5,030 research outputs found
Relationship of hypoxia to metastatic ability in rodent tumours
The relationship between tumour oxygenation in vivo and metastatic potential was investigated in 2 rodent tumour models, KHT-C fibrosarcoma and SCC-VII squamous cell carcinoma. The oxygen status in these rodent tumours transplanted intramuscularly in syngeneic mice was measured using the Eppendorf pO 2 Histograph. The results indicate a considerable heterogeneity in oxygenation between individual tumours within each tumour cell line. At different tumour sizes, animals were killed and lung lobes were examined for macroscopic and microscopic lung metastases. In the KHT-C tumours, a significant increase in early pulmonary metastasis formation was observed in mice with hypoxic primary tumours. Hypoxic SCC-VII tumours did not give rise to enhanced lung metastasis formation despite oxygenation in a range similar to the KHT-C tumours. However, the overall metastasis incidence in the SCC-VII model was very low. The results obtained in the KHT-C model, which show that hypoxic tumours are more likely to metastasize, are in agreement with recent clinical data suggesting that a hypoxic environment might be implicated in metastatic ability of human tumours. © 2001 Cancer Research Campaign http://www.bjcancer.co
Anomalous Transport in Conical Granular Piles
Experiments on 2+1-dimensional piles of elongated particles are performed.
Comparison with previous experiments in 1+1 dimensions shows that the addition
of one extra dimension to the dynamics changes completely the avalanche
properties, appearing a characteristic avalanche size. Nevertheless, the time
single grains need to cross the whole pile varies smoothly between several
orders of magnitude, from a few seconds to more than 100 hours. This behavior
is described by a power-law distribution, signaling the existence of scale
invariance in the transport process.Comment: Accepted in PR
On the complexity of some birational transformations
Using three different approaches, we analyze the complexity of various
birational maps constructed from simple operations (inversions) on square
matrices of arbitrary size. The first approach consists in the study of the
images of lines, and relies mainly on univariate polynomial algebra, the second
approach is a singularity analysis, and the third method is more numerical,
using integer arithmetics. Each method has its own domain of application, but
they give corroborating results, and lead us to a conjecture on the complexity
of a class of maps constructed from matrix inversions
Velocity Fluctuations in Electrostatically Driven Granular Media
We study experimentally the particle velocity fluctuations in an
electrostatically driven dilute granular gas. The experimentally obtained
velocity distribution functions have strong deviations from Maxwellian form in
a wide range of parameters. We have found that the tails of the distribution
functions are consistent with a stretched exponential law with typical
exponents of the order 3/2. Molecular dynamic simulations shows qualitative
agreement with experimental data. Our results suggest that this non-Gaussian
behavior is typical for most inelastic gases with both short and long range
interactions.Comment: 4 pages, 4 figure
Universal and wide shear zones in granular bulk flow
We present experiments on slow granular flows in a modified (split-bottomed)
Couette geometry in which wide and tunable shear zones are created away from
the sidewalls. For increasing layer heights, the zones grow wider (apparently
without bound) and evolve towards the inner cylinder according to a simple,
particle-independent scaling law. After rescaling, the velocity profiles across
the zones fall onto a universal master curve given by an error function. We
study the shear zones also inside the material as function of both their local
height and the total layer height.Comment: Minor corrections, accepted for PRL (4 pages, 6 figures
Smoothing of sandpile surfaces after intermittent and continuous avalanches: three models in search of an experiment
We present and analyse in this paper three models of coupled continuum
equations all united by a common theme: the intuitive notion that sandpile
surfaces are left smoother by the propagation of avalanches across them. Two of
these concern smoothing at the `bare' interface, appropriate to intermittent
avalanche flow, while one of them models smoothing at the effective surface
defined by a cloud of flowing grains across the `bare' interface, which is
appropriate to the regime where avalanches flow continuously across the
sandpile.Comment: 17 pages and 26 figures. Submitted to Physical Review
Granular Avalanches in Fluids
Three regimes of granular avalanches in fluids are put in light depending on
the Stokes number St which prescribes the relative importance of grain inertia
and fluid viscous effects, and on the grain/fluid density ratio r. In gas (r >>
1 and St > 1, e.g., the dry case), the amplitude and time duration of
avalanches do not depend on any fluid effect. In liquids (r ~ 1), for
decreasing St, the amplitude decreases and the time duration increases,
exploring an inertial regime and a viscous regime. These regimes are described
by the analysis of the elementary motion of one grain
Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins
Multicellular organisms depend on cell production, cell fate specification, and correct patterning to shape their adult body. In plants, auxin plays a prominent role in the timely coordination of these different cellular processes. A well-studied example is lateral root initiation, in which auxin triggers founder cell specification and cell cycle activation of xylem pole-positioned pericycle cells. Here, we report that the E2Fa transcription factor of Arabidopsis thaliana is an essential component that regulates the asymmetric cell division marking lateral root initiation. Moreover, we demonstrate that E2Fa expression is regulated by the LATERAL ORGAN BOUNDARY DOMAIN18/LATERAL ORGAN BOUNDARY DOMAIN33 (LBD18/LBD33) dimer that is, in turn, regulated by the auxin signaling pathway. LBD18/LBD33 mediates lateral root organogenesis through E2Fa transcriptional activation, whereas E2Fa expression under control of the LBD18 promoter eliminates the need for LBD18. Besides lateral root initiation, vascular patterning is disrupted in E2Fa knockout plants, similarly as it is affected in auxin signaling and lbd mutants, indicating that the transcriptional induction of E2Fa through LBDs represents a general mechanism for auxin-dependent cell cycle activation. Our data illustrate how a conserved mechanism driving cell cycle entry has been adapted evolutionarily to connect auxin signaling with control of processes determining plant architecture
Possible Stratification Mechanism in Granular Mixtures
We propose a mechanism to explain what occurs when a mixture of grains of
different sizes and different shapes (i.e. different repose angles) is poured
into a quasi-two-dimensional cell. Specifically, we develop a model that
displays spontaneous stratification of the large and small grains in
alternating layers. We find that the key requirement for stratification is a
difference in the repose angles of the two pure species, a prediction confirmed
by experimental findings. We also identify a kink mechanism that appears to
describe essential aspects of the dynamics of stratification.Comment: 4 pages, 4 figures, http://polymer.bu.edu/~hmakse/Home.htm
Serendipitous discovery of RR Lyrae stars in the Leo V ultra-faint galaxy
During the analysis of RR Lyrae stars discovered in the High cadence
Transient Survey (HiTS) taken with the Dark Energy Camera at the 4-m telescope
at Cerro Tololo Inter-American Observatory, we found a group of three very
distant, fundamental mode pulsator RR Lyrae (type ab). The location of these
stars agrees with them belonging to the Leo V ultra-faint satellite galaxy, for
which no variable stars have been reported to date. The heliocentric distance
derived for Leo V based on these stars is 173 +/- 5 kpc. The pulsational
properties (amplitudes and periods) of these stars locate them within the locus
of the Oosterhoff II group, similar to most other ultra-faint galaxies with
known RR Lyrae stars. This serendipitous discovery shows that distant RR Lyrae
stars may be used to search for unknown faint stellar systems in the outskirts
of the Milky Way.Comment: Accepted in ApJ Letter
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