195 research outputs found
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Depth dependence of westward-propagating North Atlantic features diagnosed from altimetry and a numerical 1/6° model
International audienceA 1/6° numerical simulation is used to investigate the vertical structure of westward propagation between 1993 and 2000 in the North Atlantic ocean. The realism of the simulated westward propagating signals, interpreted principally as the signature of first-mode baroclinic Rossby waves (RW), is first assessed by comparing the simulated amplitude and zonal phase speeds of Sea Level Anomalies (SLA) against TOPEX/Poseidon-ERS satellite altimeter data. Then, the (unobserved) subsurface signature of RW phase speeds is investigated from model outputs by means of the Radon Transform which was specifically adapted to focus on first-mode baroclinic RW. The analysis is performed on observed and simulated SLA and along 9 simulated isopycnal displacements spanning the 0-3250 m depth range. Simulated RW phase speeds agree well with their observed counterparts at the surface, although with a slight slow bias. Below the surface, the simulated phase speeds exhibit a systematic deceleration with increasing depth, by a factor that appears to vary geographically. Thus, while the reduction factor is about 15-18% on average at 3250 m over the region considered, it appears to be much weaker (about 5-8%) in the eddy-active Azores Current, where westward propagating structures might be more coherent in the vertical. In the context of linear theories, these results question the often-made normal mode assumption of many WKB-based theories that the phase speed is independent of depth. Alternatively, these results could also suggest that the vertical structure of westward propagating signals may significantly depend on their degree of nonlinearity, with the degree of vertical coherence possibly increasing with the degree of nonlinearity
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Thermobaric control of gravitational potential energy generation by diapycnal mixing in the deep ocean
Sources and sinks of gravitational potential energy (GPE)
play a rate-limiting role in the large scale ocean circulation.
A key source is turbulent diapycnal mixing, whereby irre-
versible mixing across isoneutral surfaces is enhanced by
turbulent straining of these surfaces. This has motivated
international observational efforts to map diapycnal mixing
in the global ocean. However, in order to accurately relate
the GPE supplied to the large scale circulation by diapycnal
mixing to the mixing energy source, it is first necessary to
determine the ratio, ξ , of the GPE generation rate to the
available potential energy dissipation rate associated with
turbulent mixing. Here, the link between GPE and hydro-
static pressure is used to derive the GPE budget for a com-
pressible ocean with a nonlinear equation of state. The role
of diapycnal mixing is isolated and from this a global cli-
matological distribution of ξ is calculated. It is shown that,
for a given source of mixing energy, typically three times as
much GPE is generated if the mixing takes place in bottom
waters rather than in the pycnocline. This is due to GPE
destruction by cabbelling in the pycnocline, as opposed to
thermobaric enhancement of GPE generation by diapycnal
mixing in the deep ocean
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Marginal stability and predator-prey behaviour within storm tracks
A predator-prey relationship between storm track intensity and growth rate is revealed in reanalysis data for the North Atlantic and North Pacific, as well as in an idealised global circulation model with a zonally asymmetric heating dipole. Averaging in the phase space of these two quantities reveals that both quantities oscillate on approximately monthly timescales. These oscillations occur due to quasi-periodic bursts in storm track activity that reduce excess baroclinicity and bring the flow back towards a state that is marginally stable to those bursts. Many detailed properties of these oscillations are reproduced well by a two-dimensional dynamical system, especially in respect of the North Atlantic storm track which is more zonally constrained compared to the North Pacific. It is predicted and observed that on average stronger storm events occur less frequently but grow on a shorter timescale. The results suggest that nonlinearly oscillating behaviour around a state of baroclinic neutrality is a general feature of localised storm tracks, and they offer a new perspective on the study of baroclinic instability
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An historical perspective on the development of the thermodynamic equation of seawater - 2010
Oceanography is concerned with understanding the mechanisms controlling the movement of seawater and
its contents. A fundamental tool in this process is the characterization of the thermophysical properties of seawater as functions of measured temperature and electrical conductivity, the latter used as a proxy for the concentration of dissolved matter in seawater. For many years a collection of algorithms denoted the Equation of State 1980 (EOS-80) has been the internationally accepted standard for calculating
such properties. However, modern measurement technology
now allows routine observations of temperature and electrical conductivity to be made to at least one order of magnitude more accurately than the uncertainty in this standard. Recently, a new standard has been developed, the Thermodynamical Equation of Seawater 2010 (TEOS-10). This new standard is thermodynamically consistent, valid over a wider range of temperature and salinity, and includes a mechanism to account for composition variations in seawater. Here we review the scientific development of this standard, and describe the literature involved in its development, which includes many of the articles in this special issue
