491 research outputs found
Characterizing Multi-planet Systems with Classical Secular Theory
Classical secular theory can be a powerful tool to describe the qualitative
character of multi-planet systems and offer insight into their histories. The
eigenmodes of the secular behavior, rather than current orbital elements, can
help identify tidal effects, early planet-planet scattering, and dynamical
coupling among the planets, for systems in which mean-motion resonances do not
play a role. Although tidal damping can result in aligned major axes after all
but one eigenmode have damped away, such alignment may simply be fortuitous. An
example of this is 55 Cancri (orbital solution of Fischer et al., 2008) where
multiple eigenmodes remain undamped. Various solutions for 55 Cancri are
compared, showing differing dynamical groupings, with implications for the
coupling of eccentricities and for the partitioning of damping among the
planets. Solutions for orbits that include expectations of past tidal evolution
with observational data, must take into account which eigenmodes should be
damped, rather than expecting particular eccentricities to be near zero.
Classical secular theory is only accurate for low eccentricity values, but
comparison with other results suggests that it can yield useful qualitative
descriptions of behavior even for moderately large eccentricity values, and may
have advantages for revealing underlying physical processes and, as large
numbers of new systems are discovered, for triage to identify where more
comprehensive dynamical studies should have priority.Comment: Published in Celestial Mechanics and Dynamical Astronomy, 25 pages,
10 figure
Stability of Relativistic Matter with Magnetic Fields for Nuclear Charges up to the Critical Value
We give a proof of stability of relativistic matter with magnetic fields all
the way up to the critical value of the nuclear charge .Comment: LaTeX2e, 12 page
Excitable Scale Free Networks
When a simple excitable system is continuously stimulated by a Poissonian
external source, the response function (mean activity versus stimulus rate)
generally shows a linear saturating shape. This is experimentally verified in
some classes of sensory neurons, which accordingly present a small dynamic
range (defined as the interval of stimulus intensity which can be appropriately
coded by the mean activity of the excitable element), usually about one or two
decades only. The brain, on the other hand, can handle a significantly broader
range of stimulus intensity, and a collective phenomenon involving the
interaction among excitable neurons has been suggested to account for the
enhancement of the dynamic range. Since the role of the pattern of such
interactions is still unclear, here we investigate the performance of a
scale-free (SF) network topology in this dynamic range problem. Specifically,
we study the transfer function of disordered SF networks of excitable
Greenberg-Hastings cellular automata. We observe that the dynamic range is
maximum when the coupling among the elements is critical, corroborating a
general reasoning recently proposed. Although the maximum dynamic range yielded
by general SF networks is slightly worse than that of random networks, for
special SF networks which lack loops the enhancement of the dynamic range can
be dramatic, reaching nearly five decades. In order to understand the role of
loops on the transfer function we propose a simple model in which the density
of loops in the network can be gradually increased, and show that this is
accompanied by a gradual decrease of dynamic range.Comment: 6 pages, 4 figure
Dressing the nucleon in a dispersion approach
We present a model for dressing the nucleon propagator and vertices. In the
model the use of a K-matrix approach (unitarity) and dispersion relations
(analyticity) are combined. The principal application of the model lies in
pion-nucleon scattering where we discuss effects of the dressing on the phase
shifts.Comment: 17 pages, using REVTeX, 6 figure
The First Magnetic Fields
We review current ideas on the origin of galactic and extragalactic magnetic
fields. We begin by summarizing observations of magnetic fields at cosmological
redshifts and on cosmological scales. These observations translate into
constraints on the strength and scale magnetic fields must have during the
early stages of galaxy formation in order to seed the galactic dynamo. We
examine mechanisms for the generation of magnetic fields that operate prior
during inflation and during subsequent phase transitions such as electroweak
symmetry breaking and the quark-hadron phase transition. The implications of
strong primordial magnetic fields for the reionization epoch as well as the
first generation of stars is discussed in detail. The exotic, early-Universe
mechanisms are contrasted with astrophysical processes that generate fields
after recombination. For example, a Biermann-type battery can operate in a
proto-galaxy during the early stages of structure formation. Moreover, magnetic
fields in either an early generation of stars or active galactic nuclei can be
dispersed into the intergalactic medium.Comment: Accepted for publication in Space Science Reviews. Pdf can be also
downloaded from http://canopus.cnu.ac.kr/ryu/cosmic-mag1.pd
Synaptic processes and immune-related pathways implicated in Tourette syndrome.
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS
Test of Lorentz and CPT violation with Short Baseline Neutrino Oscillation Excesses
The sidereal time dependence of MiniBooNE electron neutrino and anti-electron
neutrino appearance data are analyzed to search for evidence of Lorentz and CPT
violation. An unbinned Kolmogorov-Smirnov test shows both the electron neutrino
and anti-electron neutrino appearance data are compatible with the null
sidereal variation hypothesis to more than 5%. Using an unbinned likelihood fit
with a Lorentz-violating oscillation model derived from the Standard Model
Extension (SME) to describe any excess events over background, we find that the
electron neutrino appearance data prefer a sidereal time-independent solution,
and the anti-electron neutrino appearance data slightly prefer a sidereal
time-dependent solution. Limits of order 10E-20 GeV are placed on combinations
of SME coefficients. These limits give the best limits on certain SME
coefficients for muon neutrino to electron neutrino and anti-muon neutrino to
anti-electron neutrino oscillations. The fit values and limits of combinations
of SME coefficients are provided.Comment: 14 pages, 3 figures, and 2 tables, submitted to Physics Letters
Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)
BACKGROUND:
Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.
METHODS:
Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights.
FINDINGS:
5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease.
INTERPRETATION:
International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems
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