X-ray spectroscopy of the z=6.4 quasar J1148+5251

We present the 78-ks Chandra observations of the $z=6.4$ quasar SDSS J1148+5251. The source is clearly detected in the energy range 0.3-7 keV with 42 counts (with a significance $\gtrsim9\sigma$). The X-ray spectrum is best-fitted by a power-law with photon index $\Gamma=1.9$ absorbed by a gas column density of $\rm N_{\rm H}=2.0^{+2.0}_{-1.5}\times10^{23}\,\rm cm^{-2}$. We measure an intrinsic luminosity at 2-10 keV and 10-40 keV equal to $\sim 1.5\times 10^{45}~\rm erg~s^{-1}$, comparable with luminous local and intermediate-redshift quasar properties. Moreover, the X-ray to optical power-law slope value ($\alpha_{\rm OX}=-1.76\pm 0.14$) of J1148 is consistent with the one found in quasars with similar rest-frame 2500 \AA ~luminosity ($L_{\rm 2500}\sim 10^{32}~\rm erg~s^{-1}$\AA$^{-1}$). Then we use Chandra data to test a physically motivated model that computes the intrinsic X-ray flux emitted by a quasar starting from the properties of the powering black hole and assuming that X-ray emission is attenuated by intervening, metal-rich ($Z\geq \rm Z_{\odot}$) molecular clouds distributed on $\sim$kpc scales in the host galaxy. Our analysis favors a black hole mass $M_{\rm BH} \sim 3\times 10^9 \rm M_\odot$ and a molecular hydrogen mass $M_{\rm H_2}\sim 2\times 10^{10} \rm M_\odot$, in good agreement with estimates obtained from previous studies. We finally discuss strengths and limits of our analysis.Comment: 9 pages, 3 figures, 1 table, MNRAS in pres

Short-Term Activation by Low 17β-Estradiol Concentrations of the Na+/H+ Exchanger in Rat Aortic Smooth Muscle Cells: Physiopathological Implications

Low physiological concentrations of 17β-estradiol increased the intracellular pH of rat aortic smooth muscle cells by a rapid nongenomic mechanism. This effect was due to stimulation of the Na+/H+ exchanger activity, measured using the intracellular pH-sensitive fluorescent probe 2′,7′-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein. The 17β-estradiol gave rise to a bell-shaped dose response, with a maximum at 10−12m and no significant effect at 10−9m. The specificity of the effect was verified by the use of the Na+/H+ exchanger inhibitor 5-(ethyl-N-isopropyl)amiloride and the lack of effect of the isomer 17α-estradiol. Inhibitors of the nuclear estrogen receptors, tamoxifen and ICI 182,780, completely prevented activation of the exchanger by 17β-estradiol. The effect of low estrogen concentrations on the intracellular pH was mimicked by both norepinephrine and phenylephrine, suggesting a connection between the increase of intracellular pH and the muscle contraction process. The transduction mechanism for this nongenomic effect of estrogens did not involve modulation of the cAMP content, whereas inositol 1,4,5-trisphosphate, protein kinase C and MAPK pathways appear to play a role, as indicated by both pharmacological approaches and immunoblot experiments on protein kinase C translocation and ERK phosphorylation. These results for the first time provide evidence for a nongenomic effect of low physiological concentrations of 17β-estradiol on intracellular pH that, together with other factors, may contribute to the development of hypertension and atherosclerosis in men and postmenopausal women and increase the risk of cardiovascular disease. Paradoxically, the lack of stimulation at high physiological estradiol levels could explain the protective effects found in premenopausal women

Kiloparsec-scale gaseous clumps and star formation at z = 5–7

We investigate the morphology of the [Cii] emission in a sample of “normal” star-forming galaxies at 5 < z < 7:2 in relation to their UV (rest-frame) counterpart. We use new ALMA observations of galaxies at z 6 7, as well as a careful re-analysis of archival ALMA data. In total 29 galaxies were analysed, 21 of which are detected in [Cii]. For several of the latter the [Cii] emission breaks into multiple components. Only a fraction of these [Cii] components, if any, is associated with the primary UV systems, while the bulk of the [Cii] emission is associated either with fainter UV components, or not associated with any UV counterpart at the current limits. By taking into account the presence of all these components, we find that the L[CII]-SFR relation at early epochs is fully consistent with the local relation, but it has a dispersion of 0.48 0.07 dex, which is about two times larger than observed locally. We also find that the deviation from the local L[CII]-SFR relation has a weak anti-correlation with the EW(Ly ). The morphological analysis also reveals that [Cii] emission is generally much more extended than the UV emission. As a consequence, these primordial galaxies are characterised by a [Cii] surface brightness generally much lower than expected from the local [CII] SFR relation. These properties are likely a consequence of a combination of di erent e ects, namely: gas metallicity, [Cii] emission from obscured star-forming regions, strong variations of the ionisation parameter, and circumgalactic gas in accretion or ejected by these primeval galaxies.European Research Council RM acknowledges ERC Advanced Grant 695671 ‘QUENCH’. AF acknowledges support from the ERC Advanced Grant INTERSTELLAR H2020/740120

