99 research outputs found
The structure of typical clusters in large sparse random configurations
The initial purpose of this work is to provide a probabilistic explanation of
a recent result on a version of Smoluchowski's coagulation equations in which
the number of aggregations is limited. The latter models the deterministic
evolution of concentrations of particles in a medium where particles coalesce
pairwise as time passes and each particle can only perform a given number of
aggregations. Under appropriate assumptions, the concentrations of particles
converge as time tends to infinity to some measure which bears a striking
resemblance with the distribution of the total population of a Galton-Watson
process started from two ancestors. Roughly speaking, the configuration model
is a stochastic construction which aims at producing a typical graph on a set
of vertices with pre-described degrees. Specifically, one attaches to each
vertex a certain number of stubs, and then join pairwise the stubs uniformly at
random to create edges between vertices. In this work, we use the configuration
model as the stochastic counterpart of Smoluchowski's coagulation equations
with limited aggregations. We establish a hydrodynamical type limit theorem for
the empirical measure of the shapes of clusters in the configuration model when
the number of vertices tends to . The limit is given in terms of the
distribution of a Galton-Watson process started with two ancestors
Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4
Gluons and the quark sea at high energies: distributions, polarization, tomography
This report is based on a ten-week program on "Gluons and the quark sea at
high-energies", which took place at the Institute for Nuclear Theory in Seattle
in Fall 2010. The principal aim of the program was to develop and sharpen the
science case for an Electron-Ion Collider (EIC), a facility that will be able
to collide electrons and positrons with polarized protons and with light to
heavy nuclei at high energies, offering unprecedented possibilities for
in-depth studies of quantum chromodynamics. This report is organized around
four major themes: i) the spin and flavor structure of the proton, ii)
three-dimensional structure of nucleons and nuclei in momentum and
configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and
the search for physics beyond the Standard Model. Beginning with an executive
summary, the report contains tables of key measurements, chapter overviews for
each of the major scientific themes, and detailed individual contributions on
various aspects of the scientific opportunities presented by an EIC.Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science
case for an Electron-Ion Collider, September 13 to November 19, 2010,
Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed
versio
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis
A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms.
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage (OR: 1.47, 95% CI: 1.05-2.06, p = 0.02) and fibrosis progression rate (hazards ratio: 1.41, 95% CI: 1.04-1.90, p = 0.02). The DEPDC5 variant was not associated with any of these phenotypes. MICA expression was down-regulated in advanced fibrosis stages. Further, (T) allele carriage was associated with lower MICA expression in liver and serum. Transforming growth factor-β1 (TGF-β1) expression suppresses MICA expression in hepatic stellate cells. Our findings suggest a novel mechanism linking susceptibility to advanced fibrosis and subsequently indirectly to HCC, to the level of MICA expression through TGF-β1-dependent mechanisms
Sport policy convergence: a framework for analysis
This is an Accepted Manuscript of an article published by Taylor & Francis Group in European Sport Management Quarterly on 30th April 2012, available online at: http://www.tandfonline.com/10.1080/16184742.2012.669390The growth in the comparative analysis of sport management processes and policy has led to an increased interest in the concept of convergence. However, the concept is too often treated as unproblematic in definition, measurement and operationalisation. It is argued in this paper that a more effective framework for examining claims of convergence is one that analyses the concept in terms of seven dimensions which can be explored through a mix of quantitative and qualitative methods of data collection. It is also argued that a deeper understanding of the process of convergence can be gained by operationalising the concept in the context of a selected range of meso-level theories of the policy process or of specific aspects of the process. The proposed analytic framework provides not only a definition of convergence but also the basis for a more nuanced investigation of hypotheses of convergence
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