by another case patient as a syringe-sharing or sexual partner. HIV polymerase (pol) sequences from case patients were phylogenetically analyzed, and potential risk factors associated with HIV infection were ascertained. RESULTS: From November 18, 2014, to November 1, 2015, HIV infection was diagnosed in 181 case patients. Most of these patients (87.8%) reported having injected the extended-release formulation of the prescription opioid oxymorphone, and 92.3% were coinfected with hepatitis C virus. Among 159 case patients who had an HIV type 1 pol gene sequence, 157 (98.7%) had sequences that were highly related, as determined by phylogenetic analyses. Contact tracing investigations led to the identification of 536 persons who were named as contacts of case patients; 468 of these contacts (87.3%) were located, assessed for risk, tested for HIV, and, if infected, linked to care. The number of times a contact was named as a syringe-sharing partner by a case patient was significantly associated with the risk of HIV infection (adjusted risk ratio for each time named, 1.9; P<0.001). In response to this outbreak, a public health emergency was declared on March 26, 2015, and a syringe-service program in Indiana was established for the first time. CONCLUSIONS: Injection-drug use of extended-release oxymorphone within a network of persons who inject drugs in Indiana led to the introduction and rapid transmission of HIV. (Funded by the state government of Indiana and others.)

Effects of Hypothalamic Neurodegeneration on Energy Balance

Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of hypothalamic neurons that express agouti-related protein (Agrp) or proopiomelanocortin (Pomc), neuropeptides that promote positive or negative energy balance, respectively, through their opposing effects on melanocortin receptor signaling. In previous studies, Pomc mutant mice became obese, but Agrp mutant mice were surprisingly normal, suggesting potential compensation by neuronal circuits or genetic redundancy. Here we find that Pomc-ablation mice develop obesity similar to that described for Pomc knockout mice, but also exhibit defects in compensatory hyperphagia similar to what occurs during normal aging. Agrp-ablation female mice exhibit reduced adiposity with normal compensatory hyperphagia, while animals ablated for both Pomc and Agrp neurons exhibit an additive interaction phenotype. These findings provide new insight into the roles of hypothalamic neurons in energy balance regulation, and provide a model for understanding defects in human energy balance associated with neurodegeneration and aging

Parameter uncertainty and sensitivity in a liquid-effluent dose model

Radioactive materials which are released into streams on the Savannah River Site (SRS) eventually flow into the Savannah River. Tritium, 90 Sr, 137 Cs, and 239 Pu account for the majority of the radiation dose received by users of the Savannah River. This paper focuses on the dose uncertainties originating from variability in parameters describing the transport and uptake of these nuclides. Parameter sensitivity has also been determined for each liquid pathway exposure model. The models used here to estimate radiation dose to an exposed individual provide a range of possible dose estimates that span approximately one order of magnitude. A pathway analysis reveals that aquatic food and water consumption account for more than 95% of the total dose to an individual.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42692/1/10661_2004_Article_BF00547126.pd