1,046 research outputs found
Screening for Atrial Fibrillation and the Role of Digital Health Technologies
Atrial fibrillation is the commonest clinical arrhythmia and a leading cause of hospital admission, morbidity and mortality. New digital health technologies are now allowing patients and the general population to identify heart rhythm abnormalities before any encounter with a medical professional. This chapter will include an overview of the prevalence of atrial fibrillation and explore the current recommendations on methods for arrhythmia screening. We discuss different risk factors as well as physiological and structural markers for atrial fibrillation onset. We explore in detail the application of novel digital health technologies such as wearables, watches and mobile devices which may have an impact on screening detection rates. The article concludes with a discussion about how to manage patients with screen detected atrial fibrillation
Optical fiber fabrication using novel gas-phase deposition technique
We report a highly versatile chemical-in-crucible preform fabrication technique suitable for gas-phase deposition of doped optical fibers. Aluminosilicate and ytterbium-doped phosphosilicate fibers are presented demonstrating the technique and its potential for realizing complex fiber designs that are suitable for the next generation of high-power fiber devices. The results show aluminum-doped fiber with numerical aperture of 0.28 and ytterbium-doped fiber with a measured slope efficiency of 84% with respect to pump launch power
Recommended from our members
Applications of Solid Freeform Fabrication at the Naval Research Laboratory
Solid Freeform Fabrication (SFF) and related techniques are used at the Naval Research
Laboratory (NRL) for a variety of materials related investigations. Research and applications
conducted over the past few years are described including: Helisys Laminated Object
Manufacturing System (LOMS) fabrication of: ceramic piezoelectric actuators, tooling for
multifunctional materials, and anatomical prototypes for surgical visualization; fabrication of
mesoscale electronic and sensor components using a laser forward transfer direct write
technique; and visualization of complex, 3-D microstructures using a Stratasys Fused-Deposition
Modeler. The paper closes with a brief overview of future SFF related work at the NRL.Support for this work from DARPA, Office of Naval Research, and the Naval Research
Laboratory Core Research Program is gratefully acknowledged.Mechanical Engineerin
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ΅ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΊΠ°ΠΊ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ° Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎΡΡΠΎΡΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
Development of biomarkers of human exposures to organophosphorus compounds OPCs and their quantification is a vital component of a system of prediction and early diagnostics of OPC-induced diseases. Our study was focused on investigation of esterase status as a complex biomarker of exposure to OPCs and an aid in accurate diagnosis. We suggest that this complex biomarker should be more effective and informative than standard assays of plasma butyrylcholinesterase (BChE), erythrocyte acetylcholinesterase (RBC AChE), and lymphocyte neuropathy target esterase (NTE). It will help: 1) to assess an exposure as such and to confirm the nonexposure of individuals suspected to have been exposed; 2) to determine if the exposure was to agents expected to produce acute and/or delayed neurotoxicity; 3) to perform dosimetry of the exposure, which provides valuable information for medical treatment. To confirm this hypothesis, we have examined the changes in activity of blood AChE, NTE, BChE and carboxylesterase (CaE) 1 h after i.p. administration