Quasars as Probes of Late Reionization and Early Structure Formation

Observations of QSOs at z ~ 5.7 - 6.4 show the appearance of Gunn-Peterson troughs around z ~ 6, and a change in the slope of the IGM optical depth tau(z) near z ~ 5.5. These results are interpreted as a signature of the end of the reionization era, which probably started at considerably higher redshifts. However, there also appears to be a substantial cosmic variance in the transmission of the IGM, both along some lines of sight, and among different lines of sight, in this intriguing redshift regime. We suggest that this is indicative of a spatially uneven reionization, possibly caused by the bias-driven primordial clustering of the reionization sources. There is also some independent evidence for a strong clustering of QSOs at z ~ 4 - 5 and galaxies around them, supporting the idea of the strong biasing of the first luminous sources at these redshifts. Larger samples of high-z QSOs are needed in order to provide improved, statistically significant constraints for the models of these phenomena. We expect that the Palomar-Quest (PQ) survey will soon provide a new set of QSOs to be used as cosmological probes in this redshift regime.Comment: To appear in proceedings of UC Irvine May 2005 workshop on "First Light & Reionization", eds. E. Barton & A. Cooray, New Astronomy Reviews, in pres

Interacting supernovae and supernova impostors. LSQ13zm: an outburst heralds the death of a massive star

We report photometric and spectroscopic observations of the optical transient LSQ13zm. Historical data reveal the presence of an eruptive episode (that we label as ‘2013a’) followed by a much brighter outburst (‘2013b’) three weeks later, that we argue to be the genuine supernova explosion. This sequence of events closely resemble those observed for SN 2010mc and (in 2012) SN 2009ip. The absolute magnitude reached by LSQ13zm during 2013a (MR = ?14.87 ± 0.25?mag) is comparable with those of supernova impostors, while that of the 2013b event (MR = ?18.46 ± 0.21?mag) is consistent with those of interacting supernovae. Our spectra reveal the presence of a dense and structured circumstellar medium, probably produced through numerous pre-supernova mass-loss events. In addition, we find evidence for high-velocity ejecta, with a fraction of gas expelled at more than 20 000?km s?1. The spectra of LSQ13zm show remarkable similarity with those of well-studied core-collapse supernovae. From the analysis of the available photometric and spectroscopic data, we conclude that we first observed the last event of an eruptive sequence from a massive star, likely a Luminous Blue Variable, which a short time later exploded as a core-collapse supernova. The detailed analysis of archival images suggest that the host galaxy is a star-forming Blue Dwarf Compact Galaxy

GPIbα-vWF Rolling under Shear Stress Shows Differences between Type 2B and 2M von Willebrand Disease

Both type 2B and type 2M von Willebrand disease result in bleeding disorders; however, whereas type 2B has increased binding affinity between platelet glycoprotein Ibα and von Willebrand factor (vWF), type 2M has decreased binding affinity between these two molecules. We used R687E type 2B and G561S type 2M vWF-A1 mutations to study binding between flowing platelets and insolubilized vWF mutants. We measured rolling velocities, mean stop times, and mean go times at 37°C using high-speed video microscopy. The rolling velocities for wt-wt interactions first decrease, reach a minimum, and then increase with increasing shear stress, indicating a catch-slip transition. By changing the viscosity, we were able to quantify the effects of force versus shear rate for rolling velocities and mean stop times. Platelet interactions with loss-of-function vWF-A1 retain the catch-slip bond transition seen in wt-wt interactions, but at a higher shear stress compared with the wt-wt transition. The mean stop time for all vWF-A1 molecules reveals catch-slip transitions at different shear stresses (gain-of-function vWF-A1 < wt vWF-A1< loss-of-function vWF-A1). The shift in the catch-slip transition may indicate changes in how the different mutants become conformationally active, indicating different mechanisms leading to similar bleeding characteristics

Meningoencefalite a vírus e síndrome de Klüver-Bucy: relato de dois casos

São apresentados dois casos de meningoencefalite viral, de provável etiologia herpética, que desenvolveram síndrome de Klüver-Bucy parcial. Aspectos clinicopatológicos, diagnósticos e terapêuticos da meningoencefalite herpética são discutidos revisando-se também conceitos acerca da síndrome de Klüver-Bucy