An Intensive Winter Fixture Schedule Induces a Transient Fall in Salivary IgA in English Premier League Soccer Players

We examined the effects of an intensive fixture schedule on salivary IgA (SIgA) concentration in professional soccer players from the English Premier League. Salivary samples were obtained from 21 males who participated in 7 games over a 30-day period during December 2013 and January 2014 (games 1-5 occurred in a 15-day period). Salivary-IgA decreased (P 0.05) from game 1 (91 ± 18 and 99 ± 21 μg.mL-1, respectively). Data demonstrate for the first time that a congested winter fixture schedule induces detectable perturbations to mucosal immunity in professional soccer players

Anisotropic States of Two-Dimensional Electron Systems in High Landau Levels: Effect of an In-Plane Magnetic Field

We report the observation of an acute sensitivity of the anisotropic longitudinal resistivity of two-dimensional electron systems in half-filled high Landau levels to the magnitude and orientation of an in-plane magnetic field. In the third and higher Landau levels, at filling fractions nu=9/2, 11/2, etc., the in-plane field can lead to a striking interchange of the "hard" and "easy" transport directions. In the second Landau level the normally isotropic resistivity and the weak nu=5/2 quantized Hall state are destroyed by a large in-plane field and the transport becomes highly anisotropic.Comment: 5 pages, 4 figures, minor errors correcte

Epidemiology of diabetes mellitus among 193,435 cats attending primary-care veterinary practices in England

BACKGROUND: Diabetes mellitus (DM) is a common endocrine disease of cats. The prevalence of DM in cats in England is not well‐defined. HYPOTHESIS/OBJECTIVES: To estimate the prevalence and identify risk factors for DM in a large population of cats attending primary‐care practices. ANIMALS: A cohort of 193,563 cats in the VetCompass Programme attending 118 primary‐care practices in England. METHODS: Cross‐sectional analysis of cohort clinical data. Data were extracted covering September 1st 2009 and August 31st 2014. Period prevalence of DM was calculated. Associations between risk factors and DM were assessed using logistic regression modelling. RESULTS: Of 1,128 DM cases were identified among 194,563 cats (period prevalence 0.58%; 95% confidence interval [CI] 0.54–0.61). Multivariable modelling indicated that Tonkinese (OR 4.1; 95% CI 1.8–9.6; P = .001), Norwegian Forest (odds ratio [OR] 3.5; 95% CI 1.3–9.6; P = .001) and Burmese (OR 3.0; 95% CI 2.0–4.4; P < .001) cats had increased odds of DM compared with crossbred cats. DM odds increased as bodyweight categories increased above 4 kg (P < .001), as cats aged beyond 6 years old (P < .001) and in insured cats (OR 2.0; 95% CI 1.6–2.4; P < .001) but sex was not significantly associated with DM. CONCLUSIONS AND CLINICAL IMPORTANCE: Diabetes mellitus is an important component of the primary‐care practice caseload with 1‐in‐200 cats affected. An increased risk of DM in certain cat breeds supports a genetic predisposition. These results can guide future research and preventative healthcare

The effect of acute caffeine ingestion on physical performance in elite European competitive soccer match-play

The present study examined the effect of acute caffeine ingestion (150 mg) on the physical performance of elite European soccer players during official competitive match-play. The current investigation was a parallel-group design that collated data from a cohort of 19 male outfield players from an elite European soccer team (mean ± SD, age 26 ± 4 years; weight 80.5 ± 8.1 kg; height 1.83 ± 0.07 m; body-fat 10.8 ± 0.7%). Players were classified and matched by position and grouped accordingly: centre defender (CD) n = 5, wide defender (WD) n = 3, centre midfield (CM) n = 7, wide forward (WF) n = 2, and centre forward (CF) n = 2. For all performance variables, the mean values were compared in caffeine consumers vs. non consumers using independent-sample t-tests, with significance set at p &lt; .05. Cohen’s d was used to quantify the effect size, and was interpreted as trivial (&lt;0.2), small (0.2-0.5), medium (0.5-0.8), and large (&gt;0.8). For all examined variables, there were trivial or small non-significant (p &gt; .05) trivial or small differences between caffeine consumers and non-consumers. The findings of the present research did not confirm the study hypothesis, once running and accelerometry-based variables did not improve with the caffeine ingestion of 150 mg. Therefore, the caffeine supplement used in this study is not suggested for improving performance in the variables analysed

Orientation of the Stripe Formed by the Two-Dimensional Electrons in Higher Landau Levels

Effect of periodic potential on the stripe phase realized in the higher Landau levels is investigated by the Hartree-Fock approximation. The period of the potential is chosen to be two to six times of the fundamental period of the stripe phase. It is found that the stripe aligns perpendicularly to the external potential in contrast to a naive expectation and hydrodynamic theory. Charge modulation towards the Wigner crystallization along the stripe is essential for the present unexpected new result.Comment: 5 pages, RevTex, two figures included in the tex

Quantification of Seasonal Long Physical Load in Soccer Players With Different Starting Status From the English Premier League: Implications for Maintaining Squad Physical Fitness.