of increasing doses of three OPCs with different esterase profiles: the known neuropathic compound O,O-dipropyl-O-dichlorovinyl phosphate (C3H 7O)2P(O)OCH=CCl2 (diPr-DClVP) as the control compound and two model dialkylphosphates (C2H5O)2P(O)OCH(CF3)2 (diEt-PFP) and (C4H9O)2P(O)OCH(CF3)2 (diBu-PFP). The esterases assay was performed in hemolysed blood by spectrophotometric (AChE, BChE, CaE) and biosensor (NTE) methods. Analysis of the obtained dose-dependences for blood esterases inhibition showed that blood BChE and CaE were the most sensitive biomarkers, allowing detection of low doses. Inhibition of blood NTE and AChE can be used to assess the likelihood that an exposure to OPC would produce cholinergic and/or delayed neuropathic effects.Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠΈΡΡΠ΅ΠΌΡ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎΡΡΠΎΡΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ (Π€ΠΠ‘) Π½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΈΡ
ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ²Π»ΡΡΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠΌ ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°Π½ΠΈΡ ΠΈ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΡΡ
Π°Π½ΡΠΈΡ
ΠΎΠ»ΠΈΠ½ΡΡΡΠ΅ΡΠ°Π·Π½ΡΠΌΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ. Π¦Π΅Π»ΡΡ Π½Π°ΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ΅ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΊΠ°ΠΊ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ° Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π€ΠΠ‘ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΠΊΠΎΠ³ΠΎ ΡΠΎΠ΄Π° ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΉ. ΠΡ ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌ, ΡΡΠΎ ΡΡΠΎΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠΉ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅Ρ Π±ΡΠ΄Π΅Ρ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π±ΡΡΠΈΡΠΈΠ»Ρ
ΠΎΠ»ΠΈΠ½ΡΡΡΠ΅ΡΠ°Π·Ρ ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ (ΠΠ₯Π), Π°ΡΠ΅ΡΠΈΠ»Ρ
ΠΎΠ»ΠΈΠ½ΡΡΡΠ΅ΡΠ°Π·Ρ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² (ΠΠ₯Π) ΠΈ Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΠΉ ΡΡΡΠ΅ΡΠ°Π·Ρ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² (ΠΠ’Π). ΠΠ½ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ: 1) ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΡΡ ΠΈΠ»ΠΈ ΠΎΠΏΡΠΎΠ²Π΅ΡΠ³Π½ΡΡΡ ΡΠ°ΠΌ ΡΠ°ΠΊΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π€ΠΠ‘; 2) ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ Π»ΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ, Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΠΌΠΈ ΠΎΡΡΡΡΡ ΠΈ/ΠΈΠ»ΠΈ ΠΎΡΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ; 3) ΠΏΡΠΎΠ²Π΅ΡΡΠΈ Π΄ΠΎΠ·ΠΈΠΌΠ΅ΡΡΠΈΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ Π΄Π°ΡΡ ΡΠ΅Π½Π½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ Π΄Π»Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΡ. ΠΠ»Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΡ ΡΡΠΎΠΉ Π³ΠΈΠΏΠΎΡΠ΅Π·Ρ ΠΌΡ ΠΏΡΠΎΠ²Π΅Π»ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠ₯Π, ΠΠ’Π, ΠΠ₯Π ΠΈ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΡΡΡΠ΅ΡΠ°Π·Ρ (ΠΠ) ΠΊΡΠΎΠ²ΠΈ ΠΌΡΡΠ΅ΠΉ ΡΠ΅ΡΠ΅Π· 1 Ρ ΠΏΠΎΡΠ»Π΅ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΠΈΡ
Π΄ΠΎΠ· ΡΡΡΡ
Π€ΠΠ‘ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΡΡΡΠ΅ΡΠ°Π·Π½ΡΠΌ ΠΏΡΠΎΡΠΈΠ»Π΅ΠΌ: ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠ³ΠΎ Π½Π΅ΠΉΡΠΎΠΏΠ°ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ O,O-Π΄ΠΈΠΏΡΠΎΠΏΠΈΠ»-O-Π΄ΠΈΡ
Π»ΠΎΡΠ²ΠΈΠ½ΠΈΠ»ΡΠΎΡΡΠ°ΡΠ° (C3H 7O)2P(O)OCH=CCl2 (diPr-DClVP) Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΈ Π΄Π²ΡΡ
ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
Π΄ΠΈΠ°Π»ΠΊΠΈΠ»ΡΠΎΡΡΠ°ΡΠΎΠ² β (C2H5O)2P(O)OCH(CF3)2 (diEt-PFP) ΠΈ (C4H9O)2P(O)OCH(CF3)2 (diBu-PFP). ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΡΠ΅ΡΠ°Π· ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°Ρ