Microsatellite diversity and genetic structure among common bean (Phaseolus vulgaris L.) landraces in Brazil, a secondary center of diversity

Brazil is the largest producer and consumer of common bean (Phaseolus vulgaris L.), which is the most important source of human dietary protein in that country. This study assessed the genetic diversity and the structure of a sample of 279 geo-referenced common bean landraces from Brazil, using molecular markers. Sixty-seven microsatellite markers spread over the 11 linkage groups of the common bean genome, as well as Phaseolin, PvTFL1y, APA and four SCAR markers were used. As expected, the sample showed lower genetic diversity compared to the diversity in the primary center of diversification. Andean and Mesoamerican gene pools were both present but the latter gene pool was four times more frequent than the former. The two gene pools could be clearly distinguished; limited admixture was observed between these groups. The Mesoamerican group consisted of two sub-populations, with a high level of admixture between them leading to a large proportion of stabilized hybrids not observed in the centers of domestication. Thus, Brazil can be considered a secondary center of diversification of common bean. A high degree of genome-wide multilocus associations even among unlinked loci was observed, confirming the high level of structure in the sample and suggesting that association mapping should be conducted in separate Andean and Mesoamerican Brazilian samples

ALMA suggests outflows in z ~ 5.5 galaxies

We present the first attempt to detect outflows from galaxies approaching the Epoch of Reionization (EoR) using a sample of 9 star-forming ($\rm SFR=31\pm 20~M_{\odot}~yr^{-1}$) $z\sim 5.5$ galaxies for which the [CII]158$\mu$m line has been previously obtained with ALMA. We first fit each line with a Gaussian function and compute the residuals by subtracting the best fitting model from the data. We combine the residuals of all sample galaxies and find that the total signal is characterised by a flux excess of $\sim 0.5$ mJy extended over $\sim 1000$ km~s$^{-1}$. Although we cannot exclude that part of this signal is due to emission from faint satellite galaxies, we show that the most probable explanation for the detected flux excess is the presence of broad wings in the [CII] lines, signatures of starburst-driven outflows. We infer an average outflow rate of $\rm \dot{M}=54\pm23~ M_{\odot}~yr^{-1}$, providing a loading factor $\eta=\rm \dot{M}/SFR=1.7\pm1.3$ in agreement with observed local starbursts. Our interpretation is consistent with outcomes from zoomed hydro-simulations of {\it Dahlia}, a $z\sim 6$ galaxy ($\rm SFR\sim 100~\rm M_{\odot}~yr^{-1}$) whose feedback-regulated star formation results into an outflow rate $\rm \dot{M}\sim 30~ M_{\odot}~yr^{-1}$. The quality of the ALMA data is not sufficient for a detailed analysis of the [CII] line profile in individual galaxies. Nevertheless, our results suggest that starburst-driven outflows are in place in the EoR and provide useful indications for future ALMA campaigns. Deeper observations of the [CII] line in this sample are required to better characterise feedback at high-$z$ and to understand the role of outflows in shaping early galaxy formation

Witnessing Galaxy Assembly at the Edge of the Reionization Epoch

We report the discovery of Serenity-18, a galaxy at z=5.939 for which we could measure the content of molecular gas, M(H_2)~ 5 x10^9 M_sun, traced by the CO(6-5) emission, together with the metal poor ([Fe/H]=-3.08 +- 0.12, [Si/H]=-2.86 +- 0.14) gas clump/filament which is possibly feeding its growth. The galaxy has an estimated star formation rate of ~100 M_sun yr^{-1}, implying that it is a typical main sequence galaxy at these redshifts. The metal poor gas is detected through a damped Lyman-alpha absorber observed at a spatial separation of 40 kpc and at the same redshift of Serenity-18, along the line of sight to the quasar SDSS J2310+1855 (z_em = 6.0025). The chemical abundances measured for the damped Lyman-alpha system are in very good agreement with those measured for other DLAs discovered at similar redshifts, indicating an enrichment due to massive PopII stars. The galaxy/Damped system we discovered is a direct observational evidence of the assembly of a galaxy at the edge of the reionization epoch.STFC ER