PURPOSE: To quantify the accumulative training and match load during an annual season in English Premier League soccer players classified as starters (n=8, started ≥60% of games), fringe players (n=7, started 30-60% of games) and non-starters (n=4, started 25.2 km/h (11.2 ± 4.2, v 2.9 ± 1.2 km; ES=2.3) than non-starters. Additionally, starters also completed more sprinting (P<0.01. ES=2.0) than fringe players who accumulated 4.5 ± 1.8 km. Such differences in total high-intensity physical work done were reflective of differences in actual game time between playing groups as opposed to differences in high-intensity loading patterns during training sessions. CONCLUSIONS: Unlike total seasonal volume of training (i.e. total distance and duration), seasonal high-intensity loading patterns are dependent on players' match starting status thereby having potential implications for training programme design

The influence of nicotinamide on the development of neurons

This document is the Accepted Manuscript version of a published work that appeared in final form in Journal of Neurology, Neurosurgery and Psychiatry. To access the final edited and published work see http://dx.doi.org/10.1136/jnnp-2014-309236.199A major challenge in translating the promise of stem cell therapies to treat a myriad of neurodegenerative disorders is to rapidly and efficiently direct pluripotent stem cells to generate differentiated neurons. The application of active vitamin metabolites known to function in embryonic development and maintenance in the adult brain such as retinoic acid (vitamin A), ascorbic acid (vitamin C) and calcitriol (vitamin D3) have proven effective in current in-vitro differentiation protocols. Therefore, in this study we investigated whether the biologically active vitamin B3 metabolite, nicotinamide could enhance the differentiation of mouse embryonic stem cells, cultured as monolayers, into mature neurons at either early or late stages of development. Interestingly, nicotinamide elicited a dose-responsive increase in the percentage of neurons when added at an early developmental stage to the cells undergoing differentiation (days 0–7). Nicotinamide (10 mM) increased the proportion of β-III tubulin positive neurons by two fold and concomitantly decreased the total number of cells in culture, measured by quantification of 4′, 6-diamidino-2-phenylindole positive cells. This effect could result from induction of cell-cycle exit and/or selective cell death in non-neural populations. Higher levels of nicotinamide (20 mM) induced cytoxicity and cell death. This study supports previous evidence that vitamins and their metabolites can efficiently direct stem cells into neurons. Current work is focusing on the effect of nicotinamide on the process of neural induction and whether nicotinamide influences the generation of particular neuronal subtypes implicated in neurodegenerative diseases, specifically focusing on midbrain dopamine neurons; towards a therapy for Parkinson's disease

Evidence of strong stabilizing effects on the evolution of boreoeutherian (Mammalia) dental proportions.

The dentition is an extremely important organ in mammals with variation in timing and sequence of eruption, crown morphology, and tooth size enabling a range of behavioral, dietary, and functional adaptations across the class. Within this suite of variable mammalian dental phenotypes, relative sizes of teeth reflect variation in the underlying genetic and developmental mechanisms. Two ratios of postcanine tooth lengths capture the relative size of premolars to molars (premolar-molar module, PMM), and among the three molars (molar module component, MMC), and are known to be heritable, independent of body size, and to vary significantly across primates. Here, we explore how these dental traits vary across mammals more broadly, focusing on terrestrial taxa in the clade of Boreoeutheria (Euarchontoglires and Laurasiatheria). We measured the postcanine teeth of N = 1,523 boreoeutherian mammals spanning six orders, 14 families, 36 genera, and 49 species to test hypotheses about associations between dental proportions and phylogenetic relatedness, diet, and life history in mammals. Boreoeutherian postcanine dental proportions sampled in this study carry conserved phylogenetic signal and are not associated with variation in diet. The incorporation of paleontological data provides further evidence that dental proportions may be slower to change than is dietary specialization. These results have implications for our understanding of dental variation and dietary adaptation in mammals

Does elite European match-play affect salivary immunoglobulin- a and cortisol in soccer players? The influence of playing status and match outcome

Introduction: The aims of this study were to: a) investigate salivary immunoglobulin A (s-IgA) and cortisol (s-Cort) responses to nine competitive fixtures in starting and non- starting soccer players; and b) compare s-IgA and s Cort responses of starters and non-starters considering match outcome. Methods: Saliva from 19 male outfield players from an elite soccer team (mean ± SD, age 26 ± 4 years; weight 80.5 ± 8.1 kg; height 1.83 ± 0.07 m; body-fat 10.8% ± 0.7%) was collected. Saliva samples were taken on the day before each match (MD-1), 60-min before kick-off (MDpre), 30-min post-match (MDpost), and 72-h post-match (MD+3). There were five wins, one draw and three losses. Results: The mean s-IgA value was found to be significantly lower at MD+3 compared to MDpre and MDpost. s-Cort was significantly higher at MDpost compared to MD-1 and MDpre. When compared to MDpre, a statistically significant decrease in s-Cort was observed at MD+3 compared to MDpost. Starters displayed higher s-Cort values across the nine matches. There was a significant group-by-time interaction for s-Cort. There was a significant increase in s-Cort levels at MDpost compared to MD-1 and from MDpre to MDpost in starting players. At MDpost, starters had significantly higher s-Cort values. s-IgA values of starting and non- starting players following successful and unsuccessful matches did not reveal a significant difference. However, similar analysis of s-Cort in successful matches showed a significant difference between starters and non starters. s-IgA values at MD-1, MDpre, MDpost and MD+3 in starters and non starters following successful and unsuccessful matches revealed significant differences at MDpre and MDpost in starters, respectively. Furthermore, s-Cort values at MD-1, MDpre, MDpost and MD+3 in starters and non-starters in successful and unsuccessful matches revealed significant differences at MD+3 in starting players.Discussion: The present study suggests that in elite level soccer players, both starting status and match outcome influence s-IgA and s-Cort responses, particularly starters. Specifically, s-IgA was lower for starters before and after the match following successful outcomes. Moreover, higher s-Cort values were found before the match while lower values occurred after the match for starters in successful matches.info:eu-repo/semantics/publishedVersio