Π³Π΅ΠΌΠΎΠ»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ (ΠΠ₯Π, ΠΠ₯Π, ΠΠ) ΠΈ Π±ΠΈΠΎΡΠ΅Π½ΡΠΎΡΠ½ΡΠΌ (ΠΠ’Π) ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ. ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄ΠΎΠ·ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠ΅ΠΉ Π΄Π»Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΠ΅ΡΠ°Π· ΠΊΡΠΎΠ²ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΠ₯Π ΠΈ ΠΠ ΡΠ²Π»ΡΡΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ°ΠΌΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠΌΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡ Π½ΠΈΠ·ΠΊΠΈΠ΅ Π΄ΠΎΠ·Ρ Π€ΠΠ‘ ΡΠΎΠΊΡΠΈΠΊΠ°Π½ΡΠΎΠ². ΠΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠ₯Π ΠΈ ΠΠ’Π Π² ΠΊΡΠΎΠ²ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΎ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΡΡΡΡΡ
ΠΈ/ΠΈΠ»ΠΈ ΠΎΡΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΠΊΠ°Π½ΡΠΎΠ²
New records of marine invertebrates from Ascension Island (central Atlantic)
The sea anemone Telmatactis forskalii, the zoanthid Isaurus tuberculatus, the nemertine Baseodiscus delineatus, the echinoderms Ophiocoma wendtii and Mithrodia clavigera, the molluscs Colubraria canariensis, Glyphepithema turtoni, Tonna pennata, Trivia candidula, Melanella eburnea, Melanella n.sp., Echineulima leucophaes, Stylocheilus striatus, Limaria hians, Pteria hirundo and Callistoctopus macropus, and the crustaceans Tetraclitella sp., Oxynaspis celata, Thor amboinensis and Parribacus antarcticus are recorded from Ascension Island for the first time. A new depth record is given for the sea anemone Telmatactis cricoides. An undescribed shrimp species of the genus Lysmata and the shrimp Lysmata moorei were observed to clean fish at night.info:eu-repo/semantics/publishedVersio
Surface Normal Deconvolution: Photometric Stereo for Optically Thick Translucent Objects
Computer Vision β ECCV 2014
13th European Conference, Zurich, Switzerland, September 6-12, 2014,This paper presents a photometric stereo method that works for optically thick translucent objects exhibiting subsurface scattering. Our method is built upon the previous studies showing that subsurface scattering is approximated as convolution with a blurring kernel. We extend this observation and show that the original surface normal convolved with the scattering kernel corresponds to the blurred surface normal that can be obtained by a conventional photometric stereo technique. Based on this observation, we cast the photometric stereo problem for optically thick translucent objects as a deconvolution problem, and develop a method to recover accurate surface normals. Experimental results of both synthetic and real-world scenes show the effectiveness of the proposed method
Post-modernism's use and abuse of Nietzsche
I focus on Nietzsche's architectural metaphor of self-construction in arguing for the claim that postmodern readings of Nietzsche misunderstand his various attacks on dogmatic philosophy as paving the way for acceptance of a self characterized by fundamental disunity. Nietzsche's attack on essentialist dogmatic metaphysics is a call to engage in a purposive self-creation under a unifying will, a will that possesses the strength to reinterpret history as a pathway to "the problem that we are". Nietzsche agrees with the postmodernists that unity is not a pre-given, however he would disavow their rejection of unity as a goal. Where the postmodernists celebrate "the death of the subject" Nietzsche rejects this valorization of disunity as a form of Nihilism and prescribes the creation of a genuine unified subjectivity to those few capable of such a goal. Postmodernists are nearer Nietzsche's idea of the Last Man than his idea of the Overman.Articl
Design-for-test structure to facilitate test vector application with low performance loss in non-test mode
- β¦