Four-D global reference atmosphere users manual and programmers manual, part 2

For abstract, see N74-33021

Four-D global reference atmosphere technical description, part 1

An empirical atmospheric model was developed which generates values for pressure, density, temperature, and winds from surface levels to orbital altitudes. The output parameters consist of components for: (1) latitude, longitude, and altitude dependent monthly and annual means; (2) quasi-biennial oscillations; and (3) random perturbations to simulate partially the variability due to synoptic, diurnal, planetary wave, and gravity wave variations. Quasi-biennial and random variation perturbations are computed from parameters determined from various empirical studies and are added to the monthly mean values. This model has been developed as a computer program called PROFILE which can be used to generate altitude profiles of atmospheric parameters along any simulated trajectory through the atmosphere. The PROFILE program was developed for design applications in the space shuttle program. Other applications of the model are discussed, such as for global circulation and diffusion studies, and for generating profiles for comparison with other atmospheric measurement techniques, (e.g. satellite measured temperature profiles)

Turbulent boundary layers over nonstationary plane boundaries

Methods of predicting integral parameters and skin friction coefficients of turbulent boundary layers developing over moving ground planes were evaluated. The three methods evaluated were: relative integral parameter method; relative power law method; and modified law of the wall method

Phenotypic and functional characterization of adult brain neuropoiesis

The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer cell-culture system was developed to induce, expose, and recapitulate the entire developmental series of events of subventricular zone (SVZ) neurogenesis. We show here, using immunophentoypic, ultrastructural, electrophysiological, and time-lapse analyses, that SVZ-derived glial fibrillary acidic protein(low)/A2B5(+)/nestin(+) candidate founder cells undergo metamorphosis to eventually generate large numbers of fully differentiated interneuron phenotypes. A model of postnatal neurogenesis is considered in light of known embryonic events and reveals a limited developmental potential of SVZ stem/progenitor cells, whereby ancestral cells in both embryonic and postnatal/adult settings give rise to glia and GABAergic interneurons

Correlation of Clinical Trachoma and Infection in Aboriginal Communities

Repeated episodes of C. trachomatis infection lead to active trachoma clinically characterised by an often intense inflammatory response to chlamydial antigens with later scarring and distortion of the eyelid leading to blindness. However, the clinical signs of trachoma do not correlate well with laboratory tests to detect the presence of Chlamydia. The WHO simplified clinical grading scheme currently used for assessment of trachoma has a poor correlation with C. trachomatis genomic test findings, even though the detection of bacterial genome is strongly correlated with the prevalence and severity of active trachoma. A detailed assessment of the clinical signs using a finer grading system was studied in a population-based survey in five Australian Aboriginal communities. Much clinical activity and infection was found in those with clinical signs below the threshold used in the current WHO grading scheme. Future studies of the distribution of infection and pathogenesis should use finer grading methods than the current WHO scheme. The prevalence of trachoma in these communities confirms that trachoma remains of public health importance and sustained interventions to control trachoma are warranted

A Randomised Trial of Social Support Group Intervention for People with Aphasia: A Novel Application of Virtual Reality

About a third of strokes cause aphasia, or language loss, with profound consequences for the person’s social participation and quality of life. These problems may be mitigated by group social support. But this intervention is not available to all individuals. This study investigated whether it is feasible to deliver group social support to people with aphasia via a multi-user, virtual reality platform. It also explored the indicative effects of intervention and the costs. Intervention aimed to promote wellbeing and communicative success. It enabled participants to form new social connections and share experiences of living with aphasia. It comprised 14 sessions delivered over 6 months and was led by community based co-ordinators and volunteers. Feasibility measures comprised: recruitment and retention rates, compliance with intervention and assessment of treatment fidelity. Effects of intervention were explored using a waitlist randomised controlled design, with outcome measures of wellbeing, communication, social connectedness and quality of life. Two intervention groups were randomised to an immediate condition and two were randomised to a delayed condition. The main analysis explored scores on the measures between two time points, between which those in the immediate condition had received intervention, but those in the delayed group had not (yet). A comprehensive approach to economic data collection ensured that all costs of treatment delivery were recorded. Feasibility findings showed that the recruitment target was met (N = 34) and 85.3% (29/34) of participants completed intervention. All groups ran the 14 sessions as planned, and participants attended a mean of 11.4 sessions (s.d. 2.8), which was 81.6% of the intended dose. Fidelity checking showed minimal drift from the manualised intervention. No significant change was observed on any of the outcome measures, although the study was not powered to detect these. Costs varied across the four groups, from £7,483 - £12,562 British Pounds Sterling ($10,972 -$18,419 US dollars), depending on travel costs, the relative contributions of volunteers and the number of hardware loans that were needed. The results suggest that a larger trial of remote group support, using virtual reality, would be merited. However the treatment content and regime, and the selection of outcome measures should be reviewed before conducting the trial