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The ocean's gravitational potential energy budget in a coupled climate model
This study examines, in a unified fashion, the budgets of ocean gravitational potential energy (GPE) and available gravitational potential energy (AGPE) in the control simulation of the coupled atmosphere–ocean general
circulation model HadCM3. Only AGPE can be converted into kinetic energy by adiabatic processes. Diapycnal mixing supplies GPE, but not AGPE, whereas the reverse is true of the combined effect of surface buoyancy forcing and convection. Mixing and buoyancy forcing, thus, play complementary roles in sustaining the large scale circulation. However, the largest globally integrated source of GPE is resolved advection (+0.57 TW) and the largest sink is through parameterized eddy transports (-0.82 TW). The effect of these adiabatic processes on AGPE is identical to their effect on GPE, except for
perturbations to both budgets due to numerical leakage exacerbated by non-linearities in the equation of state
Ocean Science Preface An historical perspective on the development of the Thermodynamic Equation of Seawater -2010
Abstract. Oceanography is concerned with understanding the mechanisms controlling the movement of seawater and its contents. A fundamental tool in this process is the characterization of the thermophysical properties of seawater as functions of measured temperature and electrical conductivity, the latter used as a proxy for the concentration of dissolved matter in seawater. For many years a collection of algorithms denoted the Equation of State 1980 (EOS-80) has been the internationally accepted standard for calculating such properties. However, modern measurement technology now allows routine observations of temperature and electrical conductivity to be made to at least one order of magnitude more accurately than the uncertainty in this standard. Recently, a new standard has been developed, the Thermodynamical Equation of Seawater 2010 (TEOS-10). This new standard is thermodynamically consistent, valid over a wider range of temperature and salinity, and includes a mechanism to account for composition variations in seawater. Here we review the scientific development of this standard, and describe the literature involved in its development, which includes many of the articles in this special issue
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Antibiotics are widely used in the treatment of bacterial infections. Although known for their microbicidal activity, antibiotics may also interfere with the host's immune system. Here, we analyzed the effects of bedaquiline (BDQ), an inhibitor of the mycobacterial ATP synthase, on human macrophages. Genome-wide gene expression analysis revealed that BDQ reprogramed cells into potent bactericidal phagocytes. We found that 579 and 1,495 genes were respectively differentially expressed in naive- and M. tuberculosis-infected macrophages incubated with the drug, with an over-representation of lysosome-associated genes. BDQ treatment triggered a variety of antimicrobial defense mechanisms, including phagosome-lysosome fusion, and autophagy. These effects were associated with activation of transcription factor EB, involved in the transcription of lysosomal genes, resulting in enhanced intracellular killing of different bacterial species that were naturally insensitive to BDQ. Thus, BDQ could be used as a host-directed therapy against a wide range of bacterial infections
Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women
BACKGROUND:Although behavioral risk factors are strongly associated with urinary tract infection (UTI) risk, the role of genetics in acquiring this disease is poorly understood. METHODOLOGY/PRINCIPAL FINDINGS:To test the hypothesis that polymorphisms in Toll-like receptor (TLR) pathway genes are associated with susceptibility to UTIs, we conducted a population-based case-control study of women ages 18-49 years. We examined DNA variants in 9 TLR pathway genes in 431 recurrent cystitis (rUTI) cases, 400 pyelonephritis cases, and 430 controls with no history of UTIs. In the Caucasian subgroup of 987 women, polymorphism TLR4_A896G was associated with protection from rUTI, but not pyelonephritis, with an odds ratio (OR) of 0.54 and a 95% confidence interval (CI) of 0.31 to 0.96. Polymorphism TLR5_C1174T, which encodes a variant that abrogates flagellin-induced signaling, was associated with an increased risk of rUTI (OR(95%CI): 1.81 (1.00-3.08)), but not pyelonephritis. Polymorphism TLR1_G1805T was associated with protection from pyelonephritis (OR(95%CI): 0.53 (0.29-0.96)). CONCLUSIONS:These results provide the first evidence of associations of TLR5 and TLR1 variants with altered risks of acquiring rUTI and pyelonephritis, respectively. Although these data suggest that TLR polymorphisms are associated with adult susceptibility to UTIs, the statistical significance was modest and will require further study including validation with independent cohorts
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
This study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions. Our results also underline the extraordinary plasticity of host cell and pathogen responses to infection, and provide a solid framework to further understand the complex mechanisms involved in immunity to M. tuberculosis and in mycobacterial adaptation to different intracellular environments
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