Can FCNC transition c→ul+l−c\to ul^+l^- be seen in D→Vl+l−D\to Vl^+l^- decays?

The decays $D\to Vl^+l^-$ present in principle the opportunity to observe the short distance FCNC transition $c\to ul^+l^-$, which is sensitive to the physics beyond the Standard Model. We analyze the $D \to V l^+ l^-$ decays within the Standard Model, where in addition to the short distance dynamics also the long distance dynamics is present. The short distance contribution due to $c\to ul^+l^-$ transition, which is present only in the Cabibbo suppressed decays, is found to be three orders of magnitude smaller than the long distance contribution. The branching ratios well above $10^{-7}$ for Cabibbo suppressed decays could signal new physics. The most frequent decays are the Cabibbo allowed decays $D_s^+\to\rho^+\mu^+\mu^-$ and $D^0\to\bar K^{*0}\mu^+\mu^-$, which are expected at the branching ratios of $3\cdot 10^{-5}$ and $1.7\cdot 10^{-6}$, respectively. These rates are not much lower than the present experimental upper limit.Comment: 3 pages, latex, 3 figures, Talk given by S. Prelovsek at the Hyperons, Charm and Beauty Hadrons, Genova, Italy, 30 June -3 July 1998, to appear as proceedings in Nucl. Phys.

Shared Care, Elder and Family Member Skills Used to Manage Burden

Aim. The aim of this paper is to further develop the construct of Shared Care by comparing and contrasting it to related research, and to show how the construct can be used to guide research and practice. Background. While researchers have identified negative outcomes for family caregivers caused by providing care, less is known about positive aspects of family care for both members of a family dyad. Understanding family care relationships is important to nurses because family participation in the care of chronically ill elders is necessary to achieve optimal outcomes from nursing interventions. A previous naturalistic inquiry identified a new construct, Shared Care, which was used to describe a family care interaction that contributed to positive care outcomes. Methods. A literature review was carried out using the databases Medline, CINAHL, and Psych-info and the keywords home care, care receiver, disability, family, communication, decision-making and reciprocity. The results of the review were integrated to suggest how Shared Care could be used to study care difficulties and guide interventions. Results. The literature confirmed the importance of dyad relationships in family care. Shared Care extended previous conceptualizations of family care by capturing three critical components: communication, decision-making, and reciprocity. Shared Care provides a structure to expand the conceptualization of family care to include both members of a care dyad and account for positive and negative aspects of care. Conclusions. The extended view provided by the construct of Shared Care offers practitioners and scholars tools to use in the context of our ageing population to improve the effectiveness of family care relationships

A river model of space

Within the theory of general relativity gravitational phenomena are usually attributed to the curvature of four-dimensional spacetime. In this context we are often confronted with the question of how the concept of ordinary physical three-dimensional space fits into this picture. In this work we present a simple and intuitive model of space for both the Schwarzschild spacetime and the de Sitter spacetime in which physical space is defined as a specified set of freely moving reference particles. Using a combination of orthonormal basis fields and the usual formalism in a coordinate basis we calculate the physical velocity field of these reference particles. Thus we obtain a vivid description of space in which space behaves like a river flowing radially toward the singularity in the Schwarzschild spacetime and radially toward infinity in the de Sitter spacetime. We also consider the effect of the river of space upon light rays and material particles and show that the river model of space provides an intuitive explanation for the behavior of light and particles at and beyond the event horizons associated with these spacetimes.Comment: 22 pages, 5 figure

Thermal rates for baryon and anti-baryon production

We use a form of the fluctuation-dissipation theorem to derive formulas giving the rate of production of spin-1/2 baryons in terms of the fluctuations of either meson or quark fields. The most general formulas do not assume thermal or chemical equilibrium. When evaluated in a thermal ensemble we find equilibration times on the order of 10 fm/c near the critical temperature in QCD.Comment: 22 pages, 4 tables and 2 figures, REVTe

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

Matching and surface barrier effects of the flux-line lattice in superconducting films and multilayers.