Mechanism of Pion Production in alphaalphap Scattering at 1 GeV/nucleon

The one-pion and two-pion production in the p(alpha, alpha prime)X reaction at an energy of E{alpha} = 4.2 GeV has been studied by simultaneous registration of the scattered alpha particles and the secondary pion or proton. The obtained results demonstrate that the inelastic alpha-particle scattering on the proton at the energy of the experiment proceeds either through excitation and decay of Delta resonance in the projectile or through excitation in the target proton of the Roper resonance, which decays mainly on a nucleon and a pion or a nucleon and a sigma meson - system of two pions in the isospin I = 0, S-wave.Comment: 16 pages, 10 figures. Submitted to Proceedings of the XX International Baldin Seminar on High - Energy Physics Problems, Dubna, October 4 - 9, 201

Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues

Recently, the G protein-coupled receptor GPR30 has been identified as a novel oestrogen receptor (ER). The distribution of the receptor has been thus far mapped only in the rat central nervous system. This study was undertaken to map the distribution of GPR30 in the mouse brain and rodent peripheral tissues. Immunohistochemistry using an antibody against GPR30 revealed high levels of GPR30 immunoreactivity (ir) in the forebrain (e.g. cortex, hypothalamus and hippocampus), specific nuclei of the midbrain (e.g. the pontine nuclei and locus coeruleus) and the trigeminal nuclei and cerebellum Purkinje layer of the hindbrain in the adult mouse brain. In the rat and mouse periphery, GPR30-ir was detected in the anterior, intermediate and neural lobe of the pituitary, adrenal medulla, renal pelvis and ovary. In situ hybridisation histochemistry using GPR30 riboprobes, revealed intense hybridisation signal for GPR30 in the paraventricular nucleus and supraoptic nucleus (SON) of the hypothalamus, anterior and intermediate lobe of the pituitary, adrenal medulla, renal pelvis and ovary of both rat and mouse. Double immunofluorescence revealed GPR30 was present in both oxytocin and vasopressin neurones of the paraventricular nucleus and SON of the rat and mouse brain. The distribution of GPR30 is distinct from the other traditional ERs and offers an additional way in which oestrogen may mediate its effects in numerous brain regions and endocrine systems in the rodent

First Light and Reionisation Epoch Simulations (FLARES) X: Environmental Galaxy Bias and Survey Variance at High Redshift

Upcoming deep galaxy surveys with JWST will probe galaxy evolution during the epoch of reionisation (EoR, $5\leq z\leq10$) over relatively compact areas (e.g. $\sim$ 300\,arcmin$^2$ for the JADES GTO survey). It is therefore imperative that we understand the degree of survey variance, to evaluate how representative the galaxy populations in these studies will be. We use the First Light And Reionisation Epoch Simulations (FLARES) to measure the galaxy bias of various tracers over an unprecedentedly large range in overdensity for a hydrodynamic simulation, and use these relations to assess the impact of bias and clustering on survey variance in the EoR. Star formation is highly biased relative to the underlying dark matter distribution, with the mean ratio of the stellar to dark matter density varying by a factor of 100 between regions of low and high matter overdensity (smoothed on a scale of 14\,$h^{-1}$cMpc). This is reflected in the galaxy distribution -- the most massive galaxies are found solely in regions of high overdensity. As a consequence of the above, galaxies in the EoR are highly clustered, which can lead to large variance in survey number counts. For mean number counts $N\lesssim 100$ (1000), in a unit redshift slice of angular area 300\,arcmin$^2$ (1.4\,deg$^2$), the 2-sigma range in $N$ is roughly a factor of four (two). We present relations between the expected variance and survey area for different survey geometries; these relations will be of use to observers wishing to understand the impact of survey variance on their results.Comment: 14 pages, 17 figures. Paper 10 in the First Light and Reionisation Epoch Simulations (FLARES) serie

CP Violation in Hyperon Nonleptonic Decays within the Standard Model

We calculate the CP-violating asymmetries A(Lambda_-^0) and A(Xi_-^-) in nonleptonic hyperon decay within the Standard Model using the framework of heavy-baryon chiral perturbation theory (chiPT). We identify those terms that correspond to previous calculations and discover several errors in the existing literature. We present a new result for the lowest-order (in chiPT) contribution of the penguin operator to these asymmetries, as well as an estimate for the uncertainty of our result that is based on the calculation of the leading nonanalytic corrections.Comment: 21 pages, 2 figures; discussion clarified, results & conclusions unchanged, to appear in Phys. Rev.