9 research outputs found
The 2-Channel Kondo Model I: Review of Experimental Evidence for its Realization in Metal Nanoconstrictions
Certain zero-bias anomalies (ZBAs) in the voltage, temperature and magnetic
field dependence of the conductance of quenched Cu point contacts
have previously been interpreted to be due to non-magnetic 2-channel Kondo
(2CK) scattering from near-degenerate atomic two-level tunneling systems (Ralph
and Buhrman, 1992; Ralph et al. 1994), and hence to represent an experimental
realization of the non-Fermi-liquid physics of the T=0 fixed point of the
2-channel Kondo model. In this, the first in a series of three papers
(I,II,III) devoted to 2-channel Kondo physics, we present a comprehensive
review of the quenched Cu ZBA experiments and their 2CK interpretation,
including new results on ZBAs in constrictions made from Ti or from metallic
glasses. We first review the evidence that the ZBAs are due to electron
scattering from stuctural defects that are not static, but possess internal
dynamics. In order to distinguish between several mechanisms proposed to
explain the experiments, we then analyze the scaling properties of the
conductance at low temperature and voltage and extract from the data a
universal scaling function . The theoretical calculation of the
corresponding scaling function within the 2CK model is the subject of papers II
and III. The main conclusion of our work is that the properties of the ZBAs,
and most notably their scaling behavior, are in good agreement with the 2CK
model and clearly different from several other proposed mechanisms.Comment: 35 pages RevTeX, 19 encapsulated postscript figures; this final
published version features two additional authors, an additional section
reviewing recent experiments on Ti nanoconstrictions that agree very well
with the 2-channel Kondo model, 6 new figures (and is much shorter the
previous 53 page version, due to reformatting
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings
Observation of CP violation in the B0 meson system
We present an updated measurement of time-dependent CP-violating asymmetries
in neutral B decays with the BABAR detector at the PEP-II asymmetric B Factory
at SLAC. This result uses an additional sample of Upsilon(4S) decays collected
in 2001, bringing the data available to 32 million B-anti-B pairs. We select
events in which one neutral B meson is fully reconstructed in a final state
containing charmonium and the flavor of the other neutral B meson is determined
from its decay products. The amplitude of the CP-violating asymmetry, which in
the Standard Model is proportional to sin2beta, is derived from the decay time
distributions in such events. The result sin2beta = 0.59 +/- 0.14 (stat) +/-
0.05 (syst) establishes CP violation in the B^0 meson system. We also determine
|lambda| = 0.93 +/- 0.09 {stat} +/- 0.03 {syst}, consistent with no direct CP
violation.Comment: 8 pages, 2 figures, submitted to Physical Review Letter