How to present more readable text for people with dyslexia

The presentation of a text has a significant effect on the reading speed of people with dyslexia. This paper presents a set of recommendations to customize texts on a computer screen in a more accessible way for this target group. This set is based on an eye tracking study with 92 people, 46 with dyslexia and 46 as control group, where the reading performance of the participants was measured . The following parameters were studied: color combinations for the font and the screen background, font size, column width as well as character, line and paragraph spacings. It was found that larger text and larger character spacings lead the participants with and without dyslexia to read significantly faster . The study is complemented with questionnaires to obtain the participants’ preferences for each of these parameters, finding other significant effects. These results provide evidence that people with dyslexia may benefit from specific text presentation parameters that make text on a screen more readable. So far, these recommendations based on eye tracking data are the most complete for people with dyslexia

Comparison of the pathogen species-specific immune response in udder derived cell types and their models

The outcome of an udder infection (mastitis) largely depends on the species of the invading pathogen. Gram-negative pathogens, such as Escherichia coli often elicit acute clinical mastitis while Gram-positive pathogens, such as Staphylococcus aureus tend to cause milder subclinical inflammations. It is unclear which type of the immune competent cells residing in the udder governs the pathogen species-specific physiology of mastitis and which established cell lines might provide suitable models. We therefore profiled the pathogen species-specific immune response of different cell types derived from udder and blood. Primary cultures of bovine mammary epithelial cells (pbMEC), mammary derived fibroblasts (pbMFC), and bovine monocyte-derived macrophages (boMdM) were challenged with heat-killed E. coli, S. aureus and S. uberis mastitis pathogens and their immune response was scaled against the response of established models for MEC (bovine MAC-T) and macrophages (murine RAW 264.7). Only E. coli provoked a full scale immune reaction in pbMEC, fibroblasts and MAC-T cells, as indicated by induced cytokine and chemokine expression and NF-?B activation. Weak reactions were induced by S. aureus and none by S. uberis challenges. In contrast, both models for macrophages (boMdM and RAW 264.7) reacted strongly against all the three pathogens accompanied by strong activation of NF-?B factors. Hence, the established cell models MAC-T and RAW 264.7 properly reflected key aspects of the pathogen species-specific immune response of the respective parental cell type. Our data imply that the pathogen species-specific physiology of mastitis likely relates to the respective response of MEC rather to that of professional immune cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-016-0307-3) contains supplementary material, which is available to authorized users