Quasar outflows at z ≥ 6: the impact on the host galaxies

We investigate quasar outflows at z ≥ 6 by performing zoom-in cosmological hydrodynamical simulations. By employing the smoothed particle hydrodynamics code GADGET-3, we zoom in the 2R200 region around a 2 × 1012M· halo at z = 6, inside a (500 Mpc)3 comoving volume. We compare the results of our active galactic nuclei (AGN) runs with a control simulation in which only stellar/SN feedback is considered. Seeding 105M· black holes (BHs) at the centres of 109M· haloes, we find the following results. BHs accrete gas at the Eddington rate over z = 9-6. At z = 6, our most-massive BH has grown to MBH = 4 × 109M·. Fast (vr > 1000 km s-1), powerful (Mout ~ 2000M· yr-1) outflows of shock-heated low-density gas form at z ~ 7, and propagate up to hundreds kpc. Star formation is quenched over z = 8-6, and the total star formation rate (SFR surface density near the galaxy centre) is reduced by a factor of 5 (1000). We analyse the relative contribution of multiple physical process: (i) disrupting cosmic filamentary cold gas inflows, (ii) reducing central gas density, (iii) ejecting gas outside the galaxy; and find that AGN feedback has the following effects at z = 6. The inflowing gas mass fraction is reduced by~12 per cent, the high-density gas fraction is lowered by ~13 per cent, and ~20 per cent of the gas outflows at a speed larger than the escape velocity (500 km s-1). We conclude that quasar-host galaxies at z ≥ 6 are accreting non-negligible amount of cosmic gas, nevertheless AGN feedback quenches their star formation dominantly by powerful outflows ejecting gas out of the host galaxy halo.This work is supported by the PRIN-INAF 2014 grant ‘Windy black holes combing galaxy evolution’. CC acknowledges funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 664931. RM acknowledges support from the Science and Technology Facilities Council (STFC) and from the ERC Advanced Grant 695671 ‘QUENCH’. SC acknowledges financial support from the STFC

Missing [C ii] emission from early galaxies

ALMA observations have revealed that [CII] 158μm line emission in high-z galaxies is ~2-3× more extended than the UV continuum emission. Here we explore whether surface brightness dimming (SBD) of the [CII] line is responsible for the reported [CII] deficit, and the large L[OIII]/L[CII] luminosity ratio measured in early galaxies. We first analyse archival ALMA images of nine z>6 galaxies observed in both [CII] and [OIII]. After performing several uv-tapering experiments to optimize the identification of extended line emission, we detect [CII] emission in the whole sample, with an extent systematically larger than the [CII] emission. Next, we use interferometric simulations to study the effect of SBD on the line luminosity estimate. About 40% of the extended [CII] component might be missed at an angular resolution of 0.8′′, implying that L[CII] is underestimated by a factor ≈2 in data at low (6 galaxies lies, on average, slightly below the local L[CII]−SFR relation (Δz=6−9=−0.07±0.3), but within the intrinsic dispersion of the relation. SBD correction also yields L[OIII]/L[CII]<10, i.e. more in line with current hydrodynamical simulations.STFC ER

X-ray spectroscopy of the z\textit{z}=6.4 quasar SDSS J1148+5251

We present the 78 ks $\textit{Chandra}$ observations of the $\textit{z}$ = 6.4 quasar SDSS J1148+5251. The source is clearly detected in the energy range 0.3–7 keV with 42 counts (with a significance ≳9σ). The X-ray spectrum is best fitted by a power law with photon index Γ = 1.9 absorbed by a gas column density of N$_{H}$=2.0$^{+2.0}_{−1.5}$ %. We measure an intrinsic luminosity at 2–10 and 10–40 keV equal to ∼ 1.5 × 10$^{45}$ erg s$^{-1}$, comparable with luminous local and intermediate-redshift quasar properties. Moreover, the X-ray to optical power-law slope value (αOX = −1.76 ± 0.14) of J1148 is consistent with the one found in quasars with similar rest-frame 2500 Å luminosity ($\textit{L}$2500 ∼ 10$^{32}$ erg s$^{-1}$ Å$^{-1}$). Then we use $\textit{Chandra}$ data to test a physically motivated model that computes the intrinsic X-ray flux emitted by a quasar starting from the properties of the powering black hole and assuming that X-ray emission is attenuated by intervening, metal-rich (Z ≥ Z⊙) molecular clouds (MC) distributed on ∼kpc scales in the host galaxy. Our analysis favours a black hole mass MBH ∼ 3 × 10$^{9}$ M⊙ and a molecular hydrogen mass M$_{H2}$∼2×10$^{10}$ M⊙, in good agreement with estimates obtained from previous studies. We finally discuss strengths and limits of our analysis.RM acknowledges support from the ERC Advanced Grant 695671 ‘QUENCH’ and the Science and Technology Facilities Council (STFC)