3,183 research outputs found
Spoken Thesaurus: Sorrow
The Hindi Thesaurus addresses such questions in a series of lively, unscripted Hindi-medium conversations about groups of words of related meaning. Concentrating on selected mainstream words and phrases, we help you to broaden your active vocabulary by encountering styles of language appropriate for everyday speech. The conversations are between Rupert Snell (Hindi teacher and perpetual Hindi learner) and Neha Ladha (mother-tongue speaker of Hindi). Glossaries for each podcast can be read online or downloaded in PDF format. (Length: 7:49)Asian Studie
Pengaruh Rekrutmen dan Kompensasi terhadap Kinerja Karyawan dengan Pengawasan Kerja sebagai Variabel Moderating pada PT. Titian Abadi Lestari
Penelitian ini adalah penelitian tentang âPengaruh rekrutmen dan kompensasi terhadap kinerja karyawan dengan pengawasan kerja sebagai variabel moderating pada PT. Titian Abadi Lestariâ. Variabel dependen dalam penelitian ini adalah kinerja karyawan. Variabel independennya adalah rekrutmen dan kompensasi. Serta varibel moderating dalam penelitian ini yaitu pengawasan kerja. Populasi dan sampel dalam penelitian ini adalah seluruh karyawan atau sebanyak 70 orang. Metode analisis yang digunakan dalam penelitian ini adalah uji kelayakan data, uji hipotesis dan uji variabel moderasi. Hasil penelitian uji kelayakan data membuktikan bahwa kuesioner valid dan reliabel. Sedangkan uji hipotesis secara parsial dan simultan membuktikan bahwa rekrutmen dan kompensasi secara bersama - sama berpengaruh signifikan terhadap kinerja karyawan. Hasil uji variabel moderasi membuktikan bahwa pengawasan kerja merupakan pure moderating dikarenakan hasil pengaruh Z terhadap Y pada output pertama dan pengaruh interaksi Z*X1 pada output kedua, salah satunya signifikan. Sehingga pengawasan kerja memoderasi pengaruh rekrutmen dan kompensasi terhadap kinerja karyawan
Stochastic modeling of soil salinity
A minimalist stochastic model of primary soil salinity is proposed, in which the rate of soil salinization is determined by the balance between dry and wet salt deposition and the intermittent leaching events caused by rainfall events. The long term probability density functions of salt mass and concentration are found by reducing the coupled soil moisture and salt mass balance equation to a single stochastic differential equation driven by multiplicative Poisson noise. The novel analytical solutions provide insight on the interplay of the main soil, plant and climate parameters responsible for long-term soil salinization. In particular, they show the existence of two distinct regimes, one where the mean salt mass remains nearly constant (or decreases) with increasing rainfall frequency, and another where mean salt content increases markedly with increasing rainfall frequency. As a result, relatively small reductions of rainfall in drier climates may entail dramatic shifts in long-term soil salinization trends, with significant consequences e.g. for climate change impacts on rain-fed agricultur
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Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency.
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling factors, with causal roles in neurodevelopmental disorders. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeling factor with among the highest de novo loss-of-function mutation rates in patients with autism spectrum disorder (ASD). However, mechanisms associated with CHD8 pathology have yet to be elucidated. We analyzed published transcriptomic data across CHD8 in vitro and in vivo knockdown and knockout models and CHD8 binding across published ChIP-seq datasets to identify convergent mechanisms of gene regulation by CHD8. Differentially expressed genes (DEGs) across models varied, but overlap was observed between downregulated genes involved in neuronal development and function, cell cycle, chromatin dynamics, and RNA processing, and between upregulated genes involved in metabolism and immune response. Considering the variability in transcriptional changes and the cells and tissues represented across ChIP-seq analysis, we found a surprisingly consistent set of high-affinity CHD8 genomic interactions. CHD8 was enriched near promoters of genes involved in basic cell functions and gene regulation. Overlap between high-affinity CHD8 targets and DEGs shows that reduced dosage of CHD8 directly relates to decreased expression of cell cycle, chromatin organization, and RNA processing genes, but only in a subset of studies. This meta-analysis verifies CHD8 as a master regulator of gene expression and reveals a consistent set of high-affinity CHD8 targets across human, mouse, and rat in vivo and in vitro studies. These conserved regulatory targets include many genes that are also implicated in ASD. Our findings suggest a model where perturbation to dosage-sensitive CHD8 genomic interactions with a highly-conserved set of regulatory targets leads to model-specific downstream transcriptional impacts
Hemofiltration in sepsis: where do we go from here?
Hemofiltration as an adjunct to therapy for sepsis is now 10 years old. Despite early successes and significant theoretical advantages, the treatment remains experimental. Although feasibility has been established, efficacy has proved to be much more difficult. Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa
Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in hostâpathogen interactions. Beyond taking part to cellular metabolism and to protein synthesis, amino acids are also signaling molecules able to influence group behavior in microorganisms, such as biofilm formation. This lifestyle switch involves complex metabolic reprogramming controlled by local variation of the second messenger 3âČ, 5âČ-cyclic diguanylic acid (c-di-GMP). The intracellular levels of this dinucleotide are finely tuned by the opposite activity of dedicated diguanylate cyclases (GGDEF signature) and phosphodiesterases (EAL and HD-GYP signatures), which are usually allosterically controlled by a plethora of environmental and metabolic clues. Among the genes putatively involved in controlling c-di-GMP levels in P. aeruginosa, we found that the multidomain transmembrane protein PA0575, bearing the tandem signature GGDEF-EAL, is an l-arginine sensor able to hydrolyse c-di-GMP. Here, we investigate the basis of arginine recognition by integrating bioinformatics, molecular biophysics and microbiology. Although the role of nutrients such as l-arginine in controlling the cellular fate in P. aeruginosa (including biofilm, pathogenicity and virulence) is already well established, we identified the first l-arginine sensor able to link environment sensing, c-di-GMP signaling and biofilm formation in this bacterium
Index of aerospace mechanisms symposia proceedings 1-19
This index, organized in five sections (by symposium, by title, by author, by subject, and by project), brings together information on the first 19 Aerospace Mechanisms symposia. Key words are included, cross-referencing all the symposia, and the eighteenth and nineteenth symposia are cross-indexed by project. The Aerospace Mechanisms symposia are devoted to discussions of design, fabrication, test, and operational use of aerospace mechanisms; this is the first index that compiles information on symposia held from 1966 through 1985
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