The flux-line lattice dissipation and the pinning force of Bi2Sr2CaCu2O8 and YBa2Cu3O7 films and a Nb/Cu multilayer are investigated with the vibrating reed technique. In magnetic fields oriented under a small angle with respect to the film surfaces the Bi-2:2:1:2 film shows a series of pronounced dissipation maxima at matching fields BN in the irreversible region of the magnetic phase diagram. The Y-1:2:3 film shows tiny damping maxima, whereas no structure in the dissipation of the Nb/Cu multilayer is detected below the upper critical field. The comparison of the matching fields to an anisotropic London model shows that the dissipation maxima are caused by rearrangements of the flux-line lattice configuration due to interactions with the sample surface. The different behavior of the high-temperature superconductors and the Nb/Cu multilayer is understood by explicitly taking the surface barrier into account. Deviations from the surface induced commensurability of the flux-line lattice due to the intrinsic pinning are discussed. Our results indicate that pancake vortices in the Bi-2:2:1:2 film should be coupled below the irreversibility line and below magnetic fields B??0.5 T perpendicular to the film surface

Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII

We have isolated the bovine COX8H gene for the heart/muscle isoform of cytochrome c oxidase (COX) subunit VIII from a library of bovine genomic DNA cloned into lambda EMBL3. Primer extension assays on bovine heart mRNA mapped the 5′ ends of COX8H transcripts to a CA dinucleotide 62-bp upstream from the ATG codon. The gene thus spans 1565-bp and comprises two exons and one large intron of 1227 bp. Exon 1 encodes the 5′ untranslated region, a 24-amino acid presequence, and the first 13 amino acids of the mature COX VIII-H protein. Exon 2 encodes the remainder of the cDNA: amino acids 14 to 46 plus the 66-bp 3′ untranslated region. The exon-intron boundaries matched the consensus splice junction sequences. Two protein polymorphisms were seen: an Ala/Val polymorphism at position-6 in the presequence and the previously noted Lys/Arg polymorphism at residue 7 of the mature protein. A Taq I polymorphism occurs in the intron. The COX8H gene was mapped by bovine x rodent somatic cell hybrid mapping panels to bovine (BTA) Chromosome (Chr) 25 with 100% concordancy. BTA25 is conserved relative to the long arm of human (HSA) Chr 11, which contains COX8, the gene for the single human COX VIII subunit that is homologous to the liver isoform.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47018/1/335_2004_Article_BF00303255.pd

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

The role that mechanical forces play in shaping the structure and function of the heart is critical to understanding heart formation and the etiology of disease but is challenging to study in patients. Engineered heart tissues (EHTs) incorporating human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes have the potential to provide insight into these adaptive and maladaptive changes. However, most EHT systems cannot model both preload (stretch during chamber filling) and afterload (pressure the heart must work against to eject blood). Here, we have developed a new dynamic EHT (dyn-EHT) model that enables us to tune preload and have unconstrained contractile shortening of >10%. To do this, three-dimensional (3D) EHTs were integrated with an elastic polydimethylsiloxane strip providing mechanical preload and afterload in addition to enabling contractile force measurements based on strip bending. Our results demonstrated that dynamic loading improves the function of wild-type EHTs on the basis of the magnitude of the applied force, leading to improved alignment, conduction velocity, and contractility. For disease modeling, we used hiPSC-derived cardiomyocytes from a patient with arrhythmogenic cardiomyopathy due to mutations in the desmoplakin gene. We demonstrated that manifestation of this desmosome-linked disease state required dyn-EHT conditioning and that it could not be induced using 2D or standard 3D EHT approaches. Thus, a dynamic loading strategy is necessary to provoke the disease phenotype of diastolic lengthening, reduction of desmosome counts, and reduced contractility, which are related to primary end points of clinical disease, such as chamber thinning and reduced cardiac output.Cardiolog